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PMC:7201239 / 22012-24266 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
918 17-21 Gene denotes ACE2 Gene:59272
919 334-337 Gene denotes ACE Gene:1636
920 408-412 Gene denotes AT1R Gene:185
921 486-490 Gene denotes ACE2 Gene:59272
922 546-550 Gene denotes ACE2 Gene:59272
923 636-640 Gene denotes ACE2 Gene:59272
924 844-848 Gene denotes ACE2 Gene:59272
925 1012-1016 Gene denotes ACE2 Gene:59272
926 1043-1047 Gene denotes ACE2 Gene:59272
927 1238-1242 Gene denotes ACE2 Gene:59272
928 1357-1361 Gene denotes ACE2 Gene:59272
929 1444-1448 Gene denotes ACE2 Gene:59272
930 1613-1617 Gene denotes ACE2 Gene:59272
931 1741-1745 Gene denotes ACE2 Gene:302668
932 1766-1770 Gene denotes ACE2 Gene:302668
933 1807-1810 Gene denotes ACE Gene:24310
934 1939-1962 Gene denotes glucagon-like peptide-1 Gene:2641
935 76-84 Gene denotes Ang (1–7 Gene:7108
936 246-254 Species denotes patients Tax:9606
937 707-715 Species denotes patients Tax:9606
938 768-776 Species denotes patients Tax:9606
939 897-905 Species denotes patients Tax:9606
940 932-940 Species denotes patients Tax:9606
941 1232-1237 Species denotes human Tax:9606
942 1638-1641 Species denotes rat Tax:10116
943 2224-2232 Species denotes patients Tax:9606
944 808-818 Chemical denotes olmesartan MESH:C437965
945 820-823 Chemical denotes ARB
946 1138-1147 Chemical denotes bleomycin MESH:D001761
947 1362-1368 Chemical denotes Ser680
948 1525-1535 Chemical denotes xanthenone MESH:C009689
949 1537-1540 Chemical denotes XNT MESH:C009689
950 1546-1565 Chemical denotes dimiazene aceturate
951 1567-1571 Chemical denotes DIZE
952 1704-1708 Chemical denotes DIZE
953 1926-1935 Chemical denotes exenatide MESH:D000077270
954 2132-2139 Chemical denotes heparin MESH:D006493
955 108-116 Disease denotes COVID-19 MESH:C000657245
956 270-278 Disease denotes COVID-19 MESH:C000657245
957 956-985 Disease denotes idiopathic pulmonary fibrosis MESH:D054990
958 1086-1098 Disease denotes inflammation MESH:D007249
959 1103-1111 Disease denotes fibrosis MESH:D005355
960 1156-1174 Disease denotes pulmonary fibrosis MESH:D011658
961 1274-1301 Disease denotes decreased lung inflammation MESH:D011014
962 1306-1314 Disease denotes fibrosis MESH:D005355
963 1459-1471 Disease denotes pulmonary HT MESH:D006976
964 1651-1673 Disease denotes ischemic heart disease MESH:D003324
965 2195-2204 Disease denotes mortality MESH:D003643
966 2215-2223 Disease denotes COVID-19 MESH:C000657245
967 2238-2250 Disease denotes coagulopathy MESH:D001778

LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 2132-2139 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 2132-2139 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T175 459-471 Body_part denotes cell-surface http://purl.org/sig/ont/fma/fma67653
T176 459-463 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T177 535-545 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T178 551-555 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T179 641-645 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T180 660-664 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T181 665-681 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T182 676-681 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T183 1256-1260 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T184 1284-1288 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T185 1386-1393 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T186 1414-1425 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T187 1660-1665 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T188 1746-1750 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T189 1771-1778 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T190 1811-1815 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T191 1939-1947 Body_part denotes glucagon http://purl.org/sig/ont/fma/fma83350
T192 2132-2139 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T50 660-664 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T51 1256-1260 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T52 1284-1288 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T53 1414-1425 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T54 1660-1665 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T172 101-103 Disease denotes HT http://purl.obolibrary.org/obo/MONDO_0005044
T173 108-116 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T174 260-262 Disease denotes HT http://purl.obolibrary.org/obo/MONDO_0005044
T175 270-278 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T176 432-434 Disease denotes HT http://purl.obolibrary.org/obo/MONDO_0005044
T177 782-784 Disease denotes HT http://purl.obolibrary.org/obo/MONDO_0005044
T178 820-823 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T179 925-927 Disease denotes HT http://purl.obolibrary.org/obo/MONDO_0005044
T180 956-985 Disease denotes idiopathic pulmonary fibrosis http://purl.obolibrary.org/obo/MONDO_0008345
T181 967-985 Disease denotes pulmonary fibrosis http://purl.obolibrary.org/obo/MONDO_0002771
T182 1086-1098 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T183 1156-1174 Disease denotes pulmonary fibrosis http://purl.obolibrary.org/obo/MONDO_0002771
T184 1289-1301 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T185 1469-1471 Disease denotes HT http://purl.obolibrary.org/obo/MONDO_0005044
T186 1651-1673 Disease denotes ischemic heart disease http://purl.obolibrary.org/obo/MONDO_0024644
T187 1660-1673 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267
T188 2215-2223 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T189 2238-2250 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T327 101-103 http://purl.obolibrary.org/obo/CLO_0004265 denotes HT
T328 133-134 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T329 260-262 http://purl.obolibrary.org/obo/CLO_0004265 denotes HT
T330 432-434 http://purl.obolibrary.org/obo/CLO_0004265 denotes HT
T331 459-463 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T332 535-545 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T333 535-545 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T334 567-570 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T335 660-681 http://purl.obolibrary.org/obo/CL_0000082 denotes lung epithelial cells
T336 692-693 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T337 750-755 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T338 782-784 http://purl.obolibrary.org/obo/CLO_0004265 denotes HT
T339 925-927 http://purl.obolibrary.org/obo/CLO_0004265 denotes HT
T340 1051-1052 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T341 1122-1128 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T342 1232-1237 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T343 1256-1260 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T344 1256-1260 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T345 1284-1288 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T346 1284-1288 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T347 1376-1385 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T348 1414-1425 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
T349 1435-1436 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T350 1469-1471 http://purl.obolibrary.org/obo/CLO_0004265 denotes HT
T351 1618-1628 http://purl.obolibrary.org/obo/CLO_0001658 denotes activators
T352 1636-1637 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T353 1660-1665 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T354 1660-1665 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T355 1660-1665 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T356 1660-1665 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T357 1789-1797 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T358 1937-1938 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T359 1953-1960 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T360 2018-2019 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T187 66-69 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T188 70-72 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T189 76-79 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T190 334-348 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T191 338-348 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T192 350-354 Chemical denotes ACEi http://purl.obolibrary.org/obo/CHEBI_35457
T193 435-445 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T194 517-521 Chemical denotes ACEi http://purl.obolibrary.org/obo/CHEBI_35457
T195 627-632 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T196 808-818 Chemical denotes olmesartan http://purl.obolibrary.org/obo/CHEBI_48416
T197 1138-1147 Chemical denotes bleomycin http://purl.obolibrary.org/obo/CHEBI_22907
T198 1372-1375 Chemical denotes AMP http://purl.obolibrary.org/obo/CHEBI_16027|http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_456215
T201 1386-1393 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T202 1507-1516 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T203 1525-1535 Chemical denotes xanthenone http://purl.obolibrary.org/obo/CHEBI_37647
T204 1556-1565 Chemical denotes aceturate http://purl.obolibrary.org/obo/CHEBI_61887
T205 1576-1598 Chemical denotes anti-trypanosomal drug http://purl.obolibrary.org/obo/CHEBI_36335
T206 1594-1598 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T207 1771-1778 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T208 1908-1917 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T209 1926-1935 Chemical denotes exenatide http://purl.obolibrary.org/obo/CHEBI_64073
T210 1939-1947 Chemical denotes glucagon http://purl.obolibrary.org/obo/CHEBI_5391
T211 1953-1960 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T212 1963-1970 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T213 2132-2139 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T214 2141-2154 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T29 101-103 Phenotype denotes HT http://purl.obolibrary.org/obo/HP_0000822
T30 260-262 Phenotype denotes HT http://purl.obolibrary.org/obo/HP_0000822
T31 432-434 Phenotype denotes HT http://purl.obolibrary.org/obo/HP_0000822
T32 782-784 Phenotype denotes HT http://purl.obolibrary.org/obo/HP_0000822
T33 925-927 Phenotype denotes HT http://purl.obolibrary.org/obo/HP_0000822
T34 967-985 Phenotype denotes pulmonary fibrosis http://purl.obolibrary.org/obo/HP_0002206
T35 1156-1174 Phenotype denotes pulmonary fibrosis http://purl.obolibrary.org/obo/HP_0002206
T36 1469-1471 Phenotype denotes HT http://purl.obolibrary.org/obo/HP_0000822
T37 2238-2250 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T35 1086-1098 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T36 1289-1301 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T37 1338-1353 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T38 2032-2048 http://purl.obolibrary.org/obo/GO_0042310 denotes vasoconstrictive

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T84 0-86 Sentence denotes It is known that ACE2 can shift the RAAS balance by conversion of Ang II to Ang (1–7).
T85 87-414 Sentence denotes Consequently, HT and COVID-19 recently become a question of concern for international professional societies of cardiology regarding: i) the susceptibility of patients with HT to get COVID-19; ii) the severity of the disease; and, iii) the use of ACE inhibitors (ACEi) and AngII receptor blockers (ARBs, that targets the AT1R).
T86 415-491 Sentence denotes It is known that HT inhibitors increase the cell-surface expression of ACE2.
T87 492-764 Sentence denotes It was demonstrated that ACEi can increase intestinal ACE2 mRNA expression.102 Although data are lacking regarding the effects of such drugs on ACE2 mRNA expression in lung epithelial cells, there is a concern that patients taking those treatments can favor virus capture.
T88 765-2254 Sentence denotes In patients with HT who received long-term olmesartan (ARB) treatment, urinary ACE2 levels were higher than among untreated control patients.103 In contrast to HT, in patients suffering from idiopathic pulmonary fibrosis, the expression levels of ACE2 are markedly decreased.30 ACE2 is a major actor toward resolution of inflammation and fibrosis.104 In an animal model of bleomycin-induced pulmonary fibrosis, treatment with intraperitoneal injection of recombinant human ACE2 improved the lung function and decreased lung inflammation and fibrosis.105 Moreover, impaired phosphorylation of ACE2 Ser680 by AMP-activated protein kinase in pulmonary endothelium leads to a labile ACE2 and hence pulmonary HT.106 We must also paid attention to molecules such as xanthenone (XNT) and dimiazene aceturate (DIZE, an anti-trypanosomal drug) described as ACE2 activators.107 In a rat model of ischemic heart disease, the subcutaneous infusion of DIZE significantly increased cardiac ACE2 mRNA expression and ACE2 protein catalytic activity, reduced ACE mRNA expression, and improved cardiac remodeling.108 The possible beneficial properties of other molecules such as exenatide (a glucagon-like peptide-1 agonist) which induces an increase in vasodilatory and a decrease in vasoconstrictive mediators must also be investigated.109 In addition, it was recently reported that heparin (anticoagulant) treatment is associated with decreased mortality in severe COVID-19 patients with coagulopathy.110

2_test

Id Subject Object Predicate Lexical cue
32414646-25534429-62239840 567-570 25534429 denotes 102
32414646-24842388-62239841 906-909 24842388 denotes 103
32414646-18441099-62239842 1040-1042 18441099 denotes 30
32414646-12754187-62239843 1112-1115 12754187 denotes 104
32414646-22246130-62239844 1315-1318 22246130 denotes 105
32414646-29570986-62239845 1472-1475 29570986 denotes 106
32414646-23959549-62239846 1860-1863 23959549 denotes 108