PMC:7204663 / 5411-6576
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 61 | 848-851 | Gene | denotes | Ka1 | Gene:2900 |
| 62 | 856-859 | Gene | denotes | Ka2 | Gene:2901 |
| 63 | 203-212 | Chemical | denotes | nitrogens | MESH:D009584 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T28 | 263-271 | Body_part | denotes | lysosome | http://purl.org/sig/ont/fma/fma63836 |
| T29 | 272-276 | Body_part | denotes | back | http://purl.org/sig/ont/fma/fma25056 |
| T30 | 286-293 | Body_part | denotes | cytosol | http://purl.org/sig/ont/fma/fma66836 |
| T31 | 400-408 | Body_part | denotes | lysosome | http://purl.org/sig/ont/fma/fma63836 |
| T32 | 538-542 | Body_part | denotes | back | http://purl.org/sig/ont/fma/fma25056 |
| T33 | 550-557 | Body_part | denotes | cytosol | http://purl.org/sig/ont/fma/fma66836 |
| T34 | 1111-1120 | Body_part | denotes | lysosomes | http://purl.org/sig/ont/fma/fma63836 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T55 | 263-271 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosome |
| T56 | 400-408 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosome |
| T57 | 962-963 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T58 | 1111-1120 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosomes |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T40 | 59-67 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T41 | 460-468 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T42 | 591-594 | Chemical | denotes | ion | http://purl.obolibrary.org/obo/CHEBI_24870 |
| T43 | 729-731 | Chemical | denotes | H2 | http://purl.obolibrary.org/obo/CHEBI_18276 |
| T44 | 752-754 | Chemical | denotes | H2 | http://purl.obolibrary.org/obo/CHEBI_18276 |
| T45 | 774-780 | Chemical | denotes | proton | http://purl.obolibrary.org/obo/CHEBI_24636 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T46 | 0-109 | Sentence | denotes | However, in cases where there are two basic centers in the molecule, this effect is considerably potentiated. |
| T47 | 110-294 | Sentence | denotes | There are two different monobasic species that are produced by protonation of the respective nitrogens, and neither of these can easily diffuse from the lysosome back into the cytosol. |
| T48 | 295-409 | Sentence | denotes | Furthermore, both species are in equilibrium with the biprotonated species, which is also trapped in the lysosome. |
| T49 | 410-558 | Sentence | denotes | Therefore, there are three different forms of the molecule (two monoprotonated and one biprotonated) that cannot easily diffuse back to the cytosol. |
| T50 | 559-611 | Sentence | denotes | This tremendously magnifies the ion-trapping effect. |
| T51 | 612-900 | Sentence | denotes | The expected accumulation ratio under these conditions is calculated as follows:(2) R=C1C2=H12+Ka1*H1+Ka1*Ka2H22+Ka1*H2+Ka1*Ka2where H1 and H2 are the respective proton concentrations (=10−pH) of the two environments (pH 5 and 7.4) and Ka1 and Ka2 are the dissociation constant (=10−pKa). |
| T52 | 901-1047 | Sentence | denotes | Fig. 3B shows the magnitude of the resulting accumulation as a function of the pKa value of the compound, assuming equal values for pKa1 and pKa2. |
| T53 | 1048-1165 | Sentence | denotes | Accumulation of up to 60 000-fold higher concentrations in the lysosomes can be explained by the described mechanism. |