PMC:7204663 / 2008-2768
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 33 | 669-687 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 34 | 692-704 | Chemical | denotes | azithromycin | MESH:D017963 |
| 35 | 750-759 | Chemical | denotes | nitrogens | MESH:D009584 |
| 44 | 63-81 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 45 | 86-98 | Chemical | denotes | azithromycin | MESH:D017963 |
| 46 | 271-277 | Chemical | denotes | amines | MESH:D000588 |
| 47 | 361-373 | Chemical | denotes | Azithromycin | MESH:D017963 |
| 48 | 382-391 | Chemical | denotes | nitrogens | MESH:D009584 |
| 49 | 428-446 | Chemical | denotes | Hydroxychloroquine | MESH:D006886 |
| 50 | 457-466 | Chemical | denotes | nitrogens | MESH:D009584 |
| 51 | 530-539 | Chemical | denotes | nitrogens | MESH:D009584 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32389720-20385873-48149092 | 424-425 | 20385873 | denotes | 5 |
| 32389720-28962308-48149093 | 504-505 | 28962308 | denotes | 6 |
| T55575 | 424-425 | 20385873 | denotes | 5 |
| T26778 | 504-505 | 28962308 | denotes | 6 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T16 | 179-180 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T17 | 374-377 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T18 | 447-450 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T25 | 63-81 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T26 | 86-98 | Chemical | denotes | azithromycin | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T27 | 271-277 | Chemical | denotes | amines | http://purl.obolibrary.org/obo/CHEBI_32952 |
| T28 | 669-687 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T29 | 692-704 | Chemical | denotes | azithromycin | http://purl.obolibrary.org/obo/CHEBI_2955 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T14 | 0-22 | Sentence | denotes | 1 Chemical structures |
| T15 | 23-99 | Sentence | denotes | Fig. 1 shows the chemical structures of hydroxychloroquine and azithromycin. |
| T16 | 100-240 | Sentence | denotes | Although the two compounds are from two chemically distinct classes, they have a structural similarity that is pharmacokinetically relevant. |
| T17 | 241-360 | Sentence | denotes | Both compounds are multibasic amines with pKa values that are susceptible to protonation in the physiological pH range. |
| T18 | 361-427 | Sentence | denotes | Azithromycin has two nitrogens with pKa values of 8.1 and 8.8 [5]. |
| T19 | 428-507 | Sentence | denotes | Hydroxychloroquine has three nitrogens with pKa values of 4.0, 8.3 and 9.7 [6]. |
| T20 | 508-638 | Sentence | denotes | However, only the two nitrogens with the higher values (shown in circles in Fig. 1) are protonated under physiological conditions. |
| T21 | 639-705 | Sentence | denotes | Fig. 1 Chemical structures of hydroxychloroquine and azithromycin. |
| T22 | 706-760 | Sentence | denotes | The circles indicate the pH-sensitive basic nitrogens. |