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PMC:7204663 / 9726-10480 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
115 75-93 Chemical denotes hydroxychloroquine MESH:D006886
116 98-110 Chemical denotes azithromycin MESH:D017963
117 214-225 Chemical denotes chloroquine MESH:D002738
118 276-287 Chemical denotes chloroquine MESH:D002738
119 292-310 Chemical denotes hydroxychloroquine MESH:D006886

2_test

Id Subject Object Predicate Lexical cue
32389720-3373422-48149108 244-246 3373422 denotes 20
32389720-4607946-48149109 247-249 4607946 denotes 21
32389720-3179169-48149110 346-347 3179169 denotes 9
32389720-6169733-48149111 552-554 6169733 denotes 22
T86116 244-246 3373422 denotes 20
T74291 247-249 4607946 denotes 21
T92048 346-347 3179169 denotes 9
T72881 552-554 6169733 denotes 22

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T63 156-165 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T64 395-404 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T65 514-523 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T66 538-547 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T67 689-698 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T93 27-37 http://purl.obolibrary.org/obo/CLO_0009985 denotes is focused
T94 112-113 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T95 156-165 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T96 192-195 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T97 395-404 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T98 514-523 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T99 538-547 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T100 552-554 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T101 689-698 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T67 75-93 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T68 98-110 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T69 214-225 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T70 276-287 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T71 292-310 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T72 386-391 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T73 503-508 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T74 708-714 Chemical denotes proton http://purl.obolibrary.org/obo/CHEBI_24636

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 481-487 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T2 481-487 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T3 668-681 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T77 0-251 Sentence denotes Although the present paper is focused on the pharmacokinetic properties of hydroxychloroquine and azithromycin, a similar intracellular accumulation in the lysosomal space can be expected and has been reported for chloroquine as early as 1974 [20,21].
T78 252-349 Sentence denotes The pharmacokinetics of chloroquine and hydroxychloroquine have been described to be similar [9].
T79 350-463 Sentence denotes The very high accumulation of these drugs in lysosomes produces very high local concentrations of both compounds.
T80 464-556 Sentence denotes Furthermore, the uptake of these basic drugs into lysosomes increases the lysosomal pH [22].
T81 557-754 Sentence denotes However, it is difficult to estimate the magnitude and time course of this alkalization as there is continuous acidification of the lysosomal space by proton pumps that function to maintain low pH.