PMC:7212949 / 64087-68897
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T369 | 62-67 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T370 | 197-206 | Body_part | denotes | leukocyte | http://purl.org/sig/ont/fma/fma62852 |
| T371 | 342-352 | Body_part | denotes | neutrophil | http://purl.org/sig/ont/fma/fma62860 |
| T372 | 424-429 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T373 | 557-567 | Body_part | denotes | hemoglobin | http://purl.org/sig/ont/fma/fma62293 |
| T374 | 694-702 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T375 | 725-730 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T376 | 2750-2760 | Body_part | denotes | perimysium | http://purl.org/sig/ont/fma/fma9728 |
| T377 | 2765-2775 | Body_part | denotes | endomysium | http://purl.org/sig/ont/fma/fma9729 |
| T378 | 2832-2843 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T379 | 2857-2864 | Body_part | denotes | muscles | http://purl.org/sig/ont/fma/fma32558 |
| T380 | 3089-3095 | Body_part | denotes | Muscle | http://purl.org/sig/ont/fma/fma32558 |
| T381 | 3142-3148 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T382 | 3904-3910 | Body_part | denotes | Muscle | http://purl.org/sig/ont/fma/fma32558 |
| T383 | 3976-3982 | Body_part | denotes | Muscle | http://purl.org/sig/ont/fma/fma32558 |
| T384 | 4089-4095 | Body_part | denotes | Muscle | http://purl.org/sig/ont/fma/fma32558 |
| T385 | 4601-4609 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T386 | 4797-4806 | Body_part | denotes | platelets | http://purl.org/sig/ont/fma/fma62851 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T189 | 2750-2760 | Body_part | denotes | perimysium | http://purl.obolibrary.org/obo/UBERON_0011900 |
| T190 | 2765-2775 | Body_part | denotes | endomysium | http://purl.obolibrary.org/obo/UBERON_0011895 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T538 | 0-4 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T539 | 44-55 | Disease | denotes | lymphopenia | http://purl.obolibrary.org/obo/MONDO_0003783 |
| T540 | 103-107 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T541 | 142-160 | Disease | denotes | SARS-CoV infection | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T542 | 151-160 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T543 | 271-281 | Disease | denotes | leukopenia | http://purl.obolibrary.org/obo/MONDO_0003785 |
| T544 | 435-446 | Disease | denotes | lymphopenia | http://purl.obolibrary.org/obo/MONDO_0003783 |
| T545 | 470-478 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T546 | 625-641 | Disease | denotes | Thrombocytopenia | http://purl.obolibrary.org/obo/MONDO_0002049 |
| T547 | 962-970 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T548 | 985-993 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T549 | 995-999 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T550 | 1563-1565 | Disease | denotes | CK | http://purl.obolibrary.org/obo/MONDO_0017941 |
| T551 | 1584-1586 | Disease | denotes | CK | http://purl.obolibrary.org/obo/MONDO_0017941 |
| T552 | 1597-1599 | Disease | denotes | CK | http://purl.obolibrary.org/obo/MONDO_0017941 |
| T553 | 1601-1603 | Disease | denotes | CK | http://purl.obolibrary.org/obo/MONDO_0017941 |
| T554 | 1809-1811 | Disease | denotes | CK | http://purl.obolibrary.org/obo/MONDO_0017941 |
| T555 | 1890-1892 | Disease | denotes | CK | http://purl.obolibrary.org/obo/MONDO_0017941 |
| T556 | 1975-1977 | Disease | denotes | CK | http://purl.obolibrary.org/obo/MONDO_0017941 |
| T557 | 2086-2090 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T558 | 2112-2114 | Disease | denotes | CK | http://purl.obolibrary.org/obo/MONDO_0017941 |
| T559 | 2156-2164 | Disease | denotes | Myopathy | http://purl.obolibrary.org/obo/MONDO_0005336 |
| T560 | 2242-2250 | Disease | denotes | myopathy | http://purl.obolibrary.org/obo/MONDO_0005336 |
| T561 | 2254-2256 | Disease | denotes | CK | http://purl.obolibrary.org/obo/MONDO_0017941 |
| T562 | 2271-2279 | Disease | denotes | myositis | http://purl.obolibrary.org/obo/MONDO_0008054|http://purl.obolibrary.org/obo/MONDO_0021167 |
| T564 | 2626-2628 | Disease | denotes | CK | http://purl.obolibrary.org/obo/MONDO_0017941 |
| T565 | 3108-3120 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T566 | 3149-3157 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T567 | 3711-3713 | Disease | denotes | CK | http://purl.obolibrary.org/obo/MONDO_0017941 |
| T568 | 3722-3724 | Disease | denotes | CK | http://purl.obolibrary.org/obo/MONDO_0017941 |
| T569 | 3771-3773 | Disease | denotes | CK | http://purl.obolibrary.org/obo/MONDO_0017941 |
| T570 | 3776-3778 | Disease | denotes | CK | http://purl.obolibrary.org/obo/MONDO_0017941 |
| T571 | 3800-3802 | Disease | denotes | CK | http://purl.obolibrary.org/obo/MONDO_0017941 |
| T572 | 3813-3815 | Disease | denotes | CK | http://purl.obolibrary.org/obo/MONDO_0017941 |
| T573 | 3873-3875 | Disease | denotes | CK | http://purl.obolibrary.org/obo/MONDO_0017941 |
| T574 | 3946-3948 | Disease | denotes | CK | http://purl.obolibrary.org/obo/MONDO_0017941 |
| T575 | 4180-4182 | Disease | denotes | CK | http://purl.obolibrary.org/obo/MONDO_0017941 |
| T576 | 4228-4232 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T577 | 4234-4269 | Disease | denotes | acute respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T578 | 4240-4269 | Disease | denotes | respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0009971 |
| T579 | 4271-4273 | Disease | denotes | CK | http://purl.obolibrary.org/obo/MONDO_0017941 |
| T580 | 4374-4378 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T581 | 4384-4417 | Disease | denotes | severe acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T582 | 4451-4462 | Disease | denotes | lymphopenia | http://purl.obolibrary.org/obo/MONDO_0003783 |
| T583 | 4467-4483 | Disease | denotes | thrombocytopenia | http://purl.obolibrary.org/obo/MONDO_0002049 |
| T584 | 4487-4491 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T585 | 4648-4664 | Disease | denotes | Thrombocytopenia | http://purl.obolibrary.org/obo/MONDO_0002049 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T684 | 62-67 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T685 | 182-183 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T686 | 327-328 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T687 | 424-429 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T688 | 450-451 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T689 | 725-730 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T690 | 793-802 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T691 | 899-901 | http://purl.obolibrary.org/obo/CLO_0053799 | denotes | 45 |
| T692 | 1515-1516 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T693 | 1526-1528 | http://purl.obolibrary.org/obo/CLO_0054055 | denotes | 71 |
| T694 | 1576-1577 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T695 | 1580-1581 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T696 | 1627-1628 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T697 | 1631-1632 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T698 | 1635-1636 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T699 | 1639-1640 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T700 | 1737-1742 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T701 | 1766-1767 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T702 | 2617-2618 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T703 | 2631-2632 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T704 | 2662-2663 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T705 | 2681-2682 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T706 | 2685-2686 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T707 | 2689-2690 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T708 | 2857-2864 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscles |
| T709 | 3089-3095 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | Muscle |
| T710 | 3089-3095 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | Muscle |
| T711 | 3089-3095 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | Muscle |
| T712 | 3089-3095 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | Muscle |
| T713 | 3142-3148 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T714 | 3142-3148 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T715 | 3142-3148 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T716 | 3142-3148 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
| T717 | 3404-3406 | http://purl.obolibrary.org/obo/CLO_0001022 | denotes | Li |
| T718 | 3404-3406 | http://purl.obolibrary.org/obo/CLO_0007314 | denotes | Li |
| T719 | 3583-3585 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T720 | 3658-3660 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T721 | 3674-3676 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T722 | 3904-3910 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | Muscle |
| T723 | 3904-3910 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | Muscle |
| T724 | 3904-3910 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | Muscle |
| T725 | 3904-3910 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | Muscle |
| T726 | 3976-3982 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | Muscle |
| T727 | 3976-3982 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | Muscle |
| T728 | 3976-3982 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | Muscle |
| T729 | 3976-3982 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | Muscle |
| T730 | 4089-4095 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | Muscle |
| T731 | 4089-4095 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | Muscle |
| T732 | 4089-4095 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | Muscle |
| T733 | 4089-4095 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | Muscle |
| T734 | 4492-4495 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T735 | 4625-4626 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T45566 | 557-567 | Chemical | denotes | hemoglobin | http://purl.obolibrary.org/obo/CHEBI_35143 |
| T51 | 1723-1731 | Chemical | denotes | steroids | http://purl.obolibrary.org/obo/CHEBI_35341 |
| T81690 | 2213-2220 | Chemical | denotes | steroid | http://purl.obolibrary.org/obo/CHEBI_35341 |
| T39430 | 3404-3406 | Chemical | denotes | Li | http://purl.obolibrary.org/obo/CHEBI_30145 |
| T46196 | 4275-4283 | Chemical | denotes | creatine | http://purl.obolibrary.org/obo/CHEBI_16919|http://purl.obolibrary.org/obo/CHEBI_57947 |
| T19735 | 4571-4579 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T14614 | 4583-4589 | Chemical | denotes | ligand | http://purl.obolibrary.org/obo/CHEBI_52214 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T82 | 1670-1678 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T83 | 1670-1678 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T84 | 1670-1678 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T85 | 1670-1678 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
| T86 | 2145-2153 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T87 | 2145-2153 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T88 | 2145-2153 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T89 | 2145-2153 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
| T90 | 3089-3103 | http://purl.obolibrary.org/obo/GO_0014889 | denotes | Muscle atrophy |
| T91 | 3108-3120 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T92 | 4435-4447 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T389 | 19-32 | Phenotype | denotes | lymphocytosis | http://purl.obolibrary.org/obo/HP_0100827 |
| T390 | 44-55 | Phenotype | denotes | lymphopenia | http://purl.obolibrary.org/obo/HP_0001888 |
| T391 | 271-281 | Phenotype | denotes | leukopenia | http://purl.obolibrary.org/obo/HP_0001882 |
| T392 | 435-446 | Phenotype | denotes | lymphopenia | http://purl.obolibrary.org/obo/HP_0001888 |
| T393 | 625-641 | Phenotype | denotes | Thrombocytopenia | http://purl.obolibrary.org/obo/HP_0001873 |
| T394 | 783-830 | Phenotype | denotes | Prolonged activated partial thromboplastin time | http://purl.obolibrary.org/obo/HP_0003645 |
| T395 | 835-851 | Phenotype | denotes | elevated D-dimer | http://purl.obolibrary.org/obo/HP_0033106 |
| T396 | 1444-1451 | Phenotype | denotes | Myalgia | http://purl.obolibrary.org/obo/HP_0003326 |
| T397 | 1459-1466 | Phenotype | denotes | Myalgia | http://purl.obolibrary.org/obo/HP_0003326 |
| T398 | 1474-1481 | Phenotype | denotes | Myalgia | http://purl.obolibrary.org/obo/HP_0003326 |
| T399 | 1487-1494 | Phenotype | denotes | Myalgia | http://purl.obolibrary.org/obo/HP_0003326 |
| T400 | 1495-1505 | Phenotype | denotes | arthralgia | http://purl.obolibrary.org/obo/HP_0002829 |
| T401 | 1517-1524 | Phenotype | denotes | Myalgia | http://purl.obolibrary.org/obo/HP_0003326 |
| T402 | 1920-1927 | Phenotype | denotes | Myalgia | http://purl.obolibrary.org/obo/HP_0003326 |
| T403 | 2050-2057 | Phenotype | denotes | myalgia | http://purl.obolibrary.org/obo/HP_0003326 |
| T404 | 2058-2068 | Phenotype | denotes | arthralgia | http://purl.obolibrary.org/obo/HP_0002829 |
| T405 | 2156-2164 | Phenotype | denotes | Myopathy | http://purl.obolibrary.org/obo/HP_0003198 |
| T406 | 2242-2250 | Phenotype | denotes | myopathy | http://purl.obolibrary.org/obo/HP_0003198 |
| T407 | 2271-2279 | Phenotype | denotes | myositis | http://purl.obolibrary.org/obo/HP_0100614 |
| T408 | 2559-2566 | Phenotype | denotes | Myalgia | http://purl.obolibrary.org/obo/HP_0003326 |
| T409 | 2570-2580 | Phenotype | denotes | arthralgia | http://purl.obolibrary.org/obo/HP_0002829 |
| T410 | 2586-2593 | Phenotype | denotes | Myalgia | http://purl.obolibrary.org/obo/HP_0003326 |
| T411 | 2597-2607 | Phenotype | denotes | arthralgia | http://purl.obolibrary.org/obo/HP_0002829 |
| T412 | 2706-2723 | Phenotype | denotes | myopathic changes | http://purl.obolibrary.org/obo/HP_0003198 |
| T413 | 2966-2973 | Phenotype | denotes | Myalgia | http://purl.obolibrary.org/obo/HP_0003326 |
| T414 | 2974-2984 | Phenotype | denotes | arthralgia | http://purl.obolibrary.org/obo/HP_0002829 |
| T415 | 3089-3103 | Phenotype | denotes | Muscle atrophy | http://purl.obolibrary.org/obo/HP_0003202 |
| T416 | 3550-3557 | Phenotype | denotes | Myalgia | http://purl.obolibrary.org/obo/HP_0003326 |
| T417 | 3561-3568 | Phenotype | denotes | fatigue | http://purl.obolibrary.org/obo/HP_0012378 |
| T418 | 3574-3581 | Phenotype | denotes | Myalgia | http://purl.obolibrary.org/obo/HP_0003326 |
| T419 | 3587-3594 | Phenotype | denotes | Myalgia | http://purl.obolibrary.org/obo/HP_0003326 |
| T420 | 3602-3609 | Phenotype | denotes | Myalgia | http://purl.obolibrary.org/obo/HP_0003326 |
| T421 | 3613-3623 | Phenotype | denotes | arthralgia | http://purl.obolibrary.org/obo/HP_0002829 |
| T422 | 3631-3638 | Phenotype | denotes | Myalgia | http://purl.obolibrary.org/obo/HP_0003326 |
| T423 | 3642-3649 | Phenotype | denotes | fatigue | http://purl.obolibrary.org/obo/HP_0012378 |
| T424 | 3666-3673 | Phenotype | denotes | Myalgia | http://purl.obolibrary.org/obo/HP_0003326 |
| T425 | 3904-3915 | Phenotype | denotes | Muscle ache | http://purl.obolibrary.org/obo/HP_0003326 |
| T426 | 3976-3987 | Phenotype | denotes | Muscle ache | http://purl.obolibrary.org/obo/HP_0003326 |
| T427 | 4013-4020 | Phenotype | denotes | Myalgia | http://purl.obolibrary.org/obo/HP_0003326 |
| T428 | 4024-4031 | Phenotype | denotes | fatigue | http://purl.obolibrary.org/obo/HP_0012378 |
| T429 | 4089-4100 | Phenotype | denotes | Muscle ache | http://purl.obolibrary.org/obo/HP_0003326 |
| T430 | 4240-4260 | Phenotype | denotes | respiratory distress | http://purl.obolibrary.org/obo/HP_0002098 |
| T431 | 4451-4462 | Phenotype | denotes | lymphopenia | http://purl.obolibrary.org/obo/HP_0001888 |
| T432 | 4467-4483 | Phenotype | denotes | thrombocytopenia | http://purl.obolibrary.org/obo/HP_0001873 |
| T433 | 4601-4615 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T434 | 4648-4664 | Phenotype | denotes | Thrombocytopenia | http://purl.obolibrary.org/obo/HP_0001873 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T634 | 0-9 | Sentence | denotes | SARS-CoVa |
| T635 | 10-303 | Sentence | denotes | Reactive lymphocytosis and severe lymphopenia (<500 cells/mm3) are uncommon in patients with SARS (Table 7 ).10 , 126 Patients with SARS-CoV infection often presented with a normal total leukocyte counts.126 , 127 There was no correlation between the degree of leukopenia and disease severity. |
| T636 | 304-548 | Sentence | denotes | However, patients with a high initial neutrophil count had worse outcomes.1 Chng et al reported mild to moderate (<1000 cells/mm3) lymphopenia as a common finding in SARS-CoV (70-98% of patients), especially during the first 10 days of illness. |
| T637 | 549-920 | Sentence | denotes | Initial hemoglobin levels were often normal but gradually decrease later.10 Thrombocytopenia was present in up to half of the patients, although platelet count levels <100,000 cells/mm3 are rare, and they usually normalized later.128 Prolonged activated partial thromboplastin time and elevated D-dimer levels were also common abnormalities (63% and 45%, respectively).10 |
| T638 | 921-994 | Sentence | denotes | Table 7 Musculoskeletal Manifestation of SARS-CoV, MERS-CoV and COVID-19. |
| T639 | 995-1051 | Sentence | denotes | SARS (only studies with large study population included) |
| T640 | 1052-1425 | Sentence | denotes | Study Lee et al (2003)N = 138, confirmed casesRetrospective study Donnelly et al (2003)N = 1425, confirmed casesRetrospective study Choi et al (2003)N = 267 (227 confirmed cases)Retrospective study Chen et al (2005)N = 67, confirmed casesRetrospective study Leung et al (2005)N = 8, probableClinicopathologic study Yu et al (2006)N = 121, confirmed casesRetrospective study |
| T641 | 1426-1452 | Sentence | denotes | Clinical features Myalgia: |
| T642 | 1453-1467 | Sentence | denotes | 60.9% Myalgia: |
| T643 | 1468-1482 | Sentence | denotes | 50.8% Myalgia: |
| T644 | 1483-1506 | Sentence | denotes | 50% Myalgia/arthralgia: |
| T645 | 1507-1525 | Sentence | denotes | 13.4% N/A Myalgia: |
| T646 | 1526-1529 | Sentence | denotes | 71% |
| T647 | 1530-1609 | Sentence | denotes | Key findings on investigations ↑ CK (32.1%) N/A N/A ↑ CK (20.9%) ↑ CK ↑CK (26%) |
| T648 | 1610-1678 | Sentence | denotes | Histopathology N/A N/A N/A N/A • Focal myofiber coagulative necrosis |
| T649 | 1679-1731 | Sentence | denotes | • Myofiber atrophy in patients who received steroids |
| T650 | 1732-1767 | Sentence | denotes | • No virus detected or cultured N/A |
| T651 | 1768-2153 | Sentence | denotes | Key study findings and message High peak CK predictive of ICU admission and death (univariate, P = 0.04)(Association with CK on admission had P = 0.06) Myalgia commonly reported No significant difference in CK levels in probable and confirmed patients No difference in reporting of myalgia/arthralgia in patients with ARDS vs. without • Higher CK associated with more myofiber necrosis |
| T652 | 2154-2305 | Sentence | denotes | • Myopathy possibly immune mediated, possible component of steroid and critical illness myopathy • ↑CK likely due to myositis as cardiac enzymes normal |
| T653 | 2306-2310 | Sentence | denotes | MERS |
| T654 | 2311-2539 | Sentence | denotes | Study Omrani et al (2013)N = 3, confirmed casesRetrospective study Saad et al (2014)N = 70, confirmed casesRetrospective study Kim et al (2017)N = 23, confirmed casesRetrospective study Alsaad et al (2017)N = 1,Clinicopathologic |
| T655 | 2540-2581 | Sentence | denotes | Signs and symptoms Myalgia or arthralgia: |
| T656 | 2582-2608 | Sentence | denotes | 20% Myalgia or arthralgia: |
| T657 | 2609-2618 | Sentence | denotes | 26.9% N/A |
| T658 | 2619-2663 | Sentence | denotes | Labs ↑ CK N/A Electromyogram in 1 normal N/A |
| T659 | 2664-2723 | Sentence | denotes | Histopathology N/A N/A N/A • Atrophic and myopathic changes |
| T660 | 2724-2801 | Sentence | denotes | • Inflammatory changes in perimysium and endomysium, more in areas of atrophy |
| T661 | 2802-2864 | Sentence | denotes | • Viral particles detected in macrophages infiltrating muscles |
| T662 | 2865-3120 | Sentence | denotes | Key study findings and message Mild/asymptomatic cases may contribute to spread more than recognised Myalgia/arthralgia common nonrespiratory symptom Neuromuscular complications during MERS treatment may be underdiagnosed • Muscle atrophy and inflammation |
| T663 | 3121-3148 | Sentence | denotes | • Viral particles in muscle |
| T664 | 3149-3157 | Sentence | denotes | COVID-19 |
| T665 | 3158-3531 | Sentence | denotes | Study Huang et al (2020)N = 41, confirmed casesRetrospective study Chen et al (2020)N = 99, confirmed casesRetrospective Wang et al (2020)N = 138, confirmed cases, Retrospective study Guan et al (2020)N = 1099, confirmed casesRetrospective study Li et al (2020)N = 1994, confirmed casesMeta-analysis, 10 studies Zhang et al (2020)N = 645, confirmed casesRetrospective study |
| T666 | 3532-3569 | Sentence | denotes | Clinical features Myalgia or fatigue: |
| T667 | 3570-3582 | Sentence | denotes | 44% Myalgia: |
| T668 | 3583-3595 | Sentence | denotes | 11% Myalgia: |
| T669 | 3596-3624 | Sentence | denotes | 34.8% Myalgia or arthralgia: |
| T670 | 3625-3650 | Sentence | denotes | 14.9% Myalgia or fatigue: |
| T671 | 3651-3677 | Sentence | denotes | 35.8% (11-50%) Myalgia:11% |
| T672 | 3678-3791 | Sentence | denotes | Key findings on investigations ↑ CK (33%) ↑ CK (13%) (associated with ↑ myocardial enzymes) ↑CK ↑ CK> = 200 U/mL: |
| T673 | 3792-3803 | Sentence | denotes | 13.7% ↑ CK: |
| T674 | 3804-3815 | Sentence | denotes | 13-33% ↑ CK |
| T675 | 3816-4054 | Sentence | denotes | Key study findings and message No difference in level of CK in ICU and non-ICU patients Muscle ache less commonly reported Higher CK in ICU patients (P = 0.08) Muscle ache less commonly reported • Myalgia or fatigue more commonly reported |
| T676 | 4055-4170 | Sentence | denotes | • 5% case fatality rate overall • Muscle ache at admission associated with more severe/critical disease (P = 0.002) |
| T677 | 4171-4227 | Sentence | denotes | • Higher CK in patients with abnormal imaging (P < 0.05) |
| T678 | 4228-4430 | Sentence | denotes | ARDS, acute respiratory distress syndrome; CK, creatine kinase; ICU, intensive care unit; MERS-CoV, middle east respiratory syndrome coronavirus; SARS-COV, severe acute respiratory syndrome coronavirus. |
| T679 | 4431-4515 | Sentence | denotes | The pathogenesis of lymphopenia and thrombocytopenia in SARS has been controversial. |
| T680 | 4516-4810 | Sentence | denotes | In addition to traditional theories, vascular adhesion molecule-1, ligand and severe cytokine storm may play a vital role.129 , 130 Thrombocytopenia could be due to the result of interplay between autoantibodies, immune complexes, increased consumption and decreased production of platelets.128 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1483 | 0-9 | GO:0030168;CL:0000233 | denotes | SARS-CoVa |
| T1484 | 14-22 | SP_9 | denotes | tive lym |
| T1485 | 65-74 | CL:0000738 | denotes | ls/mm3) a |
| T1486 | 315-323 | SP_9 | denotes | tients w |
| T1487 | 407-415 | SP_9 | denotes | moderat |
| T1488 | 576-584 | SP_7 | denotes | ere ofte |
| T1489 | 604-615 | GO:0030097 | denotes | ly decrease |
| T1490 | 634-642 | SP_7 | denotes | topenia |
| T1491 | 718-728 | CL:0000738 | denotes | 00,000 cel |
| T1492 | 816-827 | NCBITaxon:11118 | denotes | boplastin t |
| T1493 | 1019-1029 | CL:0000542 | denotes | large stud |
| T1494 | 1070-1078 | SP_7 | denotes | 003)N = |
| T1495 | 1171-1179 | SP_7 | denotes | ective s |
| T1496 | 1572-1586 | GO:0007596 | denotes | ) N/A N/A ↑ CK |
| T1497 | 1705-1719 | GO:0007596 | denotes | ents who recei |
| T1498 | 1791-1806 | GO:0050817 | denotes | message High pe |
| T1499 | 1863-1881 | PR:000005897 | denotes | P = 0.04)(Associat |
| T1500 | 1990-1998 | SP_10 | denotes | obable a |
| T1501 | 2033-2041 | SP_10 | denotes | in repo |
| T1502 | 2045-2054 | GO:0007565 | denotes | g of myal |
| T1503 | 2103-2111 | GO:0007565 | denotes | • Higher |
| T1504 | 2148-2156 | GO:0007565 | denotes | rosis • |
| T1505 | 2256-2265 | GO:0007565 | denotes | likely d |
| T1506 | 2328-2332 | SP_10 | denotes | l (2 |
| T1507 | 2466-2475 | CHEBI:50905;CHEBI:50905 | denotes | irmed cas |
| T1508 | 2476-2485 | DG_29 | denotes | sRetrospe |
| T1509 | 2603-2611 | GO:0007565 | denotes | lgia: 26 |
| T1510 | 2652-2660 | GO:0007565 | denotes | normal |
| T1511 | 2667-2671 | GO:0016265 | denotes | topa |
| T1512 | 2690-2694 | GO:0016265 | denotes | • A |
| T1513 | 2807-2816 | GO:0007565 | denotes | al partic |
| T1514 | 2820-2829 | GO:0007567 | denotes | detected |
| T1515 | 2970-2978 | SP_10 | denotes | gia/arth |
| T1516 | 2980-2988 | SP_9 | denotes | lgia com |
| T1517 | 2993-3002 | SP_7 | denotes | onrespira |
| T1518 | 3009-3014 | SP_10 | denotes | mptom |
| T1519 | 3466-3477 | CL:0000542 | denotes | ies Zhang e |
| T1520 | 3492-3497 | UBERON:0000178 | denotes | 645, |
| T1521 | 3605-3619 | GO:0007596 | denotes | lgia or arthra |
| T1522 | 3640-3643 | PR:000001004 | denotes | r f |
| T1523 | 3883-3894 | CL:0000542 | denotes | and non-ICU |
| T1524 | 3978-3986 | CL:0000233 | denotes | scle ach |
| T1525 | 4017-4028 | CL:0000542 | denotes | gia or fati |
| T1526 | 4136-4150 | GO:0007596 | denotes | evere/critical |
| T1527 | 4221-4227 | UBERON:0000062 | denotes | 0.05) |
| T1528 | 4231-4241 | GO:0016265 | denotes | S, acute r |
| T1529 | 4254-4261 | UBERON:0002106 | denotes | stress |
| T1530 | 4348-4353 | GO:0016265 | denotes | ory s |
| T1531 | 4366-4369 | PR:000001004 | denotes | avi |
| T1532 | 4428-4433 | GO:0016265 | denotes | s. Th |
| T1533 | 4572-4577 | NCBITaxon:10239 | denotes | olecu |
| T1534 | 4588-4601 | GO:0030097;CL:0000037 | denotes | d and severe |
| T1535 | 4602-4612 | CL:0000037 | denotes | ytokine st |
| T1536 | 4617-4631 | CL:0000556 | denotes | ay play a vita |
| T1537 | 4660-4664 | UBERON:0002048 | denotes | enia |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1621 | 3873-3875 | Gene | denotes | CK | Gene:51727 |
| 1622 | 3711-3713 | Gene | denotes | CK | Gene:51727 |
| 1623 | 4180-4182 | Gene | denotes | CK | Gene:51727 |
| 1624 | 3946-3948 | Gene | denotes | CK | Gene:51727 |
| 1625 | 3813-3815 | Gene | denotes | CK | Gene:51727 |
| 1626 | 3800-3802 | Gene | denotes | CK | Gene:51727 |
| 1627 | 3722-3724 | Gene | denotes | CK | Gene:51727 |
| 1628 | 3895-3903 | Species | denotes | patients | Tax:9606 |
| 1629 | 3956-3964 | Species | denotes | patients | Tax:9606 |
| 1630 | 4186-4194 | Species | denotes | patients | Tax:9606 |
| 1631 | 3149-3157 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1632 | 3550-3557 | Disease | denotes | Myalgia | MESH:D063806 |
| 1633 | 3561-3568 | Disease | denotes | fatigue | MESH:D005221 |
| 1634 | 3574-3581 | Disease | denotes | Myalgia | MESH:D063806 |
| 1635 | 3587-3594 | Disease | denotes | Myalgia | MESH:D063806 |
| 1636 | 3602-3609 | Disease | denotes | Myalgia | MESH:D063806 |
| 1637 | 3613-3623 | Disease | denotes | arthralgia | MESH:D018771 |
| 1638 | 3631-3638 | Disease | denotes | Myalgia | MESH:D063806 |
| 1639 | 3642-3649 | Disease | denotes | fatigue | MESH:D005221 |
| 1640 | 3666-3673 | Disease | denotes | Myalgia | MESH:D063806 |
| 1641 | 3904-3915 | Disease | denotes | Muscle ache | MESH:D063806 |
| 1642 | 3976-3987 | Disease | denotes | Muscle ache | MESH:D063806 |
| 1643 | 4013-4020 | Disease | denotes | Myalgia | MESH:D063806 |
| 1644 | 4024-4031 | Disease | denotes | fatigue | MESH:D005221 |
| 1645 | 4089-4100 | Disease | denotes | Muscle ache | MESH:D063806 |
| 1649 | 962-970 | Species | denotes | SARS-CoV | Tax:694009 |
| 1650 | 972-980 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1651 | 985-993 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1660 | 4275-4290 | Gene | denotes | creatine kinase | |
| 1661 | 4271-4273 | Gene | denotes | CK | Gene:51727 |
| 1662 | 4318-4326 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1663 | 4328-4372 | Species | denotes | middle east respiratory syndrome coronavirus | Tax:1335626 |
| 1664 | 4374-4382 | Species | denotes | SARS-COV | Tax:694009 |
| 1665 | 4384-4429 | Species | denotes | severe acute respiratory syndrome coronavirus | Tax:694009 |
| 1666 | 4228-4232 | Disease | denotes | ARDS | MESH:D012128 |
| 1667 | 4234-4269 | Disease | denotes | acute respiratory distress syndrome | MESH:D012128 |
| 1680 | 89-97 | Species | denotes | patients | Tax:9606 |
| 1681 | 128-136 | Species | denotes | Patients | Tax:9606 |
| 1682 | 313-321 | Species | denotes | patients | Tax:9606 |
| 1683 | 470-478 | Species | denotes | SARS-CoV | Tax:694009 |
| 1684 | 490-498 | Species | denotes | patients | Tax:9606 |
| 1685 | 675-683 | Species | denotes | patients | Tax:9606 |
| 1686 | 19-32 | Disease | denotes | lymphocytosis | MESH:D008218 |
| 1687 | 44-55 | Disease | denotes | lymphopenia | MESH:D008231 |
| 1688 | 142-160 | Disease | denotes | SARS-CoV infection | MESH:C000657245 |
| 1689 | 271-281 | Disease | denotes | leukopenia | MESH:D007970 |
| 1690 | 435-446 | Disease | denotes | lymphopenia | MESH:D008231 |
| 1691 | 625-641 | Disease | denotes | Thrombocytopenia | MESH:D013921 |
| 1695 | 4451-4462 | Disease | denotes | lymphopenia | MESH:D008231 |
| 1696 | 4467-4483 | Disease | denotes | thrombocytopenia | MESH:D013921 |
| 1697 | 4648-4664 | Disease | denotes | Thrombocytopenia | MESH:D013921 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32620220-12682352-2074226 | 119-121 | 12682352 | denotes | 10 |
| 32620220-15686503-2074227 | 124-127 | 15686503 | denotes | 126 |
| 32620220-15686503-2074228 | 214-217 | 15686503 | denotes | 126 |
| 32620220-15018129-2074229 | 220-223 | 15018129 | denotes | 127 |
| 32620220-12682352-2074230 | 622-624 | 12682352 | denotes | 10 |
| 32620220-16019455-2074231 | 779-782 | 16019455 | denotes | 128 |
| 32620220-12682352-2074232 | 918-920 | 12682352 | denotes | 10 |
| 32620220-16182592-2074233 | 4638-4641 | 16182592 | denotes | 129 |
| 32620220-16019455-2074234 | 4807-4810 | 16019455 | denotes | 128 |