PMC:7212949 / 25554-26014 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T122","span":{"begin":244,"end":252},"obj":"Body_part"},{"id":"T123","span":{"begin":409,"end":414},"obj":"Body_part"}],"attributes":[{"id":"A122","pred":"fma_id","subj":"T122","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A123","pred":"fma_id","subj":"T123","obj":"http://purl.org/sig/ont/fma/fma7088"}],"text":"Key Study findings and message ↑BP more common in ICU patients (P = 0.018) ICU patients more likely to have pre-existing hypertension, develop arrhythmias, acute cardiac injury (P \u003c 0.001) Proposed mechanism of cardiac injury:• ACE 2 related\n• Cytokine storm\n• Hypoxemia • ICU admission most commonly due to hypoxemic respiratory failure, vasopressor requirement or both\n• 50% mortality • Similar symptoms in heart transplant patients as nontransplant patients"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T73","span":{"begin":409,"end":414},"obj":"Body_part"}],"attributes":[{"id":"A73","pred":"uberon_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/UBERON_0000948"}],"text":"Key Study findings and message ↑BP more common in ICU patients (P = 0.018) ICU patients more likely to have pre-existing hypertension, develop arrhythmias, acute cardiac injury (P \u003c 0.001) Proposed mechanism of cardiac injury:• ACE 2 related\n• Cytokine storm\n• Hypoxemia • ICU admission most commonly due to hypoxemic respiratory failure, vasopressor requirement or both\n• 50% mortality • Similar symptoms in heart transplant patients as nontransplant patients"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T196","span":{"begin":121,"end":133},"obj":"Disease"},{"id":"T197","span":{"begin":143,"end":154},"obj":"Disease"},{"id":"T198","span":{"begin":170,"end":176},"obj":"Disease"},{"id":"T199","span":{"begin":219,"end":225},"obj":"Disease"},{"id":"T200","span":{"begin":318,"end":337},"obj":"Disease"}],"attributes":[{"id":"A196","pred":"mondo_id","subj":"T196","obj":"http://purl.obolibrary.org/obo/MONDO_0005044"},{"id":"A197","pred":"mondo_id","subj":"T197","obj":"http://purl.obolibrary.org/obo/MONDO_0007263"},{"id":"A198","pred":"mondo_id","subj":"T198","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A199","pred":"mondo_id","subj":"T199","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A200","pred":"mondo_id","subj":"T200","obj":"http://purl.obolibrary.org/obo/MONDO_0021113"}],"text":"Key Study findings and message ↑BP more common in ICU patients (P = 0.018) ICU patients more likely to have pre-existing hypertension, develop arrhythmias, acute cardiac injury (P \u003c 0.001) Proposed mechanism of cardiac injury:• ACE 2 related\n• Cytokine storm\n• Hypoxemia • ICU admission most commonly due to hypoxemic respiratory failure, vasopressor requirement or both\n• 50% mortality • Similar symptoms in heart transplant patients as nontransplant patients"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T238","span":{"begin":409,"end":414},"obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"T239","span":{"begin":409,"end":414},"obj":"http://purl.obolibrary.org/obo/UBERON_0007100"},{"id":"T240","span":{"begin":409,"end":414},"obj":"http://purl.obolibrary.org/obo/UBERON_0015228"},{"id":"T241","span":{"begin":409,"end":414},"obj":"http://www.ebi.ac.uk/efo/EFO_0000815"}],"text":"Key Study findings and message ↑BP more common in ICU patients (P = 0.018) ICU patients more likely to have pre-existing hypertension, develop arrhythmias, acute cardiac injury (P \u003c 0.001) Proposed mechanism of cardiac injury:• ACE 2 related\n• Cytokine storm\n• Hypoxemia • ICU admission most commonly due to hypoxemic respiratory failure, vasopressor requirement or both\n• 50% mortality • Similar symptoms in heart transplant patients as nontransplant patients"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T64","span":{"begin":32,"end":34},"obj":"Chemical"}],"attributes":[{"id":"A64","pred":"chebi_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/CHEBI_29865"}],"text":"Key Study findings and message ↑BP more common in ICU patients (P = 0.018) ICU patients more likely to have pre-existing hypertension, develop arrhythmias, acute cardiac injury (P \u003c 0.001) Proposed mechanism of cardiac injury:• ACE 2 related\n• Cytokine storm\n• Hypoxemia • ICU admission most commonly due to hypoxemic respiratory failure, vasopressor requirement or both\n• 50% mortality • Similar symptoms in heart transplant patients as nontransplant patients"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T163","span":{"begin":121,"end":133},"obj":"Phenotype"},{"id":"T164","span":{"begin":143,"end":154},"obj":"Phenotype"},{"id":"T165","span":{"begin":244,"end":258},"obj":"Phenotype"},{"id":"T166","span":{"begin":261,"end":270},"obj":"Phenotype"},{"id":"T167","span":{"begin":318,"end":337},"obj":"Phenotype"}],"attributes":[{"id":"A163","pred":"hp_id","subj":"T163","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"id":"A164","pred":"hp_id","subj":"T164","obj":"http://purl.obolibrary.org/obo/HP_0011675"},{"id":"A165","pred":"hp_id","subj":"T165","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A166","pred":"hp_id","subj":"T166","obj":"http://purl.obolibrary.org/obo/HP_0012418"},{"id":"A167","pred":"hp_id","subj":"T167","obj":"http://purl.obolibrary.org/obo/HP_0002878"}],"text":"Key Study findings and message ↑BP more common in ICU patients (P = 0.018) ICU patients more likely to have pre-existing hypertension, develop arrhythmias, acute cardiac injury (P \u003c 0.001) Proposed mechanism of cardiac injury:• ACE 2 related\n• Cytokine storm\n• Hypoxemia • ICU admission most commonly due to hypoxemic respiratory failure, vasopressor requirement or both\n• 50% mortality • Similar symptoms in heart transplant patients as nontransplant patients"}

{"project":"LitCovid-sentences","denotations":[{"id":"T286","span":{"begin":0,"end":241},"obj":"Sentence"},{"id":"T287","span":{"begin":242,"end":258},"obj":"Sentence"},{"id":"T288","span":{"begin":259,"end":370},"obj":"Sentence"},{"id":"T289","span":{"begin":371,"end":460},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Key Study findings and message ↑BP more common in ICU patients (P = 0.018) ICU patients more likely to have pre-existing hypertension, develop arrhythmias, acute cardiac injury (P \u003c 0.001) Proposed mechanism of cardiac injury:• ACE 2 related\n• Cytokine storm\n• Hypoxemia • ICU admission most commonly due to hypoxemic respiratory failure, vasopressor requirement or both\n• 50% mortality • Similar symptoms in heart transplant patients as nontransplant patients"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T1748","span":{"begin":135,"end":154},"obj":"GO:0016265"},{"id":"T1749","span":{"begin":287,"end":291},"obj":"GO:0007565"},{"id":"T1750","span":{"begin":335,"end":386},"obj":"UBERON:0001004"},{"id":"T1751","span":{"begin":409,"end":425},"obj":"GO:0007567"},{"id":"T852","span":{"begin":107,"end":117},"obj":"UBERON:0000916"},{"id":"T853","span":{"begin":341,"end":346},"obj":"UBERON:0001988"},{"id":"T854","span":{"begin":355,"end":360},"obj":"NCBITaxon:10239"},{"id":"T855","span":{"begin":369,"end":373},"obj":"PR:000022138"},{"id":"T856","span":{"begin":383,"end":388},"obj":"UBERON:0001988"}],"text":"Key Study findings and message ↑BP more common in ICU patients (P = 0.018) ICU patients more likely to have pre-existing hypertension, develop arrhythmias, acute cardiac injury (P \u003c 0.001) Proposed mechanism of cardiac injury:• ACE 2 related\n• Cytokine storm\n• Hypoxemia • ICU admission most commonly due to hypoxemic respiratory failure, vasopressor requirement or both\n• 50% mortality • Similar symptoms in heart transplant patients as nontransplant patients"}

{"project":"LitCovid-PubTator","denotations":[{"id":"588","span":{"begin":228,"end":233},"obj":"Gene"},{"id":"594","span":{"begin":54,"end":62},"obj":"Species"},{"id":"595","span":{"begin":79,"end":87},"obj":"Species"},{"id":"596","span":{"begin":426,"end":434},"obj":"Species"},{"id":"597","span":{"begin":452,"end":460},"obj":"Species"},{"id":"605","span":{"begin":121,"end":133},"obj":"Disease"},{"id":"606","span":{"begin":143,"end":154},"obj":"Disease"},{"id":"607","span":{"begin":162,"end":176},"obj":"Disease"},{"id":"608","span":{"begin":211,"end":225},"obj":"Disease"},{"id":"609","span":{"begin":253,"end":270},"obj":"Disease"},{"id":"610","span":{"begin":318,"end":337},"obj":"Disease"},{"id":"611","span":{"begin":377,"end":386},"obj":"Disease"}],"attributes":[{"id":"A588","pred":"tao:has_database_id","subj":"588","obj":"Gene:59272"},{"id":"A594","pred":"tao:has_database_id","subj":"594","obj":"Tax:9606"},{"id":"A595","pred":"tao:has_database_id","subj":"595","obj":"Tax:9606"},{"id":"A596","pred":"tao:has_database_id","subj":"596","obj":"Tax:9606"},{"id":"A597","pred":"tao:has_database_id","subj":"597","obj":"Tax:9606"},{"id":"A605","pred":"tao:has_database_id","subj":"605","obj":"MESH:D006973"},{"id":"A606","pred":"tao:has_database_id","subj":"606","obj":"MESH:D001145"},{"id":"A607","pred":"tao:has_database_id","subj":"607","obj":"MESH:D006331"},{"id":"A608","pred":"tao:has_database_id","subj":"608","obj":"MESH:D006331"},{"id":"A610","pred":"tao:has_database_id","subj":"610","obj":"MESH:D012131"},{"id":"A611","pred":"tao:has_database_id","subj":"611","obj":"MESH:D003643"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Key Study findings and message ↑BP more common in ICU patients (P = 0.018) ICU patients more likely to have pre-existing hypertension, develop arrhythmias, acute cardiac injury (P \u003c 0.001) Proposed mechanism of cardiac injury:• ACE 2 related\n• Cytokine storm\n• Hypoxemia • ICU admission most commonly due to hypoxemic respiratory failure, vasopressor requirement or both\n• 50% mortality • Similar symptoms in heart transplant patients as nontransplant patients"}