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PMC:7205724 / 19815-20478 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
679 130-134 Gene denotes ACE2 Gene:103231639
680 28-37 Species denotes SARS-CoV2 Tax:2697049
681 163-172 Species denotes SARS-CoV2 Tax:2697049
682 241-249 Species denotes SARS-CoV Tax:694009
683 323-332 Species denotes SARS-CoV2 Tax:2697049
684 391-399 Species denotes SARS-CoV Tax:694009
685 500-509 Species denotes SARS-CoV2 Tax:2697049
686 514-522 Species denotes SARS-CoV Tax:694009
687 17-26 Disease denotes infection MESH:D007239
688 173-182 Disease denotes infection MESH:D007239
689 371-380 Disease denotes infection MESH:D007239
690 461-470 Disease denotes infection MESH:D007239
691 106-108 CellLine denotes E6 CVCL:4582

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T147 109-114 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T148 599-607 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T140 17-26 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T141 28-32 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T142 163-167 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T143 173-182 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T144 241-249 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T145 323-327 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T146 371-380 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T147 391-399 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T148 461-470 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T149 500-504 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T150 514-522 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T233 6-8 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T234 101-114 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T235 360-362 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T236 450-452 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T237 617-624 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T166 599-607 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T85 17-26 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T86 38-49 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T87 109-114 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T88 148-159 http://purl.obolibrary.org/obo/IDO_0000467 denotes susceptible
T89 173-182 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T90 216-227 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T91 333-344 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T92 371-380 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T93 461-470 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T94 617-624 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T108 599-607 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T187 28-37 Species denotes SARS-CoV2 NCBItxid:2697049
T188 163-172 Species denotes SARS-CoV2 NCBItxid:2697049
T189 241-249 Species denotes SARS-CoV NCBItxid:694009
T190 323-332 Species denotes SARS-CoV2 NCBItxid:2697049
T191 391-399 Species denotes SARS-CoV NCBItxid:694009
T192 500-509 Species denotes SARS-CoV2 NCBItxid:2697049
T193 514-522 Species denotes SARS-CoV NCBItxid:694009
T194 617-624 Species denotes viruses NCBItxid:10239

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T159 0-188 Sentence denotes In 24–48 h after infection, SARS-CoV2 replication reaches titer that causes the cytopathic effect in Vero E6 cells, which express ACE2 and thus are susceptible to SARS-CoV2 infection [25].
T160 189-255 Sentence denotes It is similar to the viral replication kinetics for SARS-CoV [25].
T161 256-386 Sentence denotes Pretreatment with recombinant type I IFN could effectively inhibit SARS-CoV2 replication at both 24 and 48 h after infection [25].
T162 387-476 Sentence denotes For SARS-CoV, such an effect was present at 24 h but absent at 48 h after infection [25].
T163 477-663 Sentence denotes The difference between SARS-CoV2 and SARS-CoV in response to type I IFN treatment may be due to differences in structural proteins of these viruses, including NSP3, ORF3b, and ORF6 [25].

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
687 17-26 Disease denotes infection MESH:D007239
680 28-37 Species denotes SARS-CoV2 Tax:2697049
691 106-108 CellLine denotes E6 CVCL:4582
679 130-134 Gene denotes ACE2 Gene:103231639
681 163-172 Species denotes SARS-CoV2 Tax:2697049
688 173-182 Disease denotes infection MESH:D007239
682 241-249 Species denotes SARS-CoV Tax:694009
683 323-332 Species denotes SARS-CoV2 Tax:2697049
689 371-380 Disease denotes infection MESH:D007239
684 391-399 Species denotes SARS-CoV Tax:694009
690 461-470 Disease denotes infection MESH:D007239
685 500-509 Species denotes SARS-CoV2 Tax:2697049
686 514-522 Species denotes SARS-CoV Tax:694009

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T1989 588-607 Protein denotes structural proteins https://www.uniprot.org/uniprot/Q6LEG6|https://www.uniprot.org/uniprot/Q04766|https://www.uniprot.org/uniprot/Q04765
T1992 636-640 Protein denotes NSP3 https://www.uniprot.org/uniprot/Q9QNA7|https://www.uniprot.org/uniprot/Q9PY95|https://www.uniprot.org/uniprot/Q9ICB2|https://www.uniprot.org/uniprot/Q91ME7|https://www.uniprot.org/uniprot/Q8UZL8|https://www.uniprot.org/uniprot/Q8B6X8|https://www.uniprot.org/uniprot/Q8B6X7|https://www.uniprot.org/uniprot/Q86504|https://www.uniprot.org/uniprot/Q86196|https://www.uniprot.org/uniprot/Q85014|https://www.uniprot.org/uniprot/Q82054|https://www.uniprot.org/uniprot/Q82053|https://www.uniprot.org/uniprot/Q82052|https://www.uniprot.org/uniprot/Q82051|https://www.uniprot.org/uniprot/Q82050|https://www.uniprot.org/uniprot/Q82049|https://www.uniprot.org/uniprot/Q65701|https://www.uniprot.org/uniprot/Q5Y9A9|https://www.uniprot.org/uniprot/Q5K037|https://www.uniprot.org/uniprot/Q45UF3|https://www.uniprot.org/uniprot/Q3ZK63|https://www.uniprot.org/uniprot/Q27PP2|https://www.uniprot.org/uniprot/Q0H8C1|https://www.uniprot.org/uniprot/Q00721|https://www.uniprot.org/uniprot/P34717|https://www.uniprot.org/uniprot/P27586|https://www.uniprot.org/uniprot/P04514|https://www.uniprot.org/uniprot/P03536|https://www.uniprot.org/uniprot/B3SRX7|https://www.uniprot.org/uniprot/B3SRW9|https://www.uniprot.org/uniprot/B3SRV3|https://www.uniprot.org/uniprot/B3SRU5|https://www.uniprot.org/uniprot/B3SRS9|https://www.uniprot.org/uniprot/B3SRS1|https://www.uniprot.org/uniprot/B3SRR3|https://www.uniprot.org/uniprot/B3SRQ5|https://www.uniprot.org/uniprot/B2BRG4|https://www.uniprot.org/uniprot/A4ZCW4|https://www.uniprot.org/uniprot/A3DSK9|https://www.uniprot.org/uniprot/A2T3N5|https://www.uniprot.org/uniprot/A1YTU9
T2033 653-657 Protein denotes ORF6 https://www.uniprot.org/uniprot/P51707|https://www.uniprot.org/uniprot/P42541|https://www.uniprot.org/uniprot/P0DTC6

LitCovid-sample-Enju

Id Subject Object Predicate Lexical cue
T96177 0-2 IN denotes In
T72452 3-10 NN denotes 24–48 h
T50493 11-16 IN denotes after
T17096 17-26 NN denotes infection
T97012 26-27 -COMMA- denotes ,
T67170 28-37 NN denotes SARS-CoV2
T9761 38-49 NN denotes replication
T69880 50-57 VBZ denotes reaches
T9709 58-63 NN denotes titer
T49785 64-68 WDT denotes that
T71708 69-75 VBZ denotes causes
T52777 76-79 DT denotes the
T56623 80-90 JJ denotes cytopathic
T87850 91-97 NN denotes effect
T47272 98-100 IN denotes in
T71726 101-105 NN denotes Vero
T42629 106-108 NN denotes E6
T73531 109-114 NNS denotes cells
T60353 114-115 -COMMA- denotes ,
T83400 116-121 WDT denotes which
T80948 122-129 VBP denotes express
T12338 130-134 NN denotes ACE2
T60658 135-138 CC denotes and
T41368 139-143 RB denotes thus
T89464 144-147 VBP denotes are
T62340 148-159 JJ denotes susceptible
T6873 160-162 TO denotes to
T68175 163-172 NN denotes SARS-CoV2
T16296 173-182 NN denotes infection
T12529 183-184 -LRB- denotes [
T55131 184-186 CD denotes 25
T28678 186-187 -RRB- denotes ]
T52876 189-191 PRP denotes It
T21084 192-194 VBZ denotes is
T70918 195-202 JJ denotes similar
T20327 203-205 TO denotes to
T13471 206-209 DT denotes the
T26039 210-215 JJ denotes viral
T64125 216-227 NN denotes replication
T62855 228-236 NNS denotes kinetics
T68614 237-240 IN denotes for
T64958 241-249 NN denotes SARS-CoV
T62199 250-251 -LRB- denotes [
T27403 251-253 CD denotes 25
T34963 253-254 -RRB- denotes ]
T49689 256-268 NN denotes Pretreatment
T74739 269-273 IN denotes with
T62356 274-285 JJ denotes recombinant
T67333 286-290 NN denotes type
T31833 291-292 CD denotes I
T78772 293-296 NN denotes IFN
T57406 297-302 MD denotes could
T5100 303-314 RB denotes effectively
T32529 315-322 VB denotes inhibit
T31501 323-332 NN denotes SARS-CoV2
T43668 333-344 NN denotes replication
T86722 345-347 IN denotes at
T26971 348-352 CC denotes both
T35627 353-355 CD denotes 24
T29701 356-359 CC denotes and
T48153 360-364 NN denotes 48 h
T93874 365-370 IN denotes after
T7550 371-380 NN denotes infection
T23827 381-382 -LRB- denotes [
T6071 382-384 CD denotes 25
T91011 384-385 -RRB- denotes ]
T51029 387-390 IN denotes For
T64526 391-399 NN denotes SARS-CoV
T41819 399-400 -COMMA- denotes ,
T5764 401-405 PDT denotes such
T79954 406-408 DT denotes an
T48924 409-415 NN denotes effect
T40034 416-419 VBD denotes was
T1935 420-427 JJ denotes present
T31311 428-430 IN denotes at
T94385 431-435 CD denotes 24 h
T84543 436-439 CC denotes but
T64490 440-446 JJ denotes absent
T33679 447-449 IN denotes at
T68271 450-454 NN denotes 48 h
T69307 455-460 IN denotes after
T51672 461-470 NN denotes infection
T85433 471-472 -LRB- denotes [
T72350 472-474 CD denotes 25
T63406 474-475 -RRB- denotes ]
T46096 477-480 DT denotes The
T71403 481-491 NN denotes difference
T17651 492-499 IN denotes between
T77482 500-509 NN denotes SARS-CoV2
T6733 510-513 CC denotes and
T6622 514-522 NN denotes SARS-CoV
T66580 523-525 IN denotes in
T74975 526-534 NN denotes response
T1853 535-537 TO denotes to
T87892 538-542 NN denotes type
T83308 543-544 CD denotes I
T81934 545-548 NN denotes IFN
T42652 549-558 NN denotes treatment
T91527 559-562 MD denotes may
T42839 563-565 VB denotes be
T98810 566-569 JJ denotes due
T31126 570-572 TO denotes to
T23141 573-584 NNS denotes differences
T45488 585-587 IN denotes in
T39296 588-598 JJ denotes structural
T12723 599-607 NNS denotes proteins
T40582 608-610 IN denotes of
T48639 611-616 DT denotes these
T20513 617-624 NNS denotes viruses
T37519 624-625 -COMMA- denotes ,
T18237 626-635 VBG denotes including
T17094 636-640 NN denotes NSP3
T86991 640-641 -COMMA- denotes ,
T14810 642-647 NN denotes ORF3b
T9269 647-648 -COMMA- denotes ,
T18064 649-652 CC denotes and
T40695 653-657 NN denotes ORF6
T59456 658-659 -LRB- denotes [
T34145 659-661 CD denotes 25
T98303 661-662 -RRB- denotes ]
R31420 T69880 T96177 arg1Of reaches,In
R8938 T72452 T96177 arg2Of 24–48 h,In
R22070 T72452 T50493 arg1Of 24–48 h,after
R29558 T17096 T50493 arg2Of infection,after
R81743 T69880 T97012 arg1Of reaches,","
R54619 T9761 T67170 arg1Of replication,SARS-CoV2
R28733 T9761 T69880 arg1Of replication,reaches
R54888 T9709 T69880 arg2Of titer,reaches
R54019 T9709 T49785 arg1Of titer,that
R2019 T9709 T71708 arg1Of titer,causes
R69166 T87850 T71708 arg2Of effect,causes
R70600 T87850 T52777 arg1Of effect,the
R54949 T87850 T56623 arg1Of effect,cytopathic
R67236 T71708 T47272 arg1Of causes,in
R90604 T73531 T47272 arg2Of cells,in
R51483 T73531 T71726 arg1Of cells,Vero
R13941 T73531 T42629 arg1Of cells,E6
R47369 T73531 T60353 arg1Of cells,","
R77344 T73531 T83400 arg1Of cells,which
R51996 T73531 T80948 arg1Of cells,express
R29937 T12338 T80948 arg2Of ACE2,express
R56727 T80948 T60658 arg1Of express,and
R89880 T89464 T60658 arg2Of are,and
R41139 T89464 T41368 arg1Of are,thus
R40674 T73531 T89464 arg1Of cells,are
R2313 T62340 T89464 arg2Of susceptible,are
R71574 T73531 T62340 arg1Of cells,susceptible
R18320 T62340 T6873 arg1Of susceptible,to
R10483 T16296 T6873 arg2Of infection,to
R64279 T16296 T68175 arg1Of infection,SARS-CoV2
R82228 T89464 T12529 arg1Of are,[
R14351 T55131 T12529 arg2Of 25,[
R89760 T28678 T12529 arg3Of ],[
R98431 T52876 T21084 arg1Of It,is
R14327 T70918 T21084 arg2Of similar,is
R4320 T52876 T70918 arg1Of It,similar
R34375 T70918 T20327 arg1Of similar,to
R71339 T62855 T20327 arg2Of kinetics,to
R35190 T62855 T13471 arg1Of kinetics,the
R34673 T62855 T26039 arg1Of kinetics,viral
R67158 T62855 T64125 arg1Of kinetics,replication
R90913 T70918 T68614 arg1Of similar,for
R5275 T64958 T68614 arg2Of SARS-CoV,for
R43068 T64958 T62199 arg1Of SARS-CoV,[
R10807 T27403 T62199 arg2Of 25,[
R91008 T34963 T62199 arg3Of ],[
R68776 T49689 T74739 arg1Of Pretreatment,with
R59690 T78772 T74739 arg2Of IFN,with
R64010 T78772 T62356 arg1Of IFN,recombinant
R73596 T78772 T67333 arg1Of IFN,type
R44930 T78772 T31833 arg1Of IFN,I
R49184 T49689 T57406 arg1Of Pretreatment,could
R80908 T32529 T57406 arg2Of inhibit,could
R7756 T32529 T5100 arg1Of inhibit,effectively
R41655 T49689 T32529 arg1Of Pretreatment,inhibit
R47659 T43668 T32529 arg2Of replication,inhibit
R36370 T43668 T31501 arg1Of replication,SARS-CoV2
R34213 T32529 T86722 arg1Of inhibit,at
R26206 T29701 T86722 arg2Of and,at
R82903 T29701 T26971 arg1Of and,both
R75547 T35627 T29701 arg1Of 24,and
R90827 T48153 T29701 arg2Of 48 h,and
R69068 T32529 T93874 arg1Of inhibit,after
R47977 T7550 T93874 arg2Of infection,after
R38076 T7550 T23827 arg1Of infection,[
R72421 T6071 T23827 arg2Of 25,[
R2860 T91011 T23827 arg3Of ],[
R21012 T40034 T51029 arg1Of was,For
R42425 T64526 T51029 arg2Of SARS-CoV,For
R88091 T40034 T41819 arg1Of was,","
R54495 T48924 T5764 arg1Of effect,such
R26625 T48924 T79954 arg1Of effect,an
R41534 T48924 T40034 arg1Of effect,was
R24883 T84543 T40034 arg2Of but,was
R86398 T48924 T1935 arg1Of effect,present
R81876 T1935 T31311 arg1Of present,at
R72270 T94385 T31311 arg2Of 24 h,at
R12851 T1935 T84543 arg1Of present,but
R60363 T64490 T84543 arg2Of absent,but
R81621 T48924 T64490 arg1Of effect,absent
R79664 T84543 T33679 arg1Of but,at
R9487 T68271 T33679 arg2Of 48 h,at
R71731 T68271 T69307 arg1Of 48 h,after
R56025 T51672 T69307 arg2Of infection,after
R2152 T51672 T85433 arg1Of infection,[
R22284 T72350 T85433 arg2Of 25,[
R9566 T63406 T85433 arg3Of ],[
R51347 T71403 T46096 arg1Of difference,The
R4839 T71403 T17651 arg1Of difference,between
R32316 T6733 T17651 arg2Of and,between
R84108 T77482 T6733 arg1Of SARS-CoV2,and
R18562 T6622 T6733 arg2Of SARS-CoV,and
R2587 T6733 T66580 arg1Of and,in
R24267 T74975 T66580 arg2Of response,in
R82007 T74975 T1853 arg1Of response,to
R35751 T42652 T1853 arg2Of treatment,to
R70872 T42652 T87892 arg1Of treatment,type
R16675 T42652 T83308 arg1Of treatment,I
R93961 T42652 T81934 arg1Of treatment,IFN
R17630 T71403 T91527 arg1Of difference,may
R18684 T42839 T91527 arg2Of be,may
R22926 T71403 T42839 arg1Of difference,be
R74216 T31126 T42839 arg2Of to,be
R18552 T31126 T98810 arg1Of to,due
R78491 T71403 T31126 arg1Of difference,to
R99441 T23141 T31126 arg2Of differences,to
R87106 T23141 T45488 arg1Of differences,in
R95354 T12723 T45488 arg2Of proteins,in
R28120 T12723 T39296 arg1Of proteins,structural
R78454 T12723 T40582 arg1Of proteins,of
R26738 T20513 T40582 arg2Of viruses,of
R35077 T20513 T48639 arg1Of viruses,these
R70559 T12723 T37519 arg1Of proteins,","
R50810 T12723 T18237 arg1Of proteins,including
R8147 T18064 T18237 arg2Of and,including
R72409 T17094 T86991 arg1Of NSP3,","
R12802 T14810 T86991 arg2Of ORF3b,","
R29123 T18064 T9269 arg1Of and,","
R68379 T86991 T18064 arg1Of ",",and
R4978 T40695 T18064 arg2Of ORF6,and
R22872 T18064 T59456 arg1Of and,[
R60583 T34145 T59456 arg2Of 25,[
R50503 T98303 T59456 arg3Of ],[

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T27 210-227 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T28 210-227 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T29 526-548 http://purl.obolibrary.org/obo/GO_0034340 denotes response to type I IFN

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T147 109-114 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T148 599-607 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T135 17-26 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T136 28-37 Disease denotes SARS-CoV2 http://purl.obolibrary.org/obo/MONDO_0100096
T137 163-172 Disease denotes SARS-CoV2 http://purl.obolibrary.org/obo/MONDO_0100096
T138 173-182 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T139 241-249 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T140 323-332 Disease denotes SARS-CoV2 http://purl.obolibrary.org/obo/MONDO_0100096
T141 371-380 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T142 391-399 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T143 461-470 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T144 500-509 Disease denotes SARS-CoV2 http://purl.obolibrary.org/obo/MONDO_0100096
T145 514-522 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T23 210-227 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T24 210-227 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T25 526-548 http://purl.obolibrary.org/obo/GO_0034340 denotes response to type I IFN

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T23 210-227 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T24 210-227 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T25 526-548 http://purl.obolibrary.org/obo/GO_0034340 denotes response to type I IFN

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T159 0-188 Sentence denotes In 24–48 h after infection, SARS-CoV2 replication reaches titer that causes the cytopathic effect in Vero E6 cells, which express ACE2 and thus are susceptible to SARS-CoV2 infection [25].
T160 189-255 Sentence denotes It is similar to the viral replication kinetics for SARS-CoV [25].
T161 256-386 Sentence denotes Pretreatment with recombinant type I IFN could effectively inhibit SARS-CoV2 replication at both 24 and 48 h after infection [25].
T162 387-476 Sentence denotes For SARS-CoV, such an effect was present at 24 h but absent at 48 h after infection [25].
T163 477-663 Sentence denotes The difference between SARS-CoV2 and SARS-CoV in response to type I IFN treatment may be due to differences in structural proteins of these viruses, including NSP3, ORF3b, and ORF6 [25].