PMC:7204663 / 1488-2006 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"26","span":{"begin":91,"end":99},"obj":"Species"},{"id":"27","span":{"begin":123,"end":141},"obj":"Chemical"},{"id":"28","span":{"begin":146,"end":158},"obj":"Chemical"},{"id":"29","span":{"begin":82,"end":90},"obj":"Disease"}],"attributes":[{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"Tax:9606"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"MESH:D006886"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"MESH:D017963"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Recent reports identified significant reduction or disappearance of viral load in COVID-19 patients given a combination of hydroxychloroquine and azithromycin [1,2]. However, other clinical studies could not confirm these early findings [3] and there are considerable concerns about the safety of this drug combination [4]. The present communication discusses some common pharmacokinetic properties of these two drugs that may be linked to a potential underlying mechanism of action for their pharmacological activity."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T2","span":{"begin":82,"end":90},"obj":"Disease"}],"attributes":[{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Recent reports identified significant reduction or disappearance of viral load in COVID-19 patients given a combination of hydroxychloroquine and azithromycin [1,2]. However, other clinical studies could not confirm these early findings [3] and there are considerable concerns about the safety of this drug combination [4]. The present communication discusses some common pharmacokinetic properties of these two drugs that may be linked to a potential underlying mechanism of action for their pharmacological activity."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T13","span":{"begin":106,"end":107},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T14","span":{"begin":440,"end":441},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T15","span":{"begin":509,"end":517},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"Recent reports identified significant reduction or disappearance of viral load in COVID-19 patients given a combination of hydroxychloroquine and azithromycin [1,2]. However, other clinical studies could not confirm these early findings [3] and there are considerable concerns about the safety of this drug combination [4]. The present communication discusses some common pharmacokinetic properties of these two drugs that may be linked to a potential underlying mechanism of action for their pharmacological activity."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T21","span":{"begin":123,"end":141},"obj":"Chemical"},{"id":"T22","span":{"begin":146,"end":158},"obj":"Chemical"},{"id":"T23","span":{"begin":302,"end":306},"obj":"Chemical"},{"id":"T24","span":{"begin":412,"end":417},"obj":"Chemical"}],"attributes":[{"id":"A21","pred":"chebi_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_5801"},{"id":"A22","pred":"chebi_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A23","pred":"chebi_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A24","pred":"chebi_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"Recent reports identified significant reduction or disappearance of viral load in COVID-19 patients given a combination of hydroxychloroquine and azithromycin [1,2]. However, other clinical studies could not confirm these early findings [3] and there are considerable concerns about the safety of this drug combination [4]. The present communication discusses some common pharmacokinetic properties of these two drugs that may be linked to a potential underlying mechanism of action for their pharmacological activity."}

{"project":"LitCovid-sentences","denotations":[{"id":"T11","span":{"begin":0,"end":165},"obj":"Sentence"},{"id":"T12","span":{"begin":166,"end":323},"obj":"Sentence"},{"id":"T13","span":{"begin":324,"end":518},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Recent reports identified significant reduction or disappearance of viral load in COVID-19 patients given a combination of hydroxychloroquine and azithromycin [1,2]. However, other clinical studies could not confirm these early findings [3] and there are considerable concerns about the safety of this drug combination [4]. The present communication discusses some common pharmacokinetic properties of these two drugs that may be linked to a potential underlying mechanism of action for their pharmacological activity."}