PMC:7204663 / 7591-8845
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 83 | 51-63 | Chemical | denotes | azithromycin | MESH:D017963 |
| 84 | 195-213 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 85 | 239-251 | Chemical | denotes | azithromycin | MESH:D017963 |
| 86 | 337-350 | Chemical | denotes | phospholipids | MESH:D010743 |
| 87 | 401-413 | Chemical | denotes | azithromycin | MESH:D017963 |
| 88 | 500-512 | Chemical | denotes | azithromycin | MESH:D017963 |
| 89 | 636-648 | Chemical | denotes | azithromycin | MESH:D017963 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32389720-7558665-48149098 | 352-354 | 7558665 | denotes | 10 |
| 32389720-12441132-48149099 | 358-360 | 12441132 | denotes | 11 |
| 32389720-11499789-48149100 | 364-366 | 11499789 | denotes | 12 |
| 32389720-8957238-48149101 | 370-372 | 8957238 | denotes | 13 |
| 32389720-25155592-48149102 | 438-440 | 25155592 | denotes | 14 |
| 32389720-25155592-48149103 | 1089-1091 | 25155592 | denotes | 14 |
| 32389720-431047-48149104 | 1095-1097 | 431047 | denotes | 15 |
| 32389720-12243724-48149105 | 1101-1103 | 12243724 | denotes | 16 |
| 32389720-1030706-48149106 | 1107-1109 | 1030706 | denotes | 17 |
| T35193 | 352-354 | 7558665 | denotes | 10 |
| T71814 | 358-360 | 12441132 | denotes | 11 |
| T86676 | 364-366 | 11499789 | denotes | 12 |
| T46347 | 370-372 | 8957238 | denotes | 13 |
| T79422 | 438-440 | 25155592 | denotes | 14 |
| T99834 | 1089-1091 | 25155592 | denotes | 14 |
| T30874 | 1095-1097 | 431047 | denotes | 15 |
| T42597 | 1101-1103 | 12243724 | denotes | 16 |
| T58158 | 1107-1109 | 1030706 | denotes | 17 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T43 | 100-109 | Body_part | denotes | lysosomes | http://purl.org/sig/ont/fma/fma63836 |
| T44 | 124-131 | Body_part | denotes | cytosol | http://purl.org/sig/ont/fma/fma66836 |
| T45 | 297-306 | Body_part | denotes | lysosomes | http://purl.org/sig/ont/fma/fma63836 |
| T46 | 337-350 | Body_part | denotes | phospholipids | http://purl.org/sig/ont/fma/fma82779 |
| T47 | 414-423 | Body_part | denotes | lysosomal | http://purl.org/sig/ont/fma/fma63836 |
| T48 | 549-566 | Body_part | denotes | white blood cells | http://purl.org/sig/ont/fma/fma62852 |
| T49 | 561-566 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T50 | 683-690 | Body_part | denotes | cytosol | http://purl.org/sig/ont/fma/fma66836 |
| T51 | 765-771 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T52 | 848-865 | Body_part | denotes | white blood cells | http://purl.org/sig/ont/fma/fma62852 |
| T53 | 860-865 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T54 | 949-967 | Body_part | denotes | interstitial space | http://purl.org/sig/ont/fma/fma17555 |
| T55 | 985-994 | Body_part | denotes | lysosomal | http://purl.org/sig/ont/fma/fma63836 |
| T56 | 1078-1082 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T57 | 1179-1188 | Body_part | denotes | lysosomal | http://purl.org/sig/ont/fma/fma63836 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T2 | 555-560 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T3 | 854-859 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T7 | 788-796 | Disease | denotes | subcutis | http://purl.obolibrary.org/obo/MONDO_0006591 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T67 | 100-109 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosomes |
| T68 | 149-151 | http://purl.obolibrary.org/obo/CLO_0001407 | denotes | 52 |
| T69 | 253-254 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T70 | 297-306 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosomes |
| T71 | 358-360 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T72 | 375-376 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T73 | 414-423 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosomal |
| T74 | 555-566 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood cells |
| T75 | 765-771 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T76 | 765-771 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T77 | 765-771 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T78 | 765-771 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
| T79 | 788-796 | http://purl.obolibrary.org/obo/UBERON_0002072 | denotes | subcutis |
| T80 | 854-865 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood cells |
| T81 | 985-994 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosomal |
| T82 | 1078-1087 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell type |
| T83 | 1179-1188 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosomal |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T52 | 14-17 | Chemical | denotes | ion | http://purl.obolibrary.org/obo/CHEBI_24870 |
| T53 | 51-63 | Chemical | denotes | azithromycin | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T54 | 195-213 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T55 | 239-251 | Chemical | denotes | azithromycin | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T56 | 337-350 | Chemical | denotes | phospholipids | http://purl.obolibrary.org/obo/CHEBI_16247 |
| T57 | 401-413 | Chemical | denotes | azithromycin | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T58 | 500-512 | Chemical | denotes | azithromycin | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T59 | 636-648 | Chemical | denotes | azithromycin | http://purl.obolibrary.org/obo/CHEBI_2955 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T62 | 0-214 | Sentence | denotes | When the same ion-trapping concepts are applied to azithromycin, the expected accumulation ratio in lysosomes compared with cytosol is calculated as 52 000-fold, which is very similar to that of hydroxychloroquine. |
| T63 | 215-374 | Sentence | denotes | After administration of azithromycin, a large fraction of the dose will reside in lysosomes where it also binds to acidic phospholipids [10], [11], [12], [13]. |
| T64 | 375-442 | Sentence | denotes | A clinical study supports azithromycin lysosomal accumulation [14]. |
| T65 | 443-596 | Sentence | denotes | In this study, the experimentally measured average total azithromycin concentrations in polymorphonuclear white blood cells (PMLs) was over 14 000 ng/mL. |
| T66 | 597-809 | Sentence | denotes | However, the model-predicted unionized azithromycin concentration of 6.0 ng/mL in the cytosol of PMLs was comparable to the measured interstitial concentrations in the muscle (8.7 ng/mL) and subcutis (4.1 ng/mL). |
| T67 | 810-968 | Sentence | denotes | Hence, the measured concentrations in white blood cells was approximately 2000-fold higher than the measured unbound concentrations in the interstitial space. |
| T68 | 969-1254 | Sentence | denotes | Considering the lysosomal volume is estimated to range between 0.5 to 5% of the cellular volume depending on cell type [14], [15], [16], [17], these concentrations are consistent with the expected magnitude of lysosomal accumulation and explain these very high cellular concentrations. |