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PMC:7201239 / 6470-8596 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
271 4-12 Species denotes MERS-CoV Tax:1335626
272 14-22 Species denotes SARS-CoV Tax:694009
273 24-34 Species denotes SARS-CoV-2 Tax:2697049
302 131-164 Gene denotes angiotensin I converting enzyme 2 Gene:59272
303 166-170 Gene denotes ACE2 Gene:59272
304 409-413 Gene denotes ACE2 Gene:59272
305 512-534 Gene denotes dipeptidyl peptidase 4 Gene:1803
306 536-540 Gene denotes DPP4 Gene:1803
307 672-676 Gene denotes ACE2 Gene:59272
308 773-777 Gene denotes ACE2 Gene:59272
309 942-946 Gene denotes ACE2 Gene:59272
310 967-974 Gene denotes TMPRSS2 Gene:7113
311 951-966 Gene denotes serine protease Gene:2147
312 444-457 Gene denotes type I and II
313 797-802 Gene denotes spike Gene:43740568
314 389-394 Gene denotes spike Gene:43740568
315 76-84 Species denotes SARS-CoV Tax:694009
316 181-186 Species denotes human Tax:9606
317 206-221 Species denotes Betacoronavirus Tax:694002
318 222-232 Species denotes SARS-CoV-2 Tax:2697049
319 243-252 Species denotes 2019-nCoV Tax:2697049
320 319-327 Species denotes SARS-CoV Tax:694009
321 354-363 Species denotes HCoV-NL63 Tax:277944
322 365-373 Species denotes SARS-CoV Tax:694009
323 378-388 Species denotes SARS-CoV-2 Tax:2697049
324 494-502 Species denotes MERS-CoV Tax:1335626
325 639-649 Species denotes SARS-CoV-2 Tax:2697049
326 883-893 Species denotes SARS-CoV-2 Tax:2697049
327 650-655 Gene denotes spike Gene:43740568
328 567-573 Chemical denotes serine MESH:D012694
329 266-274 Disease denotes COVID-19 MESH:C000657245
348 1087-1092 Gene denotes ACE-2 Gene:59272
349 1183-1187 Gene denotes ACE2 Gene:59272
350 1257-1261 Gene denotes ACE2 Gene:59272
351 1326-1330 Gene denotes ACE2 Gene:59272
352 1607-1611 Gene denotes ACE2 Gene:59272
353 1699-1703 Gene denotes ACE2 Gene:59272
354 1832-1836 Gene denotes ACE2 Gene:59272
355 1919-1923 Gene denotes ACE2 Gene:59272
356 2058-2062 Gene denotes ACE2 Gene:59272
357 1060-1065 Species denotes human Tax:9606
358 1120-1125 Species denotes human Tax:9606
359 1307-1312 Species denotes human Tax:9606
360 1591-1596 Species denotes human Tax:9606
361 1814-1817 Species denotes men Tax:9606
362 1866-1871 Species denotes women Tax:9606
363 1887-1893 Species denotes people Tax:9606
364 1126-1139 Disease denotes heart failure MESH:D006333
365 1144-1152 Disease denotes lymphoma MESH:D008223

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T25 187-192 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T26 294-304 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T27 395-403 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T28 458-472 Body_part denotes alveolar cells http://purl.org/sig/ont/fma/fma62499
T29 467-472 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T30 480-484 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T31 567-573 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T32 604-608 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T33 660-667 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T34 910-915 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T35 951-957 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T36 1126-1131 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T37 1188-1192 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T38 1232-1237 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T39 1313-1322 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T40 1352-1363 Body_part denotes enterocytes http://purl.org/sig/ont/fma/fma62122
T41 1371-1386 Body_part denotes small intestine http://purl.org/sig/ont/fma/fma7200
T42 1434-1437 Body_part denotes gut http://purl.org/sig/ont/fma/fma7199
T43 1532-1563 Body_part denotes endothelial cells, and arterial http://purl.org/sig/ont/fma/fma67761
T44 1532-1549 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T45 1544-1549 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T46 1571-1577 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T47 1597-1601 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T48 1612-1619 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T49 1646-1654 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T50 1666-1670 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T51 1671-1676 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T52 1729-1745 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T53 1740-1745 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T54 1749-1760 Body_part denotes oral mucosa http://purl.org/sig/ont/fma/fma59660
T55 1754-1760 Body_part denotes mucosa http://purl.org/sig/ont/fma/fma85355
T56 1771-1775 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T57 1776-1779 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T58 1837-1841 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T59 1856-1860 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T20 480-484 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T21 1126-1131 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T22 1371-1386 Body_part denotes small intestine http://purl.obolibrary.org/obo/UBERON_0002108
T23 1377-1386 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T24 1597-1601 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T25 1666-1670 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T26 1754-1760 Body_part denotes mucosa http://purl.obolibrary.org/obo/UBERON_0000344
T27 1856-1860 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T65 14-22 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T66 14-18 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T67 24-32 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T68 24-28 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T69 76-84 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T70 76-80 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T71 222-230 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T72 222-226 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T73 266-274 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T74 319-327 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T75 319-323 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T76 365-373 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T77 365-369 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T78 378-386 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T79 378-382 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T80 639-647 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T81 639-643 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T82 883-891 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T83 883-887 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T84 1126-1139 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T85 1144-1152 Disease denotes lymphoma http://purl.obolibrary.org/obo/MONDO_0005062

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T96 116-121 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T97 181-192 http://purl.obolibrary.org/obo/CLO_0053065 denotes human cells
T98 284-287 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T99 467-472 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T100 480-484 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T101 480-484 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T102 549-550 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T103 602-608 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T104 609-619 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T105 910-915 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T106 1060-1065 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T107 1120-1125 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T108 1126-1131 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T109 1126-1131 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T110 1126-1131 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T111 1126-1131 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T112 1188-1192 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T113 1232-1237 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T114 1284-1285 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T115 1307-1312 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T116 1313-1322 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T117 1323-1325 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T118 1371-1386 http://purl.obolibrary.org/obo/UBERON_0002108 denotes small intestine
T119 1434-1437 http://purl.obolibrary.org/obo/UBERON_0001007 denotes gut
T120 1434-1437 http://purl.obolibrary.org/obo/UBERON_0001555 denotes gut
T121 1434-1437 http://www.ebi.ac.uk/efo/EFO_0000834 denotes gut
T122 1452-1460 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T123 1461-1463 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T124 1512-1520 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
T125 1512-1520 http://www.ebi.ac.uk/efo/EFO_0000814 denotes arterial
T126 1532-1549 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T127 1555-1563 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
T128 1555-1563 http://www.ebi.ac.uk/efo/EFO_0000814 denotes arterial
T129 1571-1577 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T130 1571-1577 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T131 1571-1577 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T132 1571-1577 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T133 1578-1580 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T134 1591-1596 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T135 1597-1601 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T136 1597-1601 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T137 1655-1665 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T138 1666-1670 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T139 1666-1670 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T140 1671-1676 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T141 1729-1739 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T142 1740-1745 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T143 1754-1760 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa
T144 1771-1775 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T145 1823-1824 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T146 1856-1860 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T147 1856-1860 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T148 2124-2126 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T15 131-142 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T16 294-304 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T17 395-403 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T18 455-457 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T19 567-573 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T20 660-667 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T21 951-957 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T22 1438-1451 Chemical denotes antimicrobial http://purl.obolibrary.org/obo/CHEBI_33281
T23 1452-1460 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T24 1612-1619 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T25 1643-1645 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T12 1126-1139 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T13 1144-1152 Phenotype denotes lymphoma http://purl.obolibrary.org/obo/HP_0002665

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T2 602-619 http://purl.obolibrary.org/obo/GO_0042110 denotes T cell activation
T3 604-619 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T27 0-63 Sentence denotes The MERS-CoV, SARS-CoV, SARS-CoV-2 and their cellular receptors
T28 64-1055 Sentence denotes Already for SARS-CoV, it was demonstrated that this virus used the angiotensin I converting enzyme 2 (ACE2) to enter human cells.29 The novel Betacoronavirus SARS-CoV-2 (formerly 2019-nCoV), that cause COVID-19 disease, has 79.5% nucleotide identity with SARS-CoV.1 It is worth noting that HCoV-NL63, SARS-CoV and SARS-CoV-2 spike proteins bind ACE230 expressed at high levels in type I and II alveolar cells in the lung, whereas MERS-CoV bind the dipeptidyl peptidase 4 (DPP4)/CD26), a multifunctional serine peptidase known involved in T cell activation.31 The analysis of SARS-CoV-2 spike (S) protein and ACE2 three-dimensional (3-D) structures allowed identification of regions in the peptidase domain of ACE2 required for viral spike binding.3 Three very elegant papers published in the recent weeks characterized SARS-CoV-2 entry in target cells through interactions with ACE2 and serine protease TMPRSS2 priming as well as the 3-D structures involved in these interactions.3 , 32 , 33
T29 1056-2126 Sentence denotes The human monocarboxypeptidase ACE-2 was originally cloned from human heart failure and lymphoma cDNA libraries.7 Although the ACE2 gene is usually considered silent in immune cells, the expression of ACE2 mRNAs was reported in a subset of CD14+ CD16-human monocytes.34 ACE2 is also expressed by enterocytes of the small intestine and expected to regulate the expression of the gut antimicrobial peptides.35 Moreover, this peptidase is also present on the arterial and venous endothelial cells, and arterial smooth muscle.36 In normal human lung, the ACE2 protein is found on type I and II alveolar epithelial lung cells.37 High expression of ACE2 was also reported on the epithelial cells of oral mucosa.38 Single-cell RNA-seq analysis indicated that Asian men have a higher ACE2 mRNA expression in lung than women and that Asian people express higher amount of ACE2 than Caucasian and African American populations,39 but this observation remains controversial.40 Until recently, the genetic basis of ACE2 expression in different populations remained largely unknown.41

2_test

Id Subject Object Predicate Lexical cue
32414646-24172901-62239771 193-195 24172901 denotes 29
32414646-31978945-62239772 328-329 31978945 denotes 1
32414646-18441099-62239773 412-415 18441099 denotes 230
32414646-26671446-62239774 620-622 26671446 denotes 31
32414646-32375025-62239775 1048-1050 32375025 denotes 32
32414646-32075877-62239776 1053-1055 32075877 denotes 33
32414646-10969042-62239777 1168-1169 10969042 denotes 7
32414646-25707554-62239778 1323-1325 25707554 denotes 34
32414646-15141377-62239779 1578-1580 15141377 denotes 36
32414646-32094336-62239780 1761-1763 32094336 denotes 38