PMC:7205724 / 16627-17403 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"575","span":{"begin":18,"end":25},"obj":"Species"},{"id":"577","span":{"begin":79,"end":86},"obj":"Species"},{"id":"580","span":{"begin":191,"end":200},"obj":"Species"},{"id":"581","span":{"begin":298,"end":303},"obj":"Species"},{"id":"584","span":{"begin":414,"end":421},"obj":"Species"},{"id":"585","span":{"begin":484,"end":493},"obj":"Species"},{"id":"592","span":{"begin":742,"end":743},"obj":"Gene"},{"id":"593","span":{"begin":630,"end":631},"obj":"Gene"},{"id":"594","span":{"begin":521,"end":528},"obj":"Species"},{"id":"595","span":{"begin":623,"end":629},"obj":"Species"},{"id":"596","span":{"begin":735,"end":741},"obj":"Species"},{"id":"597","span":{"begin":657,"end":664},"obj":"Species"}],"attributes":[{"id":"A575","pred":"tao:has_database_id","subj":"575","obj":"Tax:9986"},{"id":"A577","pred":"tao:has_database_id","subj":"577","obj":"Tax:9986"},{"id":"A580","pred":"tao:has_database_id","subj":"580","obj":"Tax:9606"},{"id":"A581","pred":"tao:has_database_id","subj":"581","obj":"Tax:9606"},{"id":"A584","pred":"tao:has_database_id","subj":"584","obj":"Tax:9986"},{"id":"A585","pred":"tao:has_database_id","subj":"585","obj":"Tax:2697049"},{"id":"A592","pred":"tao:has_database_id","subj":"592","obj":"Gene:43740568"},{"id":"A593","pred":"tao:has_database_id","subj":"593","obj":"Gene:43740568"},{"id":"A594","pred":"tao:has_database_id","subj":"594","obj":"Tax:9986"},{"id":"A595","pred":"tao:has_database_id","subj":"595","obj":"Tax:2697049"},{"id":"A596","pred":"tao:has_database_id","subj":"596","obj":"Tax:2697049"},{"id":"A597","pred":"tao:has_database_id","subj":"597","obj":"Tax:9606"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"4.1.4 Serum from rabbits immunized with SARS\n\n4.1.4.1 Hypotheses: Serum from rabbits immunized with SARS is more effective than serum from convalescent SARS patients\nParaoxonases (PON) are mammalian enzymes associated with anti-oxidant and anti-inflammatory effects [19]. Rabbit PON differs from human PON in terms of more activity and more stability under the circumstances [20].\n\n4.1.4.2 Rational: Serum from rabbits immunized with the S1 subunit of SARS-S is able to neutralize SARS-CoV2 very efficiently\nSera from rabbits immunized with the S1 subunit of SARS-S could effectively reduce the entry of both SARS-S and SARS-2-S [16]. When compared with patient serum, rabbit serum revealed to us higher efficiency in inhibition of SARS-2-S entry at the same concentration."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T128","span":{"begin":7,"end":12},"obj":"Body_part"},{"id":"T129","span":{"begin":68,"end":73},"obj":"Body_part"},{"id":"T130","span":{"begin":130,"end":135},"obj":"Body_part"},{"id":"T131","span":{"begin":403,"end":408},"obj":"Body_part"},{"id":"T132","span":{"begin":665,"end":670},"obj":"Body_part"},{"id":"T133","span":{"begin":679,"end":684},"obj":"Body_part"}],"attributes":[{"id":"A128","pred":"fma_id","subj":"T128","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A129","pred":"fma_id","subj":"T129","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A130","pred":"fma_id","subj":"T130","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A131","pred":"fma_id","subj":"T131","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A132","pred":"fma_id","subj":"T132","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A133","pred":"fma_id","subj":"T133","obj":"http://purl.org/sig/ont/fma/fma63083"}],"text":"4.1.4 Serum from rabbits immunized with SARS\n\n4.1.4.1 Hypotheses: Serum from rabbits immunized with SARS is more effective than serum from convalescent SARS patients\nParaoxonases (PON) are mammalian enzymes associated with anti-oxidant and anti-inflammatory effects [19]. Rabbit PON differs from human PON in terms of more activity and more stability under the circumstances [20].\n\n4.1.4.2 Rational: Serum from rabbits immunized with the S1 subunit of SARS-S is able to neutralize SARS-CoV2 very efficiently\nSera from rabbits immunized with the S1 subunit of SARS-S could effectively reduce the entry of both SARS-S and SARS-2-S [16]. When compared with patient serum, rabbit serum revealed to us higher efficiency in inhibition of SARS-2-S entry at the same concentration."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T14","span":{"begin":7,"end":12},"obj":"Body_part"},{"id":"T15","span":{"begin":68,"end":73},"obj":"Body_part"},{"id":"T16","span":{"begin":130,"end":135},"obj":"Body_part"},{"id":"T17","span":{"begin":403,"end":408},"obj":"Body_part"},{"id":"T18","span":{"begin":665,"end":670},"obj":"Body_part"},{"id":"T19","span":{"begin":679,"end":684},"obj":"Body_part"}],"attributes":[{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"}],"text":"4.1.4 Serum from rabbits immunized with SARS\n\n4.1.4.1 Hypotheses: Serum from rabbits immunized with SARS is more effective than serum from convalescent SARS patients\nParaoxonases (PON) are mammalian enzymes associated with anti-oxidant and anti-inflammatory effects [19]. Rabbit PON differs from human PON in terms of more activity and more stability under the circumstances [20].\n\n4.1.4.2 Rational: Serum from rabbits immunized with the S1 subunit of SARS-S is able to neutralize SARS-CoV2 very efficiently\nSera from rabbits immunized with the S1 subunit of SARS-S could effectively reduce the entry of both SARS-S and SARS-2-S [16]. When compared with patient serum, rabbit serum revealed to us higher efficiency in inhibition of SARS-2-S entry at the same concentration."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T114","span":{"begin":41,"end":45},"obj":"Disease"},{"id":"T115","span":{"begin":102,"end":106},"obj":"Disease"},{"id":"T116","span":{"begin":154,"end":158},"obj":"Disease"},{"id":"T117","span":{"begin":455,"end":459},"obj":"Disease"},{"id":"T118","span":{"begin":484,"end":488},"obj":"Disease"},{"id":"T119","span":{"begin":562,"end":566},"obj":"Disease"},{"id":"T120","span":{"begin":612,"end":616},"obj":"Disease"},{"id":"T121","span":{"begin":623,"end":627},"obj":"Disease"},{"id":"T122","span":{"begin":735,"end":739},"obj":"Disease"}],"attributes":[{"id":"A114","pred":"mondo_id","subj":"T114","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A115","pred":"mondo_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A116","pred":"mondo_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A117","pred":"mondo_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A118","pred":"mondo_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A119","pred":"mondo_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A120","pred":"mondo_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A121","pred":"mondo_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A122","pred":"mondo_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"4.1.4 Serum from rabbits immunized with SARS\n\n4.1.4.1 Hypotheses: Serum from rabbits immunized with SARS is more effective than serum from convalescent SARS patients\nParaoxonases (PON) are mammalian enzymes associated with anti-oxidant and anti-inflammatory effects [19]. Rabbit PON differs from human PON in terms of more activity and more stability under the circumstances [20].\n\n4.1.4.2 Rational: Serum from rabbits immunized with the S1 subunit of SARS-S is able to neutralize SARS-CoV2 very efficiently\nSera from rabbits immunized with the S1 subunit of SARS-S could effectively reduce the entry of both SARS-S and SARS-2-S [16]. When compared with patient serum, rabbit serum revealed to us higher efficiency in inhibition of SARS-2-S entry at the same concentration."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T213","span":{"begin":298,"end":303},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T214","span":{"begin":325,"end":333},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T215","span":{"begin":441,"end":443},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T216","span":{"begin":548,"end":550},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"}],"text":"4.1.4 Serum from rabbits immunized with SARS\n\n4.1.4.1 Hypotheses: Serum from rabbits immunized with SARS is more effective than serum from convalescent SARS patients\nParaoxonases (PON) are mammalian enzymes associated with anti-oxidant and anti-inflammatory effects [19]. Rabbit PON differs from human PON in terms of more activity and more stability under the circumstances [20].\n\n4.1.4.2 Rational: Serum from rabbits immunized with the S1 subunit of SARS-S is able to neutralize SARS-CoV2 very efficiently\nSera from rabbits immunized with the S1 subunit of SARS-S could effectively reduce the entry of both SARS-S and SARS-2-S [16]. When compared with patient serum, rabbit serum revealed to us higher efficiency in inhibition of SARS-2-S entry at the same concentration."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T155","span":{"begin":230,"end":237},"obj":"Chemical"}],"attributes":[{"id":"A155","pred":"chebi_id","subj":"T155","obj":"http://purl.obolibrary.org/obo/CHEBI_63248"}],"text":"4.1.4 Serum from rabbits immunized with SARS\n\n4.1.4.1 Hypotheses: Serum from rabbits immunized with SARS is more effective than serum from convalescent SARS patients\nParaoxonases (PON) are mammalian enzymes associated with anti-oxidant and anti-inflammatory effects [19]. Rabbit PON differs from human PON in terms of more activity and more stability under the circumstances [20].\n\n4.1.4.2 Rational: Serum from rabbits immunized with the S1 subunit of SARS-S is able to neutralize SARS-CoV2 very efficiently\nSera from rabbits immunized with the S1 subunit of SARS-S could effectively reduce the entry of both SARS-S and SARS-2-S [16]. When compared with patient serum, rabbit serum revealed to us higher efficiency in inhibition of SARS-2-S entry at the same concentration."}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T149","span":{"begin":18,"end":25},"obj":"Species"},{"id":"T150","span":{"begin":41,"end":45},"obj":"Species"},{"id":"T151","span":{"begin":79,"end":86},"obj":"Species"},{"id":"T152","span":{"begin":102,"end":106},"obj":"Species"},{"id":"T153","span":{"begin":154,"end":158},"obj":"Species"},{"id":"T154","span":{"begin":274,"end":280},"obj":"Species"},{"id":"T155","span":{"begin":298,"end":303},"obj":"Species"},{"id":"T156","span":{"begin":414,"end":421},"obj":"Species"},{"id":"T157","span":{"begin":455,"end":459},"obj":"Species"},{"id":"T158","span":{"begin":484,"end":493},"obj":"Species"},{"id":"T159","span":{"begin":521,"end":528},"obj":"Species"},{"id":"T160","span":{"begin":562,"end":566},"obj":"Species"},{"id":"T161","span":{"begin":612,"end":616},"obj":"Species"},{"id":"T162","span":{"begin":623,"end":629},"obj":"Species"},{"id":"T163","span":{"begin":672,"end":678},"obj":"Species"},{"id":"T164","span":{"begin":735,"end":741},"obj":"Species"}],"attributes":[{"id":"A153","pred":"ncbi_taxonomy_id","subj":"T153","obj":"NCBItxid:694009"},{"id":"A150","pred":"ncbi_taxonomy_id","subj":"T150","obj":"NCBItxid:694009"},{"id":"A149","pred":"ncbi_taxonomy_id","subj":"T149","obj":"NCBItxid:9986"},{"id":"A155","pred":"ncbi_taxonomy_id","subj":"T155","obj":"NCBItxid:9606"},{"id":"A160","pred":"ncbi_taxonomy_id","subj":"T160","obj":"NCBItxid:694009"},{"id":"A154","pred":"ncbi_taxonomy_id","subj":"T154","obj":"NCBItxid:9986"},{"id":"A157","pred":"ncbi_taxonomy_id","subj":"T157","obj":"NCBItxid:694009"},{"id":"A156","pred":"ncbi_taxonomy_id","subj":"T156","obj":"NCBItxid:9986"},{"id":"A159","pred":"ncbi_taxonomy_id","subj":"T159","obj":"NCBItxid:9986"},{"id":"A151","pred":"ncbi_taxonomy_id","subj":"T151","obj":"NCBItxid:9986"},{"id":"A164","pred":"ncbi_taxonomy_id","subj":"T164","obj":"NCBItxid:2697049"},{"id":"A163","pred":"ncbi_taxonomy_id","subj":"T163","obj":"NCBItxid:9986"},{"id":"A158","pred":"ncbi_taxonomy_id","subj":"T158","obj":"NCBItxid:2697049"},{"id":"A152","pred":"ncbi_taxonomy_id","subj":"T152","obj":"NCBItxid:694009"},{"id":"A162","pred":"ncbi_taxonomy_id","subj":"T162","obj":"NCBItxid:2697049"},{"id":"A161","pred":"ncbi_taxonomy_id","subj":"T161","obj":"NCBItxid:694009"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"4.1.4 Serum from rabbits immunized with SARS\n\n4.1.4.1 Hypotheses: Serum from rabbits immunized with SARS is more effective than serum from convalescent SARS patients\nParaoxonases (PON) are mammalian enzymes associated with anti-oxidant and anti-inflammatory effects [19]. Rabbit PON differs from human PON in terms of more activity and more stability under the circumstances [20].\n\n4.1.4.2 Rational: Serum from rabbits immunized with the S1 subunit of SARS-S is able to neutralize SARS-CoV2 very efficiently\nSera from rabbits immunized with the S1 subunit of SARS-S could effectively reduce the entry of both SARS-S and SARS-2-S [16]. When compared with patient serum, rabbit serum revealed to us higher efficiency in inhibition of SARS-2-S entry at the same concentration."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T132","span":{"begin":0,"end":45},"obj":"Sentence"},{"id":"T133","span":{"begin":47,"end":67},"obj":"Sentence"},{"id":"T134","span":{"begin":68,"end":167},"obj":"Sentence"},{"id":"T135","span":{"begin":168,"end":273},"obj":"Sentence"},{"id":"T136","span":{"begin":274,"end":382},"obj":"Sentence"},{"id":"T137","span":{"begin":384,"end":402},"obj":"Sentence"},{"id":"T138","span":{"begin":403,"end":510},"obj":"Sentence"},{"id":"T139","span":{"begin":511,"end":637},"obj":"Sentence"},{"id":"T140","span":{"begin":638,"end":776},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"4.1.4 Serum from rabbits immunized with SARS\n\n4.1.4.1 Hypotheses: Serum from rabbits immunized with SARS is more effective than serum from convalescent SARS patients\nParaoxonases (PON) are mammalian enzymes associated with anti-oxidant and anti-inflammatory effects [19]. Rabbit PON differs from human PON in terms of more activity and more stability under the circumstances [20].\n\n4.1.4.2 Rational: Serum from rabbits immunized with the S1 subunit of SARS-S is able to neutralize SARS-CoV2 very efficiently\nSera from rabbits immunized with the S1 subunit of SARS-S could effectively reduce the entry of both SARS-S and SARS-2-S [16]. When compared with patient serum, rabbit serum revealed to us higher efficiency in inhibition of SARS-2-S entry at the same concentration."}

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Rabbit PON differs from human PON in terms of more activity and more stability under the circumstances [20].\n\n4.1.4.2 Rational: Serum from rabbits immunized with the S1 subunit of SARS-S is able to neutralize SARS-CoV2 very efficiently\nSera from rabbits immunized with the S1 subunit of SARS-S could effectively reduce the entry of both SARS-S and SARS-2-S [16]. When compared with patient serum, rabbit serum revealed to us higher efficiency in inhibition of SARS-2-S entry at the same concentration."}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T21","span":{"begin":511,"end":515},"obj":"http://purl.obolibrary.org/obo/GO_0004617"}],"text":"4.1.4 Serum from rabbits immunized with SARS\n\n4.1.4.1 Hypotheses: Serum from rabbits immunized with SARS is more effective than serum from convalescent SARS patients\nParaoxonases (PON) are mammalian enzymes associated with anti-oxidant and anti-inflammatory effects [19]. Rabbit PON differs from human PON in terms of more activity and more stability under the circumstances [20].\n\n4.1.4.2 Rational: Serum from rabbits immunized with the S1 subunit of SARS-S is able to neutralize SARS-CoV2 very efficiently\nSera from rabbits immunized with the S1 subunit of SARS-S could effectively reduce the entry of both SARS-S and SARS-2-S [16]. When compared with patient serum, rabbit serum revealed to us higher efficiency in inhibition of SARS-2-S entry at the same concentration."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T128","span":{"begin":7,"end":12},"obj":"Body_part"},{"id":"T129","span":{"begin":68,"end":73},"obj":"Body_part"},{"id":"T130","span":{"begin":130,"end":135},"obj":"Body_part"},{"id":"T131","span":{"begin":403,"end":408},"obj":"Body_part"},{"id":"T132","span":{"begin":665,"end":670},"obj":"Body_part"},{"id":"T133","span":{"begin":679,"end":684},"obj":"Body_part"}],"attributes":[{"id":"A133","pred":"fma_id","subj":"T133","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A129","pred":"fma_id","subj":"T129","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A132","pred":"fma_id","subj":"T132","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A131","pred":"fma_id","subj":"T131","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A130","pred":"fma_id","subj":"T130","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A128","pred":"fma_id","subj":"T128","obj":"http://purl.org/sig/ont/fma/fma63083"}],"text":"4.1.4 Serum from rabbits immunized with SARS\n\n4.1.4.1 Hypotheses: Serum from rabbits immunized with SARS is more effective than serum from convalescent SARS patients\nParaoxonases (PON) are mammalian enzymes associated with anti-oxidant and anti-inflammatory effects [19]. Rabbit PON differs from human PON in terms of more activity and more stability under the circumstances [20].\n\n4.1.4.2 Rational: Serum from rabbits immunized with the S1 subunit of SARS-S is able to neutralize SARS-CoV2 very efficiently\nSera from rabbits immunized with the S1 subunit of SARS-S could effectively reduce the entry of both SARS-S and SARS-2-S [16]. When compared with patient serum, rabbit serum revealed to us higher efficiency in inhibition of SARS-2-S entry at the same concentration."}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T110","span":{"begin":41,"end":45},"obj":"Disease"},{"id":"T111","span":{"begin":102,"end":106},"obj":"Disease"},{"id":"T112","span":{"begin":154,"end":158},"obj":"Disease"},{"id":"T113","span":{"begin":455,"end":459},"obj":"Disease"},{"id":"T114","span":{"begin":484,"end":493},"obj":"Disease"},{"id":"T115","span":{"begin":562,"end":566},"obj":"Disease"},{"id":"T116","span":{"begin":612,"end":616},"obj":"Disease"},{"id":"T117","span":{"begin":623,"end":627},"obj":"Disease"},{"id":"T118","span":{"begin":735,"end":739},"obj":"Disease"}],"attributes":[{"id":"A112","pred":"mondo_id","subj":"T112","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A114","pred":"mondo_id","subj":"T114","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A113","pred":"mondo_id","subj":"T113","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A117","pred":"mondo_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A118","pred":"mondo_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A116","pred":"mondo_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A115","pred":"mondo_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A110","pred":"mondo_id","subj":"T110","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A111","pred":"mondo_id","subj":"T111","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"4.1.4 Serum from rabbits immunized with SARS\n\n4.1.4.1 Hypotheses: Serum from rabbits immunized with SARS is more effective than serum from convalescent SARS patients\nParaoxonases (PON) are mammalian enzymes associated with anti-oxidant and anti-inflammatory effects [19]. Rabbit PON differs from human PON in terms of more activity and more stability under the circumstances [20].\n\n4.1.4.2 Rational: Serum from rabbits immunized with the S1 subunit of SARS-S is able to neutralize SARS-CoV2 very efficiently\nSera from rabbits immunized with the S1 subunit of SARS-S could effectively reduce the entry of both SARS-S and SARS-2-S [16]. When compared with patient serum, rabbit serum revealed to us higher efficiency in inhibition of SARS-2-S entry at the same concentration."}

{"project":"LitCovid-sentences","denotations":[{"id":"T132","span":{"begin":0,"end":45},"obj":"Sentence"},{"id":"T133","span":{"begin":47,"end":67},"obj":"Sentence"},{"id":"T134","span":{"begin":68,"end":167},"obj":"Sentence"},{"id":"T135","span":{"begin":168,"end":273},"obj":"Sentence"},{"id":"T136","span":{"begin":274,"end":382},"obj":"Sentence"},{"id":"T137","span":{"begin":384,"end":402},"obj":"Sentence"},{"id":"T138","span":{"begin":403,"end":510},"obj":"Sentence"},{"id":"T139","span":{"begin":511,"end":637},"obj":"Sentence"},{"id":"T140","span":{"begin":638,"end":776},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"4.1.4 Serum from rabbits immunized with SARS\n\n4.1.4.1 Hypotheses: Serum from rabbits immunized with SARS is more effective than serum from convalescent SARS patients\nParaoxonases (PON) are mammalian enzymes associated with anti-oxidant and anti-inflammatory effects [19]. Rabbit PON differs from human PON in terms of more activity and more stability under the circumstances [20].\n\n4.1.4.2 Rational: Serum from rabbits immunized with the S1 subunit of SARS-S is able to neutralize SARS-CoV2 very efficiently\nSera from rabbits immunized with the S1 subunit of SARS-S could effectively reduce the entry of both SARS-S and SARS-2-S [16]. When compared with patient serum, rabbit serum revealed to us higher efficiency in inhibition of SARS-2-S entry at the same concentration."}

{"project":"2_test","denotations":[{"id":"32413736-23181222-48112976","span":{"begin":269,"end":271},"obj":"23181222"},{"id":"32413736-8565784-48112977","span":{"begin":378,"end":380},"obj":"8565784"},{"id":"T44869","span":{"begin":269,"end":271},"obj":"23181222"},{"id":"T36197","span":{"begin":378,"end":380},"obj":"8565784"}],"text":"4.1.4 Serum from rabbits immunized with SARS\n\n4.1.4.1 Hypotheses: Serum from rabbits immunized with SARS is more effective than serum from convalescent SARS patients\nParaoxonases (PON) are mammalian enzymes associated with anti-oxidant and anti-inflammatory effects [19]. Rabbit PON differs from human PON in terms of more activity and more stability under the circumstances [20].\n\n4.1.4.2 Rational: Serum from rabbits immunized with the S1 subunit of SARS-S is able to neutralize SARS-CoV2 very efficiently\nSera from rabbits immunized with the S1 subunit of SARS-S could effectively reduce the entry of both SARS-S and SARS-2-S [16]. When compared with patient serum, rabbit serum revealed to us higher efficiency in inhibition of SARS-2-S entry at the same concentration."}