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PMC:7205724 / 15098-15946 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
503 81-92 Gene denotes cathepsin B Gene:1508
504 100-104 Gene denotes CatB Gene:1508
505 186-193 Gene denotes TMPRSS2 Gene:7113
506 204-210 Gene denotes CatB/L Gene:1508
507 345-352 Gene denotes TMPRSS2 Gene:7113
508 478-485 Gene denotes TMPRSS2 Gene:7113
509 514-518 Gene denotes CatB Gene:1508
510 575-582 Gene denotes TMPRSS2 Gene:7113
511 819-826 Gene denotes TMPRSS2 Gene:7113
512 799-800 Gene denotes S Gene:43740568
513 786-787 Gene denotes S Gene:43740568
514 741-742 Gene denotes S Gene:43740568
515 564-565 Gene denotes S Gene:43740568
516 339-340 Gene denotes S Gene:43740568
517 46-47 Gene denotes S Gene:43740568
518 33-34 Gene denotes S Gene:43740568
519 39-45 Species denotes SARS-2 Tax:2697049
520 332-338 Species denotes SARS-2 Tax:2697049
521 557-563 Species denotes SARS-2 Tax:2697049
522 611-616 Species denotes human Tax:9606
523 662-667 Species denotes human Tax:9606
524 734-740 Species denotes SARS-2 Tax:2697049
525 792-798 Species denotes SARS-2 Tax:2697049
526 140-146 Chemical denotes serine MESH:D012694
527 259-276 Chemical denotes ammonium chloride MESH:D000643
528 383-400 Chemical denotes ammonium chloride MESH:D000643
529 446-463 Chemical denotes camostat mesylate MESH:C034532
530 491-496 Chemical denotes E-64d
531 723-729 Chemical denotes SARS-S
532 617-628 Disease denotes lung cancer MESH:D008175
533 833-847 Disease denotes lung infection MESH:D012141
534 165-170 CellLine denotes 293 T CVCL:0063
535 355-361 CellLine denotes Caco-2 CVCL:0025
536 585-591 CellLine denotes Caco-2 CVCL:0025
537 639-645 CellLine denotes Calu-3 CVCL:0609

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T113 52-61 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T114 62-70 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T115 140-146 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T116 171-176 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T117 243-252 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T118 362-367 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T119 592-597 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T120 617-621 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T121 629-633 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T122 668-672 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T123 673-678 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T124 833-837 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T9 617-621 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T10 668-672 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T11 833-837 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T93 28-32 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T94 39-43 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T95 321-325 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T96 332-336 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T97 557-561 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T98 617-628 Disease denotes lung cancer http://purl.obolibrary.org/obo/MONDO_0008903
T99 622-628 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T100 723-727 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T101 734-738 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T102 781-785 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T103 792-796 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T104 838-847 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T177 91-92 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T178 165-170 http://purl.obolibrary.org/obo/CLO_0050894 denotes 293 T
T179 165-170 http://purl.obolibrary.org/obo/CLO_0051650 denotes 293 T
T180 165-170 http://purl.obolibrary.org/obo/CLO_0052052 denotes 293 T
T181 171-176 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T182 211-219 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T183 355-361 http://purl.obolibrary.org/obo/CLO_0002172 denotes Caco-2
T184 355-361 http://purl.obolibrary.org/obo/CLO_0051943 denotes Caco-2
T185 355-361 http://purl.obolibrary.org/obo/CLO_0051958 denotes Caco-2
T186 355-361 http://purl.obolibrary.org/obo/CLO_0051960 denotes Caco-2
T187 362-367 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T188 412-413 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T189 429-430 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T190 465-466 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T191 585-591 http://purl.obolibrary.org/obo/CLO_0002172 denotes Caco-2
T192 585-591 http://purl.obolibrary.org/obo/CLO_0051943 denotes Caco-2
T193 585-591 http://purl.obolibrary.org/obo/CLO_0051958 denotes Caco-2
T194 585-591 http://purl.obolibrary.org/obo/CLO_0051960 denotes Caco-2
T195 592-597 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T196 611-616 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T197 617-621 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T198 617-621 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T199 622-638 http://purl.obolibrary.org/obo/OBI_0001906 denotes cancer cell line
T200 622-638 http://www.ebi.ac.uk/cellline#cancer_cell_line denotes cancer cell line
T201 639-645 http://purl.obolibrary.org/obo/CLO_0002192 denotes Calu-3
T202 662-667 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T203 668-672 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T204 668-672 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T205 673-678 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T206 690-691 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T207 831-832 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T208 833-837 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T209 833-837 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T143 62-70 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T144 140-146 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T145 259-276 Chemical denotes ammonium chloride http://purl.obolibrary.org/obo/CHEBI_31206
T146 259-267 Chemical denotes ammonium http://purl.obolibrary.org/obo/CHEBI_28938
T147 268-276 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T148 383-400 Chemical denotes ammonium chloride http://purl.obolibrary.org/obo/CHEBI_31206
T149 383-391 Chemical denotes ammonium http://purl.obolibrary.org/obo/CHEBI_28938
T150 392-400 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T151 446-463 Chemical denotes camostat mesylate http://purl.obolibrary.org/obo/CHEBI_135632
T152 491-496 Chemical denotes E-64d http://purl.obolibrary.org/obo/CHEBI_101381
T153 501-510 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T154 746-763 Chemical denotes camostat mesylate http://purl.obolibrary.org/obo/CHEBI_135632

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T63 171-176 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T64 362-367 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T65 592-597 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T66 629-633 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T67 673-678 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T68 838-847 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T96 62-70 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T97 140-146 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T98 259-276 Chemical denotes ammonium chloride http://purl.obolibrary.org/obo/CHEBI_31206
T99 383-400 Chemical denotes ammonium chloride http://purl.obolibrary.org/obo/CHEBI_31206
T100 446-463 Chemical denotes camostat mesylate http://purl.obolibrary.org/obo/CHEBI_135632
T101 491-496 Chemical denotes E-64d http://purl.obolibrary.org/obo/CHEBI_101381
T102 746-763 Chemical denotes camostat mesylate http://purl.obolibrary.org/obo/CHEBI_135632

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T126 28-32 Species denotes SARS NCBItxid:694009
T127 39-45 Species denotes SARS-2 NCBItxid:2697049
T128 321-325 Species denotes SARS NCBItxid:694009
T129 332-338 Species denotes SARS-2 NCBItxid:2697049
T130 557-563 Species denotes SARS-2 NCBItxid:2697049
T131 611-616 Species denotes human NCBItxid:9606
T132 662-667 Species denotes human NCBItxid:9606
T133 723-727 Species denotes SARS NCBItxid:694009
T134 734-740 Species denotes SARS-2 NCBItxid:2697049
T135 781-785 Species denotes SARS NCBItxid:694009
T136 792-798 Species denotes SARS-2 NCBItxid:2697049

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T121 0-161 Sentence denotes Two main proteases for both SARS-S and SARS-2-S are endosomal cysteine proteases cathepsin B and L (CatB/L) and the transmembrane protease, serine 2TMPRSS2 [16].
T122 162-341 Sentence denotes In 293 T cells lacking 2TMPRSS2, blocking CatB/L activity through increasing the endosomal pH by ammonium chloride could significantly limit the entry of both SARS-S and SARS-2-S.
T123 342-428 Sentence denotes In TMPRSS2 + Caco-2 cells, the effect of ammonium chloride existed to a lesser extent.
T124 429-598 Sentence denotes A combination of camostat mesylate, a blocker of TMPRSS2, and E-64d, an inhibitor of CatB/L, yielded the complete inhibition of SARS-2-S entry in TMPRSS2 + Caco-2 cells.
T125 599-848 Sentence denotes In both the human lung cancer cell line Calu-3 and the primary human lung cells, there was a reduction of the entry of both SARS-S and SARS-2-S by camostat mesylate, indicating that SARS-S and SARS-2-S partially require TMPRSS2 for a lung infection.

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T9 617-621 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T10 668-672 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T11 833-837 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
518 33-34 Gene denotes S Gene:43740568
519 39-45 Species denotes SARS-2 Tax:2697049
517 46-47 Gene denotes S Gene:43740568
503 81-92 Gene denotes cathepsin B Gene:1508
504 100-104 Gene denotes CatB Gene:1508
526 140-146 Chemical denotes serine MESH:D012694
534 165-170 CellLine denotes 293 T CVCL:0063
505 186-193 Gene denotes TMPRSS2 Gene:7113
506 204-210 Gene denotes CatB/L Gene:1508
527 259-276 Chemical denotes ammonium chloride MESH:D000643
520 332-338 Species denotes SARS-2 Tax:2697049
516 339-340 Gene denotes S Gene:43740568
507 345-352 Gene denotes TMPRSS2 Gene:7113
535 355-361 CellLine denotes Caco-2 CVCL:0025
528 383-400 Chemical denotes ammonium chloride MESH:D000643
529 446-463 Chemical denotes camostat mesylate MESH:C034532
508 478-485 Gene denotes TMPRSS2 Gene:7113
530 491-496 Chemical denotes E-64d
509 514-518 Gene denotes CatB Gene:1508
521 557-563 Species denotes SARS-2 Tax:2697049
515 564-565 Gene denotes S Gene:43740568
510 575-582 Gene denotes TMPRSS2 Gene:7113
536 585-591 CellLine denotes Caco-2 CVCL:0025
522 611-616 Species denotes human Tax:9606
532 617-628 Disease denotes lung cancer MESH:D008175
537 639-645 CellLine denotes Calu-3 CVCL:0609
523 662-667 Species denotes human Tax:9606
531 723-729 Chemical denotes SARS-S
524 734-740 Species denotes SARS-2 Tax:2697049
514 741-742 Gene denotes S Gene:43740568
513 786-787 Gene denotes S Gene:43740568
525 792-798 Species denotes SARS-2 Tax:2697049
512 799-800 Gene denotes S Gene:43740568
511 819-826 Gene denotes TMPRSS2 Gene:7113
533 833-847 Disease denotes lung infection MESH:D012141

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T1696 4-18 Protein denotes main proteases https://www.uniprot.org/uniprot/Q80E51|https://www.uniprot.org/uniprot/Q80BV8|https://www.uniprot.org/uniprot/Q80BV7|https://www.uniprot.org/uniprot/Q808C0|https://www.uniprot.org/uniprot/Q7T697|https://www.uniprot.org/uniprot/Q6WGN0|https://www.uniprot.org/uniprot/P59641|https://www.uniprot.org/uniprot/P0DTD1|https://www.uniprot.org/uniprot/P0DTC1|https://www.uniprot.org/uniprot/P0C6X7|https://www.uniprot.org/uniprot/P0C6U8
T1707 62-80 Protein denotes cysteine proteases https://www.uniprot.org/uniprot/A1KXI0
T1708 81-92 Protein denotes cathepsin B https://www.uniprot.org/uniprot/W5Q0Z2|https://www.uniprot.org/uniprot/S5FR89|https://www.uniprot.org/uniprot/Q96D87|https://www.uniprot.org/uniprot/Q5R6D1|https://www.uniprot.org/uniprot/Q503A6|https://www.uniprot.org/uniprot/Q4R5M2|https://www.uniprot.org/uniprot/Q3ZC03|https://www.uniprot.org/uniprot/Q3UDW7|https://www.uniprot.org/uniprot/P83205|https://www.uniprot.org/uniprot/P81494|https://www.uniprot.org/uniprot/P43233|https://www.uniprot.org/uniprot/P10605|https://www.uniprot.org/uniprot/P07858|https://www.uniprot.org/uniprot/P07688|https://www.uniprot.org/uniprot/P00787|https://www.uniprot.org/uniprot/B3KRR5|https://www.uniprot.org/uniprot/B3KQR5|https://www.uniprot.org/uniprot/A1E295
T1726 130-138 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249

LitCovid-sample-Enju

Id Subject Object Predicate Lexical cue
T10680 0-3 CD denotes Two
T43316 4-8 JJ denotes main
T55924 9-18 NNS denotes proteases
T2463 19-22 IN denotes for
T44465 23-27 DT denotes both
T77880 28-34 NN denotes SARS-S
T81456 35-38 CC denotes and
T6788 39-47 NN denotes SARS-2-S
T40938 48-51 VBP denotes are
T56973 52-61 JJ denotes endosomal
T42812 62-70 NN denotes cysteine
T96337 71-80 VBZ denotes proteases
T16443 81-90 NN denotes cathepsin
T42466 91-92 NN denotes B
T71562 93-96 CC denotes and
T46478 97-98 NN denotes L
T46398 99-100 -LRB- denotes (
T65344 100-106 NN denotes CatB/L
T41087 106-107 -RRB- denotes )
T20678 108-111 CC denotes and
T62149 112-115 DT denotes the
T68064 116-129 JJ denotes transmembrane
T32448 130-138 NN denotes protease
T6092 138-139 -COMMA- denotes ,
T91380 140-146 NN denotes serine
T21495 147-155 NN denotes 2TMPRSS2
T43810 156-157 -LRB- denotes [
T10431 157-159 CD denotes 16
T63388 159-160 -RRB- denotes ]
T22680 162-164 IN denotes In
T74423 165-170 NN denotes 293 T
T35266 171-176 NNS denotes cells
T64338 177-184 VBG denotes lacking
T10485 185-193 NN denotes 2TMPRSS2
T85298 193-194 -COMMA- denotes ,
T71577 195-203 VBG denotes blocking
T94566 204-210 NN denotes CatB/L
T53535 211-219 NN denotes activity
T97443 220-227 IN denotes through
T35988 228-238 VBG denotes increasing
T24686 239-242 DT denotes the
T21828 243-252 JJ denotes endosomal
T57882 253-255 NN denotes pH
T2438 256-258 IN denotes by
T55605 259-267 NN denotes ammonium
T50104 268-276 NN denotes chloride
T36913 277-282 MD denotes could
T77508 283-296 RB denotes significantly
T70941 297-302 VB denotes limit
T75185 303-306 DT denotes the
T35511 307-312 NN denotes entry
T1792 313-315 IN denotes of
T53436 316-320 CC denotes both
T60629 321-327 NN denotes SARS-S
T78080 328-331 CC denotes and
T63658 332-341 JJ denotes SARS-2-S.
T98368 342-344 IN denotes In
T93115 345-361 NN denotes TMPRSS2 + Caco-2
T76285 362-367 NNS denotes cells
T31590 367-368 -COMMA- denotes ,
T25862 369-372 DT denotes the
T10314 373-379 NN denotes effect
T77548 380-382 IN denotes of
T48002 383-391 NN denotes ammonium
T31059 392-400 NN denotes chloride
T96902 401-408 VBD denotes existed
T81416 409-411 TO denotes to
T58350 412-413 DT denotes a
T53199 414-420 JJR denotes lesser
T72133 421-427 NN denotes extent
T12695 429-430 DT denotes A
T69785 431-442 NN denotes combination
T73262 443-445 IN denotes of
T77261 446-454 NN denotes camostat
T41765 455-463 NN denotes mesylate
T55852 463-464 -COMMA- denotes ,
T81348 465-466 DT denotes a
T88599 467-474 NN denotes blocker
T30022 475-477 IN denotes of
T40170 478-485 NN denotes TMPRSS2
T89506 485-486 -COMMA- denotes ,
T96381 487-490 CC denotes and
T31415 491-496 NN denotes E-64d
T14631 496-497 -COMMA- denotes ,
T42969 498-500 DT denotes an
T53416 501-510 NN denotes inhibitor
T3946 511-513 IN denotes of
T26871 514-520 NN denotes CatB/L
T27079 520-521 -COMMA- denotes ,
T56133 522-529 VBD denotes yielded
T87218 530-533 DT denotes the
T70471 534-542 JJ denotes complete
T11646 543-553 NN denotes inhibition
T91858 554-556 IN denotes of
T75023 557-565 NN denotes SARS-2-S
T21695 566-571 NN denotes entry
T17052 572-574 IN denotes in
T24463 575-591 NN denotes TMPRSS2 + Caco-2
T57029 592-597 NNS denotes cells
T57582 599-601 IN denotes In
T21513 602-606 CC denotes both
T67184 607-610 DT denotes the
T39137 611-616 JJ denotes human
T99828 617-621 NN denotes lung
T68094 622-628 NN denotes cancer
T76607 629-633 NN denotes cell
T55102 634-638 NN denotes line
T50829 639-645 NN denotes Calu-3
T53491 646-649 CC denotes and
T43867 650-653 DT denotes the
T21723 654-661 JJ denotes primary
T29104 662-667 JJ denotes human
T3411 668-672 NN denotes lung
T60390 673-678 NNS denotes cells
T81391 678-679 -COMMA- denotes ,
T33129 680-685 EX denotes there
T59040 686-689 VBD denotes was
T39475 690-691 DT denotes a
T15256 692-701 NN denotes reduction
T39714 702-704 IN denotes of
T49107 705-708 DT denotes the
T3461 709-714 NN denotes entry
T40063 715-717 IN denotes of
T3764 718-722 CC denotes both
T3726 723-729 NN denotes SARS-S
T74021 730-733 CC denotes and
T38308 734-742 NN denotes SARS-2-S
T3019 743-745 IN denotes by
T41127 746-754 NN denotes camostat
T6987 755-763 NN denotes mesylate
T21310 763-764 -COMMA- denotes ,
T88073 765-775 VBG denotes indicating
T47825 776-780 IN denotes that
T44262 781-787 NN denotes SARS-S
T25723 788-791 CC denotes and
T39073 792-800 NN denotes SARS-2-S
T85073 801-810 RB denotes partially
T75386 811-818 VBP denotes require
T13575 819-826 NN denotes TMPRSS2
T81091 827-830 IN denotes for
T10997 831-832 DT denotes a
T93402 833-837 NN denotes lung
T86423 838-847 NN denotes infection
R87525 T55924 T43316 arg1Of proteases,main
R49971 T55924 T2463 arg1Of proteases,for
R75166 T81456 T2463 arg2Of and,for
R37384 T81456 T44465 arg1Of and,both
R47275 T55924 T10680 arg1Of proteases,Two
R57168 T77880 T81456 arg1Of SARS-S,and
R44438 T6788 T81456 arg2Of SARS-2-S,and
R64377 T55924 T40938 arg1Of proteases,are
R99688 T96337 T40938 arg2Of proteases,are
R16383 T42812 T56973 arg1Of cysteine,endosomal
R87272 T42812 T96337 arg1Of cysteine,proteases
R90752 T20678 T96337 arg2Of and,proteases
R30944 T42466 T16443 arg1Of B,cathepsin
R64570 T42466 T71562 arg1Of B,and
R1755 T46478 T71562 arg2Of L,and
R43951 T46478 T46398 arg1Of L,(
R29294 T65344 T46398 arg2Of CatB/L,(
R68308 T41087 T46398 arg3Of ),(
R17527 T71562 T20678 arg1Of and,and
R85170 T32448 T20678 arg2Of protease,and
R92582 T32448 T62149 arg1Of protease,the
R84997 T32448 T68064 arg1Of protease,transmembrane
R48722 T32448 T6092 arg1Of protease,","
R91466 T21495 T6092 arg2Of 2TMPRSS2,","
R78762 T21495 T91380 arg1Of 2TMPRSS2,serine
R57869 T96337 T43810 arg1Of proteases,[
R44640 T10431 T43810 arg2Of 16,[
R49840 T63388 T43810 arg3Of ],[
R88130 T96902 T22680 arg1Of existed,In
R40101 T35266 T22680 arg2Of cells,In
R83097 T35266 T74423 arg1Of cells,293 T
R43699 T35266 T64338 arg1Of cells,lacking
R91610 T10485 T64338 arg2Of 2TMPRSS2,lacking
R41008 T64338 T85298 arg1Of lacking,","
R31293 T53535 T71577 arg2Of activity,blocking
R97859 T64338 T71577 modOf lacking,blocking
R71752 T53535 T94566 arg1Of activity,CatB/L
R39759 T71577 T97443 arg1Of blocking,through
R65744 T35988 T97443 arg2Of increasing,through
R90985 T70941 T35988 arg2Of limit,increasing
R35129 T57882 T24686 arg1Of pH,the
R18378 T57882 T21828 arg1Of pH,endosomal
R28299 T57882 T2438 arg1Of pH,by
R21546 T50104 T2438 arg2Of chloride,by
R29507 T50104 T55605 arg1Of chloride,ammonium
R55603 T57882 T36913 arg1Of pH,could
R37095 T70941 T36913 arg2Of limit,could
R6341 T70941 T77508 arg1Of limit,significantly
R23171 T57882 T70941 arg1Of pH,limit
R63866 T35511 T70941 arg2Of entry,limit
R21596 T35511 T75185 arg1Of entry,the
R28208 T35511 T1792 arg1Of entry,of
R53418 T76285 T1792 arg2Of cells,of
R45763 T78080 T53436 arg1Of and,both
R41530 T76285 T60629 arg1Of cells,SARS-S
R23478 T60629 T78080 arg1Of SARS-S,and
R16949 T63658 T78080 arg2Of SARS-2-S.,and
R53841 T76285 T63658 arg1Of cells,SARS-2-S.
R11715 T78080 T98368 arg1Of and,In
R35498 T76285 T93115 arg1Of cells,TMPRSS2 + Caco-2
R27124 T96902 T31590 arg1Of existed,","
R69904 T10314 T25862 arg1Of effect,the
R27865 T10314 T77548 arg1Of effect,of
R34331 T31059 T77548 arg2Of chloride,of
R99617 T31059 T48002 arg1Of chloride,ammonium
R46721 T10314 T96902 arg1Of effect,existed
R10115 T96902 T81416 arg1Of existed,to
R37635 T72133 T81416 arg2Of extent,to
R50435 T72133 T58350 arg1Of extent,a
R42092 T72133 T53199 arg1Of extent,lesser
R92376 T69785 T12695 arg1Of combination,A
R69283 T69785 T73262 arg1Of combination,of
R85515 T96381 T73262 arg2Of and,of
R93897 T41765 T77261 arg1Of mesylate,camostat
R16425 T41765 T55852 arg1Of mesylate,","
R61072 T88599 T55852 arg2Of blocker,","
R4025 T88599 T81348 arg1Of blocker,a
R59149 T88599 T30022 arg1Of blocker,of
R98966 T40170 T30022 arg2Of TMPRSS2,of
R56670 T96381 T89506 arg1Of and,","
R41959 T41765 T96381 arg1Of mesylate,and
R45963 T31415 T96381 arg2Of E-64d,and
R50864 T31415 T14631 arg1Of E-64d,","
R55692 T53416 T14631 arg2Of inhibitor,","
R57053 T53416 T42969 arg1Of inhibitor,an
R17401 T53416 T3946 arg1Of inhibitor,of
R23835 T26871 T3946 arg2Of CatB/L,of
R77955 T56133 T27079 arg1Of yielded,","
R76504 T69785 T56133 arg1Of combination,yielded
R87904 T11646 T56133 arg2Of inhibition,yielded
R73092 T11646 T87218 arg1Of inhibition,the
R66768 T11646 T70471 arg1Of inhibition,complete
R60748 T11646 T91858 arg1Of inhibition,of
R69633 T21695 T91858 arg2Of entry,of
R71721 T21695 T75023 arg1Of entry,SARS-2-S
R70728 T21695 T17052 arg1Of entry,in
R16622 T57029 T17052 arg2Of cells,in
R43666 T57029 T24463 arg1Of cells,TMPRSS2 + Caco-2
R50675 T59040 T57582 arg1Of was,In
R53466 T53491 T57582 arg2Of and,In
R37154 T50829 T21513 arg1Of Calu-3,both
R62865 T50829 T67184 arg1Of Calu-3,the
R56677 T50829 T39137 arg1Of Calu-3,human
R60172 T50829 T99828 arg1Of Calu-3,lung
R46163 T50829 T68094 arg1Of Calu-3,cancer
R15634 T50829 T76607 arg1Of Calu-3,cell
R2145 T50829 T55102 arg1Of Calu-3,line
R85549 T50829 T53491 arg1Of Calu-3,and
R71267 T60390 T53491 arg2Of cells,and
R59330 T60390 T43867 arg1Of cells,the
R13617 T60390 T21723 arg1Of cells,primary
R55335 T60390 T29104 arg1Of cells,human
R72699 T60390 T3411 arg1Of cells,lung
R75974 T59040 T81391 arg1Of was,","
R94945 T33129 T59040 arg1Of there,was
R68501 T15256 T59040 arg2Of reduction,was
R46469 T15256 T39475 arg1Of reduction,a
R31926 T15256 T39714 arg1Of reduction,of
R23449 T3461 T39714 arg2Of entry,of
R9006 T3461 T49107 arg1Of entry,the
R61909 T3461 T40063 arg1Of entry,of
R78407 T74021 T40063 arg2Of and,of
R6883 T74021 T3764 arg1Of and,both
R64616 T3726 T74021 arg1Of SARS-S,and
R99403 T38308 T74021 arg2Of SARS-2-S,and
R18077 T74021 T3019 arg1Of and,by
R83600 T6987 T3019 arg2Of mesylate,by
R37625 T6987 T41127 arg1Of mesylate,camostat
R62097 T59040 T21310 arg1Of was,","
R52910 T75386 T88073 arg2Of require,indicating
R91702 T59040 T88073 modOf was,indicating
R20369 T75386 T47825 arg1Of require,that
R49427 T44262 T25723 arg1Of SARS-S,and
R32622 T39073 T25723 arg2Of SARS-2-S,and
R88200 T75386 T85073 arg1Of require,partially
R57198 T25723 T75386 arg1Of and,require
R51838 T13575 T75386 arg2Of TMPRSS2,require
R63159 T75386 T81091 arg1Of require,for
R47359 T86423 T81091 arg2Of infection,for
R80027 T86423 T10997 arg1Of infection,a
R49758 T86423 T93402 arg1Of infection,lung

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T2 617-621 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T3 668-672 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T4 833-837 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T113 52-61 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T114 62-70 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T115 140-146 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T116 171-176 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T117 243-252 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T118 362-367 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T119 592-597 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T120 617-621 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T121 629-633 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T122 668-672 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T123 673-678 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T124 833-837 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T90 28-32 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T91 39-43 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T92 321-325 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T93 332-336 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T94 557-561 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T95 617-628 Disease denotes lung cancer http://purl.obolibrary.org/obo/MONDO_0008903
T96 723-727 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T97 734-738 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T98 781-785 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T99 792-796 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T100 838-847 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T3 617-628 Phenotype denotes lung cancer http://purl.obolibrary.org/obo/HP_0100526

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T121 0-161 Sentence denotes Two main proteases for both SARS-S and SARS-2-S are endosomal cysteine proteases cathepsin B and L (CatB/L) and the transmembrane protease, serine 2TMPRSS2 [16].
T122 162-341 Sentence denotes In 293 T cells lacking 2TMPRSS2, blocking CatB/L activity through increasing the endosomal pH by ammonium chloride could significantly limit the entry of both SARS-S and SARS-2-S.
T123 342-428 Sentence denotes In TMPRSS2 + Caco-2 cells, the effect of ammonium chloride existed to a lesser extent.
T124 429-598 Sentence denotes A combination of camostat mesylate, a blocker of TMPRSS2, and E-64d, an inhibitor of CatB/L, yielded the complete inhibition of SARS-2-S entry in TMPRSS2 + Caco-2 cells.
T125 599-848 Sentence denotes In both the human lung cancer cell line Calu-3 and the primary human lung cells, there was a reduction of the entry of both SARS-S and SARS-2-S by camostat mesylate, indicating that SARS-S and SARS-2-S partially require TMPRSS2 for a lung infection.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T3 617-628 Phenotype denotes lung cancer http://purl.obolibrary.org/obo/HP_0100526