PMC:7204663 / 2031-2768
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 33 | 646-664 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 34 | 669-681 | Chemical | denotes | azithromycin | MESH:D017963 |
| 35 | 727-736 | Chemical | denotes | nitrogens | MESH:D009584 |
| 44 | 40-58 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 45 | 63-75 | Chemical | denotes | azithromycin | MESH:D017963 |
| 46 | 248-254 | Chemical | denotes | amines | MESH:D000588 |
| 47 | 338-350 | Chemical | denotes | Azithromycin | MESH:D017963 |
| 48 | 359-368 | Chemical | denotes | nitrogens | MESH:D009584 |
| 49 | 405-423 | Chemical | denotes | Hydroxychloroquine | MESH:D006886 |
| 50 | 434-443 | Chemical | denotes | nitrogens | MESH:D009584 |
| 51 | 507-516 | Chemical | denotes | nitrogens | MESH:D009584 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32389720-20385873-48149092 | 401-402 | 20385873 | denotes | 5 |
| 32389720-28962308-48149093 | 481-482 | 28962308 | denotes | 6 |
| T55575 | 401-402 | 20385873 | denotes | 5 |
| T26778 | 481-482 | 28962308 | denotes | 6 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T16 | 156-157 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T17 | 351-354 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T18 | 424-427 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T25 | 40-58 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T26 | 63-75 | Chemical | denotes | azithromycin | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T27 | 248-254 | Chemical | denotes | amines | http://purl.obolibrary.org/obo/CHEBI_32952 |
| T28 | 646-664 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T29 | 669-681 | Chemical | denotes | azithromycin | http://purl.obolibrary.org/obo/CHEBI_2955 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T15 | 0-76 | Sentence | denotes | Fig. 1 shows the chemical structures of hydroxychloroquine and azithromycin. |
| T16 | 77-217 | Sentence | denotes | Although the two compounds are from two chemically distinct classes, they have a structural similarity that is pharmacokinetically relevant. |
| T17 | 218-337 | Sentence | denotes | Both compounds are multibasic amines with pKa values that are susceptible to protonation in the physiological pH range. |
| T18 | 338-404 | Sentence | denotes | Azithromycin has two nitrogens with pKa values of 8.1 and 8.8 [5]. |
| T19 | 405-484 | Sentence | denotes | Hydroxychloroquine has three nitrogens with pKa values of 4.0, 8.3 and 9.7 [6]. |
| T20 | 485-615 | Sentence | denotes | However, only the two nitrogens with the higher values (shown in circles in Fig. 1) are protonated under physiological conditions. |
| T21 | 616-682 | Sentence | denotes | Fig. 1 Chemical structures of hydroxychloroquine and azithromycin. |
| T22 | 683-737 | Sentence | denotes | The circles indicate the pH-sensitive basic nitrogens. |