PMC:7204663 / 6600-7573
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
70 | 49-67 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
71 | 312-330 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
72 | 478-496 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
73 | 857-875 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32389720-3179169-48149097 | 578-579 | 3179169 | denotes | 9 |
T38067 | 578-579 | 3179169 | denotes | 9 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T35 | 104-113 | Body_part | denotes | lysosomes | http://purl.org/sig/ont/fma/fma63836 |
T36 | 128-135 | Body_part | denotes | cytosol | http://purl.org/sig/ont/fma/fma66836 |
T37 | 239-248 | Body_part | denotes | lysosomes | http://purl.org/sig/ont/fma/fma63836 |
T38 | 344-350 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
T39 | 622-626 | Body_part | denotes | body | http://purl.org/sig/ont/fma/fma256135 |
T40 | 642-649 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
T41 | 711-720 | Body_part | denotes | lysosomal | http://purl.org/sig/ont/fma/fma63836 |
T42 | 903-908 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 903-908 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T59 | 104-113 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosomes |
T60 | 195-196 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T61 | 239-248 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosomes |
T62 | 344-350 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
T63 | 711-720 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosomal |
T64 | 903-908 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T65 | 903-908 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
T66 | 934-935 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T46 | 49-67 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
T47 | 183-187 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T48 | 312-330 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
T49 | 478-496 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
T50 | 610-614 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T51 | 857-875 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T55 | 0-249 | Sentence | denotes | When the above described concepts are applied to hydroxychloroquine, the expected accumulation ratio in lysosomes compared with cytosol is calculated as 56 000-fold; therefore, after drug intake a large fraction of the dose will reside in lysosomes. |
T56 | 250-366 | Sentence | denotes | This is confirmed by the known pharmacokinetic parameters for hydroxychloroquine derived from plasma concentrations. |
T57 | 367-581 | Sentence | denotes | After intravenous administration to healthy volunteers (average weight 63.5 kg), the volume of distribution of hydroxychloroquine was reported to be over 44 000 L, which is equivalent to approximately 700 L/kg [9]. |
T58 | 582-740 | Sentence | denotes | This means that most of the drug in the body resides in the tissues, which is consistent with the predicted extraordinarily high lysosomal accumulation ratio. |
T59 | 741-841 | Sentence | denotes | Furthermore, it explains the very long half-life (approximately 40 days) reported in the same study. |
T60 | 842-973 | Sentence | denotes | In this study, hydroxychloroquine could still be detected in blood more than 6 months after a single dose administration of 310 mg. |