PMC:7201239 / 8626-9707
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 375 | 4-8 | Gene | denotes | ACE2 | Gene:59272 |
| 376 | 383-393 | Gene | denotes | Collectrin | Gene:57393 |
| 377 | 717-726 | Chemical | denotes | histidine | MESH:D006639 |
| 378 | 866-875 | Chemical | denotes | histidine | MESH:D006639 |
| 379 | 888-901 | Chemical | denotes | glutamic acid | MESH:D018698 |
| 380 | 965-974 | Chemical | denotes | histidine | MESH:D006639 |
| 381 | 1062-1063 | Chemical | denotes | N | MESH:D009584 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T60 | 9-13 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T61 | 39-42 | Body_part | denotes | DNA | http://purl.org/sig/ont/fma/fma74412 |
| T62 | 77-87 | Body_part | denotes | chromosome | http://purl.org/sig/ont/fma/fma67093 |
| T63 | 129-141 | Body_part | denotes | cell-surface | http://purl.org/sig/ont/fma/fma67653 |
| T64 | 129-133 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T65 | 142-154 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T66 | 189-200 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
| T67 | 256-266 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
| T68 | 416-426 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
| T69 | 441-448 | Body_part | denotes | insulin | http://purl.org/sig/ont/fma/fma83365 |
| T70 | 525-529 | Body_part | denotes | Neck | http://purl.org/sig/ont/fma/fma7155 |
| T71 | 604-609 | Body_part | denotes | helix | http://purl.org/sig/ont/fma/fma60992 |
| T72 | 623-633 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
| T73 | 686-696 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
| T74 | 717-726 | Body_part | denotes | histidine | http://purl.org/sig/ont/fma/fma82755 |
| T75 | 866-875 | Body_part | denotes | histidine | http://purl.org/sig/ont/fma/fma82755 |
| T76 | 888-901 | Body_part | denotes | glutamic acid | http://purl.org/sig/ont/fma/fma82762 |
| T77 | 941-952 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
| T78 | 965-974 | Body_part | denotes | histidine | http://purl.org/sig/ont/fma/fma82755 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T28 | 525-529 | Body_part | denotes | Neck | http://purl.obolibrary.org/obo/UBERON_0000974 |
| T29 | 604-609 | Body_part | denotes | helix | http://purl.obolibrary.org/obo/UBERON_0002488 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T86 | 463-466 | Disease | denotes | CLD | http://purl.obolibrary.org/obo/MONDO_0008964 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T149 | 9-13 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T150 | 25-27 | http://purl.obolibrary.org/obo/CLO_0007074 | denotes | kb |
| T151 | 25-27 | http://purl.obolibrary.org/obo/CLO_0051988 | denotes | kb |
| T152 | 56-58 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
| T153 | 120-121 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T154 | 129-133 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T155 | 222-223 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T156 | 235-241 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
| T157 | 242-249 | http://purl.obolibrary.org/obo/PR_000018263 | denotes | peptide |
| T158 | 256-275 | http://purl.obolibrary.org/obo/CHEBI_33708 | denotes | amino acid residues |
| T159 | 256-275 | http://purl.obolibrary.org/obo/PR_000036907 | denotes | amino acid residues |
| T160 | 277-278 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T161 | 370-371 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T162 | 395-396 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T163 | 441-448 | http://purl.obolibrary.org/obo/PR_000009054 | denotes | insulin |
| T164 | 501-502 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T165 | 525-529 | http://www.ebi.ac.uk/efo/EFO_0000967 | denotes | Neck |
| T166 | 620-622 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
| T167 | 623-642 | http://purl.obolibrary.org/obo/CHEBI_33708 | denotes | amino acid residues |
| T168 | 623-642 | http://purl.obolibrary.org/obo/PR_000036907 | denotes | amino acid residues |
| T169 | 686-705 | http://purl.obolibrary.org/obo/CHEBI_33708 | denotes | amino acid residues |
| T170 | 686-705 | http://purl.obolibrary.org/obo/PR_000036907 | denotes | amino acid residues |
| T171 | 779-780 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T172 | 957-958 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T26 | 39-42 | Chemical | denotes | DNA | http://purl.obolibrary.org/obo/CHEBI_16991 |
| T27 | 142-154 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T28 | 189-200 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T29 | 189-194 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T30 | 195-200 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T31 | 242-249 | Chemical | denotes | peptide | http://purl.obolibrary.org/obo/CHEBI_16670 |
| T32 | 256-266 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T33 | 256-261 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T34 | 262-266 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T35 | 297-299 | Chemical | denotes | PD | http://purl.obolibrary.org/obo/CHEBI_74756 |
| T36 | 334-338 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
| T38 | 416-426 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T39 | 416-421 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T40 | 422-426 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T41 | 441-448 | Chemical | denotes | insulin | http://purl.obolibrary.org/obo/CHEBI_145810 |
| T42 | 503-513 | Chemical | denotes | ferredoxin | http://purl.obolibrary.org/obo/CHEBI_5017 |
| T43 | 623-633 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T44 | 623-628 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T45 | 629-633 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T46 | 686-696 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T47 | 686-691 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T48 | 692-696 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T49 | 717-726 | Chemical | denotes | histidine | http://purl.obolibrary.org/obo/CHEBI_27570 |
| T50 | 797-801 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
| T52 | 866-875 | Chemical | denotes | histidine | http://purl.obolibrary.org/obo/CHEBI_27570 |
| T53 | 888-901 | Chemical | denotes | glutamic acid | http://purl.obolibrary.org/obo/CHEBI_16015|http://purl.obolibrary.org/obo/CHEBI_18237 |
| T55 | 897-901 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T56 | 941-952 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T57 | 941-946 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T58 | 947-952 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T59 | 965-974 | Chemical | denotes | histidine | http://purl.obolibrary.org/obo/CHEBI_27570 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T4 | 416-436 | http://purl.obolibrary.org/obo/GO_0006865 | denotes | amino acid transport |
| T5 | 427-436 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transport |
| T6 | 1062-1078 | http://purl.obolibrary.org/obo/GO_0006487 | denotes | N-glycosylations |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T31 | 0-65 | Sentence | denotes | The ACE2 gene span 39.98 kb of genomic DNA and contains 18 exons. |
| T32 | 66-1081 | Sentence | denotes | It maps to chromosome X at position Xp22.8 It encodes a type I cell-surface glycoprotein of about 100 kDa, composed by 805 amino acids and characterized by a N-terminal signal peptide of 17 amino acid residues, a peptidase domain (PD) (residues 19–615) with its HEXXH zinc binding metalloprotease motif, a C-terminal Collectrin (a regulator of renal amino acid transport and insulin)-like domain (CLD) (residues 616–768) that includes a ferredoxin-like fold “Neck” domain (615–726), that end with an hydrophobic transmembrane hydrophobic helix region of 22 amino acid residues followed by an intracellular segment of 43 amino acid residues.7 , 42 The histidine motif HEXXH identified as an important component in a wide variety of zinc-dependent metalloproteases consists of five residues, the first histidine followed by glutamic acid being conserved, then the two variable amino acids and a final histidine.43 Crystal structure analysis have suggested the presence of several hinge regions and N-glycosylations.44 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32414646-10924499-62239781 | 107-108 | 10924499 | denotes | 8 |
| 32414646-10969042-62239782 | 706-707 | 10969042 | denotes | 7 |
| 32414646-11278314-62239783 | 710-712 | 11278314 | denotes | 42 |
| 32414646-2914602-62239784 | 975-977 | 2914602 | denotes | 43 |