PMC:7201239 / 703-1483 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"40","span":{"begin":34,"end":38},"obj":"Gene"},{"id":"41","span":{"begin":271,"end":275},"obj":"Gene"},{"id":"42","span":{"begin":287,"end":291},"obj":"Gene"},{"id":"43","span":{"begin":397,"end":401},"obj":"Gene"},{"id":"44","span":{"begin":633,"end":637},"obj":"Gene"},{"id":"45","span":{"begin":656,"end":670},"obj":"Gene"},{"id":"56","span":{"begin":196,"end":202},"obj":"Species"},{"id":"57","span":{"begin":333,"end":338},"obj":"Species"},{"id":"58","span":{"begin":476,"end":482},"obj":"Species"},{"id":"59","span":{"begin":694,"end":702},"obj":"Species"},{"id":"60","span":{"begin":176,"end":187},"obj":"Chemical"},{"id":"63","span":{"begin":486,"end":506},"obj":"Disease"},{"id":"64","span":{"begin":530,"end":538},"obj":"Disease"},{"id":"65","span":{"begin":674,"end":693},"obj":"Disease"}],"attributes":[{"id":"A40","pred":"tao:has_database_id","subj":"40","obj":"Gene:59272"},{"id":"A41","pred":"tao:has_database_id","subj":"41","obj":"Gene:59272"},{"id":"A42","pred":"tao:has_database_id","subj":"42","obj":"Gene:59272"},{"id":"A43","pred":"tao:has_database_id","subj":"43","obj":"Gene:59272"},{"id":"A44","pred":"tao:has_database_id","subj":"44","obj":"Gene:59272"},{"id":"A45","pred":"tao:has_database_id","subj":"45","obj":"Gene:183"},{"id":"A56","pred":"tao:has_database_id","subj":"56","obj":"Tax:9606"},{"id":"A57","pred":"tao:has_database_id","subj":"57","obj":"Tax:9606"},{"id":"A58","pred":"tao:has_database_id","subj":"58","obj":"Tax:9606"},{"id":"A59","pred":"tao:has_database_id","subj":"59","obj":"Tax:9606"},{"id":"A60","pred":"tao:has_database_id","subj":"60","obj":"MESH:D000450"},{"id":"A63","pred":"tao:has_database_id","subj":"63","obj":"MESH:C000657245"},{"id":"A64","pred":"tao:has_database_id","subj":"64","obj":"MESH:C000657245"},{"id":"A65","pred":"tao:has_database_id","subj":"65","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"ngiotensin I converting enzyme 2 (ACE2). This molecule is a peptidase expressed at the surface of lung epithelial cells and other tissues, that regulates the renin-angiotensin-aldosterone system. Humans are not equal with respect to the expression levels of the cellular ACE2. Moreover, ACE2 polymorphisms were recently described in human populations. Here we review the most recent evidence that ACE2 expression and/or polymorphism could influence both the susceptibility of people to SARS-CoV-2 infection and the outcome of the COVID-19 disease. Further exploration of the relationship between the virus, the peptidase function of ACE2 and the levels of angiotensin II in SARS-CoV-2 infected patients should help to better understand the pathophysiology of the disease and the m"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T3","span":{"begin":87,"end":102},"obj":"Body_part"},{"id":"T4","span":{"begin":103,"end":119},"obj":"Body_part"},{"id":"T5","span":{"begin":114,"end":119},"obj":"Body_part"},{"id":"T6","span":{"begin":130,"end":137},"obj":"Body_part"}],"attributes":[{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma17530"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma9637"}],"text":"ngiotensin I converting enzyme 2 (ACE2). This molecule is a peptidase expressed at the surface of lung epithelial cells and other tissues, that regulates the renin-angiotensin-aldosterone system. Humans are not equal with respect to the expression levels of the cellular ACE2. Moreover, ACE2 polymorphisms were recently described in human populations. Here we review the most recent evidence that ACE2 expression and/or polymorphism could influence both the susceptibility of people to SARS-CoV-2 infection and the outcome of the COVID-19 disease. Further exploration of the relationship between the virus, the peptidase function of ACE2 and the levels of angiotensin II in SARS-CoV-2 infected patients should help to better understand the pathophysiology of the disease and the m"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T2","span":{"begin":98,"end":102},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"ngiotensin I converting enzyme 2 (ACE2). This molecule is a peptidase expressed at the surface of lung epithelial cells and other tissues, that regulates the renin-angiotensin-aldosterone system. Humans are not equal with respect to the expression levels of the cellular ACE2. Moreover, ACE2 polymorphisms were recently described in human populations. Here we review the most recent evidence that ACE2 expression and/or polymorphism could influence both the susceptibility of people to SARS-CoV-2 infection and the outcome of the COVID-19 disease. Further exploration of the relationship between the virus, the peptidase function of ACE2 and the levels of angiotensin II in SARS-CoV-2 infected patients should help to better understand the pathophysiology of the disease and the m"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T15","span":{"begin":486,"end":494},"obj":"Disease"},{"id":"T16","span":{"begin":486,"end":490},"obj":"Disease"},{"id":"T17","span":{"begin":497,"end":506},"obj":"Disease"},{"id":"T18","span":{"begin":530,"end":538},"obj":"Disease"},{"id":"T19","span":{"begin":674,"end":682},"obj":"Disease"},{"id":"T20","span":{"begin":674,"end":678},"obj":"Disease"}],"attributes":[{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A20","pred":"mondo_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"ngiotensin I converting enzyme 2 (ACE2). This molecule is a peptidase expressed at the surface of lung epithelial cells and other tissues, that regulates the renin-angiotensin-aldosterone system. Humans are not equal with respect to the expression levels of the cellular ACE2. Moreover, ACE2 polymorphisms were recently described in human populations. Here we review the most recent evidence that ACE2 expression and/or polymorphism could influence both the susceptibility of people to SARS-CoV-2 infection and the outcome of the COVID-19 disease. Further exploration of the relationship between the virus, the peptidase function of ACE2 and the levels of angiotensin II in SARS-CoV-2 infected patients should help to better understand the pathophysiology of the disease and the m"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T13","span":{"begin":58,"end":59},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T14","span":{"begin":98,"end":119},"obj":"http://purl.obolibrary.org/obo/CL_0000082"},{"id":"T15","span":{"begin":196,"end":202},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T16","span":{"begin":333,"end":338},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T17","span":{"begin":600,"end":605},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":"ngiotensin I converting enzyme 2 (ACE2). This molecule is a peptidase expressed at the surface of lung epithelial cells and other tissues, that regulates the renin-angiotensin-aldosterone system. Humans are not equal with respect to the expression levels of the cellular ACE2. Moreover, ACE2 polymorphisms were recently described in human populations. Here we review the most recent evidence that ACE2 expression and/or polymorphism could influence both the susceptibility of people to SARS-CoV-2 infection and the outcome of the COVID-19 disease. Further exploration of the relationship between the virus, the peptidase function of ACE2 and the levels of angiotensin II in SARS-CoV-2 infected patients should help to better understand the pathophysiology of the disease and the m"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T3","span":{"begin":46,"end":54},"obj":"Chemical"},{"id":"T4","span":{"begin":164,"end":175},"obj":"Chemical"},{"id":"T5","span":{"begin":176,"end":187},"obj":"Chemical"},{"id":"T7","span":{"begin":656,"end":670},"obj":"Chemical"},{"id":"T10","span":{"begin":656,"end":667},"obj":"Chemical"},{"id":"T11","span":{"begin":668,"end":670},"obj":"Chemical"}],"attributes":[{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_27584"},{"id":"A6","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_30834"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_2719"},{"id":"A8","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_48432"},{"id":"A9","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_58506"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"}],"text":"ngiotensin I converting enzyme 2 (ACE2). This molecule is a peptidase expressed at the surface of lung epithelial cells and other tissues, that regulates the renin-angiotensin-aldosterone system. Humans are not equal with respect to the expression levels of the cellular ACE2. Moreover, ACE2 polymorphisms were recently described in human populations. Here we review the most recent evidence that ACE2 expression and/or polymorphism could influence both the susceptibility of people to SARS-CoV-2 infection and the outcome of the COVID-19 disease. Further exploration of the relationship between the virus, the peptidase function of ACE2 and the levels of angiotensin II in SARS-CoV-2 infected patients should help to better understand the pathophysiology of the disease and the m"}

{"project":"LitCovid-sentences","denotations":[{"id":"T7","span":{"begin":41,"end":195},"obj":"Sentence"},{"id":"T8","span":{"begin":196,"end":276},"obj":"Sentence"},{"id":"T9","span":{"begin":277,"end":351},"obj":"Sentence"},{"id":"T10","span":{"begin":352,"end":547},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ngiotensin I converting enzyme 2 (ACE2). This molecule is a peptidase expressed at the surface of lung epithelial cells and other tissues, that regulates the renin-angiotensin-aldosterone system. Humans are not equal with respect to the expression levels of the cellular ACE2. Moreover, ACE2 polymorphisms were recently described in human populations. Here we review the most recent evidence that ACE2 expression and/or polymorphism could influence both the susceptibility of people to SARS-CoV-2 infection and the outcome of the COVID-19 disease. Further exploration of the relationship between the virus, the peptidase function of ACE2 and the levels of angiotensin II in SARS-CoV-2 infected patients should help to better understand the pathophysiology of the disease and the m"}