PMC:7204663 / 8846-9695 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7204663","sourcedb":"PMC","sourceid":"7204663","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7204663","text":"Just as for hydroxychloroquine, the pharmacokinetic parameters of azithromycin confirm these extreme distribution properties. The volume of distribution of azithromycin was reported to be 31 L/kg and the half-life was 68 h, despite a relatively rapid clearance of 630 mL/min [18]. Furthermore, the pharmacokinetics of azithromycin have been shown to be affected by the disease state [19]. In a preclinical investigation, azithromycin was injected into rats and interstitial concentrations were measured in both thighs using microdialysis. After 3 h, an infection was induced in only one leg. Shortly after, the unbound interstitial tissue concentrations increased in the infected leg, without any additional dosing. 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