PMC:7204663 / 9726-10480
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
115 | 75-93 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
116 | 98-110 | Chemical | denotes | azithromycin | MESH:D017963 |
117 | 214-225 | Chemical | denotes | chloroquine | MESH:D002738 |
118 | 276-287 | Chemical | denotes | chloroquine | MESH:D002738 |
119 | 292-310 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32389720-3373422-48149108 | 244-246 | 3373422 | denotes | 20 |
32389720-4607946-48149109 | 247-249 | 4607946 | denotes | 21 |
32389720-3179169-48149110 | 346-347 | 3179169 | denotes | 9 |
32389720-6169733-48149111 | 552-554 | 6169733 | denotes | 22 |
T86116 | 244-246 | 3373422 | denotes | 20 |
T74291 | 247-249 | 4607946 | denotes | 21 |
T92048 | 346-347 | 3179169 | denotes | 9 |
T72881 | 552-554 | 6169733 | denotes | 22 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T63 | 156-165 | Body_part | denotes | lysosomal | http://purl.org/sig/ont/fma/fma63836 |
T64 | 395-404 | Body_part | denotes | lysosomes | http://purl.org/sig/ont/fma/fma63836 |
T65 | 514-523 | Body_part | denotes | lysosomes | http://purl.org/sig/ont/fma/fma63836 |
T66 | 538-547 | Body_part | denotes | lysosomal | http://purl.org/sig/ont/fma/fma63836 |
T67 | 689-698 | Body_part | denotes | lysosomal | http://purl.org/sig/ont/fma/fma63836 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T93 | 27-37 | http://purl.obolibrary.org/obo/CLO_0009985 | denotes | is focused |
T94 | 112-113 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T95 | 156-165 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosomal |
T96 | 192-195 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T97 | 395-404 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosomes |
T98 | 514-523 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosomes |
T99 | 538-547 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosomal |
T100 | 552-554 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
T101 | 689-698 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosomal |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T67 | 75-93 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
T68 | 98-110 | Chemical | denotes | azithromycin | http://purl.obolibrary.org/obo/CHEBI_2955 |
T69 | 214-225 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
T70 | 276-287 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
T71 | 292-310 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
T72 | 386-391 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T73 | 503-508 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T74 | 708-714 | Chemical | denotes | proton | http://purl.obolibrary.org/obo/CHEBI_24636 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 481-487 | http://purl.obolibrary.org/obo/GO_0098739 | denotes | uptake |
T2 | 481-487 | http://purl.obolibrary.org/obo/GO_0098657 | denotes | uptake |
T3 | 668-681 | http://purl.obolibrary.org/obo/GO_0045851 | denotes | acidification |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T77 | 0-251 | Sentence | denotes | Although the present paper is focused on the pharmacokinetic properties of hydroxychloroquine and azithromycin, a similar intracellular accumulation in the lysosomal space can be expected and has been reported for chloroquine as early as 1974 [20,21]. |
T78 | 252-349 | Sentence | denotes | The pharmacokinetics of chloroquine and hydroxychloroquine have been described to be similar [9]. |
T79 | 350-463 | Sentence | denotes | The very high accumulation of these drugs in lysosomes produces very high local concentrations of both compounds. |
T80 | 464-556 | Sentence | denotes | Furthermore, the uptake of these basic drugs into lysosomes increases the lysosomal pH [22]. |
T81 | 557-754 | Sentence | denotes | However, it is difficult to estimate the magnitude and time course of this alkalization as there is continuous acidification of the lysosomal space by proton pumps that function to maintain low pH. |