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PMC:7205724 / 24000-25277 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
853 1114-1121 Gene denotes TMPRSS2 Gene:103219191
854 1248-1255 Gene denotes TMPRSS2 Gene:7113
855 161-169 Species denotes MERS-CoV Tax:1335626
856 344-349 Species denotes human Tax:9606
857 350-363 Species denotes coronaviruses Tax:11118
858 387-395 Species denotes SARS-CoV Tax:694009
859 542-569 Species denotes respiratory syncytial virus Tax:12814
860 579-587 Species denotes MERS-CoV Tax:1335626
861 746-754 Species denotes MERS-CoV Tax:1335626
862 827-835 Species denotes MERS-CoV Tax:1335626
863 845-854 Species denotes SARS-CoV2 Tax:2697049
864 1156-1165 Species denotes SARS-CoV2 Tax:2697049
865 528-537 Species denotes influenza Tax:11309
866 66-77 Chemical denotes ciclesonide MESH:C120481
867 79-88 Chemical denotes cortisone MESH:D003348
868 90-102 Chemical denotes prednisolone MESH:D011239
869 104-117 Chemical denotes dexamethasone MESH:D003907
870 123-134 Chemical denotes fluticasone MESH:D000068298
871 206-217 Chemical denotes ciclesonide MESH:C120481
872 269-280 Chemical denotes ciclesonide MESH:C120481
873 657-668 Chemical denotes ciclesonide MESH:C120481
874 758-769 Chemical denotes ciclesonide MESH:C120481
875 771-781 Chemical denotes Mometasone MESH:D000068656
876 866-877 Chemical denotes ciclesonide MESH:C120481
877 879-889 Chemical denotes mometasone MESH:D000068656
878 895-904 Chemical denotes lopinavir MESH:D061466
879 1018-1024 Chemical denotes serine MESH:D012694
880 1052-1062 Chemical denotes nafamostat MESH:C032855
881 373-382 CellLine denotes HCoV-229E CVCL:D748

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T169 425-428 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T170 509-512 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T171 605-612 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T172 673-683 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T173 1018-1024 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T174 1079-1084 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T175 1095-1100 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T176 1179-1183 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T177 1206-1215 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T178 1256-1268 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T179 1256-1260 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T185 387-395 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T186 436-443 Disease denotes rubella http://purl.obolibrary.org/obo/MONDO_0004656
T187 528-537 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T188 845-849 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T189 1156-1160 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T276 289-290 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T277 344-349 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T278 429-434 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T279 444-449 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T280 513-520 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T281 564-569 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T282 589-590 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T283 947-948 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T284 1079-1084 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T285 1090-1094 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T286 1090-1094 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T287 1095-1100 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T288 1179-1183 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T289 1256-1260 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T180 50-65 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T181 79-88 Chemical denotes cortisone http://purl.obolibrary.org/obo/CHEBI_16962
T182 90-102 Chemical denotes prednisolone http://purl.obolibrary.org/obo/CHEBI_8378
T183 104-117 Chemical denotes dexamethasone http://purl.obolibrary.org/obo/CHEBI_41879
T184 123-134 Chemical denotes fluticasone http://purl.obolibrary.org/obo/CHEBI_5134
T185 605-612 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T186 673-683 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T187 673-678 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T188 679-683 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T189 771-781 Chemical denotes Mometasone http://purl.obolibrary.org/obo/CHEBI_6970
T190 879-889 Chemical denotes mometasone http://purl.obolibrary.org/obo/CHEBI_6970
T191 895-904 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T192 1018-1044 Chemical denotes serine protease inhibitors http://purl.obolibrary.org/obo/CHEBI_64926
T193 1018-1024 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T194 1025-1044 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T196 1034-1044 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T197 1052-1062 Chemical denotes nafamostat http://purl.obolibrary.org/obo/CHEBI_135466
T198 1067-1075 Chemical denotes camostat http://purl.obolibrary.org/obo/CHEBI_135632

LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T24 15-27 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T107 142-153 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T108 250-261 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T109 323-334 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T110 429-434 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T111 444-449 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T112 478-489 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T113 513-520 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T114 564-569 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T115 932-943 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T116 1079-1084 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T117 1095-1100 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T118 1179-1183 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T119 1256-1260 http://purl.obolibrary.org/obo/CL_0000000 denotes cell

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T115 50-65 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T116 79-88 Chemical denotes cortisone http://purl.obolibrary.org/obo/CHEBI_16962
T117 90-102 Chemical denotes prednisolone http://purl.obolibrary.org/obo/CHEBI_8378
T118 104-117 Chemical denotes dexamethasone http://purl.obolibrary.org/obo/CHEBI_41879
T119 123-134 Chemical denotes fluticasone http://purl.obolibrary.org/obo/CHEBI_5134
T120 425-428 Chemical denotes RNA http://purl.obolibrary.org/obo/CHEBI_33697
T121 509-512 Chemical denotes RNA http://purl.obolibrary.org/obo/CHEBI_33697
T122 605-612 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T123 673-683 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T124 771-781 Chemical denotes Mometasone http://purl.obolibrary.org/obo/CHEBI_6970
T125 879-889 Chemical denotes mometasone http://purl.obolibrary.org/obo/CHEBI_6970
T126 895-904 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T127 1018-1024 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T128 1052-1062 Chemical denotes nafamostat http://purl.obolibrary.org/obo/CHEBI_135466
T129 1067-1075 Chemical denotes camostat http://purl.obolibrary.org/obo/CHEBI_135632

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T222 161-169 Species denotes MERS-CoV NCBItxid:1335626
T223 344-363 Species denotes human coronaviruses NCBItxid:694448
T224 373-382 Species denotes HCoV-229E NCBItxid:11137
T225 387-395 Species denotes SARS-CoV NCBItxid:694009
T226 425-434 Species denotes RNA virus NCBItxid:2559587
T227 436-449 Species denotes rubella virus NCBItxid:11041
T228 493-520 Species denotes negative-strand RNA viruses NCBItxid:2497569
T229 542-569 Species denotes respiratory syncytial virus NCBItxid:12814
T230 579-587 Species denotes MERS-CoV NCBItxid:1335626
T231 746-754 Species denotes MERS-CoV NCBItxid:1335626
T232 827-835 Species denotes MERS-CoV NCBItxid:1335626
T233 845-854 Species denotes SARS-CoV2 NCBItxid:2697049
T234 1156-1165 Species denotes SARS-CoV2 NCBItxid:2697049

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T198 0-170 Sentence denotes The study [30] investigated the effect of inhaled corticosteroids ciclesonide, cortisone, prednisolone, dexamethasone, and fluticasone on the replication of the MERS-CoV.
T199 171-262 Sentence denotes Among the four compounds, the only ciclesonide was capable of inhibiting viral replication.
T200 263-570 Sentence denotes Also, ciclesonide induced a significant inhibition of viral replication of other human coronaviruses, such as HCoV-229E and SARS-CoV, and another positive-strand RNA virus, rubella virus, while not affect the viral replication of negative-strand RNA viruses, e.g., influenza and respiratory syncytial virus.
T201 571-669 Sentence denotes For the MERS-CoV, a nonstructural protein 15 (NSP15) appeared to act as the target of ciclesonide.
T202 670-770 Sentence denotes An amino acid substitution in the NSP15 conferred resistance of the mutated MERS-CoV to ciclesonide.
T203 771-836 Sentence denotes Mometasone could help deal effectively with the mutated MERS-CoV.
T204 837-964 Sentence denotes For the SARS-CoV2, all three ciclesonide, mometasone, and lopinavir were able to inhibit viral replication to a similar degree.
T205 965-1122 Sentence denotes Interestingly, their effect was more noticeable than serine protease inhibitors, e.g., nafamostat and camostat in cells that Vero cells that express TMPRSS2.
T206 1123-1277 Sentence denotes It indicates the tendency of the SARS-CoV2 to enter the cell through the cathepsin/endosomal pathway rather than through the TMPRSS2/cell surface pathway.

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
866 66-77 Chemical denotes ciclesonide MESH:C120481
867 79-88 Chemical denotes cortisone MESH:D003348
868 90-102 Chemical denotes prednisolone MESH:D011239
869 104-117 Chemical denotes dexamethasone MESH:D003907
870 123-134 Chemical denotes fluticasone MESH:D000068298
855 161-169 Species denotes MERS-CoV Tax:1335626
871 206-217 Chemical denotes ciclesonide MESH:C120481
872 269-280 Chemical denotes ciclesonide MESH:C120481
856 344-349 Species denotes human Tax:9606
857 350-363 Species denotes coronaviruses Tax:11118
881 373-382 CellLine denotes HCoV-229E CVCL:D748
858 387-395 Species denotes SARS-CoV Tax:694009
865 528-537 Species denotes influenza Tax:11309
859 542-569 Species denotes respiratory syncytial virus Tax:12814
860 579-587 Species denotes MERS-CoV Tax:1335626
873 657-668 Chemical denotes ciclesonide MESH:C120481
861 746-754 Species denotes MERS-CoV Tax:1335626
874 758-769 Chemical denotes ciclesonide MESH:C120481
875 771-781 Chemical denotes Mometasone MESH:D000068656
862 827-835 Species denotes MERS-CoV Tax:1335626
863 845-854 Species denotes SARS-CoV2 Tax:2697049
876 866-877 Chemical denotes ciclesonide MESH:C120481
877 879-889 Chemical denotes mometasone MESH:D000068656
878 895-904 Chemical denotes lopinavir MESH:D061466
879 1018-1024 Chemical denotes serine MESH:D012694
880 1052-1062 Chemical denotes nafamostat MESH:C032855
853 1114-1121 Gene denotes TMPRSS2 Gene:103219191
864 1156-1165 Species denotes SARS-CoV2 Tax:2697049
854 1248-1255 Gene denotes TMPRSS2 Gene:7113

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T2261 591-615 Protein denotes nonstructural protein 15 https://www.uniprot.org/uniprot/Q80E51|https://www.uniprot.org/uniprot/Q80BV8|https://www.uniprot.org/uniprot/Q80BV7|https://www.uniprot.org/uniprot/Q808C0|https://www.uniprot.org/uniprot/Q7T697|https://www.uniprot.org/uniprot/Q6WGN0|https://www.uniprot.org/uniprot/P59641|https://www.uniprot.org/uniprot/P0DTD1|https://www.uniprot.org/uniprot/P0C6X7
T2270 617-622 Protein denotes NSP15 https://www.uniprot.org/uniprot/Q80E51
T2271 704-709 Protein denotes NSP15 https://www.uniprot.org/uniprot/Q80E51
T2272 1018-1044 Protein denotes serine protease inhibitors https://www.uniprot.org/uniprot/Q6J201

LitCovid-sample-Enju

Id Subject Object Predicate Lexical cue
T19799 0-3 DT denotes The
T20594 4-9 NN denotes study
T82079 10-11 -LRB- denotes [
T66365 11-13 CD denotes 30
T51925 13-14 -RRB- denotes ]
T58773 15-27 VBD denotes investigated
T62943 28-31 DT denotes the
T17766 32-38 NN denotes effect
T91507 39-41 IN denotes of
T41721 42-49 VBN denotes inhaled
T68865 50-65 NNS denotes corticosteroids
T72129 66-77 NN denotes ciclesonide
T75975 77-78 -COMMA- denotes ,
T94153 79-88 NN denotes cortisone
T58635 88-89 -COMMA- denotes ,
T32129 90-102 NN denotes prednisolone
T52544 102-103 -COMMA- denotes ,
T7734 104-117 NN denotes dexamethasone
T48772 117-118 -COMMA- denotes ,
T59239 119-122 CC denotes and
T36302 123-134 NN denotes fluticasone
T2290 135-137 IN denotes on
T42645 138-141 DT denotes the
T67274 142-153 NN denotes replication
T25492 154-156 IN denotes of
T52796 157-160 DT denotes the
T27491 161-169 NN denotes MERS-CoV
T5267 171-176 IN denotes Among
T36393 177-180 DT denotes the
T1788 181-185 CD denotes four
T60636 186-195 NNS denotes compounds
T50162 195-196 -COMMA- denotes ,
T78874 197-200 DT denotes the
T22199 201-205 JJ denotes only
T45806 206-217 NN denotes ciclesonide
T86672 218-221 VBD denotes was
T12794 222-229 JJ denotes capable
T91797 230-232 IN denotes of
T13593 233-243 VBG denotes inhibiting
T5717 244-249 JJ denotes viral
T7401 250-261 NN denotes replication
T65340 263-267 RB denotes Also
T92623 267-268 -COMMA- denotes ,
T81617 269-280 NN denotes ciclesonide
T95958 281-288 VBD denotes induced
T85366 289-290 DT denotes a
T21714 291-302 JJ denotes significant
T15429 303-313 NN denotes inhibition
T16699 314-316 IN denotes of
T25584 317-322 JJ denotes viral
T73696 323-334 NN denotes replication
T7458 335-337 IN denotes of
T20174 338-343 JJ denotes other
T58259 344-349 JJ denotes human
T40953 350-363 NNS denotes coronaviruses
T84867 363-364 -COMMA- denotes ,
T83672 365-369 JJ denotes such
T19443 370-372 IN denotes as
T95806 373-382 NN denotes HCoV-229E
T84685 383-386 CC denotes and
T17277 387-395 NN denotes SARS-CoV
T94349 395-396 -COMMA- denotes ,
T72578 397-400 CC denotes and
T26171 401-408 DT denotes another
T39629 409-424 JJ denotes positive-strand
T10581 425-428 NN denotes RNA
T42602 429-434 NN denotes virus
T70474 434-435 -COMMA- denotes ,
T82553 436-443 NN denotes rubella
T68058 444-449 NN denotes virus
T24019 449-450 -COMMA- denotes ,
T62462 451-456 IN denotes while
T32300 457-460 RB denotes not
T38146 461-467 VB denotes affect
T72944 468-471 DT denotes the
T97423 472-477 JJ denotes viral
T43382 478-489 NN denotes replication
T16861 490-492 IN denotes of
T53501 493-508 JJ denotes negative-strand
T3387 509-512 NN denotes RNA
T51732 513-520 NNS denotes viruses
T35282 520-521 -COMMA- denotes ,
T32607 522-526 FW denotes e.g.
T24756 526-527 -COMMA- denotes ,
T29751 528-537 NN denotes influenza
T16801 538-541 CC denotes and
T19789 542-553 JJ denotes respiratory
T17323 554-563 JJ denotes syncytial
T9582 564-569 NN denotes virus
T55931 571-574 IN denotes For
T42084 575-578 DT denotes the
T92915 579-587 NN denotes MERS-CoV
T45016 587-588 -COMMA- denotes ,
T62094 589-590 DT denotes a
T52727 591-604 JJ denotes nonstructural
T37738 605-612 NN denotes protein
T44869 613-615 CD denotes 15
T12678 616-617 -LRB- denotes (
T67952 617-622 NN denotes NSP15
T62960 622-623 -RRB- denotes )
T99202 624-632 VBD denotes appeared
T16450 633-635 TO denotes to
T75671 636-639 VB denotes act
T10168 640-642 IN denotes as
T75263 643-646 DT denotes the
T95644 647-653 NN denotes target
T19735 654-656 IN denotes of
T45429 657-668 NN denotes ciclesonide
T28790 670-672 DT denotes An
T72966 673-678 JJ denotes amino
T10430 679-683 NN denotes acid
T13644 684-696 NN denotes substitution
T66951 697-699 IN denotes in
T16733 700-703 DT denotes the
T82047 704-709 NN denotes NSP15
T5298 710-719 VBD denotes conferred
T82196 720-730 NN denotes resistance
T91861 731-733 IN denotes of
T16541 734-737 DT denotes the
T11735 738-745 VBN denotes mutated
T77495 746-754 NN denotes MERS-CoV
T54348 755-757 TO denotes to
T98167 758-769 NN denotes ciclesonide
T36698 771-781 NN denotes Mometasone
T83057 782-787 MD denotes could
T32973 788-792 VB denotes help
T81462 793-797 VB denotes deal
T7177 798-809 RB denotes effectively
T91822 810-814 IN denotes with
T40647 815-818 DT denotes the
T69218 819-826 VBN denotes mutated
T94051 827-835 NN denotes MERS-CoV
T94597 837-840 IN denotes For
T52862 841-844 DT denotes the
T49143 845-854 NN denotes SARS-CoV2
T76216 854-855 -COMMA- denotes ,
T48579 856-859 DT denotes all
T87735 860-865 CD denotes three
T54792 866-877 NN denotes ciclesonide
T41003 877-878 -COMMA- denotes ,
T64594 879-889 NN denotes mometasone
T89636 889-890 -COMMA- denotes ,
T45337 891-894 CC denotes and
T31426 895-904 NN denotes lopinavir
T30995 905-909 VBD denotes were
T47275 910-914 JJ denotes able
T43506 915-917 TO denotes to
T13737 918-925 VB denotes inhibit
T48184 926-931 JJ denotes viral
T45532 932-943 NN denotes replication
T78456 944-946 TO denotes to
T84667 947-948 DT denotes a
T50127 949-956 JJ denotes similar
T63329 957-963 NN denotes degree
T13824 965-978 RB denotes Interestingly
T97722 978-979 -COMMA- denotes ,
T32551 980-985 PRP-DOLLAR- denotes their
T29877 986-992 NN denotes effect
T26799 993-996 VBD denotes was
T38163 997-1001 RBR denotes more
T71857 1002-1012 JJ denotes noticeable
T13399 1013-1017 IN denotes than
T61277 1018-1024 NN denotes serine
T95334 1025-1033 NN denotes protease
T18879 1034-1044 NNS denotes inhibitors
T2889 1044-1045 -COMMA- denotes ,
T73448 1046-1050 FW denotes e.g.
T12218 1050-1051 -COMMA- denotes ,
T97193 1052-1062 NN denotes nafamostat
T84364 1063-1066 CC denotes and
T56231 1067-1075 NN denotes camostat
T36295 1076-1078 IN denotes in
T50002 1079-1084 NNS denotes cells
T41374 1085-1089 WDT denotes that
T64051 1090-1094 NN denotes Vero
T69995 1095-1100 NNS denotes cells
T3328 1101-1105 WDT denotes that
T80806 1106-1113 VBP denotes express
T14927 1114-1121 NN denotes TMPRSS2
T77594 1123-1125 PRP denotes It
T50088 1126-1135 VBZ denotes indicates
T80437 1136-1139 DT denotes the
T11181 1140-1148 NN denotes tendency
T22059 1149-1151 IN denotes of
T93173 1152-1155 DT denotes the
T10513 1156-1165 NN denotes SARS-CoV2
T35356 1166-1168 TO denotes to
T95799 1169-1174 VB denotes enter
T54387 1175-1178 DT denotes the
T81737 1179-1183 NN denotes cell
T49362 1184-1191 IN denotes through
T16554 1192-1195 DT denotes the
T7152 1196-1215 JJ denotes cathepsin/endosomal
T53710 1216-1223 NN denotes pathway
T21481 1224-1230 RB denotes rather
T71892 1231-1235 IN denotes than
T13882 1236-1243 IN denotes through
T1912 1244-1247 DT denotes the
T96928 1248-1260 NN denotes TMPRSS2/cell
T71956 1261-1268 NN denotes surface
T74893 1269-1276 NN denotes pathway
R65562 T20594 T19799 arg1Of study,The
R91543 T20594 T82079 arg1Of study,[
R68043 T66365 T82079 arg2Of 30,[
R8765 T51925 T82079 arg3Of ],[
R52690 T20594 T58773 arg1Of study,investigated
R62362 T17766 T58773 arg2Of effect,investigated
R80214 T17766 T62943 arg1Of effect,the
R30204 T17766 T91507 arg1Of effect,of
R57298 T59239 T91507 arg2Of and,of
R63916 T58635 T41721 arg2Of ",",inhaled
R43023 T58635 T68865 arg1Of ",",corticosteroids
R83908 T72129 T75975 arg1Of ciclesonide,","
R40147 T94153 T75975 arg2Of cortisone,","
R68981 T75975 T58635 arg1Of ",",","
R34809 T32129 T58635 arg2Of prednisolone,","
R35158 T58635 T52544 arg1Of ",",","
R94218 T7734 T52544 arg2Of dexamethasone,","
R66797 T59239 T48772 arg1Of and,","
R18975 T52544 T59239 arg1Of ",",and
R17941 T36302 T59239 arg2Of fluticasone,and
R76759 T36302 T2290 arg1Of fluticasone,on
R65488 T67274 T2290 arg2Of replication,on
R83692 T67274 T42645 arg1Of replication,the
R83433 T67274 T25492 arg1Of replication,of
R69453 T27491 T25492 arg2Of MERS-CoV,of
R5640 T27491 T52796 arg1Of MERS-CoV,the
R14892 T86672 T5267 arg1Of was,Among
R12867 T60636 T5267 arg2Of compounds,Among
R20551 T60636 T36393 arg1Of compounds,the
R45638 T60636 T1788 arg1Of compounds,four
R19889 T86672 T50162 arg1Of was,","
R6925 T45806 T78874 arg1Of ciclesonide,the
R51502 T45806 T22199 arg1Of ciclesonide,only
R80549 T45806 T86672 arg1Of ciclesonide,was
R88441 T12794 T86672 arg2Of capable,was
R54150 T45806 T12794 arg1Of ciclesonide,capable
R84902 T12794 T91797 arg1Of capable,of
R90818 T13593 T91797 arg2Of inhibiting,of
R59467 T45806 T13593 arg1Of ciclesonide,inhibiting
R61171 T7401 T13593 arg2Of replication,inhibiting
R62948 T7401 T5717 arg1Of replication,viral
R72412 T72578 T65340 arg1Of and,Also
R83353 T72578 T92623 arg1Of and,","
R13827 T81617 T95958 arg1Of ciclesonide,induced
R67632 T15429 T95958 arg2Of inhibition,induced
R52903 T15429 T85366 arg1Of inhibition,a
R95901 T15429 T21714 arg1Of inhibition,significant
R59832 T15429 T16699 arg1Of inhibition,of
R67342 T73696 T16699 arg2Of replication,of
R82929 T73696 T25584 arg1Of replication,viral
R28660 T73696 T7458 arg1Of replication,of
R31825 T40953 T7458 arg2Of coronaviruses,of
R98296 T40953 T20174 arg1Of coronaviruses,other
R36062 T40953 T58259 arg1Of coronaviruses,human
R24201 T40953 T84867 arg1Of coronaviruses,","
R18026 T19443 T83672 arg1Of as,such
R24587 T40953 T19443 arg1Of coronaviruses,as
R57525 T84685 T19443 arg2Of and,as
R99041 T95806 T84685 arg1Of HCoV-229E,and
R18584 T17277 T84685 arg2Of SARS-CoV,and
R60299 T72578 T94349 arg1Of and,","
R84710 T95958 T72578 arg1Of induced,and
R44966 T38146 T72578 arg2Of affect,and
R50591 T42602 T26171 arg1Of virus,another
R36647 T42602 T39629 arg1Of virus,positive-strand
R98576 T42602 T10581 arg1Of virus,RNA
R27749 T42602 T70474 arg1Of virus,","
R18576 T68058 T70474 arg2Of virus,","
R11915 T68058 T82553 arg1Of virus,rubella
R43356 T38146 T24019 arg1Of affect,","
R75887 T32300 T62462 arg1Of not,while
R44280 T38146 T32300 arg1Of affect,not
R91937 T42602 T38146 arg1Of virus,affect
R80466 T43382 T38146 arg2Of replication,affect
R95276 T43382 T72944 arg1Of replication,the
R61734 T43382 T97423 arg1Of replication,viral
R88271 T43382 T16861 arg1Of replication,of
R61511 T16801 T16861 arg2Of and,of
R90433 T51732 T53501 arg1Of viruses,negative-strand
R66191 T51732 T3387 arg1Of viruses,RNA
R5188 T51732 T35282 arg1Of viruses,","
R15638 T51732 T32607 arg1Of viruses,e.g.
R93190 T51732 T24756 arg1Of viruses,","
R92859 T29751 T24756 arg2Of influenza,","
R78785 T24756 T16801 arg1Of ",",and
R68118 T9582 T16801 arg2Of virus,and
R38873 T9582 T19789 arg1Of virus,respiratory
R7863 T9582 T17323 arg1Of virus,syncytial
R1995 T99202 T55931 arg1Of appeared,For
R6126 T92915 T55931 arg2Of MERS-CoV,For
R88085 T92915 T42084 arg1Of MERS-CoV,the
R79940 T99202 T45016 arg1Of appeared,","
R94118 T37738 T62094 arg1Of protein,a
R82408 T37738 T52727 arg1Of protein,nonstructural
R48240 T37738 T44869 arg1Of protein,15
R71223 T37738 T12678 arg1Of protein,(
R55825 T67952 T12678 arg2Of NSP15,(
R53099 T62960 T12678 arg3Of ),(
R16785 T37738 T99202 arg1Of protein,appeared
R13520 T75671 T99202 arg2Of act,appeared
R46727 T75671 T16450 arg1Of act,to
R20444 T37738 T75671 arg1Of protein,act
R15573 T75671 T10168 arg1Of act,as
R48367 T95644 T10168 arg2Of target,as
R90497 T95644 T75263 arg1Of target,the
R83237 T95644 T19735 arg1Of target,of
R92697 T45429 T19735 arg2Of ciclesonide,of
R20783 T13644 T28790 arg1Of substitution,An
R76164 T13644 T72966 arg1Of substitution,amino
R83793 T13644 T10430 arg1Of substitution,acid
R73378 T13644 T66951 arg1Of substitution,in
R18787 T82047 T66951 arg2Of NSP15,in
R39227 T82047 T16733 arg1Of NSP15,the
R65371 T13644 T5298 arg1Of substitution,conferred
R22776 T82196 T5298 arg2Of resistance,conferred
R90200 T82196 T91861 arg1Of resistance,of
R3544 T77495 T91861 arg2Of MERS-CoV,of
R34537 T77495 T16541 arg1Of MERS-CoV,the
R58093 T77495 T11735 arg2Of MERS-CoV,mutated
R53774 T82196 T54348 arg1Of resistance,to
R82049 T98167 T54348 arg2Of ciclesonide,to
R2236 T36698 T83057 arg1Of Mometasone,could
R84671 T32973 T83057 arg2Of help,could
R24093 T36698 T32973 arg1Of Mometasone,help
R32776 T81462 T32973 arg2Of deal,help
R18020 T36698 T81462 arg1Of Mometasone,deal
R11857 T81462 T7177 arg1Of deal,effectively
R16336 T81462 T91822 arg1Of deal,with
R70505 T94051 T91822 arg2Of MERS-CoV,with
R65523 T94051 T40647 arg1Of MERS-CoV,the
R9228 T94051 T69218 arg2Of MERS-CoV,mutated
R68878 T30995 T94597 arg1Of were,For
R91823 T49143 T94597 arg2Of SARS-CoV2,For
R46848 T49143 T52862 arg1Of SARS-CoV2,the
R23184 T30995 T76216 arg1Of were,","
R58043 T45337 T48579 arg1Of and,all
R7552 T54792 T87735 arg1Of ciclesonide,three
R28224 T54792 T41003 arg1Of ciclesonide,","
R78599 T64594 T41003 arg2Of mometasone,","
R82759 T45337 T89636 arg1Of and,","
R76678 T41003 T45337 arg1Of ",",and
R77720 T31426 T45337 arg2Of lopinavir,and
R11228 T45337 T30995 arg1Of and,were
R32948 T47275 T30995 arg2Of able,were
R73540 T45337 T47275 arg1Of and,able
R73449 T13737 T47275 arg2Of inhibit,able
R44161 T13737 T43506 arg1Of inhibit,to
R92204 T45337 T13737 arg1Of and,inhibit
R76291 T45532 T13737 arg2Of replication,inhibit
R30994 T45532 T48184 arg1Of replication,viral
R12341 T13737 T78456 arg1Of inhibit,to
R48043 T63329 T78456 arg2Of degree,to
R67825 T63329 T84667 arg1Of degree,a
R44939 T63329 T50127 arg1Of degree,similar
R15596 T26799 T13824 arg1Of was,Interestingly
R24705 T26799 T97722 arg1Of was,","
R73525 T29877 T32551 arg1Of effect,their
R81635 T29877 T26799 arg1Of effect,was
R5706 T71857 T26799 arg2Of noticeable,was
R45433 T71857 T38163 arg1Of noticeable,more
R94349 T29877 T71857 arg1Of effect,noticeable
R94809 T71857 T13399 arg1Of noticeable,than
R75113 T18879 T13399 arg2Of inhibitors,than
R31379 T18879 T61277 arg1Of inhibitors,serine
R89388 T18879 T95334 arg1Of inhibitors,protease
R12797 T18879 T2889 arg1Of inhibitors,","
R55160 T18879 T73448 arg1Of inhibitors,e.g.
R26094 T18879 T12218 arg1Of inhibitors,","
R31915 T84364 T12218 arg2Of and,","
R26263 T97193 T84364 arg1Of nafamostat,and
R85915 T56231 T84364 arg2Of camostat,and
R23540 T84364 T36295 arg1Of and,in
R7945 T50002 T36295 arg2Of cells,in
R37915 T50002 T41374 arg1Of cells,that
R79286 T50002 T64051 arg1Of cells,Vero
R22588 T69995 T64051 arg2Of cells,Vero
R48556 T69995 T3328 arg1Of cells,that
R51539 T69995 T80806 arg1Of cells,express
R51824 T14927 T80806 arg2Of TMPRSS2,express
R69829 T77594 T50088 arg1Of It,indicates
R64885 T11181 T50088 arg2Of tendency,indicates
R66606 T11181 T80437 arg1Of tendency,the
R72062 T11181 T22059 arg1Of tendency,of
R63884 T10513 T22059 arg2Of SARS-CoV2,of
R52625 T10513 T93173 arg1Of SARS-CoV2,the
R66017 T95799 T35356 arg1Of enter,to
R58532 T11181 T35356 modOf tendency,to
R56550 T81737 T95799 arg2Of cell,enter
R54662 T81737 T54387 arg1Of cell,the
R41067 T95799 T49362 arg1Of enter,through
R93053 T53710 T49362 arg2Of pathway,through
R36961 T53710 T16554 arg1Of pathway,the
R13940 T53710 T7152 arg1Of pathway,cathepsin/endosomal
R62122 T71892 T21481 arg1Of than,rather
R3351 T49362 T71892 arg1Of through,than
R57039 T13882 T71892 arg2Of through,than
R65615 T95799 T13882 arg1Of enter,through
R49728 T74893 T13882 arg2Of pathway,through
R87204 T74893 T1912 arg1Of pathway,the
R67917 T74893 T96928 arg1Of pathway,TMPRSS2/cell
R10707 T74893 T71956 arg1Of pathway,surface

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T37 233-261 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibiting viral replication
T38 244-261 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T39 244-261 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T40 303-334 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibition of viral replication
T41 317-334 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T42 317-334 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T43 472-489 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T44 472-489 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T45 918-943 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibit viral replication
T46 926-943 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T47 926-943 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T169 425-428 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T170 509-512 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T171 605-612 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T172 673-683 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T173 1018-1024 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T174 1079-1084 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T175 1095-1100 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T176 1179-1183 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T177 1206-1215 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T178 1256-1268 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T179 1256-1260 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T175 387-395 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T176 436-443 Disease denotes rubella http://purl.obolibrary.org/obo/MONDO_0004656
T177 528-537 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T178 845-854 Disease denotes SARS-CoV2 http://purl.obolibrary.org/obo/MONDO_0100096
T179 1156-1165 Disease denotes SARS-CoV2 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T33 233-261 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibiting viral replication
T34 244-261 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T35 244-261 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T36 303-334 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibition of viral replication
T37 317-334 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T38 317-334 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T39 472-489 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T40 472-489 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T41 918-943 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibit viral replication
T42 926-943 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T43 926-943 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T33 233-261 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibiting viral replication
T34 244-261 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T35 244-261 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T36 303-334 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibition of viral replication
T37 317-334 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T38 317-334 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T39 472-489 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T40 472-489 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T41 918-943 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibit viral replication
T42 926-943 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T43 926-943 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T198 0-170 Sentence denotes The study [30] investigated the effect of inhaled corticosteroids ciclesonide, cortisone, prednisolone, dexamethasone, and fluticasone on the replication of the MERS-CoV.
T199 171-262 Sentence denotes Among the four compounds, the only ciclesonide was capable of inhibiting viral replication.
T200 263-570 Sentence denotes Also, ciclesonide induced a significant inhibition of viral replication of other human coronaviruses, such as HCoV-229E and SARS-CoV, and another positive-strand RNA virus, rubella virus, while not affect the viral replication of negative-strand RNA viruses, e.g., influenza and respiratory syncytial virus.
T201 571-669 Sentence denotes For the MERS-CoV, a nonstructural protein 15 (NSP15) appeared to act as the target of ciclesonide.
T202 670-770 Sentence denotes An amino acid substitution in the NSP15 conferred resistance of the mutated MERS-CoV to ciclesonide.
T203 771-836 Sentence denotes Mometasone could help deal effectively with the mutated MERS-CoV.
T204 837-964 Sentence denotes For the SARS-CoV2, all three ciclesonide, mometasone, and lopinavir were able to inhibit viral replication to a similar degree.
T205 965-1122 Sentence denotes Interestingly, their effect was more noticeable than serine protease inhibitors, e.g., nafamostat and camostat in cells that Vero cells that express TMPRSS2.
T206 1123-1277 Sentence denotes It indicates the tendency of the SARS-CoV2 to enter the cell through the cathepsin/endosomal pathway rather than through the TMPRSS2/cell surface pathway.