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PMC:7205724 / 7828-9529 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
275 7-16 Species denotes SARS-CoV2 Tax:2697049
284 227-255 Gene denotes glucose‐regulated protein 78 Gene:3309
285 257-262 Gene denotes GRP78 Gene:3309
286 305-310 Gene denotes GRP78 Gene:3309
287 326-329 Gene denotes BiP Gene:3309
288 333-338 Gene denotes HSPA5 Gene:3309
289 737-742 Gene denotes GRP78 Gene:3309
290 280-303 Disease denotes kDa heat shock proteins MESH:D012769
291 691-703 Disease denotes inflammation MESH:D007249
301 1373-1378 Gene denotes GRP78 Gene:3309
302 1495-1500 Gene denotes GRP78 Gene:3309
303 1574-1579 Gene denotes GRP78 Gene:3309
304 1038-1043 Gene denotes spike Gene:43740568
305 780-785 Gene denotes spike Gene:43740568
306 770-779 Species denotes 2019-nCoV Tax:2697049
307 798-807 Chemical denotes disulfide MESH:D004220
308 907-912 Chemical denotes Pep42
309 1256-1261 Chemical denotes Pep42

LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T3 227-234 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T55 96-108 Body_part denotes cell-surface http://purl.org/sig/ont/fma/fma67653
T56 96-100 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T57 214-226 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T58 214-218 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T59 227-234 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T60 245-252 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T61 295-303 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T62 346-367 Body_part denotes endoplasmic reticulum http://purl.org/sig/ont/fma/fma63842
T63 405-426 Body_part denotes endoplasmic reticulum http://purl.org/sig/ont/fma/fma63842
T64 587-594 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T65 639-643 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T66 786-793 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T53 7-11 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T54 691-703 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T86 96-100 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T87 124-125 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T88 214-218 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T89 265-266 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T90 434-442 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T91 639-643 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T92 644-653 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T93 984-985 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94 1229-1230 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T95 1345-1346 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T107 133-145 Chemical denotes oligopeptide http://purl.obolibrary.org/obo/CHEBI_25676
T108 227-234 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167
T110 245-252 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T111 295-303 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T112 587-594 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T113 786-793 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T114 798-807 Chemical denotes disulfide http://purl.obolibrary.org/obo/CHEBI_48343
T115 946-948 Chemical denotes IV http://purl.obolibrary.org/obo/CHEBI_74327
T116 1207-1209 Chemical denotes IV http://purl.obolibrary.org/obo/CHEBI_74327
T117 1339-1341 Chemical denotes IV http://purl.obolibrary.org/obo/CHEBI_74327
T118 1462-1464 Chemical denotes IV http://purl.obolibrary.org/obo/CHEBI_74327
T119 1513-1515 Chemical denotes IV http://purl.obolibrary.org/obo/CHEBI_74327

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T40 96-100 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T41 214-218 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T42 564-573 http://purl.obolibrary.org/obo/BFO_0000034 denotes functions
T43 639-643 http://purl.obolibrary.org/obo/CL_0000000 denotes cell

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T74 133-145 Chemical denotes oligopeptide http://purl.obolibrary.org/obo/CHEBI_25676
T75 227-234 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_4167|http://purl.obolibrary.org/obo/CHEBI_17234
T77 245-252 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T78 295-303 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T79 587-594 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T80 786-793 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T81 798-807 Chemical denotes disulfide http://purl.obolibrary.org/obo/CHEBI_48343

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T71 7-16 Species denotes SARS-CoV2 NCBItxid:2697049
T72 770-779 Species denotes 2019-nCoV NCBItxid:2697049

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T68 0-114 Sentence denotes 3.1.4 SARS-CoV2 receptor binding domain contains cyclic regions that can make interaction with cell-surface GRP78
T69 115-304 Sentence denotes Pep42 is a cyclic oligopeptide that, with its hydrophobic character, can selectively interact with cell surface glucose‐regulated protein 78 (GRP78), a member of 70 kDa heat shock proteins.
T70 305-526 Sentence denotes GRP78, also known as BiP or HSPA5, under endoplasmic reticulum stress, can be translocated from the endoplasmic reticulum to the membrane and helps to maintain cellular integrity under physiologic and pathological stress.
T71 527-718 Sentence denotes It critically contributes to various functions ranging from protein folding, transportation, and degradation to cell-signaling, proliferation, survival, apoptosis, inflammation, and immunity.
T72 719-762 Sentence denotes The expression of GRP78 decreases with age.
T73 763-917 Sentence denotes On the 2019-nCoV spike protein, 13 disulfide bonds are corresponding to 13 different cyclic regions thought to be similar to the cyclic form of Pep42 [8].
T74 918-1083 Sentence denotes Among these, four regions I-IV take place in the outer surface of a putative receptor-binding domain (RBD) on the viral spike., including C361, C379, C391, and C480.
T75 1084-1166 Sentence denotes These regions share sequence similarity with Pep42, ranging from 15.38% to 46.15%.
T76 1167-1276 Sentence denotes However, only one of them, i.e., region IV (GRAVY = 0.08), is a hydrophobic region, like Pep42 (GRAVY = 1.1).
T77 1277-1501 Sentence denotes Structural models evaluate the energy contribution for region IV as a part of region III to the GRP78 to be about (−9.8 out of −14.0 kcal/mol), and the docking platform proposes region IV as the best region binding to GRP78.
T78 1502-1701 Sentence denotes The region IV can be linked to the substrate-binding domain β (SBDB) of GRP78 using five H-bonds (through P479, N481, E484, and N487) and four hydrophobic interactions (through T478, E484, and F486).

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
275 7-16 Species denotes SARS-CoV2 Tax:2697049
284 227-255 Gene denotes glucose‐regulated protein 78 Gene:3309
285 257-262 Gene denotes GRP78 Gene:3309
290 280-303 Disease denotes kDa heat shock proteins MESH:D012769
286 305-310 Gene denotes GRP78 Gene:3309
287 326-329 Gene denotes BiP Gene:3309
288 333-338 Gene denotes HSPA5 Gene:3309
291 691-703 Disease denotes inflammation MESH:D007249
289 737-742 Gene denotes GRP78 Gene:3309
306 770-779 Species denotes 2019-nCoV Tax:2697049
305 780-785 Gene denotes spike Gene:43740568
307 798-807 Chemical denotes disulfide MESH:D004220
308 907-912 Chemical denotes Pep42
304 1038-1043 Gene denotes spike Gene:43740568
309 1256-1261 Chemical denotes Pep42
301 1373-1378 Gene denotes GRP78 Gene:3309
302 1495-1500 Gene denotes GRP78 Gene:3309
303 1574-1579 Gene denotes GRP78 Gene:3309

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T1044 109-114 Protein denotes GRP78 https://www.uniprot.org/uniprot/Q9UK02|https://www.uniprot.org/uniprot/Q9NPF1|https://www.uniprot.org/uniprot/Q91883|https://www.uniprot.org/uniprot/Q90593|https://www.uniprot.org/uniprot/Q61630|https://www.uniprot.org/uniprot/Q5R4P0|https://www.uniprot.org/uniprot/Q3UFF2|https://www.uniprot.org/uniprot/Q3S4T7|https://www.uniprot.org/uniprot/Q2EF78|https://www.uniprot.org/uniprot/Q0VCX2|https://www.uniprot.org/uniprot/P34935|https://www.uniprot.org/uniprot/P20029|https://www.uniprot.org/uniprot/P16392|https://www.uniprot.org/uniprot/P11021|https://www.uniprot.org/uniprot/P07823|https://www.uniprot.org/uniprot/P06761|https://www.uniprot.org/uniprot/O35642|https://www.uniprot.org/uniprot/G3I8R9|https://www.uniprot.org/uniprot/B0QZ61|https://www.uniprot.org/uniprot/A7E3V5
T1064 257-262 Protein denotes GRP78 https://www.uniprot.org/uniprot/Q9UK02|https://www.uniprot.org/uniprot/Q9NPF1|https://www.uniprot.org/uniprot/Q91883|https://www.uniprot.org/uniprot/Q90593|https://www.uniprot.org/uniprot/Q61630|https://www.uniprot.org/uniprot/Q5R4P0|https://www.uniprot.org/uniprot/Q3UFF2|https://www.uniprot.org/uniprot/Q3S4T7|https://www.uniprot.org/uniprot/Q2EF78|https://www.uniprot.org/uniprot/Q0VCX2|https://www.uniprot.org/uniprot/P34935|https://www.uniprot.org/uniprot/P20029|https://www.uniprot.org/uniprot/P16392|https://www.uniprot.org/uniprot/P11021|https://www.uniprot.org/uniprot/P07823|https://www.uniprot.org/uniprot/P06761|https://www.uniprot.org/uniprot/O35642|https://www.uniprot.org/uniprot/G3I8R9|https://www.uniprot.org/uniprot/B0QZ61|https://www.uniprot.org/uniprot/A7E3V5
T1084 305-310 Protein denotes GRP78 https://www.uniprot.org/uniprot/Q9UK02|https://www.uniprot.org/uniprot/Q9NPF1|https://www.uniprot.org/uniprot/Q91883|https://www.uniprot.org/uniprot/Q90593|https://www.uniprot.org/uniprot/Q61630|https://www.uniprot.org/uniprot/Q5R4P0|https://www.uniprot.org/uniprot/Q3UFF2|https://www.uniprot.org/uniprot/Q3S4T7|https://www.uniprot.org/uniprot/Q2EF78|https://www.uniprot.org/uniprot/Q0VCX2|https://www.uniprot.org/uniprot/P34935|https://www.uniprot.org/uniprot/P20029|https://www.uniprot.org/uniprot/P16392|https://www.uniprot.org/uniprot/P11021|https://www.uniprot.org/uniprot/P07823|https://www.uniprot.org/uniprot/P06761|https://www.uniprot.org/uniprot/O35642|https://www.uniprot.org/uniprot/G3I8R9|https://www.uniprot.org/uniprot/B0QZ61|https://www.uniprot.org/uniprot/A7E3V5
T1104 326-329 Protein denotes BiP https://www.uniprot.org/uniprot/Q9VYU3|https://www.uniprot.org/uniprot/Q9VYU2|https://www.uniprot.org/uniprot/Q9UK02|https://www.uniprot.org/uniprot/Q9NPF1|https://www.uniprot.org/uniprot/Q91883|https://www.uniprot.org/uniprot/Q90593|https://www.uniprot.org/uniprot/Q86NM3|https://www.uniprot.org/uniprot/Q61630|https://www.uniprot.org/uniprot/Q5R4P0|https://www.uniprot.org/uniprot/Q3UFF2|https://www.uniprot.org/uniprot/Q3S4T7|https://www.uniprot.org/uniprot/Q2EF78|https://www.uniprot.org/uniprot/Q24895|https://www.uniprot.org/uniprot/Q24798|https://www.uniprot.org/uniprot/Q16956|https://www.uniprot.org/uniprot/Q0VCX2|https://www.uniprot.org/uniprot/P34935|https://www.uniprot.org/uniprot/P29844|https://www.uniprot.org/uniprot/P20029|https://www.uniprot.org/uniprot/P16392|https://www.uniprot.org/uniprot/P11021|https://www.uniprot.org/uniprot/P07823|https://www.uniprot.org/uniprot/P06761|https://www.uniprot.org/uniprot/O35642|https://www.uniprot.org/uniprot/G3I8R9|https://www.uniprot.org/uniprot/B0QZ61|https://www.uniprot.org/uniprot/A7E3V5|https://www.uniprot.org/uniprot/A4V4C4
T1132 737-742 Protein denotes GRP78 https://www.uniprot.org/uniprot/Q9UK02|https://www.uniprot.org/uniprot/Q9NPF1|https://www.uniprot.org/uniprot/Q91883|https://www.uniprot.org/uniprot/Q90593|https://www.uniprot.org/uniprot/Q61630|https://www.uniprot.org/uniprot/Q5R4P0|https://www.uniprot.org/uniprot/Q3UFF2|https://www.uniprot.org/uniprot/Q3S4T7|https://www.uniprot.org/uniprot/Q2EF78|https://www.uniprot.org/uniprot/Q0VCX2|https://www.uniprot.org/uniprot/P34935|https://www.uniprot.org/uniprot/P20029|https://www.uniprot.org/uniprot/P16392|https://www.uniprot.org/uniprot/P11021|https://www.uniprot.org/uniprot/P07823|https://www.uniprot.org/uniprot/P06761|https://www.uniprot.org/uniprot/O35642|https://www.uniprot.org/uniprot/G3I8R9|https://www.uniprot.org/uniprot/B0QZ61|https://www.uniprot.org/uniprot/A7E3V5
T1152 780-793 Protein denotes spike protein https://www.uniprot.org/uniprot/P31340
T1153 1020-1023 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T1162 1373-1378 Protein denotes GRP78 https://www.uniprot.org/uniprot/Q9UK02|https://www.uniprot.org/uniprot/Q9NPF1|https://www.uniprot.org/uniprot/Q91883|https://www.uniprot.org/uniprot/Q90593|https://www.uniprot.org/uniprot/Q61630|https://www.uniprot.org/uniprot/Q5R4P0|https://www.uniprot.org/uniprot/Q3UFF2|https://www.uniprot.org/uniprot/Q3S4T7|https://www.uniprot.org/uniprot/Q2EF78|https://www.uniprot.org/uniprot/Q0VCX2|https://www.uniprot.org/uniprot/P34935|https://www.uniprot.org/uniprot/P20029|https://www.uniprot.org/uniprot/P16392|https://www.uniprot.org/uniprot/P11021|https://www.uniprot.org/uniprot/P07823|https://www.uniprot.org/uniprot/P06761|https://www.uniprot.org/uniprot/O35642|https://www.uniprot.org/uniprot/G3I8R9|https://www.uniprot.org/uniprot/B0QZ61|https://www.uniprot.org/uniprot/A7E3V5
T1182 1495-1500 Protein denotes GRP78 https://www.uniprot.org/uniprot/Q9UK02|https://www.uniprot.org/uniprot/Q9NPF1|https://www.uniprot.org/uniprot/Q91883|https://www.uniprot.org/uniprot/Q90593|https://www.uniprot.org/uniprot/Q61630|https://www.uniprot.org/uniprot/Q5R4P0|https://www.uniprot.org/uniprot/Q3UFF2|https://www.uniprot.org/uniprot/Q3S4T7|https://www.uniprot.org/uniprot/Q2EF78|https://www.uniprot.org/uniprot/Q0VCX2|https://www.uniprot.org/uniprot/P34935|https://www.uniprot.org/uniprot/P20029|https://www.uniprot.org/uniprot/P16392|https://www.uniprot.org/uniprot/P11021|https://www.uniprot.org/uniprot/P07823|https://www.uniprot.org/uniprot/P06761|https://www.uniprot.org/uniprot/O35642|https://www.uniprot.org/uniprot/G3I8R9|https://www.uniprot.org/uniprot/B0QZ61|https://www.uniprot.org/uniprot/A7E3V5
T1202 1574-1579 Protein denotes GRP78 https://www.uniprot.org/uniprot/Q9UK02|https://www.uniprot.org/uniprot/Q9NPF1|https://www.uniprot.org/uniprot/Q91883|https://www.uniprot.org/uniprot/Q90593|https://www.uniprot.org/uniprot/Q61630|https://www.uniprot.org/uniprot/Q5R4P0|https://www.uniprot.org/uniprot/Q3UFF2|https://www.uniprot.org/uniprot/Q3S4T7|https://www.uniprot.org/uniprot/Q2EF78|https://www.uniprot.org/uniprot/Q0VCX2|https://www.uniprot.org/uniprot/P34935|https://www.uniprot.org/uniprot/P20029|https://www.uniprot.org/uniprot/P16392|https://www.uniprot.org/uniprot/P11021|https://www.uniprot.org/uniprot/P07823|https://www.uniprot.org/uniprot/P06761|https://www.uniprot.org/uniprot/O35642|https://www.uniprot.org/uniprot/G3I8R9|https://www.uniprot.org/uniprot/B0QZ61|https://www.uniprot.org/uniprot/A7E3V5

LitCovid-sample-Enju

Id Subject Object Predicate Lexical cue
T1318 0-5 CD denotes 3.1.4
T1319 7-16 NN denotes SARS-CoV2
T1320 17-25 NN denotes receptor
T1321 26-33 NN denotes binding
T1322 34-40 NN denotes domain
T1323 41-49 VBZ denotes contains
T1324 50-56 JJ denotes cyclic
T1325 57-64 NNS denotes regions
T1326 65-69 WDT denotes that
T1327 70-73 MD denotes can
T1328 74-78 VB denotes make
T1329 79-90 NN denotes interaction
T1330 91-95 IN denotes with
T1331 96-108 JJ denotes cell-surface
T1332 109-114 NN denotes GRP78
T1333 115-120 NN denotes Pep42
T1334 121-123 VBZ denotes is
T1335 124-125 DT denotes a
T1336 126-132 JJ denotes cyclic
T1337 133-145 NN denotes oligopeptide
T1338 146-150 IN denotes that
T1339 150-151 -COMMA- denotes ,
T1340 152-156 IN denotes with
T1341 157-160 PRP-DOLLAR- denotes its
T1342 161-172 JJ denotes hydrophobic
T1343 173-182 NN denotes character
T1344 182-183 -COMMA- denotes ,
T1345 184-187 MD denotes can
T1346 188-199 RB denotes selectively
T1347 200-208 VB denotes interact
T1348 209-213 IN denotes with
T1349 214-218 NN denotes cell
T1350 219-226 NN denotes surface
T1351 227-244 VBN denotes glucose‐regulated
T1352 245-252 NN denotes protein
T1353 253-255 CD denotes 78
T1354 256-257 -LRB- denotes (
T1355 257-262 NN denotes GRP78
T1356 262-263 -RRB- denotes )
T1357 263-264 -COMMA- denotes ,
T1358 265-266 DT denotes a
T1359 267-273 NN denotes member
T1360 274-276 IN denotes of
T1361 277-283 NN denotes 70 kDa
T1362 284-288 NN denotes heat
T1363 289-294 NN denotes shock
T1364 295-303 NNS denotes proteins
T1365 305-310 NN denotes GRP78
T1366 310-311 -COMMA- denotes ,
T1367 312-316 RB denotes also
T1368 317-322 VBN denotes known
T1369 323-325 IN denotes as
T1370 326-329 NN denotes BiP
T1371 330-332 CC denotes or
T1372 333-338 NN denotes HSPA5
T1373 338-339 -COMMA- denotes ,
T1374 340-345 IN denotes under
T1375 346-357 JJ denotes endoplasmic
T1376 358-367 NN denotes reticulum
T1377 368-374 NN denotes stress
T1378 374-375 -COMMA- denotes ,
T1379 376-379 MD denotes can
T1380 380-382 VB denotes be
T1381 383-395 VBN denotes translocated
T1382 396-400 IN denotes from
T1383 401-404 DT denotes the
T1384 405-416 JJ denotes endoplasmic
T1385 417-426 NN denotes reticulum
T1386 427-429 TO denotes to
T1387 430-433 DT denotes the
T1388 434-442 NN denotes membrane
T1389 443-446 CC denotes and
T1390 447-452 VBZ denotes helps
T1391 453-455 TO denotes to
T1392 456-464 VB denotes maintain
T1393 465-473 JJ denotes cellular
T1394 474-483 NN denotes integrity
T1395 484-489 IN denotes under
T1396 490-501 JJ denotes physiologic
T1397 502-505 CC denotes and
T1398 506-518 JJ denotes pathological
T1399 519-525 NN denotes stress
T1400 527-529 PRP denotes It
T1401 530-540 RB denotes critically
T1402 541-552 VBZ denotes contributes
T1403 553-555 TO denotes to
T1404 556-563 JJ denotes various
T1405 564-573 NNS denotes functions
T1406 574-581 VBG denotes ranging
T1407 582-586 IN denotes from
T1408 587-594 NN denotes protein
T1409 595-602 NN denotes folding
T1410 602-603 -COMMA- denotes ,
T1411 604-618 NN denotes transportation
T1412 618-619 -COMMA- denotes ,
T1413 620-623 CC denotes and
T1414 624-635 NN denotes degradation
T1415 636-638 TO denotes to
T1416 639-653 JJ denotes cell-signaling
T1417 653-654 -COMMA- denotes ,
T1418 655-668 NN denotes proliferation
T1419 668-669 -COMMA- denotes ,
T1420 670-678 NN denotes survival
T1421 678-679 -COMMA- denotes ,
T1422 680-689 NN denotes apoptosis
T1423 689-690 -COMMA- denotes ,
T1424 691-703 NN denotes inflammation
T1425 703-704 -COMMA- denotes ,
T1426 705-708 CC denotes and
T1427 709-717 NN denotes immunity
T1428 719-722 DT denotes The
T1429 723-733 NN denotes expression
T1430 734-736 IN denotes of
T1431 737-742 NN denotes GRP78
T1432 743-752 VBZ denotes decreases
T1433 753-757 IN denotes with
T1434 758-761 NN denotes age
T1435 763-765 IN denotes On
T1436 766-769 DT denotes the
T1437 770-779 JJ denotes 2019-nCoV
T1438 780-785 NN denotes spike
T1439 786-793 NN denotes protein
T1440 793-794 -COMMA- denotes ,
T1441 795-797 CD denotes 13
T1442 798-807 NN denotes disulfide
T1443 808-813 NNS denotes bonds
T1444 814-817 VBP denotes are
T1445 818-831 VBG denotes corresponding
T1446 832-834 TO denotes to
T1447 835-837 CD denotes 13
T1448 838-847 JJ denotes different
T1449 848-854 JJ denotes cyclic
T1450 855-862 NNS denotes regions
T1451 863-870 VBN denotes thought
T1452 871-873 TO denotes to
T1453 874-876 VB denotes be
T1454 877-884 JJ denotes similar
T1455 885-887 TO denotes to
T1456 888-891 DT denotes the
T1457 892-898 JJ denotes cyclic
T1458 899-903 NN denotes form
T1459 904-906 IN denotes of
T1460 907-912 NN denotes Pep42
T1461 913-914 -LRB- denotes [
T1462 914-915 CD denotes 8
T1463 915-916 -RRB- denotes ]
T1464 918-923 IN denotes Among
T1465 924-929 DT denotes these
T1466 929-930 -COMMA- denotes ,
T1467 931-935 CD denotes four
T1468 936-943 NNS denotes regions
T1469 944-948 NN denotes I-IV
T1470 949-953 VBP denotes take
T1471 954-959 NN denotes place
T1472 960-962 IN denotes in
T1473 963-966 DT denotes the
T1474 967-972 JJ denotes outer
T1475 973-980 NN denotes surface
T1476 981-983 IN denotes of
T1477 984-985 DT denotes a
T1478 986-994 JJ denotes putative
T1479 995-1011 JJ denotes receptor-binding
T1480 1012-1018 NN denotes domain
T1481 1019-1020 -LRB- denotes (
T1482 1020-1023 NN denotes RBD
T1483 1023-1024 -RRB- denotes )
T1484 1025-1027 IN denotes on
T1485 1028-1031 DT denotes the
T1486 1032-1037 JJ denotes viral
T1487 1038-1044 NN denotes spike.
T1488 1044-1045 -COMMA- denotes ,
T1489 1046-1055 VBG denotes including
T1490 1056-1060 NN denotes C361
T1491 1060-1061 -COMMA- denotes ,
T1492 1062-1066 NN denotes C379
T1493 1066-1067 -COMMA- denotes ,
T1494 1068-1072 NN denotes C391
T1495 1072-1073 -COMMA- denotes ,
T1496 1074-1077 CC denotes and
T1497 1078-1082 NN denotes C480
T1498 1084-1089 DT denotes These
T1499 1090-1097 NNS denotes regions
T1500 1098-1103 VBP denotes share
T1501 1104-1112 NN denotes sequence
T1502 1113-1123 NN denotes similarity
T1503 1124-1128 IN denotes with
T1504 1129-1134 NN denotes Pep42
T1505 1134-1135 -COMMA- denotes ,
T1506 1136-1143 VBG denotes ranging
T1507 1144-1148 IN denotes from
T1508 1149-1154 CD denotes 15.38
T1509 1154-1155 NN denotes %
T1510 1156-1158 TO denotes to
T1511 1159-1164 CD denotes 46.15
T1512 1164-1165 NN denotes %
T1513 1167-1174 RB denotes However
T1514 1174-1175 -COMMA- denotes ,
T1515 1176-1180 RB denotes only
T1516 1181-1184 CD denotes one
T1517 1185-1187 IN denotes of
T1518 1188-1192 PRP denotes them
T1519 1192-1193 -COMMA- denotes ,
T1520 1194-1198 FW denotes i.e.
T1521 1198-1199 -COMMA- denotes ,
T1522 1200-1206 NN denotes region
T1523 1207-1209 CD denotes IV
T1524 1210-1211 -LRB- denotes (
T1525 1211-1223 NN denotes GRAVY = 0.08
T1526 1223-1224 -RRB- denotes )
T1527 1224-1225 -COMMA- denotes ,
T1528 1226-1228 VBZ denotes is
T1529 1229-1230 DT denotes a
T1530 1231-1242 JJ denotes hydrophobic
T1531 1243-1249 NN denotes region
T1532 1249-1250 -COMMA- denotes ,
T1533 1251-1255 IN denotes like
T1534 1256-1261 NN denotes Pep42
T1535 1262-1263 -LRB- denotes (
T1536 1263-1274 NN denotes GRAVY = 1.1
T1537 1274-1275 -RRB- denotes )
T1538 1277-1287 JJ denotes Structural
T1539 1288-1294 NNS denotes models
T1540 1295-1303 VBP denotes evaluate
T1541 1304-1307 DT denotes the
T1542 1308-1314 NN denotes energy
T1543 1315-1327 NN denotes contribution
T1544 1328-1331 IN denotes for
T1545 1332-1338 NN denotes region
T1546 1339-1341 CD denotes IV
T1547 1342-1344 IN denotes as
T1548 1345-1346 DT denotes a
T1549 1347-1351 NN denotes part
T1550 1352-1354 IN denotes of
T1551 1355-1361 NN denotes region
T1552 1362-1365 CD denotes III
T1553 1366-1368 TO denotes to
T1554 1369-1372 DT denotes the
T1555 1373-1378 NN denotes GRP78
T1556 1379-1381 TO denotes to
T1557 1382-1384 VB denotes be
T1558 1385-1390 IN denotes about
T1559 1391-1392 -LRB- denotes (
T1560 1392-1396 CD denotes −9.8
T1561 1397-1400 IN denotes out
T1562 1401-1403 IN denotes of
T1563 1404-1418 NN denotes −14.0 kcal/mol
T1564 1418-1419 -RRB- denotes )
T1565 1419-1420 -COMMA- denotes ,
T1566 1421-1424 CC denotes and
T1567 1425-1428 DT denotes the
T1568 1429-1436 NN denotes docking
T1569 1437-1445 NN denotes platform
T1570 1446-1454 VBZ denotes proposes
T1571 1455-1461 NN denotes region
T1572 1462-1464 CD denotes IV
T1573 1465-1467 IN denotes as
T1574 1468-1471 DT denotes the
T1575 1472-1476 JJS denotes best
T1576 1477-1483 NN denotes region
T1577 1484-1491 VBG denotes binding
T1578 1492-1494 TO denotes to
T1579 1495-1500 NN denotes GRP78
T1580 1502-1505 DT denotes The
T1581 1506-1512 NN denotes region
T1582 1513-1515 CD denotes IV
T1583 1516-1519 MD denotes can
T1584 1520-1522 VB denotes be
T1585 1523-1529 VBN denotes linked
T1586 1530-1532 TO denotes to
T1587 1533-1536 DT denotes the
T1588 1537-1554 JJ denotes substrate-binding
T1589 1555-1561 NN denotes domain
T1590 1562-1563 NN denotes β
T1591 1564-1565 -LRB- denotes (
T1592 1565-1569 NN denotes SBDB
T1593 1569-1570 -RRB- denotes )
T1594 1571-1573 IN denotes of
T1595 1574-1579 NN denotes GRP78
T1596 1580-1585 VBG denotes using
T1597 1586-1590 CD denotes five
T1598 1591-1598 NNS denotes H-bonds
T1599 1599-1600 -LRB- denotes (
T1600 1600-1607 IN denotes through
T1601 1608-1612 NN denotes P479
T1602 1612-1613 -COMMA- denotes ,
T1603 1614-1618 NN denotes N481
T1604 1618-1619 -COMMA- denotes ,
T1605 1620-1624 NN denotes E484
T1606 1624-1625 -COMMA- denotes ,
T1607 1626-1629 CC denotes and
T1608 1630-1634 NN denotes N487
T1609 1634-1635 -RRB- denotes )
T1610 1636-1639 CC denotes and
T1611 1640-1644 CD denotes four
T1612 1645-1656 JJ denotes hydrophobic
T1613 1657-1669 NNS denotes interactions
T1614 1670-1671 -LRB- denotes (
T1615 1671-1678 IN denotes through
T1616 1679-1683 NN denotes T478
T1617 1683-1684 -COMMA- denotes ,
T1618 1685-1689 NN denotes E484
T1619 1689-1690 -COMMA- denotes ,
T1620 1691-1694 CC denotes and
T1621 1695-1699 NN denotes F486
T1622 1699-1700 -RRB- denotes )
R1605 T1613 T1611 arg1Of interactions,four
R1606 T1613 T1612 arg1Of interactions,hydrophobic
R1607 T1613 T1614 arg1Of interactions,(
R1608 T1615 T1614 arg2Of through,(
R1609 T1622 T1614 arg3Of ),(
R1610 T1620 T1615 arg2Of and,through
R1611 T1616 T1617 arg1Of T478,","
R1308 T1322 T1318 arg1Of domain,3.1.4
R1309 T1322 T1319 arg1Of domain,SARS-CoV2
R1310 T1322 T1320 arg1Of domain,receptor
R1311 T1322 T1321 arg1Of domain,binding
R1312 T1322 T1323 arg1Of domain,contains
R1313 T1325 T1323 arg2Of regions,contains
R1314 T1325 T1324 arg1Of regions,cyclic
R1315 T1325 T1326 arg1Of regions,that
R1316 T1325 T1327 arg1Of regions,can
R1317 T1328 T1327 arg2Of make,can
R1318 T1325 T1328 arg1Of regions,make
R1319 T1329 T1328 arg2Of interaction,make
R1320 T1329 T1330 arg1Of interaction,with
R1321 T1332 T1330 arg2Of GRP78,with
R1322 T1332 T1331 arg1Of GRP78,cell-surface
R1323 T1333 T1334 arg1Of Pep42,is
R1324 T1337 T1334 arg2Of oligopeptide,is
R1325 T1337 T1335 arg1Of oligopeptide,a
R1326 T1337 T1336 arg1Of oligopeptide,cyclic
R1327 T1337 T1338 arg1Of oligopeptide,that
R1328 T1347 T1339 arg1Of interact,","
R1329 T1347 T1340 arg1Of interact,with
R1330 T1343 T1340 arg2Of character,with
R1331 T1343 T1341 arg1Of character,its
R1332 T1343 T1342 arg1Of character,hydrophobic
R1333 T1347 T1344 arg1Of interact,","
R1334 T1337 T1345 arg1Of oligopeptide,can
R1335 T1347 T1345 arg2Of interact,can
R1336 T1347 T1346 arg1Of interact,selectively
R1337 T1337 T1347 arg1Of oligopeptide,interact
R1338 T1347 T1348 arg1Of interact,with
R1339 T1350 T1348 arg2Of surface,with
R1340 T1350 T1349 arg1Of surface,cell
R1341 T1350 T1351 arg2Of surface,glucose‐regulated
R1342 T1352 T1351 arg3Of protein,glucose‐regulated
R1343 T1352 T1353 arg1Of protein,78
R1344 T1352 T1354 arg1Of protein,(
R1345 T1355 T1354 arg2Of GRP78,(
R1346 T1356 T1354 arg3Of ),(
R1347 T1352 T1357 arg1Of protein,","
R1348 T1359 T1357 arg2Of member,","
R1349 T1359 T1358 arg1Of member,a
R1350 T1359 T1360 arg1Of member,of
R1351 T1364 T1360 arg2Of proteins,of
R1352 T1364 T1361 arg1Of proteins,70 kDa
R1353 T1364 T1362 arg1Of proteins,heat
R1354 T1364 T1363 arg1Of proteins,shock
R1355 T1365 T1366 arg1Of GRP78,","
R1356 T1368 T1367 arg1Of known,also
R1357 T1365 T1368 arg2Of GRP78,known
R1358 T1368 T1369 arg1Of known,as
R1359 T1371 T1369 arg2Of or,as
R1360 T1370 T1371 arg1Of BiP,or
R1361 T1372 T1371 arg2Of HSPA5,or
R1362 T1389 T1373 arg1Of and,","
R1363 T1389 T1374 arg1Of and,under
R1364 T1377 T1374 arg2Of stress,under
R1365 T1377 T1375 arg1Of stress,endoplasmic
R1366 T1377 T1376 arg1Of stress,reticulum
R1367 T1389 T1378 arg1Of and,","
R1368 T1365 T1379 arg1Of GRP78,can
R1369 T1381 T1379 arg2Of translocated,can
R1370 T1365 T1380 arg1Of GRP78,be
R1371 T1381 T1380 arg2Of translocated,be
R1372 T1365 T1381 arg2Of GRP78,translocated
R1373 T1381 T1382 arg1Of translocated,from
R1374 T1385 T1382 arg2Of reticulum,from
R1375 T1385 T1383 arg1Of reticulum,the
R1376 T1385 T1384 arg1Of reticulum,endoplasmic
R1377 T1385 T1386 arg1Of reticulum,to
R1378 T1388 T1386 arg2Of membrane,to
R1379 T1388 T1387 arg1Of membrane,the
R1380 T1381 T1389 arg1Of translocated,and
R1381 T1390 T1389 arg2Of helps,and
R1382 T1365 T1390 arg1Of GRP78,helps
R1383 T1392 T1390 arg2Of maintain,helps
R1384 T1392 T1391 arg1Of maintain,to
R1385 T1365 T1392 arg1Of GRP78,maintain
R1386 T1394 T1392 arg2Of integrity,maintain
R1387 T1394 T1393 arg1Of integrity,cellular
R1388 T1392 T1395 arg1Of maintain,under
R1389 T1399 T1395 arg2Of stress,under
R1390 T1399 T1396 arg1Of stress,physiologic
R1391 T1396 T1397 arg1Of physiologic,and
R1392 T1398 T1397 arg2Of pathological,and
R1393 T1399 T1398 arg1Of stress,pathological
R1394 T1402 T1401 arg1Of contributes,critically
R1395 T1400 T1402 arg1Of It,contributes
R1396 T1402 T1403 arg1Of contributes,to
R1397 T1405 T1403 arg2Of functions,to
R1398 T1405 T1404 arg1Of functions,various
R1399 T1405 T1406 arg1Of functions,ranging
R1400 T1406 T1407 arg1Of ranging,from
R1401 T1413 T1407 arg2Of and,from
R1402 T1409 T1408 arg1Of folding,protein
R1403 T1409 T1410 arg1Of folding,","
R1404 T1411 T1410 arg2Of transportation,","
R1405 T1413 T1412 arg1Of and,","
R1406 T1410 T1413 arg1Of ",",and
R1407 T1414 T1413 arg2Of degradation,and
R1408 T1405 T1415 arg1Of functions,to
R1409 T1426 T1415 arg2Of and,to
R1410 T1421 T1416 arg1Of ",",cell-signaling
R1411 T1421 T1417 arg1Of ",",","
R1412 T1418 T1419 arg1Of proliferation,","
R1413 T1420 T1419 arg2Of survival,","
R1414 T1419 T1421 arg1Of ",",","
R1415 T1422 T1421 arg2Of apoptosis,","
R1416 T1421 T1423 arg1Of ",",","
R1417 T1424 T1423 arg2Of inflammation,","
R1418 T1426 T1425 arg1Of and,","
R1419 T1423 T1426 arg1Of ",",and
R1420 T1427 T1426 arg2Of immunity,and
R1421 T1429 T1428 arg1Of expression,The
R1422 T1429 T1430 arg1Of expression,of
R1423 T1431 T1430 arg2Of GRP78,of
R1424 T1429 T1432 arg1Of expression,decreases
R1425 T1432 T1433 arg1Of decreases,with
R1426 T1434 T1433 arg2Of age,with
R1427 T1445 T1435 arg1Of corresponding,On
R1428 T1439 T1435 arg2Of protein,On
R1429 T1439 T1436 arg1Of protein,the
R1430 T1439 T1437 arg1Of protein,2019-nCoV
R1431 T1439 T1438 arg1Of protein,spike
R1432 T1445 T1440 arg1Of corresponding,","
R1433 T1443 T1441 arg1Of bonds,13
R1434 T1443 T1442 arg1Of bonds,disulfide
R1435 T1443 T1444 arg1Of bonds,are
R1436 T1445 T1444 arg2Of corresponding,are
R1437 T1443 T1445 arg1Of bonds,corresponding
R1438 T1445 T1446 arg1Of corresponding,to
R1439 T1450 T1446 arg2Of regions,to
R1440 T1450 T1447 arg1Of regions,13
R1441 T1450 T1448 arg1Of regions,different
R1442 T1450 T1449 arg1Of regions,cyclic
R1443 T1450 T1451 arg2Of regions,thought
R1444 T1453 T1451 arg3Of be,thought
R1445 T1453 T1452 arg1Of be,to
R1446 T1450 T1453 arg1Of regions,be
R1447 T1454 T1453 arg2Of similar,be
R1448 T1450 T1454 arg1Of regions,similar
R1449 T1454 T1455 arg1Of similar,to
R1450 T1458 T1455 arg2Of form,to
R1451 T1458 T1456 arg1Of form,the
R1452 T1458 T1457 arg1Of form,cyclic
R1453 T1458 T1459 arg1Of form,of
R1454 T1460 T1459 arg2Of Pep42,of
R1455 T1460 T1461 arg1Of Pep42,[
R1456 T1462 T1461 arg2Of 8,[
R1457 T1463 T1461 arg3Of ],[
R1458 T1470 T1464 arg1Of take,Among
R1459 T1465 T1464 arg2Of these,Among
R1460 T1470 T1466 arg1Of take,","
R1461 T1469 T1467 arg1Of I-IV,four
R1462 T1469 T1468 arg1Of I-IV,regions
R1463 T1469 T1470 arg1Of I-IV,take
R1464 T1471 T1470 arg2Of place,take
R1465 T1470 T1472 arg1Of take,in
R1466 T1475 T1472 arg2Of surface,in
R1467 T1475 T1473 arg1Of surface,the
R1468 T1475 T1474 arg1Of surface,outer
R1469 T1475 T1476 arg1Of surface,of
R1470 T1480 T1476 arg2Of domain,of
R1471 T1480 T1477 arg1Of domain,a
R1472 T1480 T1478 arg1Of domain,putative
R1473 T1480 T1479 arg1Of domain,receptor-binding
R1474 T1480 T1481 arg1Of domain,(
R1475 T1482 T1481 arg2Of RBD,(
R1476 T1483 T1481 arg3Of ),(
R1477 T1480 T1484 arg1Of domain,on
R1478 T1487 T1484 arg2Of spike.,on
R1479 T1487 T1485 arg1Of spike.,the
R1480 T1487 T1486 arg1Of spike.,viral
R1481 T1475 T1488 arg1Of surface,","
R1482 T1475 T1489 arg1Of surface,including
R1483 T1496 T1489 arg2Of and,including
R1484 T1490 T1491 arg1Of C361,","
R1485 T1492 T1491 arg2Of C379,","
R1486 T1491 T1493 arg1Of ",",","
R1487 T1494 T1493 arg2Of C391,","
R1488 T1496 T1495 arg1Of and,","
R1489 T1493 T1496 arg1Of ",",and
R1490 T1497 T1496 arg2Of C480,and
R1491 T1499 T1498 arg1Of regions,These
R1492 T1499 T1500 arg1Of regions,share
R1493 T1502 T1500 arg2Of similarity,share
R1494 T1502 T1501 arg1Of similarity,sequence
R1495 T1500 T1503 arg1Of share,with
R1496 T1504 T1503 arg2Of Pep42,with
R1497 T1500 T1505 arg1Of share,","
R1498 T1499 T1506 arg1Of regions,ranging
R1499 T1512 T1506 arg2Of %,ranging
R1500 T1500 T1506 modOf share,ranging
R1501 T1506 T1507 arg1Of ranging,from
R1502 T1509 T1507 arg2Of %,from
R1503 T1509 T1508 arg1Of %,15.38
R1504 T1512 T1510 arg1Of %,to
R1505 T1512 T1511 arg1Of %,46.15
R1506 T1528 T1513 arg1Of is,However
R1507 T1528 T1514 arg1Of is,","
R1508 T1516 T1515 arg1Of one,only
R1509 T1516 T1517 arg1Of one,of
R1510 T1518 T1517 arg2Of them,of
R1511 T1516 T1519 arg1Of one,","
R1512 T1516 T1520 arg1Of one,i.e.
R1513 T1522 T1520 arg2Of region,i.e.
R1514 T1520 T1521 arg1Of i.e.,","
R1515 T1522 T1523 arg1Of region,IV
R1516 T1522 T1524 arg1Of region,(
R1517 T1525 T1524 arg2Of GRAVY = 0.08,(
R1518 T1526 T1524 arg3Of ),(
R1519 T1528 T1527 arg1Of is,","
R1520 T1516 T1528 arg1Of one,is
R1521 T1531 T1528 arg2Of region,is
R1522 T1531 T1529 arg1Of region,a
R1523 T1531 T1530 arg1Of region,hydrophobic
R1524 T1528 T1532 arg1Of is,","
R1525 T1528 T1533 arg1Of is,like
R1526 T1534 T1533 arg2Of Pep42,like
R1527 T1534 T1535 arg1Of Pep42,(
R1528 T1536 T1535 arg2Of GRAVY = 1.1,(
R1529 T1537 T1535 arg3Of ),(
R1530 T1539 T1538 arg1Of models,Structural
R1531 T1539 T1540 arg1Of models,evaluate
R1532 T1543 T1540 arg2Of contribution,evaluate
R1533 T1543 T1541 arg1Of contribution,the
R1534 T1543 T1542 arg1Of contribution,energy
R1535 T1543 T1544 arg1Of contribution,for
R1536 T1545 T1544 arg2Of region,for
R1537 T1545 T1546 arg1Of region,IV
R1538 T1545 T1547 arg1Of region,as
R1539 T1549 T1547 arg2Of part,as
R1540 T1549 T1548 arg1Of part,a
R1541 T1549 T1550 arg1Of part,of
R1542 T1551 T1550 arg2Of region,of
R1543 T1551 T1552 arg1Of region,III
R1544 T1543 T1553 arg1Of contribution,to
R1545 T1555 T1553 arg2Of GRP78,to
R1546 T1555 T1554 arg1Of GRP78,the
R1547 T1557 T1556 arg1Of be,to
R1548 T1555 T1556 modOf GRP78,to
R1549 T1555 T1557 arg2Of GRP78,be
R1550 T1557 T1558 arg1Of be,about
R1551 T1558 T1559 arg1Of about,(
R1552 T1562 T1559 arg2Of of,(
R1553 T1564 T1559 arg3Of ),(
R1554 T1562 T1561 arg1Of of,out
R1555 T1560 T1562 arg1Of −9.8,of
R1556 T1563 T1562 arg2Of −14.0 kcal/mol,of
R1557 T1566 T1565 arg1Of and,","
R1558 T1540 T1566 arg1Of evaluate,and
R1559 T1570 T1566 arg2Of proposes,and
R1560 T1569 T1567 arg1Of platform,the
R1561 T1569 T1568 arg1Of platform,docking
R1562 T1569 T1570 arg1Of platform,proposes
R1563 T1571 T1570 arg2Of region,proposes
R1564 T1571 T1572 arg1Of region,IV
R1565 T1570 T1573 arg1Of proposes,as
R1566 T1576 T1573 arg2Of region,as
R1567 T1576 T1574 arg1Of region,the
R1568 T1576 T1575 arg1Of region,best
R1569 T1576 T1577 arg1Of region,binding
R1570 T1577 T1578 arg1Of binding,to
R1571 T1579 T1578 arg2Of GRP78,to
R1572 T1581 T1580 arg1Of region,The
R1573 T1581 T1582 arg1Of region,IV
R1574 T1581 T1583 arg1Of region,can
R1575 T1585 T1583 arg2Of linked,can
R1576 T1581 T1584 arg1Of region,be
R1577 T1585 T1584 arg2Of linked,be
R1578 T1581 T1585 arg2Of region,linked
R1579 T1585 T1586 arg1Of linked,to
R1580 T1590 T1586 arg2Of β,to
R1581 T1590 T1587 arg1Of β,the
R1582 T1590 T1588 arg1Of β,substrate-binding
R1583 T1590 T1589 arg1Of β,domain
R1584 T1590 T1591 arg1Of β,(
R1585 T1592 T1591 arg2Of SBDB,(
R1586 T1593 T1591 arg3Of ),(
R1587 T1590 T1594 arg1Of β,of
R1588 T1595 T1594 arg2Of GRP78,of
R1589 T1595 T1596 arg1Of GRP78,using
R1590 T1610 T1596 arg2Of and,using
R1591 T1598 T1597 arg1Of H-bonds,five
R1592 T1598 T1599 arg1Of H-bonds,(
R1593 T1600 T1599 arg2Of through,(
R1594 T1609 T1599 arg3Of ),(
R1595 T1607 T1600 arg2Of and,through
R1596 T1601 T1602 arg1Of P479,","
R1597 T1603 T1602 arg2Of N481,","
R1598 T1602 T1604 arg1Of ",",","
R1599 T1605 T1604 arg2Of E484,","
R1600 T1607 T1606 arg1Of and,","
R1601 T1604 T1607 arg1Of ",",and
R1602 T1608 T1607 arg2Of N487,and
R1603 T1598 T1610 arg1Of H-bonds,and
R1604 T1613 T1610 arg2Of interactions,and
R1612 T1618 T1617 arg2Of E484,","
R1613 T1620 T1619 arg1Of and,","
R1614 T1617 T1620 arg1Of ",",and
R1615 T1621 T1620 arg2Of F486,and

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T14 587-602 http://purl.obolibrary.org/obo/GO_0006457 denotes protein folding
T15 624-635 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T16 644-653 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T17 680-689 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T18 680-689 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T19 691-703 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T55 96-108 Body_part denotes cell-surface http://purl.org/sig/ont/fma/fma67653
T56 96-100 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T57 214-226 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T58 214-218 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T59 227-234 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T60 245-252 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T61 295-303 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T62 346-367 Body_part denotes endoplasmic reticulum http://purl.org/sig/ont/fma/fma63842
T63 405-426 Body_part denotes endoplasmic reticulum http://purl.org/sig/ont/fma/fma63842
T64 587-594 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T65 639-643 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T66 786-793 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T52 7-16 Disease denotes SARS-CoV2 http://purl.obolibrary.org/obo/MONDO_0100096
T53 691-703 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T2 289-294 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T12 587-602 http://purl.obolibrary.org/obo/GO_0006457 denotes protein folding
T13 624-635 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T14 644-653 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T15 680-689 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T16 680-689 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T17 691-703 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T12 587-602 http://purl.obolibrary.org/obo/GO_0006457 denotes protein folding
T13 624-635 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T14 644-653 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T15 680-689 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T16 680-689 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T17 691-703 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T68 0-114 Sentence denotes 3.1.4 SARS-CoV2 receptor binding domain contains cyclic regions that can make interaction with cell-surface GRP78
T69 115-304 Sentence denotes Pep42 is a cyclic oligopeptide that, with its hydrophobic character, can selectively interact with cell surface glucose‐regulated protein 78 (GRP78), a member of 70 kDa heat shock proteins.
T70 305-526 Sentence denotes GRP78, also known as BiP or HSPA5, under endoplasmic reticulum stress, can be translocated from the endoplasmic reticulum to the membrane and helps to maintain cellular integrity under physiologic and pathological stress.
T71 527-718 Sentence denotes It critically contributes to various functions ranging from protein folding, transportation, and degradation to cell-signaling, proliferation, survival, apoptosis, inflammation, and immunity.
T72 719-762 Sentence denotes The expression of GRP78 decreases with age.
T73 763-917 Sentence denotes On the 2019-nCoV spike protein, 13 disulfide bonds are corresponding to 13 different cyclic regions thought to be similar to the cyclic form of Pep42 [8].
T74 918-1083 Sentence denotes Among these, four regions I-IV take place in the outer surface of a putative receptor-binding domain (RBD) on the viral spike., including C361, C379, C391, and C480.
T75 1084-1166 Sentence denotes These regions share sequence similarity with Pep42, ranging from 15.38% to 46.15%.
T76 1167-1276 Sentence denotes However, only one of them, i.e., region IV (GRAVY = 0.08), is a hydrophobic region, like Pep42 (GRAVY = 1.1).
T77 1277-1501 Sentence denotes Structural models evaluate the energy contribution for region IV as a part of region III to the GRP78 to be about (−9.8 out of −14.0 kcal/mol), and the docking platform proposes region IV as the best region binding to GRP78.
T78 1502-1701 Sentence denotes The region IV can be linked to the substrate-binding domain β (SBDB) of GRP78 using five H-bonds (through P479, N481, E484, and N487) and four hydrophobic interactions (through T478, E484, and F486).

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T2 289-294 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273

LitCovid-sample-Glycan

Id Subject Object Predicate Lexical cue
T90 227-234 http://rdf.glyconavi.org/CarTNa/CarTNa210/trivialname denotes glucose