PMC:7204663 / 4582-5072
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T19 | 18-27 | Body_part | denotes | lysosomal | http://purl.org/sig/ont/fma/fma63836 |
| T20 | 275-283 | Body_part | denotes | lysosome | http://purl.org/sig/ont/fma/fma63836 |
| T21 | 328-336 | Body_part | denotes | lysosome | http://purl.org/sig/ont/fma/fma63836 |
| T22 | 386-390 | Body_part | denotes | back | http://purl.org/sig/ont/fma/fma25056 |
| T23 | 400-407 | Body_part | denotes | cytosol | http://purl.org/sig/ont/fma/fma66836 |
| T24 | 480-489 | Body_part | denotes | lysosomes | http://purl.org/sig/ont/fma/fma63836 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T5 | 177-179 | Disease | denotes | BH | http://purl.obolibrary.org/obo/MONDO_0010873 |
| T6 | 360-362 | Disease | denotes | BH | http://purl.obolibrary.org/obo/MONDO_0010873 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T37 | 18-27 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosomal |
| T38 | 83-84 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T39 | 112-113 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T40 | 137-146 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membranes |
| T41 | 152-153 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T42 | 207-216 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membranes |
| T43 | 273-274 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T44 | 275-283 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosome |
| T45 | 328-336 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosome |
| T46 | 412-413 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T47 | 480-489 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosomes |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T37 | 28-31 | Chemical | denotes | ion | http://purl.obolibrary.org/obo/CHEBI_24870 |
| T38 | 235-239 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T38 | 0-41 | Sentence | denotes | Fig. 2 Concept of lysosomal ion-trapping. |
| T39 | 42-217 | Sentence | denotes | Basic compounds are in an equilibrium of a less polar unionized form (B) that can easily cross membranes, and a polar protonated form (BH+) that cannot easily cross membranes. |
| T40 | 218-408 | Sentence | denotes | As the unionized drug enters the acidic environment of a lysosome, it will be protonated and ‘trapped’ in the lysosome as the protonated form BH+ cannot easily diffuse back into the cytosol. |
| T41 | 409-490 | Sentence | denotes | As a result, high concentrations of the compound can accumulate in the lysosomes. |