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PMC:7205724 / 20533-21806 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
696 107-116 Species denotes SARS-CoV2 Tax:2697049
697 117-126 Disease denotes infection MESH:D007239
713 765-766 Gene denotes S Gene:43740568
714 752-753 Gene denotes S Gene:43740568
715 609-610 Gene denotes S Gene:43740568
716 550-551 Gene denotes S Gene:43740568
717 538-539 Gene denotes S Gene:43740568
718 406-407 Gene denotes S Gene:43740568
719 207-222 Species denotes transgenic mice Tax:10090
720 240-245 Species denotes human Tax:9606
721 288-291 Species denotes rat Tax:10116
722 399-405 Species denotes SARS-2 Tax:2697049
723 544-549 Species denotes SARS2 Tax:2697049
724 603-608 Species denotes SARS2 Tax:2697049
725 758-764 Species denotes SARS-2 Tax:2697049
726 493-511 Disease denotes decreased syncytia MESH:D002303
727 571-577 CellLine denotes VeroE6 CVCL:0574
729 836-841 Species denotes human Tax:9606
739 1134-1138 Gene denotes ACE2 Gene:59272
740 1268-1272 Gene denotes ACE2 Gene:59272
741 1221-1222 Gene denotes S Gene:43740568
742 1020-1021 Gene denotes S Gene:43740568
743 1007-1008 Gene denotes S Gene:43740568
744 969-970 Gene denotes S Gene:43740568
745 947-948 Gene denotes S Gene:43740568
746 962-968 Species denotes SARS-2 Tax:2697049
747 1013-1019 Species denotes SARS-2 Tax:2697049

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T150 21-28 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T151 171-179 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T152 246-260 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T153 299-313 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T154 438-446 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T155 578-583 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T156 842-846 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T157 847-852 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T158 1048-1056 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T21 842-846 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T151 107-111 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T152 117-126 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T153 388-392 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T154 399-403 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T155 533-537 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T156 592-596 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T157 747-751 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T158 758-762 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T159 942-946 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T160 962-966 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T161 1002-1006 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T162 1013-1017 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T163 1216-1220 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T240 49-50 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T241 89-94 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T242 137-146 http://purl.obolibrary.org/obo/CLO_0036932 denotes hybridoma
T243 240-245 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T244 462-463 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T245 483-491 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T246 571-583 http://purl.obolibrary.org/obo/CLO_0051719 denotes VeroE6 cells
T247 623-628 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T248 716-718 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T249 836-841 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T250 842-846 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T251 842-846 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T252 847-870 http://purl.obolibrary.org/obo/CL_0001034 denotes cells as it is in vitro
T253 885-886 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T254 928-930 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T255 928-930 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T256 1128-1130 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T257 1128-1130 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T258 1250-1252 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T259 1250-1252 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T167 21-28 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T168 928-930 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T169 1128-1130 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T170 1250-1252 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387

LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T19 246-260 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes immunoglobulin http://purl.bioontology.org/ontology/MEDDRA/10021496
T20 299-313 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes immunoglobulin http://purl.bioontology.org/ontology/MEDDRA/10021496
T21 1167-1190 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes neutralizing antibodies http://purl.bioontology.org/ontology/MEDDRA/10058063

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T95 89-94 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T96 117-126 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T97 578-583 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T98 623-628 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T99 847-852 http://purl.obolibrary.org/obo/CL_0000000 denotes cells

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T109 21-28 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T196 107-116 Species denotes SARS-CoV2 NCBItxid:2697049
T197 218-222 Species denotes mice NCBItxid:10095|NCBItxid:10088
T199 240-245 Species denotes human NCBItxid:9606
T200 288-291 Species denotes rat NCBItxid:10116|NCBItxid:10114
T202 388-392 Species denotes SARS NCBItxid:694009
T203 399-405 Species denotes SARS-2 NCBItxid:2697049
T204 533-537 Species denotes SARS NCBItxid:694009
T205 544-549 Species denotes SARS2 NCBItxid:2697049
T206 592-596 Species denotes SARS NCBItxid:694009
T207 603-608 Species denotes SARS2 NCBItxid:2697049
T208 747-751 Species denotes SARS NCBItxid:694009
T209 758-764 Species denotes SARS-2 NCBItxid:2697049
T210 836-841 Species denotes human NCBItxid:9606
T211 942-946 Species denotes SARS NCBItxid:694009
T212 962-968 Species denotes SARS-2 NCBItxid:2697049
T213 1002-1006 Species denotes SARS NCBItxid:694009
T214 1013-1019 Species denotes SARS-2 NCBItxid:2697049
T215 1216-1220 Species denotes SARS NCBItxid:694009

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T165 0-28 Sentence denotes 6.1 Targeting the S protein
T166 30-48 Sentence denotes 6.1.1 Hypothesis:
T167 49-126 Sentence denotes A mAb against the binding domain of the virus can inhibit SARS-CoV2 infection
T168 127-413 Sentence denotes Recently, hybridoma supernatants containing antibody repertoires from immunized transgenic mice that express the human immunoglobulin heavy and light chains and rat origin immunoglobulin constant regions were used to detect antibodies that can cross neutralize SARS-S and SARS-2-S [26].
T169 414-634 Sentence denotes One chimeric 47D11 H2L2 antibody displayed such a cross-neutralizing activity, decreased syncytia formation induced by SARS-S and SARS2-S, and could protect VeroE6 cells against SARS-S and SARS2-S pseudotyped virus [26].
T170 635-767 Sentence denotes It may lie in its similar affinities for interacting with the same domain of the S1 subunit, i.e., S1B, of each SARS-S and SARS-2-S.
T171 769-785 Sentence denotes 6.1.2 Rational:
T172 786-870 Sentence denotes The chimeric 47D11 H2L2 might not be effective in human lung cells as it is in vitro
T173 871-971 Sentence denotes 47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S.
T174 972-1153 Sentence denotes It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26].
T175 1154-1273 Sentence denotes By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2.

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T21 842-846 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
696 107-116 Species denotes SARS-CoV2 Tax:2697049
697 117-126 Disease denotes infection MESH:D007239
719 207-222 Species denotes transgenic mice Tax:10090
720 240-245 Species denotes human Tax:9606
721 288-291 Species denotes rat Tax:10116
722 399-405 Species denotes SARS-2 Tax:2697049
718 406-407 Gene denotes S Gene:43740568
726 493-511 Disease denotes decreased syncytia MESH:D002303
717 538-539 Gene denotes S Gene:43740568
723 544-549 Species denotes SARS2 Tax:2697049
716 550-551 Gene denotes S Gene:43740568
727 571-577 CellLine denotes VeroE6 CVCL:0574
724 603-608 Species denotes SARS2 Tax:2697049
715 609-610 Gene denotes S Gene:43740568
714 752-753 Gene denotes S Gene:43740568
725 758-764 Species denotes SARS-2 Tax:2697049
713 765-766 Gene denotes S Gene:43740568
729 836-841 Species denotes human Tax:9606
745 947-948 Gene denotes S Gene:43740568
746 962-968 Species denotes SARS-2 Tax:2697049
744 969-970 Gene denotes S Gene:43740568
743 1007-1008 Gene denotes S Gene:43740568
747 1013-1019 Species denotes SARS-2 Tax:2697049
742 1020-1021 Gene denotes S Gene:43740568
739 1134-1138 Gene denotes ACE2 Gene:59272
741 1221-1222 Gene denotes S Gene:43740568
740 1268-1272 Gene denotes ACE2 Gene:59272

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T2036 19-28 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T2069 734-737 Protein denotes S1B https://www.uniprot.org/uniprot/P47835
T2070 1077-1080 Protein denotes S1B https://www.uniprot.org/uniprot/P47835
T2071 1120-1123 Protein denotes S1B https://www.uniprot.org/uniprot/P47835
T2072 1242-1245 Protein denotes S1B https://www.uniprot.org/uniprot/P47835

LitCovid-sample-Enju

Id Subject Object Predicate Lexical cue
T20998 0-3 CD denotes 6.1
T79456 5-14 VBG denotes Targeting
T24060 15-18 DT denotes the
T56819 19-20 NN denotes S
T25577 21-28 NN denotes protein
T96682 30-35 CD denotes 6.1.1
T17328 37-47 NN denotes Hypothesis
T61727 47-48 -COLON- denotes :
T32221 49-50 DT denotes A
T25878 51-54 NN denotes mAb
T8625 55-62 IN denotes against
T32030 63-66 DT denotes the
T55531 67-74 NN denotes binding
T9970 75-81 NN denotes domain
T76093 82-84 IN denotes of
T80345 85-88 DT denotes the
T93532 89-94 NN denotes virus
T16199 95-98 MD denotes can
T28417 99-106 VB denotes inhibit
T48409 107-116 NN denotes SARS-CoV2
T36310 117-126 NN denotes infection
T27915 127-135 RB denotes Recently
T56144 135-136 -COMMA- denotes ,
T55915 137-146 NN denotes hybridoma
T72012 147-159 NNS denotes supernatants
T47163 160-170 VBG denotes containing
T24138 171-179 NN denotes antibody
T98139 180-191 NNS denotes repertoires
T66535 192-196 IN denotes from
T86473 197-206 VBN denotes immunized
T66245 207-217 JJ denotes transgenic
T17100 218-222 NNS denotes mice
T85324 223-227 WDT denotes that
T55347 228-235 VBP denotes express
T14738 236-239 DT denotes the
T52540 240-245 JJ denotes human
T35586 246-260 NN denotes immunoglobulin
T72563 261-266 JJ denotes heavy
T65069 267-270 CC denotes and
T5967 271-276 JJ denotes light
T98095 277-283 NNS denotes chains
T78221 284-287 CC denotes and
T28318 288-291 NN denotes rat
T19776 292-298 NN denotes origin
T32531 299-313 NN denotes immunoglobulin
T16968 314-322 NN denotes constant
T56920 323-330 NNS denotes regions
T36716 331-335 VBD denotes were
T74827 336-340 VBN denotes used
T21382 341-343 TO denotes to
T11788 344-350 VB denotes detect
T40665 351-361 NNS denotes antibodies
T56747 362-366 WDT denotes that
T54239 367-370 MD denotes can
T71867 371-376 VB denotes cross
T35671 377-387 VB denotes neutralize
T77445 388-394 NN denotes SARS-S
T34654 395-398 CC denotes and
T83470 399-407 NN denotes SARS-2-S
T76245 408-409 -LRB- denotes [
T33581 409-411 CD denotes 26
T80577 411-412 -RRB- denotes ]
T78516 414-417 CD denotes One
T34464 418-426 JJ denotes chimeric
T13041 427-432 NN denotes 47D11
T83927 433-437 NN denotes H2L2
T57345 438-446 NN denotes antibody
T44833 447-456 VBD denotes displayed
T94688 457-461 PDT denotes such
T52983 462-463 DT denotes a
T30646 464-482 JJ denotes cross-neutralizing
T37245 483-491 NN denotes activity
T11300 491-492 -COMMA- denotes ,
T30814 493-502 VBD denotes decreased
T23282 503-511 NN denotes syncytia
T72581 512-521 NN denotes formation
T71888 522-529 VBN denotes induced
T44111 530-532 IN denotes by
T7869 533-539 NN denotes SARS-S
T80909 540-543 CC denotes and
T58127 544-551 NN denotes SARS2-S
T9479 551-552 -COMMA- denotes ,
T96346 553-556 CC denotes and
T43362 557-562 MD denotes could
T48435 563-570 VB denotes protect
T44775 571-577 NN denotes VeroE6
T25625 578-583 NNS denotes cells
T19104 584-591 IN denotes against
T51640 592-598 NN denotes SARS-S
T22676 599-602 CC denotes and
T37470 603-610 NN denotes SARS2-S
T64695 611-622 VBD denotes pseudotyped
T26978 623-628 NN denotes virus
T79137 629-630 -LRB- denotes [
T95558 630-632 CD denotes 26
T95168 632-633 -RRB- denotes ]
T45371 635-637 PRP denotes It
T75403 638-641 MD denotes may
T86603 642-645 VB denotes lie
T91829 646-648 IN denotes in
T48175 649-652 PRP-DOLLAR- denotes its
T69338 653-660 JJ denotes similar
T68140 661-671 NNS denotes affinities
T76951 672-675 IN denotes for
T38362 676-687 VBG denotes interacting
T39715 688-692 IN denotes with
T48378 693-696 DT denotes the
T63623 697-701 JJ denotes same
T2491 702-708 NN denotes domain
T57621 709-711 IN denotes of
T77993 712-715 DT denotes the
T52886 716-718 NN denotes S1
T27554 719-726 NN denotes subunit
T41139 726-727 -COMMA- denotes ,
T99819 728-732 FW denotes i.e.
T40027 732-733 -COMMA- denotes ,
T73637 734-737 NN denotes S1B
T71055 737-738 -COMMA- denotes ,
T88888 739-741 IN denotes of
T40209 742-746 DT denotes each
T2572 747-753 NN denotes SARS-S
T97128 754-757 CC denotes and
T91104 758-766 NN denotes SARS-2-S
T63608 769-774 CD denotes 6.1.2
T11815 776-784 NNP denotes Rational
T73902 784-785 -COLON- denotes :
T21134 786-789 DT denotes The
T30867 790-798 JJ denotes chimeric
T42126 799-804 NN denotes 47D11
T93924 805-809 NN denotes H2L2
T85248 810-815 MD denotes might
T92338 816-819 RB denotes not
T49873 820-822 VB denotes be
T69919 823-832 JJ denotes effective
T60557 833-835 IN denotes in
T77242 836-841 JJ denotes human
T86725 842-846 NN denotes lung
T18333 847-852 NNS denotes cells
T22947 853-855 IN denotes as
T22184 856-858 PRP denotes it
T1922 859-861 VBZ denotes is
T72123 862-864 FW denotes in
T38972 865-870 FW denotes vitro
T22398 871-876 NN denotes 47D11
T15962 877-884 VBD denotes carried
T83196 885-886 DT denotes a
T61532 887-893 JJR denotes higher
T47874 894-902 NN denotes affinity
T77580 903-906 IN denotes for
T95631 907-918 VBG denotes interacting
T94847 919-923 IN denotes with
T20163 924-927 DT denotes the
T18520 928-930 NN denotes S2
T89003 931-938 NN denotes subunit
T41606 939-941 IN denotes of
T4784 942-948 NN denotes SARS-S
T32288 949-953 IN denotes than
T68894 954-958 DT denotes that
T97000 959-961 IN denotes of
T32517 962-971 NN denotes SARS-2-S.
T24633 972-974 PRP denotes It
T45480 975-977 VBZ denotes is
T10954 978-987 JJ denotes important
T96386 988-992 IN denotes that
T80967 993-996 IN denotes for
T24571 997-1001 DT denotes both
T18211 1002-1008 NN denotes SARS-S
T39196 1009-1012 CC denotes and
T83081 1013-1021 NN denotes SARS-2-S
T70298 1021-1022 -COMMA- denotes ,
T91479 1023-1026 DT denotes the
T56884 1027-1034 NN denotes binding
T11559 1035-1037 IN denotes of
T2922 1038-1041 DT denotes the
T11592 1042-1047 NN denotes 47D11
T36887 1048-1056 NN denotes antibody
T46706 1057-1059 TO denotes to
T40788 1060-1063 DT denotes the
T37833 1064-1070 NN denotes target
T37378 1071-1072 VBZ denotes –
T15003 1073-1076 DT denotes the
T4372 1077-1080 NN denotes S1B
T31100 1081-1087 NN denotes domain
T82065 1088-1089 NN denotes –
T43926 1090-1094 VBZ denotes does
T69422 1095-1098 RB denotes not
T3419 1099-1104 VB denotes block
T21955 1105-1108 DT denotes the
T12942 1109-1116 NN denotes binding
T83444 1117-1119 IN denotes of
T49120 1120-1123 NN denotes S1B
T55070 1124-1127 CC denotes and
T98634 1128-1130 NN denotes S2
T48321 1131-1133 TO denotes to
T80580 1134-1138 NN denotes ACE2
T18877 1139-1147 NN denotes receptor
T18503 1148-1149 -LRB- denotes [
T33177 1149-1151 CD denotes 26
T92006 1151-1152 -RRB- denotes ]
T53652 1154-1156 IN denotes By
T58622 1157-1165 NN denotes contrast
T35381 1165-1166 -COMMA- denotes ,
T41843 1167-1179 VBG denotes neutralizing
T81589 1180-1190 NNS denotes antibodies
T68196 1191-1195 WDT denotes that
T30816 1196-1208 RB denotes specifically
T53446 1209-1215 NN denotes target
T89813 1216-1222 NN denotes SARS-S
T95236 1223-1228 MD denotes could
T7888 1229-1236 VB denotes compete
T34125 1237-1241 IN denotes with
T82101 1242-1245 NN denotes S1B
T1902 1246-1249 CC denotes and
T24277 1250-1252 NN denotes S2
T37015 1253-1256 IN denotes for
T86465 1257-1264 VBG denotes binding
T1893 1265-1267 TO denotes to
T91196 1268-1272 NN denotes ACE2
R5031 T20998 T79456 arg1Of 6.1,Targeting
R28532 T25577 T79456 arg2Of protein,Targeting
R81579 T25577 T24060 arg1Of protein,the
R73916 T25577 T56819 arg1Of protein,S
R32719 T17328 T96682 arg1Of Hypothesis,6.1.1
R34441 T17328 T61727 arg1Of Hypothesis,:
R7667 T25878 T32221 arg1Of mAb,A
R91773 T25878 T8625 arg1Of mAb,against
R23833 T9970 T8625 arg2Of domain,against
R92213 T9970 T32030 arg1Of domain,the
R57443 T9970 T55531 arg1Of domain,binding
R31979 T9970 T76093 arg1Of domain,of
R76879 T93532 T76093 arg2Of virus,of
R54102 T93532 T80345 arg1Of virus,the
R20587 T25878 T16199 arg1Of mAb,can
R25119 T28417 T16199 arg2Of inhibit,can
R58250 T17328 T16199 modOf Hypothesis,can
R15396 T25878 T28417 arg1Of mAb,inhibit
R9435 T36310 T28417 arg2Of infection,inhibit
R6804 T36310 T48409 arg1Of infection,SARS-CoV2
R33983 T74827 T27915 arg1Of used,Recently
R66835 T74827 T56144 arg1Of used,","
R79461 T72012 T55915 arg1Of supernatants,hybridoma
R93366 T72012 T47163 arg1Of supernatants,containing
R25704 T98139 T47163 arg2Of repertoires,containing
R90990 T98139 T24138 arg1Of repertoires,antibody
R94676 T98139 T66535 arg1Of repertoires,from
R63011 T17100 T66535 arg2Of mice,from
R10738 T17100 T86473 arg2Of mice,immunized
R74916 T17100 T66245 arg1Of mice,transgenic
R8726 T98139 T85324 arg1Of repertoires,that
R22914 T98139 T55347 arg1Of repertoires,express
R91506 T78221 T55347 arg2Of and,express
R63116 T78221 T14738 arg1Of and,the
R50898 T98095 T52540 arg1Of chains,human
R6996 T98095 T35586 arg1Of chains,immunoglobulin
R54748 T98095 T72563 arg1Of chains,heavy
R94533 T72563 T65069 arg1Of heavy,and
R51991 T5967 T65069 arg2Of light,and
R10518 T98095 T5967 arg1Of chains,light
R78842 T98095 T78221 arg1Of chains,and
R33937 T56920 T78221 arg2Of regions,and
R92294 T56920 T28318 arg1Of regions,rat
R87268 T56920 T19776 arg1Of regions,origin
R7737 T56920 T32531 arg1Of regions,immunoglobulin
R98342 T56920 T16968 arg1Of regions,constant
R65646 T72012 T36716 arg1Of supernatants,were
R67139 T74827 T36716 arg2Of used,were
R67837 T72012 T74827 arg2Of supernatants,used
R69341 T11788 T74827 arg3Of detect,used
R12801 T11788 T21382 arg1Of detect,to
R52958 T40665 T11788 arg2Of antibodies,detect
R77806 T40665 T56747 arg1Of antibodies,that
R37476 T40665 T54239 arg1Of antibodies,can
R87983 T35671 T54239 arg2Of neutralize,can
R24714 T40665 T71867 arg1Of antibodies,cross
R29418 T35671 T71867 arg2Of neutralize,cross
R8917 T40665 T35671 arg1Of antibodies,neutralize
R70086 T34654 T35671 arg2Of and,neutralize
R88560 T77445 T34654 arg1Of SARS-S,and
R74668 T83470 T34654 arg2Of SARS-2-S,and
R89642 T35671 T76245 arg1Of neutralize,[
R10178 T33581 T76245 arg2Of 26,[
R12224 T80577 T76245 arg3Of ],[
R55425 T57345 T78516 arg1Of antibody,One
R85824 T57345 T34464 arg1Of antibody,chimeric
R91166 T57345 T13041 arg1Of antibody,47D11
R74139 T57345 T83927 arg1Of antibody,H2L2
R37082 T57345 T44833 arg1Of antibody,displayed
R42165 T37245 T44833 arg2Of activity,displayed
R8404 T37245 T94688 arg1Of activity,such
R58851 T37245 T52983 arg1Of activity,a
R6725 T37245 T30646 arg1Of activity,cross-neutralizing
R48595 T44833 T11300 arg1Of displayed,","
R75181 T30814 T11300 arg2Of decreased,","
R32317 T57345 T30814 arg1Of antibody,decreased
R66912 T72581 T30814 arg2Of formation,decreased
R2953 T72581 T23282 arg1Of formation,syncytia
R53752 T80909 T71888 arg1Of and,induced
R39715 T72581 T71888 arg2Of formation,induced
R78219 T80909 T44111 arg2Of and,by
R96452 T7869 T80909 arg1Of SARS-S,and
R84017 T58127 T80909 arg2Of SARS2-S,and
R48482 T96346 T9479 arg1Of and,","
R37253 T11300 T96346 arg1Of ",",and
R96321 T48435 T96346 arg2Of protect,and
R73215 T57345 T43362 arg1Of antibody,could
R33694 T48435 T43362 arg2Of protect,could
R79302 T57345 T48435 arg1Of antibody,protect
R44320 T25625 T48435 arg2Of cells,protect
R54339 T25625 T44775 arg1Of cells,VeroE6
R74716 T48435 T19104 arg1Of protect,against
R67161 T22676 T19104 arg2Of and,against
R67960 T51640 T22676 arg1Of SARS-S,and
R58716 T37470 T22676 arg2Of SARS2-S,and
R42573 T22676 T64695 arg2Of and,pseudotyped
R23893 T26978 T64695 arg3Of virus,pseudotyped
R62516 T26978 T79137 arg1Of virus,[
R68991 T95558 T79137 arg2Of 26,[
R21425 T95168 T79137 arg3Of ],[
R57799 T45371 T75403 arg1Of It,may
R22045 T86603 T75403 arg2Of lie,may
R27208 T45371 T86603 arg1Of It,lie
R30853 T86603 T91829 arg1Of lie,in
R8563 T68140 T91829 arg2Of affinities,in
R84051 T68140 T48175 arg1Of affinities,its
R54251 T68140 T69338 arg1Of affinities,similar
R17475 T68140 T76951 arg1Of affinities,for
R24043 T38362 T76951 arg2Of interacting,for
R92728 T38362 T39715 arg1Of interacting,with
R17122 T2491 T39715 arg2Of domain,with
R47571 T2491 T48378 arg1Of domain,the
R29816 T2491 T63623 arg1Of domain,same
R3874 T2491 T57621 arg1Of domain,of
R51485 T27554 T57621 arg2Of subunit,of
R73905 T27554 T77993 arg1Of subunit,the
R30509 T27554 T52886 arg1Of subunit,S1
R24972 T68140 T41139 arg1Of affinities,","
R48015 T68140 T99819 arg1Of affinities,i.e.
R85163 T73637 T99819 arg2Of S1B,i.e.
R34990 T99819 T40027 arg1Of i.e.,","
R84082 T68140 T71055 arg1Of affinities,","
R73965 T68140 T88888 arg1Of affinities,of
R44270 T97128 T88888 arg2Of and,of
R2062 T97128 T40209 arg1Of and,each
R35318 T2572 T97128 arg1Of SARS-S,and
R89938 T91104 T97128 arg2Of SARS-2-S,and
R6870 T11815 T63608 arg1Of Rational,6.1.2
R99987 T11815 T73902 arg1Of Rational,:
R39394 T93924 T21134 arg1Of H2L2,The
R27252 T93924 T30867 arg1Of H2L2,chimeric
R91021 T93924 T42126 arg1Of H2L2,47D11
R85301 T93924 T85248 arg1Of H2L2,might
R68664 T49873 T85248 arg2Of be,might
R85602 T49873 T92338 arg1Of be,not
R73472 T93924 T49873 arg1Of H2L2,be
R56902 T69919 T49873 arg2Of effective,be
R30813 T93924 T69919 arg1Of H2L2,effective
R6463 T49873 T60557 arg1Of be,in
R98023 T18333 T60557 arg2Of cells,in
R22781 T18333 T77242 arg1Of cells,human
R95568 T18333 T86725 arg1Of cells,lung
R57926 T49873 T22947 arg1Of be,as
R49211 T1922 T22947 arg2Of is,as
R60499 T22184 T1922 arg1Of it,is
R70730 T38972 T72123 arg1Of vitro,in
R68061 T1922 T38972 arg1Of is,vitro
R37108 T22398 T15962 arg1Of 47D11,carried
R43602 T47874 T15962 arg2Of affinity,carried
R3397 T47874 T83196 arg1Of affinity,a
R69683 T47874 T61532 arg1Of affinity,higher
R78190 T47874 T77580 arg1Of affinity,for
R68969 T95631 T77580 arg2Of interacting,for
R15040 T95631 T94847 arg1Of interacting,with
R25517 T89003 T94847 arg2Of subunit,with
R53417 T89003 T20163 arg1Of subunit,the
R3997 T89003 T18520 arg1Of subunit,S2
R34556 T89003 T41606 arg1Of subunit,of
R37706 T4784 T41606 arg2Of SARS-S,of
R45826 T47874 T32288 arg1Of affinity,than
R81151 T68894 T32288 arg2Of that,than
R10947 T68894 T97000 arg1Of that,of
R87567 T32517 T97000 arg2Of SARS-2-S.,of
R92430 T24633 T45480 arg1Of It,is
R27880 T10954 T45480 arg2Of important,is
R16446 T47874 T45480 modOf affinity,is
R5059 T24633 T10954 arg1Of It,important
R77514 T47874 T96386 arg1Of affinity,that
R45591 T37378 T96386 arg2Of –,that
R6871 T96386 T80967 arg1Of that,for
R86711 T39196 T80967 arg2Of and,for
R85187 T39196 T24571 arg1Of and,both
R57766 T18211 T39196 arg1Of SARS-S,and
R60594 T83081 T39196 arg2Of SARS-2-S,and
R15467 T37378 T70298 arg1Of –,","
R5494 T56884 T91479 arg1Of binding,the
R79151 T56884 T11559 arg1Of binding,of
R6992 T36887 T11559 arg2Of antibody,of
R62361 T36887 T2922 arg1Of antibody,the
R48343 T36887 T11592 arg1Of antibody,47D11
R35747 T56884 T46706 arg1Of binding,to
R10371 T37833 T46706 arg2Of target,to
R36916 T37833 T40788 arg1Of target,the
R17566 T56884 T37378 arg1Of binding,–
R23617 T3419 T37378 arg2Of block,–
R26619 T82065 T15003 arg1Of –,the
R64854 T82065 T4372 arg1Of –,S1B
R97129 T82065 T31100 arg1Of –,domain
R47400 T82065 T43926 arg1Of –,does
R34720 T3419 T43926 arg2Of block,does
R55812 T3419 T69422 arg1Of block,not
R51826 T82065 T3419 arg1Of –,block
R99609 T12942 T3419 arg2Of binding,block
R35148 T12942 T21955 arg1Of binding,the
R30150 T12942 T83444 arg1Of binding,of
R36055 T55070 T83444 arg2Of and,of
R9737 T49120 T55070 arg1Of S1B,and
R3528 T98634 T55070 arg2Of S2,and
R55511 T12942 T48321 arg1Of binding,to
R91010 T18877 T48321 arg2Of receptor,to
R37042 T18877 T80580 arg1Of receptor,ACE2
R82088 T18877 T18503 arg1Of receptor,[
R55576 T33177 T18503 arg2Of 26,[
R41077 T92006 T18503 arg3Of ],[
R68866 T41843 T53652 arg1Of neutralizing,By
R80894 T58622 T53652 arg2Of contrast,By
R42535 T41843 T35381 arg1Of neutralizing,","
R99048 T81589 T41843 arg1Of antibodies,neutralizing
R45757 T81589 T68196 arg1Of antibodies,that
R2391 T7888 T30816 arg1Of compete,specifically
R14961 T89813 T53446 arg1Of SARS-S,target
R96775 T89813 T95236 arg1Of SARS-S,could
R6780 T7888 T95236 arg2Of compete,could
R40504 T89813 T7888 arg1Of SARS-S,compete
R84230 T81589 T7888 arg2Of antibodies,compete
R48027 T7888 T34125 arg1Of compete,with
R59163 T1902 T34125 arg2Of and,with
R39175 T82101 T1902 arg1Of S1B,and
R95020 T24277 T1902 arg2Of S2,and
R6420 T1902 T37015 arg1Of and,for
R67300 T86465 T37015 arg2Of binding,for
R53767 T86465 T1893 arg1Of binding,to
R3636 T91196 T1893 arg2Of ACE2,to

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T5 842-846 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T30 512-521 http://purl.obolibrary.org/obo/GO_0009058 denotes formation

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T150 21-28 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T151 171-179 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T152 246-260 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T153 299-313 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T154 438-446 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T155 578-583 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T156 842-846 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T157 847-852 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T158 1048-1056 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T146 107-116 Disease denotes SARS-CoV2 http://purl.obolibrary.org/obo/MONDO_0100096
T147 117-126 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T148 388-392 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T149 399-403 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T150 533-537 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T151 592-596 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T152 747-751 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T153 758-762 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T154 942-946 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T155 962-966 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T156 1002-1006 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T157 1013-1017 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T158 1216-1220 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T26 512-521 http://purl.obolibrary.org/obo/GO_0009058 denotes formation

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T26 512-521 http://purl.obolibrary.org/obo/GO_0009058 denotes formation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T165 0-28 Sentence denotes 6.1 Targeting the S protein
T166 30-48 Sentence denotes 6.1.1 Hypothesis:
T167 49-126 Sentence denotes A mAb against the binding domain of the virus can inhibit SARS-CoV2 infection
T168 127-413 Sentence denotes Recently, hybridoma supernatants containing antibody repertoires from immunized transgenic mice that express the human immunoglobulin heavy and light chains and rat origin immunoglobulin constant regions were used to detect antibodies that can cross neutralize SARS-S and SARS-2-S [26].
T169 414-634 Sentence denotes One chimeric 47D11 H2L2 antibody displayed such a cross-neutralizing activity, decreased syncytia formation induced by SARS-S and SARS2-S, and could protect VeroE6 cells against SARS-S and SARS2-S pseudotyped virus [26].
T170 635-767 Sentence denotes It may lie in its similar affinities for interacting with the same domain of the S1 subunit, i.e., S1B, of each SARS-S and SARS-2-S.
T171 769-785 Sentence denotes 6.1.2 Rational:
T172 786-870 Sentence denotes The chimeric 47D11 H2L2 might not be effective in human lung cells as it is in vitro
T173 871-971 Sentence denotes 47D11 carried a higher affinity for interacting with the S2 subunit of SARS-S than that of SARS-2-S.
T174 972-1153 Sentence denotes It is important that for both SARS-S and SARS-2-S, the binding of the 47D11 antibody to the target – the S1B domain – does not block the binding of S1B and S2 to ACE2 receptor [26].
T175 1154-1273 Sentence denotes By contrast, neutralizing antibodies that specifically target SARS-S could compete with S1B and S2 for binding to ACE2.