PMC:7204663 / 4589-5072 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T19","span":{"begin":11,"end":20},"obj":"Body_part"},{"id":"T20","span":{"begin":268,"end":276},"obj":"Body_part"},{"id":"T21","span":{"begin":321,"end":329},"obj":"Body_part"},{"id":"T22","span":{"begin":379,"end":383},"obj":"Body_part"},{"id":"T23","span":{"begin":393,"end":400},"obj":"Body_part"},{"id":"T24","span":{"begin":473,"end":482},"obj":"Body_part"}],"attributes":[{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma63836"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma63836"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma63836"},{"id":"A22","pred":"fma_id","subj":"T22","obj":"http://purl.org/sig/ont/fma/fma25056"},{"id":"A23","pred":"fma_id","subj":"T23","obj":"http://purl.org/sig/ont/fma/fma66836"},{"id":"A24","pred":"fma_id","subj":"T24","obj":"http://purl.org/sig/ont/fma/fma63836"}],"text":"Concept of lysosomal ion-trapping. Basic compounds are in an equilibrium of a less polar unionized form (B) that can easily cross membranes, and a polar protonated form (BH+) that cannot easily cross membranes. As the unionized drug enters the acidic environment of a lysosome, it will be protonated and ‘trapped’ in the lysosome as the protonated form BH+ cannot easily diffuse back into the cytosol. As a result, high concentrations of the compound can accumulate in the lysosomes."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T5","span":{"begin":170,"end":172},"obj":"Disease"},{"id":"T6","span":{"begin":353,"end":355},"obj":"Disease"}],"attributes":[{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0010873"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0010873"}],"text":"Concept of lysosomal ion-trapping. Basic compounds are in an equilibrium of a less polar unionized form (B) that can easily cross membranes, and a polar protonated form (BH+) that cannot easily cross membranes. As the unionized drug enters the acidic environment of a lysosome, it will be protonated and ‘trapped’ in the lysosome as the protonated form BH+ cannot easily diffuse back into the cytosol. As a result, high concentrations of the compound can accumulate in the lysosomes."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T37","span":{"begin":11,"end":20},"obj":"http://purl.obolibrary.org/obo/GO_0005764"},{"id":"T38","span":{"begin":76,"end":77},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T39","span":{"begin":105,"end":106},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T40","span":{"begin":130,"end":139},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T41","span":{"begin":145,"end":146},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T42","span":{"begin":200,"end":209},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T43","span":{"begin":266,"end":267},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T44","span":{"begin":268,"end":276},"obj":"http://purl.obolibrary.org/obo/GO_0005764"},{"id":"T45","span":{"begin":321,"end":329},"obj":"http://purl.obolibrary.org/obo/GO_0005764"},{"id":"T46","span":{"begin":405,"end":406},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T47","span":{"begin":473,"end":482},"obj":"http://purl.obolibrary.org/obo/GO_0005764"}],"text":"Concept of lysosomal ion-trapping. Basic compounds are in an equilibrium of a less polar unionized form (B) that can easily cross membranes, and a polar protonated form (BH+) that cannot easily cross membranes. As the unionized drug enters the acidic environment of a lysosome, it will be protonated and ‘trapped’ in the lysosome as the protonated form BH+ cannot easily diffuse back into the cytosol. As a result, high concentrations of the compound can accumulate in the lysosomes."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T37","span":{"begin":21,"end":24},"obj":"Chemical"},{"id":"T38","span":{"begin":228,"end":232},"obj":"Chemical"}],"attributes":[{"id":"A37","pred":"chebi_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/CHEBI_24870"},{"id":"A38","pred":"chebi_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"Concept of lysosomal ion-trapping. Basic compounds are in an equilibrium of a less polar unionized form (B) that can easily cross membranes, and a polar protonated form (BH+) that cannot easily cross membranes. As the unionized drug enters the acidic environment of a lysosome, it will be protonated and ‘trapped’ in the lysosome as the protonated form BH+ cannot easily diffuse back into the cytosol. As a result, high concentrations of the compound can accumulate in the lysosomes."}

{"project":"LitCovid-sentences","denotations":[{"id":"T39","span":{"begin":35,"end":210},"obj":"Sentence"},{"id":"T40","span":{"begin":211,"end":401},"obj":"Sentence"},{"id":"T41","span":{"begin":402,"end":483},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Concept of lysosomal ion-trapping. Basic compounds are in an equilibrium of a less polar unionized form (B) that can easily cross membranes, and a polar protonated form (BH+) that cannot easily cross membranes. As the unionized drug enters the acidic environment of a lysosome, it will be protonated and ‘trapped’ in the lysosome as the protonated form BH+ cannot easily diffuse back into the cytosol. As a result, high concentrations of the compound can accumulate in the lysosomes."}