PMC:7212949 / 42147-43972 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7212949","sourcedb":"PMC","sourceid":"7212949","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7212949","text":"COVID-19\nStudy Wang et al (2020)N = 138, confirmed casesClinicopathologic study Guan et al (2020)N = 1099, confirmed casesRetrospective study To et al (2020)N = 12, suspected casesClinicopathologic study Xie et al (2020)N = 19 suspected (9 confirmed cases)Clinicopathologic study Pan et al (2020)N = 204, confirmed casesRetrospective study Wu et al (2020)N = 74, confirmed casesClinicopathologic study\nClinical features • Anorexia (39.9)\n• Diarrhea (10.1)\n• Nausea (10.1%)\n• Vomiting (3.6%)\n• Abdominal pain (2.2%) • Diarrhea (3.8%)\n• Nausea or vomiting (5%) Diarrhea (11.1% of confirmed) • Any GI symptom: 50.5%\n• Only GI symptoms: 0.03%\n• Loss of appetite (39.7% of total, 78.6% of all GI symptoms)\n• Diarrhea (17.1%, 34%, usually 3/day)\n• Vomiting (0.02%, 3.9%)\n• Abdominal pain (0.01%, 1.9%) Diarrhea/Vomit/Stomachache (44.6%)\nKey findings on investigations N/A N/A • 2019-nCoV detected in 91.7% saliva samples\n• Virus cultured from 3/12 saliva samples RNA positive stool samples: 88.9% of confirmed (overall 42%) ↑ALT, AST↑ PT↓monocyte count • RNA positive stool samples: 55%\nKey study findings and message ICU patients more likely to have anorexia and abdominal pain (P \u003c 0.001, P = 0.02) GI symptoms less common • Presence of GI symptoms not associated with stool RNA positivity\n• Fecal transmission possible • Patients with GI symptoms had longer interval from symptom onset to admission (P = 0.013)\n• GI symptoms worsened with severity of disease\n• Patients with GI symptoms more likely to get antibiotics (P = 0.018)\n• No association presence of GI symptoms with total hospital stay, ICU days or mortality • Presence of GI symptoms not associated with stool positivity\n• Prolonged fecal viral shedding up to 5 weeks\n• Disease severity not associated with prolonged fecal 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