PMC:7205724 / 10608-11458 JSONTXT

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    LitCovid-PubTator

    {"project":"LitCovid-PubTator","denotations":[{"id":"342","span":{"begin":45,"end":53},"obj":"Species"},{"id":"343","span":{"begin":88,"end":96},"obj":"Species"},{"id":"344","span":{"begin":69,"end":77},"obj":"Disease"},{"id":"345","span":{"begin":109,"end":117},"obj":"Disease"},{"id":"353","span":{"begin":510,"end":513},"obj":"Gene"},{"id":"354","span":{"begin":352,"end":360},"obj":"Species"},{"id":"355","span":{"begin":436,"end":444},"obj":"Species"},{"id":"356","span":{"begin":575,"end":583},"obj":"Species"},{"id":"357","span":{"begin":593,"end":602},"obj":"Species"},{"id":"358","span":{"begin":665,"end":674},"obj":"Species"},{"id":"359","span":{"begin":373,"end":381},"obj":"Disease"}],"attributes":[{"id":"A342","pred":"tao:has_database_id","subj":"342","obj":"Tax:9606"},{"id":"A343","pred":"tao:has_database_id","subj":"343","obj":"Tax:9606"},{"id":"A344","pred":"tao:has_database_id","subj":"344","obj":"MESH:C000657245"},{"id":"A345","pred":"tao:has_database_id","subj":"345","obj":"MESH:C000657245"},{"id":"A353","pred":"tao:has_database_id","subj":"353","obj":"Gene:1401"},{"id":"A354","pred":"tao:has_database_id","subj":"354","obj":"Tax:9606"},{"id":"A355","pred":"tao:has_database_id","subj":"355","obj":"Tax:9606"},{"id":"A356","pred":"tao:has_database_id","subj":"356","obj":"Tax:9606"},{"id":"A357","pred":"tao:has_database_id","subj":"357","obj":"Tax:2697049"},{"id":"A358","pred":"tao:has_database_id","subj":"358","obj":"Tax:2697049"},{"id":"A359","pred":"tao:has_database_id","subj":"359","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"4.1.1.2 Rationale: Convalescent plasma from patients recovered from COVID-19 can treat patients with severe COVID-19\nA pilot study [11] recently has investigated the safety and effect of convalescent plasma that contain antibody levels higher than 1:640 combined with regular anti-viral agents and standard supportive care on clinical outcomes of ten patients with severe COVID-19. The study showed clinical improvement of all the ten patients accompanied by an increase in lymphocyte count and a decrease in CRP. Following transfusion of convalescent plasma, all the seven patients who were SARS-CoV2 RNA positive before transfusion of convalescent plasma turned SARS-CoV2 negative. There were no control groups receiving convalescent plasma alone or standard therapy without convalescent therapy to evaluate the main effect of convalescent plasma."}

    LitCovid-PD-FMA-UBERON

    {"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T74","span":{"begin":33,"end":39},"obj":"Body_part"},{"id":"T75","span":{"begin":201,"end":207},"obj":"Body_part"},{"id":"T76","span":{"begin":221,"end":229},"obj":"Body_part"},{"id":"T77","span":{"begin":475,"end":485},"obj":"Body_part"},{"id":"T78","span":{"begin":553,"end":559},"obj":"Body_part"},{"id":"T79","span":{"begin":603,"end":606},"obj":"Body_part"},{"id":"T80","span":{"begin":651,"end":657},"obj":"Body_part"},{"id":"T81","span":{"begin":737,"end":743},"obj":"Body_part"},{"id":"T82","span":{"begin":843,"end":849},"obj":"Body_part"}],"attributes":[{"id":"A74","pred":"fma_id","subj":"T74","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A75","pred":"fma_id","subj":"T75","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A76","pred":"fma_id","subj":"T76","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A77","pred":"fma_id","subj":"T77","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A78","pred":"fma_id","subj":"T78","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A79","pred":"fma_id","subj":"T79","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A80","pred":"fma_id","subj":"T80","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A81","pred":"fma_id","subj":"T81","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A82","pred":"fma_id","subj":"T82","obj":"http://purl.org/sig/ont/fma/fma62970"}],"text":"4.1.1.2 Rationale: Convalescent plasma from patients recovered from COVID-19 can treat patients with severe COVID-19\nA pilot study [11] recently has investigated the safety and effect of convalescent plasma that contain antibody levels higher than 1:640 combined with regular anti-viral agents and standard supportive care on clinical outcomes of ten patients with severe COVID-19. The study showed clinical improvement of all the ten patients accompanied by an increase in lymphocyte count and a decrease in CRP. Following transfusion of convalescent plasma, all the seven patients who were SARS-CoV2 RNA positive before transfusion of convalescent plasma turned SARS-CoV2 negative. There were no control groups receiving convalescent plasma alone or standard therapy without convalescent therapy to evaluate the main effect of convalescent plasma."}

    LitCovid-PD-MONDO

    {"project":"LitCovid-PD-MONDO","denotations":[{"id":"T65","span":{"begin":69,"end":77},"obj":"Disease"},{"id":"T66","span":{"begin":109,"end":117},"obj":"Disease"},{"id":"T67","span":{"begin":373,"end":381},"obj":"Disease"},{"id":"T68","span":{"begin":593,"end":597},"obj":"Disease"},{"id":"T69","span":{"begin":665,"end":669},"obj":"Disease"}],"attributes":[{"id":"A65","pred":"mondo_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A66","pred":"mondo_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A67","pred":"mondo_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A68","pred":"mondo_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A69","pred":"mondo_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"4.1.1.2 Rationale: Convalescent plasma from patients recovered from COVID-19 can treat patients with severe COVID-19\nA pilot study [11] recently has investigated the safety and effect of convalescent plasma that contain antibody levels higher than 1:640 combined with regular anti-viral agents and standard supportive care on clinical outcomes of ten patients with severe COVID-19. The study showed clinical improvement of all the ten patients accompanied by an increase in lymphocyte count and a decrease in CRP. Following transfusion of convalescent plasma, all the seven patients who were SARS-CoV2 RNA positive before transfusion of convalescent plasma turned SARS-CoV2 negative. There were no control groups receiving convalescent plasma alone or standard therapy without convalescent therapy to evaluate the main effect of convalescent plasma."}

    LitCovid-PD-CLO

    {"project":"LitCovid-PD-CLO","denotations":[{"id":"T112","span":{"begin":33,"end":39},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T113","span":{"begin":118,"end":119},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T114","span":{"begin":133,"end":135},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T115","span":{"begin":146,"end":149},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T116","span":{"begin":201,"end":207},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T117","span":{"begin":348,"end":351},"obj":"http://purl.obolibrary.org/obo/CLO_0050884"},{"id":"T118","span":{"begin":432,"end":435},"obj":"http://purl.obolibrary.org/obo/CLO_0050884"},{"id":"T119","span":{"begin":496,"end":497},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T120","span":{"begin":553,"end":559},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T121","span":{"begin":651,"end":657},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T122","span":{"begin":737,"end":743},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T123","span":{"begin":843,"end":849},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"}],"text":"4.1.1.2 Rationale: Convalescent plasma from patients recovered from COVID-19 can treat patients with severe COVID-19\nA pilot study [11] recently has investigated the safety and effect of convalescent plasma that contain antibody levels higher than 1:640 combined with regular anti-viral agents and standard supportive care on clinical outcomes of ten patients with severe COVID-19. The study showed clinical improvement of all the ten patients accompanied by an increase in lymphocyte count and a decrease in CRP. Following transfusion of convalescent plasma, all the seven patients who were SARS-CoV2 RNA positive before transfusion of convalescent plasma turned SARS-CoV2 negative. There were no control groups receiving convalescent plasma alone or standard therapy without convalescent therapy to evaluate the main effect of convalescent plasma."}

    LitCovid-PD-CHEBI

    {"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T121","span":{"begin":277,"end":294},"obj":"Chemical"}],"attributes":[{"id":"A121","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"}],"text":"4.1.1.2 Rationale: Convalescent plasma from patients recovered from COVID-19 can treat patients with severe COVID-19\nA pilot study [11] recently has investigated the safety and effect of convalescent plasma that contain antibody levels higher than 1:640 combined with regular anti-viral agents and standard supportive care on clinical outcomes of ten patients with severe COVID-19. The study showed clinical improvement of all the ten patients accompanied by an increase in lymphocyte count and a decrease in CRP. Following transfusion of convalescent plasma, all the seven patients who were SARS-CoV2 RNA positive before transfusion of convalescent plasma turned SARS-CoV2 negative. There were no control groups receiving convalescent plasma alone or standard therapy without convalescent therapy to evaluate the main effect of convalescent plasma."}

    LitCovid-sample-MedDRA

    {"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T6","span":{"begin":150,"end":162},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T7","span":{"begin":475,"end":491},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A7","pred":"meddra_id","subj":"T7","obj":"http://purl.bioontology.org/ontology/MEDDRA/10025251"},{"id":"A6","pred":"meddra_id","subj":"T6","obj":"http://purl.bioontology.org/ontology/MEDDRA/10062026"}],"text":"4.1.1.2 Rationale: Convalescent plasma from patients recovered from COVID-19 can treat patients with severe COVID-19\nA pilot study [11] recently has investigated the safety and effect of convalescent plasma that contain antibody levels higher than 1:640 combined with regular anti-viral agents and standard supportive care on clinical outcomes of ten patients with severe COVID-19. The study showed clinical improvement of all the ten patients accompanied by an increase in lymphocyte count and a decrease in CRP. Following transfusion of convalescent plasma, all the seven patients who were SARS-CoV2 RNA positive before transfusion of convalescent plasma turned SARS-CoV2 negative. There were no control groups receiving convalescent plasma alone or standard therapy without convalescent therapy to evaluate the main effect of convalescent plasma."}

    LitCovid-sample-CHEBI

    {"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T82","span":{"begin":603,"end":606},"obj":"Chemical"}],"attributes":[{"id":"A82","pred":"chebi_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/CHEBI_33697"}],"text":"4.1.1.2 Rationale: Convalescent plasma from patients recovered from COVID-19 can treat patients with severe COVID-19\nA pilot study [11] recently has investigated the safety and effect of convalescent plasma that contain antibody levels higher than 1:640 combined with regular anti-viral agents and standard supportive care on clinical outcomes of ten patients with severe COVID-19. The study showed clinical improvement of all the ten patients accompanied by an increase in lymphocyte count and a decrease in CRP. Following transfusion of convalescent plasma, all the seven patients who were SARS-CoV2 RNA positive before transfusion of convalescent plasma turned SARS-CoV2 negative. There were no control groups receiving convalescent plasma alone or standard therapy without convalescent therapy to evaluate the main effect of convalescent plasma."}

    LitCovid-sample-PD-NCBITaxon

    {"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T80","span":{"begin":69,"end":77},"obj":"Species"},{"id":"T81","span":{"begin":109,"end":117},"obj":"Species"},{"id":"T82","span":{"begin":373,"end":381},"obj":"Species"},{"id":"T83","span":{"begin":593,"end":602},"obj":"Species"},{"id":"T84","span":{"begin":665,"end":674},"obj":"Species"}],"attributes":[{"id":"A82","pred":"ncbi_taxonomy_id","subj":"T82","obj":"NCBItxid:2697049"},{"id":"A81","pred":"ncbi_taxonomy_id","subj":"T81","obj":"NCBItxid:2697049"},{"id":"A83","pred":"ncbi_taxonomy_id","subj":"T83","obj":"NCBItxid:2697049"},{"id":"A80","pred":"ncbi_taxonomy_id","subj":"T80","obj":"NCBItxid:2697049"},{"id":"A84","pred":"ncbi_taxonomy_id","subj":"T84","obj":"NCBItxid:2697049"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"4.1.1.2 Rationale: Convalescent plasma from patients recovered from COVID-19 can treat patients with severe COVID-19\nA pilot study [11] recently has investigated the safety and effect of convalescent plasma that contain antibody levels higher than 1:640 combined with regular anti-viral agents and standard supportive care on clinical outcomes of ten patients with severe COVID-19. The study showed clinical improvement of all the ten patients accompanied by an increase in lymphocyte count and a decrease in CRP. Following transfusion of convalescent plasma, all the seven patients who were SARS-CoV2 RNA positive before transfusion of convalescent plasma turned SARS-CoV2 negative. There were no control groups receiving convalescent plasma alone or standard therapy without convalescent therapy to evaluate the main effect of convalescent plasma."}

    LitCovid-sample-sentences

    {"project":"LitCovid-sample-sentences","denotations":[{"id":"T90","span":{"begin":0,"end":19},"obj":"Sentence"},{"id":"T91","span":{"begin":20,"end":117},"obj":"Sentence"},{"id":"T92","span":{"begin":118,"end":382},"obj":"Sentence"},{"id":"T93","span":{"begin":383,"end":514},"obj":"Sentence"},{"id":"T94","span":{"begin":515,"end":684},"obj":"Sentence"},{"id":"T95","span":{"begin":685,"end":850},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"4.1.1.2 Rationale: Convalescent plasma from patients recovered from COVID-19 can treat patients with severe COVID-19\nA pilot study [11] recently has investigated the safety and effect of convalescent plasma that contain antibody levels higher than 1:640 combined with regular anti-viral agents and standard supportive care on clinical outcomes of ten patients with severe COVID-19. The study showed clinical improvement of all the ten patients accompanied by an increase in lymphocyte count and a decrease in CRP. Following transfusion of convalescent plasma, all the seven patients who were SARS-CoV2 RNA positive before transfusion of convalescent plasma turned SARS-CoV2 negative. There were no control groups receiving convalescent plasma alone or standard therapy without convalescent therapy to evaluate the main effect of convalescent plasma."}

    LitCovid-sample-Pubtator

    {"project":"LitCovid-sample-Pubtator","denotations":[{"id":"342","span":{"begin":45,"end":53},"obj":"Species"},{"id":"344","span":{"begin":69,"end":77},"obj":"Disease"},{"id":"343","span":{"begin":88,"end":96},"obj":"Species"},{"id":"345","span":{"begin":109,"end":117},"obj":"Disease"},{"id":"354","span":{"begin":352,"end":360},"obj":"Species"},{"id":"359","span":{"begin":373,"end":381},"obj":"Disease"},{"id":"355","span":{"begin":436,"end":444},"obj":"Species"},{"id":"353","span":{"begin":510,"end":513},"obj":"Gene"},{"id":"356","span":{"begin":575,"end":583},"obj":"Species"},{"id":"357","span":{"begin":593,"end":602},"obj":"Species"},{"id":"358","span":{"begin":665,"end":674},"obj":"Species"}],"attributes":[{"id":"A357","pred":"pubann:denotes","subj":"357","obj":"Tax:2697049"},{"id":"A343","pred":"pubann:denotes","subj":"343","obj":"Tax:9606"},{"id":"A355","pred":"pubann:denotes","subj":"355","obj":"Tax:9606"},{"id":"A353","pred":"pubann:denotes","subj":"353","obj":"Gene:1401"},{"id":"A354","pred":"pubann:denotes","subj":"354","obj":"Tax:9606"},{"id":"A359","pred":"pubann:denotes","subj":"359","obj":"MESH:C000657245"},{"id":"A342","pred":"pubann:denotes","subj":"342","obj":"Tax:9606"},{"id":"A345","pred":"pubann:denotes","subj":"345","obj":"MESH:C000657245"},{"id":"A358","pred":"pubann:denotes","subj":"358","obj":"Tax:2697049"},{"id":"A356","pred":"pubann:denotes","subj":"356","obj":"Tax:9606"},{"id":"A344","pred":"pubann:denotes","subj":"344","obj":"MESH:C000657245"}],"text":"4.1.1.2 Rationale: Convalescent plasma from patients recovered from COVID-19 can treat patients with severe COVID-19\nA pilot study [11] recently has investigated the safety and effect of convalescent plasma that contain antibody levels higher than 1:640 combined with regular anti-viral agents and standard supportive care on clinical outcomes of ten patients with severe COVID-19. The study showed clinical improvement of all the ten patients accompanied by an increase in lymphocyte count and a decrease in CRP. Following transfusion of convalescent plasma, all the seven patients who were SARS-CoV2 RNA positive before transfusion of convalescent plasma turned SARS-CoV2 negative. There were no control groups receiving convalescent plasma alone or standard therapy without convalescent therapy to evaluate the main effect of convalescent plasma."}

    LitCovid-sample-UniProt

    {"project":"LitCovid-sample-UniProt","denotations":[{"id":"T1222","span":{"begin":510,"end":513},"obj":"Protein"}],"attributes":[{"id":"A1222","pred":"uniprot_id","subj":"T1222","obj":"https://www.uniprot.org/uniprot/Q5U0J2"},{"id":"A1223","pred":"uniprot_id","subj":"T1222","obj":"https://www.uniprot.org/uniprot/Q07203"},{"id":"A1224","pred":"uniprot_id","subj":"T1222","obj":"https://www.uniprot.org/uniprot/Q01687"},{"id":"A1225","pred":"uniprot_id","subj":"T1222","obj":"https://www.uniprot.org/uniprot/P97315"},{"id":"A1226","pred":"uniprot_id","subj":"T1222","obj":"https://www.uniprot.org/uniprot/P67967"},{"id":"A1227","pred":"uniprot_id","subj":"T1222","obj":"https://www.uniprot.org/uniprot/P67966"},{"id":"A1228","pred":"uniprot_id","subj":"T1222","obj":"https://www.uniprot.org/uniprot/P47875"},{"id":"A1229","pred":"uniprot_id","subj":"T1222","obj":"https://www.uniprot.org/uniprot/P32965"},{"id":"A1230","pred":"uniprot_id","subj":"T1222","obj":"https://www.uniprot.org/uniprot/P21291"},{"id":"A1231","pred":"uniprot_id","subj":"T1222","obj":"https://www.uniprot.org/uniprot/P08462"},{"id":"A1232","pred":"uniprot_id","subj":"T1222","obj":"https://www.uniprot.org/uniprot/A8K268"}],"text":"4.1.1.2 Rationale: Convalescent plasma from patients recovered from COVID-19 can treat patients with severe COVID-19\nA pilot study [11] recently has investigated the safety and effect of convalescent plasma that contain antibody levels higher than 1:640 combined with regular anti-viral agents and standard supportive care on clinical outcomes of ten patients with severe COVID-19. The study showed clinical improvement of all the ten patients accompanied by an increase in lymphocyte count and a decrease in CRP. Following transfusion of convalescent plasma, all the seven patients who were SARS-CoV2 RNA positive before transfusion of convalescent plasma turned SARS-CoV2 negative. There were no control groups receiving convalescent plasma alone or standard therapy without convalescent therapy to evaluate the main effect of convalescent plasma."}

    LitCovid-sample-Enju

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    LitCovid-sample-PD-FMA

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