PMC:7205724 / 14269-15946 JSONTXT

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    LitCovid-PubTator

    {"project":"LitCovid-PubTator","denotations":[{"id":"442","span":{"begin":21,"end":29},"obj":"Species"},{"id":"443","span":{"begin":34,"end":43},"obj":"Species"},{"id":"456","span":{"begin":462,"end":466},"obj":"Gene"},{"id":"457","span":{"begin":556,"end":560},"obj":"Gene"},{"id":"458","span":{"begin":826,"end":827},"obj":"Gene"},{"id":"459","span":{"begin":785,"end":786},"obj":"Gene"},{"id":"460","span":{"begin":316,"end":317},"obj":"Gene"},{"id":"461","span":{"begin":122,"end":130},"obj":"Species"},{"id":"462","span":{"begin":135,"end":144},"obj":"Species"},{"id":"463","span":{"begin":652,"end":657},"obj":"Species"},{"id":"464","span":{"begin":778,"end":784},"obj":"Species"},{"id":"465","span":{"begin":658,"end":674},"obj":"Disease"},{"id":"466","span":{"begin":676,"end":679},"obj":"CellLine"},{"id":"467","span":{"begin":692,"end":697},"obj":"CellLine"},{"id":"503","span":{"begin":910,"end":921},"obj":"Gene"},{"id":"504","span":{"begin":929,"end":933},"obj":"Gene"},{"id":"505","span":{"begin":1015,"end":1022},"obj":"Gene"},{"id":"506","span":{"begin":1033,"end":1039},"obj":"Gene"},{"id":"507","span":{"begin":1174,"end":1181},"obj":"Gene"},{"id":"508","span":{"begin":1307,"end":1314},"obj":"Gene"},{"id":"509","span":{"begin":1343,"end":1347},"obj":"Gene"},{"id":"510","span":{"begin":1404,"end":1411},"obj":"Gene"},{"id":"511","span":{"begin":1648,"end":1655},"obj":"Gene"},{"id":"512","span":{"begin":1628,"end":1629},"obj":"Gene"},{"id":"513","span":{"begin":1615,"end":1616},"obj":"Gene"},{"id":"514","span":{"begin":1570,"end":1571},"obj":"Gene"},{"id":"515","span":{"begin":1393,"end":1394},"obj":"Gene"},{"id":"516","span":{"begin":1168,"end":1169},"obj":"Gene"},{"id":"517","span":{"begin":875,"end":876},"obj":"Gene"},{"id":"518","span":{"begin":862,"end":863},"obj":"Gene"},{"id":"519","span":{"begin":868,"end":874},"obj":"Species"},{"id":"520","span":{"begin":1161,"end":1167},"obj":"Species"},{"id":"521","span":{"begin":1386,"end":1392},"obj":"Species"},{"id":"522","span":{"begin":1440,"end":1445},"obj":"Species"},{"id":"523","span":{"begin":1491,"end":1496},"obj":"Species"},{"id":"524","span":{"begin":1563,"end":1569},"obj":"Species"},{"id":"525","span":{"begin":1621,"end":1627},"obj":"Species"},{"id":"526","span":{"begin":969,"end":975},"obj":"Chemical"},{"id":"527","span":{"begin":1088,"end":1105},"obj":"Chemical"},{"id":"528","span":{"begin":1212,"end":1229},"obj":"Chemical"},{"id":"529","span":{"begin":1275,"end":1292},"obj":"Chemical"},{"id":"530","span":{"begin":1320,"end":1325},"obj":"Chemical"},{"id":"531","span":{"begin":1552,"end":1558},"obj":"Chemical"},{"id":"532","span":{"begin":1446,"end":1457},"obj":"Disease"},{"id":"533","span":{"begin":1662,"end":1676},"obj":"Disease"},{"id":"534","span":{"begin":994,"end":999},"obj":"CellLine"},{"id":"535","span":{"begin":1184,"end":1190},"obj":"CellLine"},{"id":"536","span":{"begin":1414,"end":1420},"obj":"CellLine"},{"id":"537","span":{"begin":1468,"end":1474},"obj":"CellLine"}],"attributes":[{"id":"A508","pred":"tao:has_database_id","subj":"508","obj":"Gene:7113"},{"id":"A524","pred":"tao:has_database_id","subj":"524","obj":"Tax:2697049"},{"id":"A537","pred":"tao:has_database_id","subj":"537","obj":"CVCL:0609"},{"id":"A442","pred":"tao:has_database_id","subj":"442","obj":"Tax:694009"},{"id":"A503","pred":"tao:has_database_id","subj":"503","obj":"Gene:1508"},{"id":"A527","pred":"tao:has_database_id","subj":"527","obj":"MESH:D000643"},{"id":"A507","pred":"tao:has_database_id","subj":"507","obj":"Gene:7113"},{"id":"A518","pred":"tao:has_database_id","subj":"518","obj":"Gene:43740568"},{"id":"A509","pred":"tao:has_database_id","subj":"509","obj":"Gene:1508"},{"id":"A525","pred":"tao:has_database_id","subj":"525","obj":"Tax:2697049"},{"id":"A443","pred":"tao:has_database_id","subj":"443","obj":"Tax:2697049"},{"id":"A460","pred":"tao:has_database_id","subj":"460","obj":"Gene:43740568"},{"id":"A462","pred":"tao:has_database_id","subj":"462","obj":"Tax:2697049"},{"id":"A463","pred":"tao:has_database_id","subj":"463","obj":"Tax:9606"},{"id":"A523","pred":"tao:has_database_id","subj":"523","obj":"Tax:9606"},{"id":"A457","pred":"tao:has_database_id","subj":"457","obj":"Gene:59272"},{"id":"A511","pred":"tao:has_database_id","subj":"511","obj":"Gene:7113"},{"id":"A516","pred":"tao:has_database_id","subj":"516","obj":"Gene:43740568"},{"id":"A528","pred":"tao:has_database_id","subj":"528","obj":"MESH:D000643"},{"id":"A529","pred":"tao:has_database_id","subj":"529","obj":"MESH:C034532"},{"id":"A465","pred":"tao:has_database_id","subj":"465","obj":"MESH:D007674"},{"id":"A510","pred":"tao:has_database_id","subj":"510","obj":"Gene:7113"},{"id":"A521","pred":"tao:has_database_id","subj":"521","obj":"Tax:2697049"},{"id":"A536","pred":"tao:has_database_id","subj":"536","obj":"CVCL:0025"},{"id":"A519","pred":"tao:has_database_id","subj":"519","obj":"Tax:2697049"},{"id":"A506","pred":"tao:has_database_id","subj":"506","obj":"Gene:1508"},{"id":"A466","pred":"tao:has_database_id","subj":"466","obj":"CVCL:M624"},{"id":"A532","pred":"tao:has_database_id","subj":"532","obj":"MESH:D008175"},{"id":"A526","pred":"tao:has_database_id","subj":"526","obj":"MESH:D012694"},{"id":"A535","pred":"tao:has_database_id","subj":"535","obj":"CVCL:0025"},{"id":"A517","pred":"tao:has_database_id","subj":"517","obj":"Gene:43740568"},{"id":"A458","pred":"tao:has_database_id","subj":"458","obj":"Gene:43740568"},{"id":"A513","pred":"tao:has_database_id","subj":"513","obj":"Gene:43740568"},{"id":"A467","pred":"tao:has_database_id","subj":"467","obj":"CVCL:0063"},{"id":"A459","pred":"tao:has_database_id","subj":"459","obj":"Gene:43740568"},{"id":"A504","pred":"tao:has_database_id","subj":"504","obj":"Gene:1508"},{"id":"A505","pred":"tao:has_database_id","subj":"505","obj":"Gene:7113"},{"id":"A522","pred":"tao:has_database_id","subj":"522","obj":"Tax:9606"},{"id":"A514","pred":"tao:has_database_id","subj":"514","obj":"Gene:43740568"},{"id":"A515","pred":"tao:has_database_id","subj":"515","obj":"Gene:43740568"},{"id":"A461","pred":"tao:has_database_id","subj":"461","obj":"Tax:694009"},{"id":"A512","pred":"tao:has_database_id","subj":"512","obj":"Gene:43740568"},{"id":"A456","pred":"tao:has_database_id","subj":"456","obj":"Gene:59272"},{"id":"A533","pred":"tao:has_database_id","subj":"533","obj":"MESH:D012141"},{"id":"A534","pred":"tao:has_database_id","subj":"534","obj":"CVCL:0063"},{"id":"A464","pred":"tao:has_database_id","subj":"464","obj":"Tax:2697049"},{"id":"A520","pred":"tao:has_database_id","subj":"520","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"4.1.3.1 Hypothesis: SARS-CoV and SARS-CoV2 are ideally similar in the structure and the cell entry receptor and protease\nSARS-CoV and SARS-CoV2 share absolutely the same cleavage junctions, almost the same sequence (96%) of their main protease, a high degree (76%) of similarity in the amino acid sequence of their S protein, a similar S2′ cleavage site, a similar spectrum of cells they can enter, and the similarity of the most residues essential for binding ACE2 [16], [17], [18]. Also, both of them utilize the same domain of S1B to interact with the ACE2 receptor. However, they differ in proteolytic processing to some degree. Study [16] of the human embryonic kidney (HEK) cell line, 293 T, has shown that a signal for the S2 subunit is present in cells inoculated with SARS-2-S, but not in cells inoculated with SARS-S.\nTwo main proteases for both SARS-S and SARS-2-S are endosomal cysteine proteases cathepsin B and L (CatB/L) and the transmembrane protease, serine 2TMPRSS2 [16]. In 293 T cells lacking 2TMPRSS2, blocking CatB/L activity through increasing the endosomal pH by ammonium chloride could significantly limit the entry of both SARS-S and SARS-2-S. In TMPRSS2 + Caco-2 cells, the effect of ammonium chloride existed to a lesser extent. A combination of camostat mesylate, a blocker of TMPRSS2, and E-64d, an inhibitor of CatB/L, yielded the complete inhibition of SARS-2-S entry in TMPRSS2 + Caco-2 cells. In both the human lung cancer cell line Calu-3 and the primary human lung cells, there was a reduction of the entry of both SARS-S and SARS-2-S by camostat mesylate, indicating that SARS-S and SARS-2-S partially require TMPRSS2 for a lung infection."}

    LitCovid-PD-FMA-UBERON

    {"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T105","span":{"begin":89,"end":93},"obj":"Body_part"},{"id":"T106","span":{"begin":287,"end":297},"obj":"Body_part"},{"id":"T107","span":{"begin":318,"end":325},"obj":"Body_part"},{"id":"T108","span":{"begin":378,"end":383},"obj":"Body_part"},{"id":"T109","span":{"begin":668,"end":674},"obj":"Body_part"},{"id":"T110","span":{"begin":681,"end":685},"obj":"Body_part"},{"id":"T111","span":{"begin":756,"end":761},"obj":"Body_part"},{"id":"T112","span":{"begin":799,"end":804},"obj":"Body_part"},{"id":"T113","span":{"begin":881,"end":890},"obj":"Body_part"},{"id":"T114","span":{"begin":891,"end":899},"obj":"Body_part"},{"id":"T115","span":{"begin":969,"end":975},"obj":"Body_part"},{"id":"T116","span":{"begin":1000,"end":1005},"obj":"Body_part"},{"id":"T117","span":{"begin":1072,"end":1081},"obj":"Body_part"},{"id":"T118","span":{"begin":1191,"end":1196},"obj":"Body_part"},{"id":"T119","span":{"begin":1421,"end":1426},"obj":"Body_part"},{"id":"T120","span":{"begin":1446,"end":1450},"obj":"Body_part"},{"id":"T121","span":{"begin":1458,"end":1462},"obj":"Body_part"},{"id":"T122","span":{"begin":1497,"end":1501},"obj":"Body_part"},{"id":"T123","span":{"begin":1502,"end":1507},"obj":"Body_part"},{"id":"T124","span":{"begin":1662,"end":1666},"obj":"Body_part"}],"attributes":[{"id":"A105","pred":"fma_id","subj":"T105","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A106","pred":"fma_id","subj":"T106","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A107","pred":"fma_id","subj":"T107","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A108","pred":"fma_id","subj":"T108","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A109","pred":"fma_id","subj":"T109","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A110","pred":"fma_id","subj":"T110","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A111","pred":"fma_id","subj":"T111","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A112","pred":"fma_id","subj":"T112","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A113","pred":"fma_id","subj":"T113","obj":"http://purl.org/sig/ont/fma/fma67180"},{"id":"A114","pred":"fma_id","subj":"T114","obj":"http://purl.org/sig/ont/fma/fma82751"},{"id":"A115","pred":"fma_id","subj":"T115","obj":"http://purl.org/sig/ont/fma/fma82764"},{"id":"A116","pred":"fma_id","subj":"T116","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A117","pred":"fma_id","subj":"T117","obj":"http://purl.org/sig/ont/fma/fma67180"},{"id":"A118","pred":"fma_id","subj":"T118","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A119","pred":"fma_id","subj":"T119","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A120","pred":"fma_id","subj":"T120","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A121","pred":"fma_id","subj":"T121","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A122","pred":"fma_id","subj":"T122","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A123","pred":"fma_id","subj":"T123","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A124","pred":"fma_id","subj":"T124","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":"4.1.3.1 Hypothesis: SARS-CoV and SARS-CoV2 are ideally similar in the structure and the cell entry receptor and protease\nSARS-CoV and SARS-CoV2 share absolutely the same cleavage junctions, almost the same sequence (96%) of their main protease, a high degree (76%) of similarity in the amino acid sequence of their S protein, a similar S2′ cleavage site, a similar spectrum of cells they can enter, and the similarity of the most residues essential for binding ACE2 [16], [17], [18]. Also, both of them utilize the same domain of S1B to interact with the ACE2 receptor. However, they differ in proteolytic processing to some degree. Study [16] of the human embryonic kidney (HEK) cell line, 293 T, has shown that a signal for the S2 subunit is present in cells inoculated with SARS-2-S, but not in cells inoculated with SARS-S.\nTwo main proteases for both SARS-S and SARS-2-S are endosomal cysteine proteases cathepsin B and L (CatB/L) and the transmembrane protease, serine 2TMPRSS2 [16]. In 293 T cells lacking 2TMPRSS2, blocking CatB/L activity through increasing the endosomal pH by ammonium chloride could significantly limit the entry of both SARS-S and SARS-2-S. In TMPRSS2 + Caco-2 cells, the effect of ammonium chloride existed to a lesser extent. A combination of camostat mesylate, a blocker of TMPRSS2, and E-64d, an inhibitor of CatB/L, yielded the complete inhibition of SARS-2-S entry in TMPRSS2 + Caco-2 cells. In both the human lung cancer cell line Calu-3 and the primary human lung cells, there was a reduction of the entry of both SARS-S and SARS-2-S by camostat mesylate, indicating that SARS-S and SARS-2-S partially require TMPRSS2 for a lung infection."}

    LitCovid-PD-UBERON

    {"project":"LitCovid-PD-UBERON","denotations":[{"id":"T8","span":{"begin":668,"end":674},"obj":"Body_part"},{"id":"T9","span":{"begin":1446,"end":1450},"obj":"Body_part"},{"id":"T10","span":{"begin":1497,"end":1501},"obj":"Body_part"},{"id":"T11","span":{"begin":1662,"end":1666},"obj":"Body_part"}],"attributes":[{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"4.1.3.1 Hypothesis: SARS-CoV and SARS-CoV2 are ideally similar in the structure and the cell entry receptor and protease\nSARS-CoV and SARS-CoV2 share absolutely the same cleavage junctions, almost the same sequence (96%) of their main protease, a high degree (76%) of similarity in the amino acid sequence of their S protein, a similar S2′ cleavage site, a similar spectrum of cells they can enter, and the similarity of the most residues essential for binding ACE2 [16], [17], [18]. Also, both of them utilize the same domain of S1B to interact with the ACE2 receptor. However, they differ in proteolytic processing to some degree. Study [16] of the human embryonic kidney (HEK) cell line, 293 T, has shown that a signal for the S2 subunit is present in cells inoculated with SARS-2-S, but not in cells inoculated with SARS-S.\nTwo main proteases for both SARS-S and SARS-2-S are endosomal cysteine proteases cathepsin B and L (CatB/L) and the transmembrane protease, serine 2TMPRSS2 [16]. In 293 T cells lacking 2TMPRSS2, blocking CatB/L activity through increasing the endosomal pH by ammonium chloride could significantly limit the entry of both SARS-S and SARS-2-S. In TMPRSS2 + Caco-2 cells, the effect of ammonium chloride existed to a lesser extent. A combination of camostat mesylate, a blocker of TMPRSS2, and E-64d, an inhibitor of CatB/L, yielded the complete inhibition of SARS-2-S entry in TMPRSS2 + Caco-2 cells. In both the human lung cancer cell line Calu-3 and the primary human lung cells, there was a reduction of the entry of both SARS-S and SARS-2-S by camostat mesylate, indicating that SARS-S and SARS-2-S partially require TMPRSS2 for a lung infection."}

    LitCovid-PD-MONDO

    {"project":"LitCovid-PD-MONDO","denotations":[{"id":"T87","span":{"begin":21,"end":29},"obj":"Disease"},{"id":"T88","span":{"begin":34,"end":38},"obj":"Disease"},{"id":"T89","span":{"begin":122,"end":130},"obj":"Disease"},{"id":"T90","span":{"begin":135,"end":139},"obj":"Disease"},{"id":"T91","span":{"begin":778,"end":782},"obj":"Disease"},{"id":"T92","span":{"begin":821,"end":825},"obj":"Disease"},{"id":"T93","span":{"begin":857,"end":861},"obj":"Disease"},{"id":"T94","span":{"begin":868,"end":872},"obj":"Disease"},{"id":"T95","span":{"begin":1150,"end":1154},"obj":"Disease"},{"id":"T96","span":{"begin":1161,"end":1165},"obj":"Disease"},{"id":"T97","span":{"begin":1386,"end":1390},"obj":"Disease"},{"id":"T98","span":{"begin":1446,"end":1457},"obj":"Disease"},{"id":"T99","span":{"begin":1451,"end":1457},"obj":"Disease"},{"id":"T100","span":{"begin":1552,"end":1556},"obj":"Disease"},{"id":"T101","span":{"begin":1563,"end":1567},"obj":"Disease"},{"id":"T102","span":{"begin":1610,"end":1614},"obj":"Disease"},{"id":"T103","span":{"begin":1621,"end":1625},"obj":"Disease"},{"id":"T104","span":{"begin":1667,"end":1676},"obj":"Disease"}],"attributes":[{"id":"A87","pred":"mondo_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A88","pred":"mondo_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A89","pred":"mondo_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A90","pred":"mondo_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A91","pred":"mondo_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A92","pred":"mondo_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A93","pred":"mondo_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A94","pred":"mondo_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A95","pred":"mondo_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A96","pred":"mondo_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A97","pred":"mondo_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A98","pred":"mondo_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/MONDO_0008903"},{"id":"A99","pred":"mondo_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"A100","pred":"mondo_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A101","pred":"mondo_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A102","pred":"mondo_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A103","pred":"mondo_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A104","pred":"mondo_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"4.1.3.1 Hypothesis: SARS-CoV and SARS-CoV2 are ideally similar in the structure and the cell entry receptor and protease\nSARS-CoV and SARS-CoV2 share absolutely the same cleavage junctions, almost the same sequence (96%) of their main protease, a high degree (76%) of similarity in the amino acid sequence of their S protein, a similar S2′ cleavage site, a similar spectrum of cells they can enter, and the similarity of the most residues essential for binding ACE2 [16], [17], [18]. Also, both of them utilize the same domain of S1B to interact with the ACE2 receptor. However, they differ in proteolytic processing to some degree. Study [16] of the human embryonic kidney (HEK) cell line, 293 T, has shown that a signal for the S2 subunit is present in cells inoculated with SARS-2-S, but not in cells inoculated with SARS-S.\nTwo main proteases for both SARS-S and SARS-2-S are endosomal cysteine proteases cathepsin B and L (CatB/L) and the transmembrane protease, serine 2TMPRSS2 [16]. In 293 T cells lacking 2TMPRSS2, blocking CatB/L activity through increasing the endosomal pH by ammonium chloride could significantly limit the entry of both SARS-S and SARS-2-S. In TMPRSS2 + Caco-2 cells, the effect of ammonium chloride existed to a lesser extent. A combination of camostat mesylate, a blocker of TMPRSS2, and E-64d, an inhibitor of CatB/L, yielded the complete inhibition of SARS-2-S entry in TMPRSS2 + Caco-2 cells. In both the human lung cancer cell line Calu-3 and the primary human lung cells, there was a reduction of the entry of both SARS-S and SARS-2-S by camostat mesylate, indicating that SARS-S and SARS-2-S partially require TMPRSS2 for a lung infection."}

    LitCovid-PD-CLO

    {"project":"LitCovid-PD-CLO","denotations":[{"id":"T155","span":{"begin":89,"end":93},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T156","span":{"begin":180,"end":189},"obj":"http://purl.obolibrary.org/obo/UBERON_0007651"},{"id":"T157","span":{"begin":246,"end":247},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T158","span":{"begin":327,"end":328},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T159","span":{"begin":337,"end":339},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T160","span":{"begin":337,"end":339},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T161","span":{"begin":356,"end":357},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T162","span":{"begin":378,"end":383},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T163","span":{"begin":480,"end":482},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T164","span":{"begin":652,"end":657},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T165","span":{"begin":658,"end":674},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T166","span":{"begin":681,"end":690},"obj":"http://purl.obolibrary.org/obo/CLO_0000031"},{"id":"T167","span":{"begin":692,"end":697},"obj":"http://purl.obolibrary.org/obo/CLO_0050894"},{"id":"T168","span":{"begin":692,"end":697},"obj":"http://purl.obolibrary.org/obo/CLO_0051650"},{"id":"T169","span":{"begin":692,"end":697},"obj":"http://purl.obolibrary.org/obo/CLO_0052052"},{"id":"T170","span":{"begin":699,"end":702},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T171","span":{"begin":714,"end":715},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T172","span":{"begin":716,"end":722},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T173","span":{"begin":731,"end":733},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T174","span":{"begin":731,"end":733},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T175","span":{"begin":756,"end":761},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T176","span":{"begin":799,"end":804},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T177","span":{"begin":920,"end":921},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T178","span":{"begin":994,"end":999},"obj":"http://purl.obolibrary.org/obo/CLO_0050894"},{"id":"T179","span":{"begin":994,"end":999},"obj":"http://purl.obolibrary.org/obo/CLO_0051650"},{"id":"T180","span":{"begin":994,"end":999},"obj":"http://purl.obolibrary.org/obo/CLO_0052052"},{"id":"T181","span":{"begin":1000,"end":1005},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T182","span":{"begin":1040,"end":1048},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T183","span":{"begin":1184,"end":1190},"obj":"http://purl.obolibrary.org/obo/CLO_0002172"},{"id":"T184","span":{"begin":1184,"end":1190},"obj":"http://purl.obolibrary.org/obo/CLO_0051943"},{"id":"T185","span":{"begin":1184,"end":1190},"obj":"http://purl.obolibrary.org/obo/CLO_0051958"},{"id":"T186","span":{"begin":1184,"end":1190},"obj":"http://purl.obolibrary.org/obo/CLO_0051960"},{"id":"T187","span":{"begin":1191,"end":1196},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T188","span":{"begin":1241,"end":1242},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T189","span":{"begin":1258,"end":1259},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T190","span":{"begin":1294,"end":1295},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T191","span":{"begin":1414,"end":1420},"obj":"http://purl.obolibrary.org/obo/CLO_0002172"},{"id":"T192","span":{"begin":1414,"end":1420},"obj":"http://purl.obolibrary.org/obo/CLO_0051943"},{"id":"T193","span":{"begin":1414,"end":1420},"obj":"http://purl.obolibrary.org/obo/CLO_0051958"},{"id":"T194","span":{"begin":1414,"end":1420},"obj":"http://purl.obolibrary.org/obo/CLO_0051960"},{"id":"T195","span":{"begin":1421,"end":1426},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T196","span":{"begin":1440,"end":1445},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T197","span":{"begin":1446,"end":1450},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T198","span":{"begin":1446,"end":1450},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T199","span":{"begin":1451,"end":1467},"obj":"http://purl.obolibrary.org/obo/OBI_0001906"},{"id":"T200","span":{"begin":1451,"end":1467},"obj":"http://www.ebi.ac.uk/cellline#cancer_cell_line"},{"id":"T201","span":{"begin":1468,"end":1474},"obj":"http://purl.obolibrary.org/obo/CLO_0002192"},{"id":"T202","span":{"begin":1491,"end":1496},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T203","span":{"begin":1497,"end":1501},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T204","span":{"begin":1497,"end":1501},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T205","span":{"begin":1502,"end":1507},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T206","span":{"begin":1519,"end":1520},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T207","span":{"begin":1660,"end":1661},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T208","span":{"begin":1662,"end":1666},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T209","span":{"begin":1662,"end":1666},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"}],"text":"4.1.3.1 Hypothesis: SARS-CoV and SARS-CoV2 are ideally similar in the structure and the cell entry receptor and protease\nSARS-CoV and SARS-CoV2 share absolutely the same cleavage junctions, almost the same sequence (96%) of their main protease, a high degree (76%) of similarity in the amino acid sequence of their S protein, a similar S2′ cleavage site, a similar spectrum of cells they can enter, and the similarity of the most residues essential for binding ACE2 [16], [17], [18]. Also, both of them utilize the same domain of S1B to interact with the ACE2 receptor. However, they differ in proteolytic processing to some degree. Study [16] of the human embryonic kidney (HEK) cell line, 293 T, has shown that a signal for the S2 subunit is present in cells inoculated with SARS-2-S, but not in cells inoculated with SARS-S.\nTwo main proteases for both SARS-S and SARS-2-S are endosomal cysteine proteases cathepsin B and L (CatB/L) and the transmembrane protease, serine 2TMPRSS2 [16]. In 293 T cells lacking 2TMPRSS2, blocking CatB/L activity through increasing the endosomal pH by ammonium chloride could significantly limit the entry of both SARS-S and SARS-2-S. In TMPRSS2 + Caco-2 cells, the effect of ammonium chloride existed to a lesser extent. A combination of camostat mesylate, a blocker of TMPRSS2, and E-64d, an inhibitor of CatB/L, yielded the complete inhibition of SARS-2-S entry in TMPRSS2 + Caco-2 cells. In both the human lung cancer cell line Calu-3 and the primary human lung cells, there was a reduction of the entry of both SARS-S and SARS-2-S by camostat mesylate, indicating that SARS-S and SARS-2-S partially require TMPRSS2 for a lung infection."}

    LitCovid-PD-CHEBI

    {"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T137","span":{"begin":287,"end":297},"obj":"Chemical"},{"id":"T138","span":{"begin":287,"end":292},"obj":"Chemical"},{"id":"T139","span":{"begin":293,"end":297},"obj":"Chemical"},{"id":"T140","span":{"begin":318,"end":325},"obj":"Chemical"},{"id":"T141","span":{"begin":337,"end":339},"obj":"Chemical"},{"id":"T142","span":{"begin":731,"end":733},"obj":"Chemical"},{"id":"T143","span":{"begin":891,"end":899},"obj":"Chemical"},{"id":"T144","span":{"begin":969,"end":975},"obj":"Chemical"},{"id":"T145","span":{"begin":1088,"end":1105},"obj":"Chemical"},{"id":"T146","span":{"begin":1088,"end":1096},"obj":"Chemical"},{"id":"T147","span":{"begin":1097,"end":1105},"obj":"Chemical"},{"id":"T148","span":{"begin":1212,"end":1229},"obj":"Chemical"},{"id":"T149","span":{"begin":1212,"end":1220},"obj":"Chemical"},{"id":"T150","span":{"begin":1221,"end":1229},"obj":"Chemical"},{"id":"T151","span":{"begin":1275,"end":1292},"obj":"Chemical"},{"id":"T152","span":{"begin":1320,"end":1325},"obj":"Chemical"},{"id":"T153","span":{"begin":1330,"end":1339},"obj":"Chemical"},{"id":"T154","span":{"begin":1575,"end":1592},"obj":"Chemical"}],"attributes":[{"id":"A137","pred":"chebi_id","subj":"T137","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A138","pred":"chebi_id","subj":"T138","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A139","pred":"chebi_id","subj":"T139","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A140","pred":"chebi_id","subj":"T140","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A141","pred":"chebi_id","subj":"T141","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A142","pred":"chebi_id","subj":"T142","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A143","pred":"chebi_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/CHEBI_15356"},{"id":"A144","pred":"chebi_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/CHEBI_17822"},{"id":"A145","pred":"chebi_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/CHEBI_31206"},{"id":"A146","pred":"chebi_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/CHEBI_28938"},{"id":"A147","pred":"chebi_id","subj":"T147","obj":"http://purl.obolibrary.org/obo/CHEBI_17996"},{"id":"A148","pred":"chebi_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/CHEBI_31206"},{"id":"A149","pred":"chebi_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/CHEBI_28938"},{"id":"A150","pred":"chebi_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/CHEBI_17996"},{"id":"A151","pred":"chebi_id","subj":"T151","obj":"http://purl.obolibrary.org/obo/CHEBI_135632"},{"id":"A152","pred":"chebi_id","subj":"T152","obj":"http://purl.obolibrary.org/obo/CHEBI_101381"},{"id":"A153","pred":"chebi_id","subj":"T153","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A154","pred":"chebi_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/CHEBI_135632"}],"text":"4.1.3.1 Hypothesis: SARS-CoV and SARS-CoV2 are ideally similar in the structure and the cell entry receptor and protease\nSARS-CoV and SARS-CoV2 share absolutely the same cleavage junctions, almost the same sequence (96%) of their main protease, a high degree (76%) of similarity in the amino acid sequence of their S protein, a similar S2′ cleavage site, a similar spectrum of cells they can enter, and the similarity of the most residues essential for binding ACE2 [16], [17], [18]. Also, both of them utilize the same domain of S1B to interact with the ACE2 receptor. However, they differ in proteolytic processing to some degree. Study [16] of the human embryonic kidney (HEK) cell line, 293 T, has shown that a signal for the S2 subunit is present in cells inoculated with SARS-2-S, but not in cells inoculated with SARS-S.\nTwo main proteases for both SARS-S and SARS-2-S are endosomal cysteine proteases cathepsin B and L (CatB/L) and the transmembrane protease, serine 2TMPRSS2 [16]. In 293 T cells lacking 2TMPRSS2, blocking CatB/L activity through increasing the endosomal pH by ammonium chloride could significantly limit the entry of both SARS-S and SARS-2-S. In TMPRSS2 + Caco-2 cells, the effect of ammonium chloride existed to a lesser extent. A combination of camostat mesylate, a blocker of TMPRSS2, and E-64d, an inhibitor of CatB/L, yielded the complete inhibition of SARS-2-S entry in TMPRSS2 + Caco-2 cells. In both the human lung cancer cell line Calu-3 and the primary human lung cells, there was a reduction of the entry of both SARS-S and SARS-2-S by camostat mesylate, indicating that SARS-S and SARS-2-S partially require TMPRSS2 for a lung infection."}

    LitCovid-sample-PD-IDO

    {"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T55","span":{"begin":89,"end":93},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T56","span":{"begin":350,"end":354},"obj":"http://purl.obolibrary.org/obo/BFO_0000029"},{"id":"T57","span":{"begin":378,"end":383},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T58","span":{"begin":681,"end":685},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T59","span":{"begin":756,"end":761},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T60","span":{"begin":762,"end":772},"obj":"http://purl.obolibrary.org/obo/IDO_0000498"},{"id":"T61","span":{"begin":799,"end":804},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T62","span":{"begin":805,"end":815},"obj":"http://purl.obolibrary.org/obo/IDO_0000498"},{"id":"T63","span":{"begin":1000,"end":1005},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T64","span":{"begin":1191,"end":1196},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T65","span":{"begin":1421,"end":1426},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T66","span":{"begin":1458,"end":1462},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T67","span":{"begin":1502,"end":1507},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T68","span":{"begin":1667,"end":1676},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"}],"text":"4.1.3.1 Hypothesis: SARS-CoV and SARS-CoV2 are ideally similar in the structure and the cell entry receptor and protease\nSARS-CoV and SARS-CoV2 share absolutely the same cleavage junctions, almost the same sequence (96%) of their main protease, a high degree (76%) of similarity in the amino acid sequence of their S protein, a similar S2′ cleavage site, a similar spectrum of cells they can enter, and the similarity of the most residues essential for binding ACE2 [16], [17], [18]. Also, both of them utilize the same domain of S1B to interact with the ACE2 receptor. However, they differ in proteolytic processing to some degree. Study [16] of the human embryonic kidney (HEK) cell line, 293 T, has shown that a signal for the S2 subunit is present in cells inoculated with SARS-2-S, but not in cells inoculated with SARS-S.\nTwo main proteases for both SARS-S and SARS-2-S are endosomal cysteine proteases cathepsin B and L (CatB/L) and the transmembrane protease, serine 2TMPRSS2 [16]. In 293 T cells lacking 2TMPRSS2, blocking CatB/L activity through increasing the endosomal pH by ammonium chloride could significantly limit the entry of both SARS-S and SARS-2-S. In TMPRSS2 + Caco-2 cells, the effect of ammonium chloride existed to a lesser extent. A combination of camostat mesylate, a blocker of TMPRSS2, and E-64d, an inhibitor of CatB/L, yielded the complete inhibition of SARS-2-S entry in TMPRSS2 + Caco-2 cells. In both the human lung cancer cell line Calu-3 and the primary human lung cells, there was a reduction of the entry of both SARS-S and SARS-2-S by camostat mesylate, indicating that SARS-S and SARS-2-S partially require TMPRSS2 for a lung infection."}

    LitCovid-sample-CHEBI

    {"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T94","span":{"begin":287,"end":297},"obj":"Chemical"},{"id":"T95","span":{"begin":318,"end":325},"obj":"Chemical"},{"id":"T96","span":{"begin":891,"end":899},"obj":"Chemical"},{"id":"T97","span":{"begin":969,"end":975},"obj":"Chemical"},{"id":"T98","span":{"begin":1088,"end":1105},"obj":"Chemical"},{"id":"T99","span":{"begin":1212,"end":1229},"obj":"Chemical"},{"id":"T100","span":{"begin":1275,"end":1292},"obj":"Chemical"},{"id":"T101","span":{"begin":1320,"end":1325},"obj":"Chemical"},{"id":"T102","span":{"begin":1575,"end":1592},"obj":"Chemical"}],"attributes":[{"id":"A100","pred":"chebi_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/CHEBI_135632"},{"id":"A94","pred":"chebi_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A102","pred":"chebi_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/CHEBI_135632"},{"id":"A99","pred":"chebi_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/CHEBI_31206"},{"id":"A101","pred":"chebi_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/CHEBI_101381"},{"id":"A98","pred":"chebi_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/CHEBI_31206"},{"id":"A96","pred":"chebi_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/CHEBI_15356"},{"id":"A97","pred":"chebi_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/CHEBI_17822"},{"id":"A95","pred":"chebi_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"4.1.3.1 Hypothesis: SARS-CoV and SARS-CoV2 are ideally similar in the structure and the cell entry receptor and protease\nSARS-CoV and SARS-CoV2 share absolutely the same cleavage junctions, almost the same sequence (96%) of their main protease, a high degree (76%) of similarity in the amino acid sequence of their S protein, a similar S2′ cleavage site, a similar spectrum of cells they can enter, and the similarity of the most residues essential for binding ACE2 [16], [17], [18]. Also, both of them utilize the same domain of S1B to interact with the ACE2 receptor. However, they differ in proteolytic processing to some degree. Study [16] of the human embryonic kidney (HEK) cell line, 293 T, has shown that a signal for the S2 subunit is present in cells inoculated with SARS-2-S, but not in cells inoculated with SARS-S.\nTwo main proteases for both SARS-S and SARS-2-S are endosomal cysteine proteases cathepsin B and L (CatB/L) and the transmembrane protease, serine 2TMPRSS2 [16]. In 293 T cells lacking 2TMPRSS2, blocking CatB/L activity through increasing the endosomal pH by ammonium chloride could significantly limit the entry of both SARS-S and SARS-2-S. In TMPRSS2 + Caco-2 cells, the effect of ammonium chloride existed to a lesser extent. A combination of camostat mesylate, a blocker of TMPRSS2, and E-64d, an inhibitor of CatB/L, yielded the complete inhibition of SARS-2-S entry in TMPRSS2 + Caco-2 cells. In both the human lung cancer cell line Calu-3 and the primary human lung cells, there was a reduction of the entry of both SARS-S and SARS-2-S by camostat mesylate, indicating that SARS-S and SARS-2-S partially require TMPRSS2 for a lung infection."}

    LitCovid-sample-PD-NCBITaxon

    {"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T119","span":{"begin":21,"end":29},"obj":"Species"},{"id":"T120","span":{"begin":34,"end":43},"obj":"Species"},{"id":"T121","span":{"begin":122,"end":130},"obj":"Species"},{"id":"T122","span":{"begin":135,"end":144},"obj":"Species"},{"id":"T123","span":{"begin":652,"end":657},"obj":"Species"},{"id":"T124","span":{"begin":778,"end":784},"obj":"Species"},{"id":"T125","span":{"begin":821,"end":825},"obj":"Species"},{"id":"T126","span":{"begin":857,"end":861},"obj":"Species"},{"id":"T127","span":{"begin":868,"end":874},"obj":"Species"},{"id":"T128","span":{"begin":1150,"end":1154},"obj":"Species"},{"id":"T129","span":{"begin":1161,"end":1167},"obj":"Species"},{"id":"T130","span":{"begin":1386,"end":1392},"obj":"Species"},{"id":"T131","span":{"begin":1440,"end":1445},"obj":"Species"},{"id":"T132","span":{"begin":1491,"end":1496},"obj":"Species"},{"id":"T133","span":{"begin":1552,"end":1556},"obj":"Species"},{"id":"T134","span":{"begin":1563,"end":1569},"obj":"Species"},{"id":"T135","span":{"begin":1610,"end":1614},"obj":"Species"},{"id":"T136","span":{"begin":1621,"end":1627},"obj":"Species"}],"attributes":[{"id":"A134","pred":"ncbi_taxonomy_id","subj":"T134","obj":"NCBItxid:2697049"},{"id":"A123","pred":"ncbi_taxonomy_id","subj":"T123","obj":"NCBItxid:9606"},{"id":"A131","pred":"ncbi_taxonomy_id","subj":"T131","obj":"NCBItxid:9606"},{"id":"A136","pred":"ncbi_taxonomy_id","subj":"T136","obj":"NCBItxid:2697049"},{"id":"A126","pred":"ncbi_taxonomy_id","subj":"T126","obj":"NCBItxid:694009"},{"id":"A121","pred":"ncbi_taxonomy_id","subj":"T121","obj":"NCBItxid:694009"},{"id":"A129","pred":"ncbi_taxonomy_id","subj":"T129","obj":"NCBItxid:2697049"},{"id":"A127","pred":"ncbi_taxonomy_id","subj":"T127","obj":"NCBItxid:2697049"},{"id":"A128","pred":"ncbi_taxonomy_id","subj":"T128","obj":"NCBItxid:694009"},{"id":"A120","pred":"ncbi_taxonomy_id","subj":"T120","obj":"NCBItxid:2697049"},{"id":"A122","pred":"ncbi_taxonomy_id","subj":"T122","obj":"NCBItxid:2697049"},{"id":"A119","pred":"ncbi_taxonomy_id","subj":"T119","obj":"NCBItxid:694009"},{"id":"A132","pred":"ncbi_taxonomy_id","subj":"T132","obj":"NCBItxid:9606"},{"id":"A125","pred":"ncbi_taxonomy_id","subj":"T125","obj":"NCBItxid:694009"},{"id":"A135","pred":"ncbi_taxonomy_id","subj":"T135","obj":"NCBItxid:694009"},{"id":"A130","pred":"ncbi_taxonomy_id","subj":"T130","obj":"NCBItxid:2697049"},{"id":"A133","pred":"ncbi_taxonomy_id","subj":"T133","obj":"NCBItxid:694009"},{"id":"A124","pred":"ncbi_taxonomy_id","subj":"T124","obj":"NCBItxid:2697049"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"4.1.3.1 Hypothesis: SARS-CoV and SARS-CoV2 are ideally similar in the structure and the cell entry receptor and protease\nSARS-CoV and SARS-CoV2 share absolutely the same cleavage junctions, almost the same sequence (96%) of their main protease, a high degree (76%) of similarity in the amino acid sequence of their S protein, a similar S2′ cleavage site, a similar spectrum of cells they can enter, and the similarity of the most residues essential for binding ACE2 [16], [17], [18]. Also, both of them utilize the same domain of S1B to interact with the ACE2 receptor. However, they differ in proteolytic processing to some degree. Study [16] of the human embryonic kidney (HEK) cell line, 293 T, has shown that a signal for the S2 subunit is present in cells inoculated with SARS-2-S, but not in cells inoculated with SARS-S.\nTwo main proteases for both SARS-S and SARS-2-S are endosomal cysteine proteases cathepsin B and L (CatB/L) and the transmembrane protease, serine 2TMPRSS2 [16]. In 293 T cells lacking 2TMPRSS2, blocking CatB/L activity through increasing the endosomal pH by ammonium chloride could significantly limit the entry of both SARS-S and SARS-2-S. In TMPRSS2 + Caco-2 cells, the effect of ammonium chloride existed to a lesser extent. A combination of camostat mesylate, a blocker of TMPRSS2, and E-64d, an inhibitor of CatB/L, yielded the complete inhibition of SARS-2-S entry in TMPRSS2 + Caco-2 cells. In both the human lung cancer cell line Calu-3 and the primary human lung cells, there was a reduction of the entry of both SARS-S and SARS-2-S by camostat mesylate, indicating that SARS-S and SARS-2-S partially require TMPRSS2 for a lung infection."}

    LitCovid-sample-sentences

    {"project":"LitCovid-sample-sentences","denotations":[{"id":"T116","span":{"begin":0,"end":121},"obj":"Sentence"},{"id":"T117","span":{"begin":122,"end":484},"obj":"Sentence"},{"id":"T118","span":{"begin":485,"end":570},"obj":"Sentence"},{"id":"T119","span":{"begin":571,"end":633},"obj":"Sentence"},{"id":"T120","span":{"begin":634,"end":828},"obj":"Sentence"},{"id":"T121","span":{"begin":829,"end":990},"obj":"Sentence"},{"id":"T122","span":{"begin":991,"end":1170},"obj":"Sentence"},{"id":"T123","span":{"begin":1171,"end":1257},"obj":"Sentence"},{"id":"T124","span":{"begin":1258,"end":1427},"obj":"Sentence"},{"id":"T125","span":{"begin":1428,"end":1677},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"4.1.3.1 Hypothesis: SARS-CoV and SARS-CoV2 are ideally similar in the structure and the cell entry receptor and protease\nSARS-CoV and SARS-CoV2 share absolutely the same cleavage junctions, almost the same sequence (96%) of their main protease, a high degree (76%) of similarity in the amino acid sequence of their S protein, a similar S2′ cleavage site, a similar spectrum of cells they can enter, and the similarity of the most residues essential for binding ACE2 [16], [17], [18]. Also, both of them utilize the same domain of S1B to interact with the ACE2 receptor. However, they differ in proteolytic processing to some degree. Study [16] of the human embryonic kidney (HEK) cell line, 293 T, has shown that a signal for the S2 subunit is present in cells inoculated with SARS-2-S, but not in cells inoculated with SARS-S.\nTwo main proteases for both SARS-S and SARS-2-S are endosomal cysteine proteases cathepsin B and L (CatB/L) and the transmembrane protease, serine 2TMPRSS2 [16]. In 293 T cells lacking 2TMPRSS2, blocking CatB/L activity through increasing the endosomal pH by ammonium chloride could significantly limit the entry of both SARS-S and SARS-2-S. In TMPRSS2 + Caco-2 cells, the effect of ammonium chloride existed to a lesser extent. A combination of camostat mesylate, a blocker of TMPRSS2, and E-64d, an inhibitor of CatB/L, yielded the complete inhibition of SARS-2-S entry in TMPRSS2 + Caco-2 cells. In both the human lung cancer cell line Calu-3 and the primary human lung cells, there was a reduction of the entry of both SARS-S and SARS-2-S by camostat mesylate, indicating that SARS-S and SARS-2-S partially require TMPRSS2 for a lung infection."}

    LitCovid-sample-PD-UBERON

    {"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T8","span":{"begin":668,"end":674},"obj":"Body_part"},{"id":"T9","span":{"begin":1446,"end":1450},"obj":"Body_part"},{"id":"T10","span":{"begin":1497,"end":1501},"obj":"Body_part"},{"id":"T11","span":{"begin":1662,"end":1666},"obj":"Body_part"}],"attributes":[{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"4.1.3.1 Hypothesis: SARS-CoV and SARS-CoV2 are ideally similar in the structure and the cell entry receptor and protease\nSARS-CoV and SARS-CoV2 share absolutely the same cleavage junctions, almost the same sequence (96%) of their main protease, a high degree (76%) of similarity in the amino acid sequence of their S protein, a similar S2′ cleavage site, a similar spectrum of cells they can enter, and the similarity of the most residues essential for binding ACE2 [16], [17], [18]. Also, both of them utilize the same domain of S1B to interact with the ACE2 receptor. However, they differ in proteolytic processing to some degree. Study [16] of the human embryonic kidney (HEK) cell line, 293 T, has shown that a signal for the S2 subunit is present in cells inoculated with SARS-2-S, but not in cells inoculated with SARS-S.\nTwo main proteases for both SARS-S and SARS-2-S are endosomal cysteine proteases cathepsin B and L (CatB/L) and the transmembrane protease, serine 2TMPRSS2 [16]. In 293 T cells lacking 2TMPRSS2, blocking CatB/L activity through increasing the endosomal pH by ammonium chloride could significantly limit the entry of both SARS-S and SARS-2-S. In TMPRSS2 + Caco-2 cells, the effect of ammonium chloride existed to a lesser extent. A combination of camostat mesylate, a blocker of TMPRSS2, and E-64d, an inhibitor of CatB/L, yielded the complete inhibition of SARS-2-S entry in TMPRSS2 + Caco-2 cells. In both the human lung cancer cell line Calu-3 and the primary human lung cells, there was a reduction of the entry of both SARS-S and SARS-2-S by camostat mesylate, indicating that SARS-S and SARS-2-S partially require TMPRSS2 for a lung infection."}

    LitCovid-sample-Pubtator

    {"project":"LitCovid-sample-Pubtator","denotations":[{"id":"461","span":{"begin":21,"end":29},"obj":"Species"},{"id":"442","span":{"begin":21,"end":29},"obj":"Species"},{"id":"462","span":{"begin":34,"end":43},"obj":"Species"},{"id":"443","span":{"begin":34,"end":43},"obj":"Species"},{"id":"460","span":{"begin":316,"end":317},"obj":"Gene"},{"id":"456","span":{"begin":462,"end":466},"obj":"Gene"},{"id":"457","span":{"begin":556,"end":560},"obj":"Gene"},{"id":"463","span":{"begin":652,"end":657},"obj":"Species"},{"id":"465","span":{"begin":658,"end":674},"obj":"Disease"},{"id":"466","span":{"begin":676,"end":679},"obj":"CellLine"},{"id":"467","span":{"begin":692,"end":697},"obj":"CellLine"},{"id":"464","span":{"begin":778,"end":784},"obj":"Species"},{"id":"459","span":{"begin":785,"end":786},"obj":"Gene"},{"id":"458","span":{"begin":826,"end":827},"obj":"Gene"},{"id":"518","span":{"begin":862,"end":863},"obj":"Gene"},{"id":"519","span":{"begin":868,"end":874},"obj":"Species"},{"id":"517","span":{"begin":875,"end":876},"obj":"Gene"},{"id":"503","span":{"begin":910,"end":921},"obj":"Gene"},{"id":"504","span":{"begin":929,"end":933},"obj":"Gene"},{"id":"526","span":{"begin":969,"end":975},"obj":"Chemical"},{"id":"534","span":{"begin":994,"end":999},"obj":"CellLine"},{"id":"505","span":{"begin":1015,"end":1022},"obj":"Gene"},{"id":"506","span":{"begin":1033,"end":1039},"obj":"Gene"},{"id":"527","span":{"begin":1088,"end":1105},"obj":"Chemical"},{"id":"520","span":{"begin":1161,"end":1167},"obj":"Species"},{"id":"516","span":{"begin":1168,"end":1169},"obj":"Gene"},{"id":"507","span":{"begin":1174,"end":1181},"obj":"Gene"},{"id":"535","span":{"begin":1184,"end":1190},"obj":"CellLine"},{"id":"528","span":{"begin":1212,"end":1229},"obj":"Chemical"},{"id":"529","span":{"begin":1275,"end":1292},"obj":"Chemical"},{"id":"508","span":{"begin":1307,"end":1314},"obj":"Gene"},{"id":"530","span":{"begin":1320,"end":1325},"obj":"Chemical"},{"id":"509","span":{"begin":1343,"end":1347},"obj":"Gene"},{"id":"521","span":{"begin":1386,"end":1392},"obj":"Species"},{"id":"515","span":{"begin":1393,"end":1394},"obj":"Gene"},{"id":"510","span":{"begin":1404,"end":1411},"obj":"Gene"},{"id":"536","span":{"begin":1414,"end":1420},"obj":"CellLine"},{"id":"522","span":{"begin":1440,"end":1445},"obj":"Species"},{"id":"532","span":{"begin":1446,"end":1457},"obj":"Disease"},{"id":"537","span":{"begin":1468,"end":1474},"obj":"CellLine"},{"id":"523","span":{"begin":1491,"end":1496},"obj":"Species"},{"id":"531","span":{"begin":1552,"end":1558},"obj":"Chemical"},{"id":"524","span":{"begin":1563,"end":1569},"obj":"Species"},{"id":"514","span":{"begin":1570,"end":1571},"obj":"Gene"},{"id":"513","span":{"begin":1615,"end":1616},"obj":"Gene"},{"id":"525","span":{"begin":1621,"end":1627},"obj":"Species"},{"id":"512","span":{"begin":1628,"end":1629},"obj":"Gene"},{"id":"511","span":{"begin":1648,"end":1655},"obj":"Gene"},{"id":"533","span":{"begin":1662,"end":1676},"obj":"Disease"}],"attributes":[{"id":"A532","pred":"pubann:denotes","subj":"532","obj":"MESH:D008175"},{"id":"A536","pred":"pubann:denotes","subj":"536","obj":"CVCL:0025"},{"id":"A512","pred":"pubann:denotes","subj":"512","obj":"Gene:43740568"},{"id":"A525","pred":"pubann:denotes","subj":"525","obj":"Tax:2697049"},{"id":"A461","pred":"pubann:denotes","subj":"461","obj":"Tax:694009"},{"id":"A514","pred":"pubann:denotes","subj":"514","obj":"Gene:43740568"},{"id":"A535","pred":"pubann:denotes","subj":"535","obj":"CVCL:0025"},{"id":"A457","pred":"pubann:denotes","subj":"457","obj":"Gene:59272"},{"id":"A526","pred":"pubann:denotes","subj":"526","obj":"MESH:D012694"},{"id":"A503","pred":"pubann:denotes","subj":"503","obj":"Gene:1508"},{"id":"A518","pred":"pubann:denotes","subj":"518","obj":"Gene:43740568"},{"id":"A506","pred":"pubann:denotes","subj":"506","obj":"Gene:1508"},{"id":"A513","pred":"pubann:denotes","subj":"513","obj":"Gene:43740568"},{"id":"A504","pred":"pubann:denotes","subj":"504","obj":"Gene:1508"},{"id":"A511","pred":"pubann:denotes","subj":"511","obj":"Gene:7113"},{"id":"A459","pred":"pubann:denotes","subj":"459","obj":"Gene:43740568"},{"id":"A515","pred":"pubann:denotes","subj":"515","obj":"Gene:43740568"},{"id":"A527","pred":"pubann:denotes","subj":"527","obj":"MESH:D000643"},{"id":"A458","pred":"pubann:denotes","subj":"458","obj":"Gene:43740568"},{"id":"A467","pred":"pubann:denotes","subj":"467","obj":"CVCL:0063"},{"id":"A460","pred":"pubann:denotes","subj":"460","obj":"Gene:43740568"},{"id":"A465","pred":"pubann:denotes","subj":"465","obj":"MESH:D007674"},{"id":"A521","pred":"pubann:denotes","subj":"521","obj":"Tax:2697049"},{"id":"A528","pred":"pubann:denotes","subj":"528","obj":"MESH:D000643"},{"id":"A533","pred":"pubann:denotes","subj":"533","obj":"MESH:D012141"},{"id":"A517","pred":"pubann:denotes","subj":"517","obj":"Gene:43740568"},{"id":"A507","pred":"pubann:denotes","subj":"507","obj":"Gene:7113"},{"id":"A516","pred":"pubann:denotes","subj":"516","obj":"Gene:43740568"},{"id":"A519","pred":"pubann:denotes","subj":"519","obj":"Tax:2697049"},{"id":"A534","pred":"pubann:denotes","subj":"534","obj":"CVCL:0063"},{"id":"A537","pred":"pubann:denotes","subj":"537","obj":"CVCL:0609"},{"id":"A510","pred":"pubann:denotes","subj":"510","obj":"Gene:7113"},{"id":"A520","pred":"pubann:denotes","subj":"520","obj":"Tax:2697049"},{"id":"A522","pred":"pubann:denotes","subj":"522","obj":"Tax:9606"},{"id":"A456","pred":"pubann:denotes","subj":"456","obj":"Gene:59272"},{"id":"A524","pred":"pubann:denotes","subj":"524","obj":"Tax:2697049"},{"id":"A466","pred":"pubann:denotes","subj":"466","obj":"CVCL:M624"},{"id":"A523","pred":"pubann:denotes","subj":"523","obj":"Tax:9606"},{"id":"A509","pred":"pubann:denotes","subj":"509","obj":"Gene:1508"},{"id":"A443","pred":"pubann:denotes","subj":"443","obj":"Tax:2697049"},{"id":"A508","pred":"pubann:denotes","subj":"508","obj":"Gene:7113"},{"id":"A505","pred":"pubann:denotes","subj":"505","obj":"Gene:7113"},{"id":"A462","pred":"pubann:denotes","subj":"462","obj":"Tax:2697049"},{"id":"A464","pred":"pubann:denotes","subj":"464","obj":"Tax:2697049"},{"id":"A529","pred":"pubann:denotes","subj":"529","obj":"MESH:C034532"},{"id":"A442","pred":"pubann:denotes","subj":"442","obj":"Tax:694009"},{"id":"A463","pred":"pubann:denotes","subj":"463","obj":"Tax:9606"}],"text":"4.1.3.1 Hypothesis: SARS-CoV and SARS-CoV2 are ideally similar in the structure and the cell entry receptor and protease\nSARS-CoV and SARS-CoV2 share absolutely the same cleavage junctions, almost the same sequence (96%) of their main protease, a high degree (76%) of similarity in the amino acid sequence of their S protein, a similar S2′ cleavage site, a similar spectrum of cells they can enter, and the similarity of the most residues essential for binding ACE2 [16], [17], [18]. Also, both of them utilize the same domain of S1B to interact with the ACE2 receptor. However, they differ in proteolytic processing to some degree. Study [16] of the human embryonic kidney (HEK) cell line, 293 T, has shown that a signal for the S2 subunit is present in cells inoculated with SARS-2-S, but not in cells inoculated with SARS-S.\nTwo main proteases for both SARS-S and SARS-2-S are endosomal cysteine proteases cathepsin B and L (CatB/L) and the transmembrane protease, serine 2TMPRSS2 [16]. In 293 T cells lacking 2TMPRSS2, blocking CatB/L activity through increasing the endosomal pH by ammonium chloride could significantly limit the entry of both SARS-S and SARS-2-S. In TMPRSS2 + Caco-2 cells, the effect of ammonium chloride existed to a lesser extent. A combination of camostat mesylate, a blocker of TMPRSS2, and E-64d, an inhibitor of CatB/L, yielded the complete inhibition of SARS-2-S entry in TMPRSS2 + Caco-2 cells. In both the human lung cancer cell line Calu-3 and the primary human lung cells, there was a reduction of the entry of both SARS-S and SARS-2-S by camostat mesylate, indicating that SARS-S and SARS-2-S partially require TMPRSS2 for a lung infection."}

    LitCovid-sample-UniProt

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t.org/uniprot/P04589"},{"id":"A1963","pred":"uniprot_id","subj":"T1726","obj":"https://www.uniprot.org/uniprot/P04588"},{"id":"A1964","pred":"uniprot_id","subj":"T1726","obj":"https://www.uniprot.org/uniprot/P04587"},{"id":"A1965","pred":"uniprot_id","subj":"T1726","obj":"https://www.uniprot.org/uniprot/P04585"},{"id":"A1966","pred":"uniprot_id","subj":"T1726","obj":"https://www.uniprot.org/uniprot/P04584"},{"id":"A1967","pred":"uniprot_id","subj":"T1726","obj":"https://www.uniprot.org/uniprot/Q1HVC6"},{"id":"A1968","pred":"uniprot_id","subj":"T1726","obj":"https://www.uniprot.org/uniprot/Q1A267"},{"id":"A1969","pred":"uniprot_id","subj":"T1726","obj":"https://www.uniprot.org/uniprot/Q1A249"}],"text":"4.1.3.1 Hypothesis: SARS-CoV and SARS-CoV2 are ideally similar in the structure and the cell entry receptor and protease\nSARS-CoV and SARS-CoV2 share absolutely the same cleavage junctions, almost the same sequence (96%) of their main protease, a high degree (76%) of similarity in the amino acid sequence of their S protein, a similar S2′ cleavage site, a similar spectrum of cells they can enter, and the similarity of the most residues essential for binding ACE2 [16], [17], [18]. Also, both of them utilize the same domain of S1B to interact with the ACE2 receptor. However, they differ in proteolytic processing to some degree. Study [16] of the human embryonic kidney (HEK) cell line, 293 T, has shown that a signal for the S2 subunit is present in cells inoculated with SARS-2-S, but not in cells inoculated with SARS-S.\nTwo main proteases for both SARS-S and SARS-2-S are endosomal cysteine proteases cathepsin B and L (CatB/L) and the transmembrane protease, serine 2TMPRSS2 [16]. In 293 T cells lacking 2TMPRSS2, blocking CatB/L activity through increasing the endosomal pH by ammonium chloride could significantly limit the entry of both SARS-S and SARS-2-S. In TMPRSS2 + Caco-2 cells, the effect of ammonium chloride existed to a lesser extent. A combination of camostat mesylate, a blocker of TMPRSS2, and E-64d, an inhibitor of CatB/L, yielded the complete inhibition of SARS-2-S entry in TMPRSS2 + Caco-2 cells. In both the human lung cancer cell line Calu-3 and the primary human lung cells, there was a reduction of the entry of both SARS-S and SARS-2-S by camostat mesylate, indicating that SARS-S and SARS-2-S partially require TMPRSS2 for a lung infection."}

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Hypothesis: SARS-CoV and SARS-CoV2 are ideally similar in the structure and the cell entry receptor and protease\nSARS-CoV and SARS-CoV2 share absolutely the same cleavage junctions, almost the same sequence (96%) of their main protease, a high degree (76%) of similarity in the amino acid sequence of their S protein, a similar S2′ cleavage site, a similar spectrum of cells they can enter, and the similarity of the most residues essential for binding ACE2 [16], [17], [18]. Also, both of them utilize the same domain of S1B to interact with the ACE2 receptor. However, they differ in proteolytic processing to some degree. Study [16] of the human embryonic kidney (HEK) cell line, 293 T, has shown that a signal for the S2 subunit is present in cells inoculated with SARS-2-S, but not in cells inoculated with SARS-S.\nTwo main proteases for both SARS-S and SARS-2-S are endosomal cysteine proteases cathepsin B and L (CatB/L) and the transmembrane protease, serine 2TMPRSS2 [16]. In 293 T cells lacking 2TMPRSS2, blocking CatB/L activity through increasing the endosomal pH by ammonium chloride could significantly limit the entry of both SARS-S and SARS-2-S. In TMPRSS2 + Caco-2 cells, the effect of ammonium chloride existed to a lesser extent. A combination of camostat mesylate, a blocker of TMPRSS2, and E-64d, an inhibitor of CatB/L, yielded the complete inhibition of SARS-2-S entry in TMPRSS2 + Caco-2 cells. In both the human lung cancer cell line Calu-3 and the primary human lung cells, there was a reduction of the entry of both SARS-S and SARS-2-S by camostat mesylate, indicating that SARS-S and SARS-2-S partially require TMPRSS2 for a lung infection."}

    LitCovid-sample-PD-MAT

    {"project":"LitCovid-sample-PD-MAT","denotations":[{"id":"T1","span":{"begin":668,"end":674},"obj":"http://purl.obolibrary.org/obo/MAT_0000119"},{"id":"T2","span":{"begin":1446,"end":1450},"obj":"http://purl.obolibrary.org/obo/MAT_0000135"},{"id":"T3","span":{"begin":1497,"end":1501},"obj":"http://purl.obolibrary.org/obo/MAT_0000135"},{"id":"T4","span":{"begin":1662,"end":1666},"obj":"http://purl.obolibrary.org/obo/MAT_0000135"}],"text":"4.1.3.1 Hypothesis: SARS-CoV and SARS-CoV2 are ideally similar in the structure and the cell entry receptor and protease\nSARS-CoV and SARS-CoV2 share absolutely the same cleavage junctions, almost the same sequence (96%) of their main protease, a high degree (76%) of similarity in the amino acid sequence of their S protein, a similar S2′ cleavage site, a similar spectrum of cells they can enter, and the similarity of the most residues essential for binding ACE2 [16], [17], [18]. Also, both of them utilize the same domain of S1B to interact with the ACE2 receptor. However, they differ in proteolytic processing to some degree. Study [16] of the human embryonic kidney (HEK) cell line, 293 T, has shown that a signal for the S2 subunit is present in cells inoculated with SARS-2-S, but not in cells inoculated with SARS-S.\nTwo main proteases for both SARS-S and SARS-2-S are endosomal cysteine proteases cathepsin B and L (CatB/L) and the transmembrane protease, serine 2TMPRSS2 [16]. In 293 T cells lacking 2TMPRSS2, blocking CatB/L activity through increasing the endosomal pH by ammonium chloride could significantly limit the entry of both SARS-S and SARS-2-S. In TMPRSS2 + Caco-2 cells, the effect of ammonium chloride existed to a lesser extent. A combination of camostat mesylate, a blocker of TMPRSS2, and E-64d, an inhibitor of CatB/L, yielded the complete inhibition of SARS-2-S entry in TMPRSS2 + Caco-2 cells. In both the human lung cancer cell line Calu-3 and the primary human lung cells, there was a reduction of the entry of both SARS-S and SARS-2-S by camostat mesylate, indicating that SARS-S and SARS-2-S partially require TMPRSS2 for a lung infection."}

    LitCovid-sample-PD-FMA

    {"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T105","span":{"begin":89,"end":93},"obj":"Body_part"},{"id":"T106","span":{"begin":287,"end":297},"obj":"Body_part"},{"id":"T107","span":{"begin":318,"end":325},"obj":"Body_part"},{"id":"T108","span":{"begin":378,"end":383},"obj":"Body_part"},{"id":"T109","span":{"begin":668,"end":674},"obj":"Body_part"},{"id":"T110","span":{"begin":681,"end":685},"obj":"Body_part"},{"id":"T111","span":{"begin":756,"end":761},"obj":"Body_part"},{"id":"T112","span":{"begin":799,"end":804},"obj":"Body_part"},{"id":"T113","span":{"begin":881,"end":890},"obj":"Body_part"},{"id":"T114","span":{"begin":891,"end":899},"obj":"Body_part"},{"id":"T115","span":{"begin":969,"end":975},"obj":"Body_part"},{"id":"T116","span":{"begin":1000,"end":1005},"obj":"Body_part"},{"id":"T117","span":{"begin":1072,"end":1081},"obj":"Body_part"},{"id":"T118","span":{"begin":1191,"end":1196},"obj":"Body_part"},{"id":"T119","span":{"begin":1421,"end":1426},"obj":"Body_part"},{"id":"T120","span":{"begin":1446,"end":1450},"obj":"Body_part"},{"id":"T121","span":{"begin":1458,"end":1462},"obj":"Body_part"},{"id":"T122","span":{"begin":1497,"end":1501},"obj":"Body_part"},{"id":"T123","span":{"begin":1502,"end":1507},"obj":"Body_part"},{"id":"T124","span":{"begin":1662,"end":1666},"obj":"Body_part"}],"attributes":[{"id":"A124","pred":"fma_id","subj":"T124","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A113","pred":"fma_id","subj":"T113","obj":"http://purl.org/sig/ont/fma/fma67180"},{"id":"A117","pred":"fma_id","subj":"T117","obj":"http://purl.org/sig/ont/fma/fma67180"},{"id":"A115","pred":"fma_id","subj":"T115","obj":"http://purl.org/sig/ont/fma/fma82764"},{"id":"A109","pred":"fma_id","subj":"T109","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A114","pred":"fma_id","subj":"T114","obj":"http://purl.org/sig/ont/fma/fma82751"},{"id":"A105","pred":"fma_id","subj":"T105","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A123","pred":"fma_id","subj":"T123","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A111","pred":"fma_id","subj":"T111","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A120","pred":"fma_id","subj":"T120","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A108","pred":"fma_id","subj":"T108","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A116","pred":"fma_id","subj":"T116","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A107","pred":"fma_id","subj":"T107","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A122","pred":"fma_id","subj":"T122","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A118","pred":"fma_id","subj":"T118","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A121","pred":"fma_id","subj":"T121","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A106","pred":"fma_id","subj":"T106","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A110","pred":"fma_id","subj":"T110","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A119","pred":"fma_id","subj":"T119","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A112","pred":"fma_id","subj":"T112","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"4.1.3.1 Hypothesis: SARS-CoV and SARS-CoV2 are ideally similar in the structure and the cell entry receptor and protease\nSARS-CoV and SARS-CoV2 share absolutely the same cleavage junctions, almost the same sequence (96%) of their main protease, a high degree (76%) of similarity in the amino acid sequence of their S protein, a similar S2′ cleavage site, a similar spectrum of cells they can enter, and the similarity of the most residues essential for binding ACE2 [16], [17], [18]. Also, both of them utilize the same domain of S1B to interact with the ACE2 receptor. However, they differ in proteolytic processing to some degree. Study [16] of the human embryonic kidney (HEK) cell line, 293 T, has shown that a signal for the S2 subunit is present in cells inoculated with SARS-2-S, but not in cells inoculated with SARS-S.\nTwo main proteases for both SARS-S and SARS-2-S are endosomal cysteine proteases cathepsin B and L (CatB/L) and the transmembrane protease, serine 2TMPRSS2 [16]. In 293 T cells lacking 2TMPRSS2, blocking CatB/L activity through increasing the endosomal pH by ammonium chloride could significantly limit the entry of both SARS-S and SARS-2-S. In TMPRSS2 + Caco-2 cells, the effect of ammonium chloride existed to a lesser extent. A combination of camostat mesylate, a blocker of TMPRSS2, and E-64d, an inhibitor of CatB/L, yielded the complete inhibition of SARS-2-S entry in TMPRSS2 + Caco-2 cells. In both the human lung cancer cell line Calu-3 and the primary human lung cells, there was a reduction of the entry of both SARS-S and SARS-2-S by camostat mesylate, indicating that SARS-S and SARS-2-S partially require TMPRSS2 for a lung infection."}

    LitCovid-sample-PD-MONDO

    {"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T84","span":{"begin":21,"end":29},"obj":"Disease"},{"id":"T85","span":{"begin":34,"end":43},"obj":"Disease"},{"id":"T86","span":{"begin":122,"end":130},"obj":"Disease"},{"id":"T87","span":{"begin":135,"end":144},"obj":"Disease"},{"id":"T88","span":{"begin":778,"end":782},"obj":"Disease"},{"id":"T89","span":{"begin":821,"end":825},"obj":"Disease"},{"id":"T90","span":{"begin":857,"end":861},"obj":"Disease"},{"id":"T91","span":{"begin":868,"end":872},"obj":"Disease"},{"id":"T92","span":{"begin":1150,"end":1154},"obj":"Disease"},{"id":"T93","span":{"begin":1161,"end":1165},"obj":"Disease"},{"id":"T94","span":{"begin":1386,"end":1390},"obj":"Disease"},{"id":"T95","span":{"begin":1446,"end":1457},"obj":"Disease"},{"id":"T96","span":{"begin":1552,"end":1556},"obj":"Disease"},{"id":"T97","span":{"begin":1563,"end":1567},"obj":"Disease"},{"id":"T98","span":{"begin":1610,"end":1614},"obj":"Disease"},{"id":"T99","span":{"begin":1621,"end":1625},"obj":"Disease"},{"id":"T100","span":{"begin":1667,"end":1676},"obj":"Disease"}],"attributes":[{"id":"A99","pred":"mondo_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A100","pred":"mondo_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A87","pred":"mondo_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A85","pred":"mondo_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A90","pred":"mondo_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A98","pred":"mondo_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A91","pred":"mondo_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A92","pred":"mondo_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A84","pred":"mondo_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A94","pred":"mondo_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A95","pred":"mondo_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/MONDO_0008903"},{"id":"A97","pred":"mondo_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A93","pred":"mondo_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A96","pred":"mondo_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A88","pred":"mondo_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A89","pred":"mondo_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A86","pred":"mondo_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"4.1.3.1 Hypothesis: SARS-CoV and SARS-CoV2 are ideally similar in the structure and the cell entry receptor and protease\nSARS-CoV and SARS-CoV2 share absolutely the same cleavage junctions, almost the same sequence (96%) of their main protease, a high degree (76%) of similarity in the amino acid sequence of their S protein, a similar S2′ cleavage site, a similar spectrum of cells they can enter, and the similarity of the most residues essential for binding ACE2 [16], [17], [18]. Also, both of them utilize the same domain of S1B to interact with the ACE2 receptor. However, they differ in proteolytic processing to some degree. Study [16] of the human embryonic kidney (HEK) cell line, 293 T, has shown that a signal for the S2 subunit is present in cells inoculated with SARS-2-S, but not in cells inoculated with SARS-S.\nTwo main proteases for both SARS-S and SARS-2-S are endosomal cysteine proteases cathepsin B and L (CatB/L) and the transmembrane protease, serine 2TMPRSS2 [16]. In 293 T cells lacking 2TMPRSS2, blocking CatB/L activity through increasing the endosomal pH by ammonium chloride could significantly limit the entry of both SARS-S and SARS-2-S. In TMPRSS2 + Caco-2 cells, the effect of ammonium chloride existed to a lesser extent. A combination of camostat mesylate, a blocker of TMPRSS2, and E-64d, an inhibitor of CatB/L, yielded the complete inhibition of SARS-2-S entry in TMPRSS2 + Caco-2 cells. In both the human lung cancer cell line Calu-3 and the primary human lung cells, there was a reduction of the entry of both SARS-S and SARS-2-S by camostat mesylate, indicating that SARS-S and SARS-2-S partially require TMPRSS2 for a lung infection."}

    LitCovid-sample-PD-HP

    {"project":"LitCovid-sample-PD-HP","denotations":[{"id":"T3","span":{"begin":1446,"end":1457},"obj":"Phenotype"}],"attributes":[{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0100526"}],"text":"4.1.3.1 Hypothesis: SARS-CoV and SARS-CoV2 are ideally similar in the structure and the cell entry receptor and protease\nSARS-CoV and SARS-CoV2 share absolutely the same cleavage junctions, almost the same sequence (96%) of their main protease, a high degree (76%) of similarity in the amino acid sequence of their S protein, a similar S2′ cleavage site, a similar spectrum of cells they can enter, and the similarity of the most residues essential for binding ACE2 [16], [17], [18]. Also, both of them utilize the same domain of S1B to interact with the ACE2 receptor. However, they differ in proteolytic processing to some degree. Study [16] of the human embryonic kidney (HEK) cell line, 293 T, has shown that a signal for the S2 subunit is present in cells inoculated with SARS-2-S, but not in cells inoculated with SARS-S.\nTwo main proteases for both SARS-S and SARS-2-S are endosomal cysteine proteases cathepsin B and L (CatB/L) and the transmembrane protease, serine 2TMPRSS2 [16]. In 293 T cells lacking 2TMPRSS2, blocking CatB/L activity through increasing the endosomal pH by ammonium chloride could significantly limit the entry of both SARS-S and SARS-2-S. In TMPRSS2 + Caco-2 cells, the effect of ammonium chloride existed to a lesser extent. A combination of camostat mesylate, a blocker of TMPRSS2, and E-64d, an inhibitor of CatB/L, yielded the complete inhibition of SARS-2-S entry in TMPRSS2 + Caco-2 cells. In both the human lung cancer cell line Calu-3 and the primary human lung cells, there was a reduction of the entry of both SARS-S and SARS-2-S by camostat mesylate, indicating that SARS-S and SARS-2-S partially require TMPRSS2 for a lung infection."}

    LitCovid-sentences

    {"project":"LitCovid-sentences","denotations":[{"id":"T116","span":{"begin":0,"end":121},"obj":"Sentence"},{"id":"T117","span":{"begin":122,"end":484},"obj":"Sentence"},{"id":"T118","span":{"begin":485,"end":570},"obj":"Sentence"},{"id":"T119","span":{"begin":571,"end":633},"obj":"Sentence"},{"id":"T120","span":{"begin":634,"end":828},"obj":"Sentence"},{"id":"T121","span":{"begin":829,"end":990},"obj":"Sentence"},{"id":"T122","span":{"begin":991,"end":1170},"obj":"Sentence"},{"id":"T123","span":{"begin":1171,"end":1257},"obj":"Sentence"},{"id":"T124","span":{"begin":1258,"end":1427},"obj":"Sentence"},{"id":"T125","span":{"begin":1428,"end":1677},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"4.1.3.1 Hypothesis: SARS-CoV and SARS-CoV2 are ideally similar in the structure and the cell entry receptor and protease\nSARS-CoV and SARS-CoV2 share absolutely the same cleavage junctions, almost the same sequence (96%) of their main protease, a high degree (76%) of similarity in the amino acid sequence of their S protein, a similar S2′ cleavage site, a similar spectrum of cells they can enter, and the similarity of the most residues essential for binding ACE2 [16], [17], [18]. Also, both of them utilize the same domain of S1B to interact with the ACE2 receptor. However, they differ in proteolytic processing to some degree. Study [16] of the human embryonic kidney (HEK) cell line, 293 T, has shown that a signal for the S2 subunit is present in cells inoculated with SARS-2-S, but not in cells inoculated with SARS-S.\nTwo main proteases for both SARS-S and SARS-2-S are endosomal cysteine proteases cathepsin B and L (CatB/L) and the transmembrane protease, serine 2TMPRSS2 [16]. In 293 T cells lacking 2TMPRSS2, blocking CatB/L activity through increasing the endosomal pH by ammonium chloride could significantly limit the entry of both SARS-S and SARS-2-S. In TMPRSS2 + Caco-2 cells, the effect of ammonium chloride existed to a lesser extent. A combination of camostat mesylate, a blocker of TMPRSS2, and E-64d, an inhibitor of CatB/L, yielded the complete inhibition of SARS-2-S entry in TMPRSS2 + Caco-2 cells. In both the human lung cancer cell line Calu-3 and the primary human lung cells, there was a reduction of the entry of both SARS-S and SARS-2-S by camostat mesylate, indicating that SARS-S and SARS-2-S partially require TMPRSS2 for a lung infection."}

    LitCovid-PD-HP

    {"project":"LitCovid-PD-HP","denotations":[{"id":"T3","span":{"begin":1446,"end":1457},"obj":"Phenotype"}],"attributes":[{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0100526"}],"text":"4.1.3.1 Hypothesis: SARS-CoV and SARS-CoV2 are ideally similar in the structure and the cell entry receptor and protease\nSARS-CoV and SARS-CoV2 share absolutely the same cleavage junctions, almost the same sequence (96%) of their main protease, a high degree (76%) of similarity in the amino acid sequence of their S protein, a similar S2′ cleavage site, a similar spectrum of cells they can enter, and the similarity of the most residues essential for binding ACE2 [16], [17], [18]. Also, both of them utilize the same domain of S1B to interact with the ACE2 receptor. However, they differ in proteolytic processing to some degree. Study [16] of the human embryonic kidney (HEK) cell line, 293 T, has shown that a signal for the S2 subunit is present in cells inoculated with SARS-2-S, but not in cells inoculated with SARS-S.\nTwo main proteases for both SARS-S and SARS-2-S are endosomal cysteine proteases cathepsin B and L (CatB/L) and the transmembrane protease, serine 2TMPRSS2 [16]. In 293 T cells lacking 2TMPRSS2, blocking CatB/L activity through increasing the endosomal pH by ammonium chloride could significantly limit the entry of both SARS-S and SARS-2-S. In TMPRSS2 + Caco-2 cells, the effect of ammonium chloride existed to a lesser extent. A combination of camostat mesylate, a blocker of TMPRSS2, and E-64d, an inhibitor of CatB/L, yielded the complete inhibition of SARS-2-S entry in TMPRSS2 + Caco-2 cells. In both the human lung cancer cell line Calu-3 and the primary human lung cells, there was a reduction of the entry of both SARS-S and SARS-2-S by camostat mesylate, indicating that SARS-S and SARS-2-S partially require TMPRSS2 for a lung infection."}