PMC:7204663 / 5073-5410 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"53","span":{"begin":197,"end":204},"obj":"Chemical"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Fig. 3 Magnitude of lysosomal ion-trapping depending on the pKa of the compound of interest. For a monobasic compound (A), up to 250-fold higher concentrations are possible depending on pKa. For a dibasic compound (B), the accumulation can be over 60 000-fold. These simulations assume a pH gradient of 5.0 (lysosomes) and 7.4 (cytosol)."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T25","span":{"begin":20,"end":29},"obj":"Body_part"},{"id":"T26","span":{"begin":308,"end":317},"obj":"Body_part"},{"id":"T27","span":{"begin":328,"end":335},"obj":"Body_part"}],"attributes":[{"id":"A25","pred":"fma_id","subj":"T25","obj":"http://purl.org/sig/ont/fma/fma63836"},{"id":"A26","pred":"fma_id","subj":"T26","obj":"http://purl.org/sig/ont/fma/fma63836"},{"id":"A27","pred":"fma_id","subj":"T27","obj":"http://purl.org/sig/ont/fma/fma66836"}],"text":"Fig. 3 Magnitude of lysosomal ion-trapping depending on the pKa of the compound of interest. For a monobasic compound (A), up to 250-fold higher concentrations are possible depending on pKa. For a dibasic compound (B), the accumulation can be over 60 000-fold. These simulations assume a pH gradient of 5.0 (lysosomes) and 7.4 (cytosol)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T48","span":{"begin":20,"end":29},"obj":"http://purl.obolibrary.org/obo/GO_0005764"},{"id":"T49","span":{"begin":97,"end":98},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T50","span":{"begin":119,"end":120},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T51","span":{"begin":195,"end":196},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T52","span":{"begin":215,"end":216},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T53","span":{"begin":286,"end":287},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T54","span":{"begin":308,"end":317},"obj":"http://purl.obolibrary.org/obo/GO_0005764"}],"text":"Fig. 3 Magnitude of lysosomal ion-trapping depending on the pKa of the compound of interest. For a monobasic compound (A), up to 250-fold higher concentrations are possible depending on pKa. For a dibasic compound (B), the accumulation can be over 60 000-fold. These simulations assume a pH gradient of 5.0 (lysosomes) and 7.4 (cytosol)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T39","span":{"begin":30,"end":33},"obj":"Chemical"}],"attributes":[{"id":"A39","pred":"chebi_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/CHEBI_24870"}],"text":"Fig. 3 Magnitude of lysosomal ion-trapping depending on the pKa of the compound of interest. For a monobasic compound (A), up to 250-fold higher concentrations are possible depending on pKa. For a dibasic compound (B), the accumulation can be over 60 000-fold. These simulations assume a pH gradient of 5.0 (lysosomes) and 7.4 (cytosol)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T42","span":{"begin":0,"end":92},"obj":"Sentence"},{"id":"T43","span":{"begin":93,"end":190},"obj":"Sentence"},{"id":"T44","span":{"begin":191,"end":260},"obj":"Sentence"},{"id":"T45","span":{"begin":261,"end":337},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Fig. 3 Magnitude of lysosomal ion-trapping depending on the pKa of the compound of interest. For a monobasic compound (A), up to 250-fold higher concentrations are possible depending on pKa. For a dibasic compound (B), the accumulation can be over 60 000-fold. These simulations assume a pH gradient of 5.0 (lysosomes) and 7.4 (cytosol)."}