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PMC:7204663 / 6600-7573 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
70 49-67 Chemical denotes hydroxychloroquine MESH:D006886
71 312-330 Chemical denotes hydroxychloroquine MESH:D006886
72 478-496 Chemical denotes hydroxychloroquine MESH:D006886
73 857-875 Chemical denotes hydroxychloroquine MESH:D006886

2_test

Id Subject Object Predicate Lexical cue
32389720-3179169-48149097 578-579 3179169 denotes 9
T38067 578-579 3179169 denotes 9

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T35 104-113 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T36 128-135 Body_part denotes cytosol http://purl.org/sig/ont/fma/fma66836
T37 239-248 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T38 344-350 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T39 622-626 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T40 642-649 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T41 711-720 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T42 903-908 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 903-908 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T59 104-113 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T60 195-196 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T61 239-248 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T62 344-350 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T63 711-720 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T64 903-908 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T65 903-908 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T66 934-935 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T46 49-67 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T47 183-187 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T48 312-330 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T49 478-496 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T50 610-614 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T51 857-875 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T55 0-249 Sentence denotes When the above described concepts are applied to hydroxychloroquine, the expected accumulation ratio in lysosomes compared with cytosol is calculated as 56 000-fold; therefore, after drug intake a large fraction of the dose will reside in lysosomes.
T56 250-366 Sentence denotes This is confirmed by the known pharmacokinetic parameters for hydroxychloroquine derived from plasma concentrations.
T57 367-581 Sentence denotes After intravenous administration to healthy volunteers (average weight 63.5 kg), the volume of distribution of hydroxychloroquine was reported to be over 44 000 L, which is equivalent to approximately 700 L/kg [9].
T58 582-740 Sentence denotes This means that most of the drug in the body resides in the tissues, which is consistent with the predicted extraordinarily high lysosomal accumulation ratio.
T59 741-841 Sentence denotes Furthermore, it explains the very long half-life (approximately 40 days) reported in the same study.
T60 842-973 Sentence denotes In this study, hydroxychloroquine could still be detected in blood more than 6 months after a single dose administration of 310 mg.