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PMC:7200337 / 98549-99871 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
32505227-31774948-46575433 678-682 31774948 denotes 2019
T74065 678-682 31774948 denotes 2019

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T749 299-307 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T750 372-380 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T751 541-549 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T752 935-943 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T753 1055-1062 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T569 62-70 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T570 346-354 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T571 455-463 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T572 657-662 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T573 731-739 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T574 1287-1295 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T575 1302-1310 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1023 0-6 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes Animal
T1024 120-121 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1025 145-150 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1026 200-201 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1027 395-396 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1028 397-402 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1029 403-405 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T1030 474-476 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T1031 531-540 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humanized
T1032 550-555 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T1033 663-668 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T1034 709-716 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T1035 793-799 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T1036 1071-1073 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T1037 1196-1198 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T1038 1230-1232 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T1039 1234-1236 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T1040 1234-1236 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T320 218-220 Chemical denotes VH http://purl.obolibrary.org/obo/CHEBI_73700
T321 372-380 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T322 1055-1062 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T323 1234-1236 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3276 1050-1054 Gene denotes ACE2 Gene:59272
3277 1191-1195 Gene denotes ACE2 Gene:59272
3278 1268-1270 Gene denotes to Gene:6999
3279 836-838 Gene denotes to Gene:6999
3280 757-759 Gene denotes to Gene:6999
3281 573-575 Gene denotes to Gene:93898
3282 392-394 Gene denotes to Gene:6999
3283 131-133 Gene denotes to Gene:6999
3284 37-39 Gene denotes to Gene:6999
3285 62-72 Species denotes SARS-CoV-2 Tax:2697049
3286 145-150 Species denotes human Tax:9606
3287 346-354 Species denotes SARS-CoV Tax:694009
3288 361-369 Species denotes MERS-CoV Tax:1335626
3289 397-402 Species denotes human Tax:9606
3290 455-465 Species denotes SARS-CoV-2 Tax:2697049
3291 521-525 Species denotes mice Tax:10090
3292 657-668 Species denotes Ebola virus Tax:1570291
3293 731-741 Species denotes SARS-CoV-2 Tax:2697049
3294 848-856 Species denotes patients Tax:9606
3295 1162-1166 Species denotes CoVs Tax:11118
3296 1287-1295 Species denotes SARS-CoV Tax:694009
3297 1302-1312 Species denotes SARS-CoV-2 Tax:2697049
3298 49-53 Chemical denotes nAbs
3299 786-789 Chemical denotes nAb
3300 1023-1026 Chemical denotes nAb
3301 839-847 Disease denotes infected MESH:D007239

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T578 0-83 Sentence denotes Animal models represent another tool to generate nAbs against SARS-CoV-2 (Table 3).
T579 84-290 Sentence denotes In one study, the authors developed a protocol to synthetize human nanobodies, smaller antibodies that only contain a variable heavy (VH) chain as first described in camelids (Wu et al., 2020c) (Figure 6D).
T580 291-499 Sentence denotes Another antibody isolated from camelids immunized with SARS-CoV-1 and MERS-CoV S proteins then fused to a human Fc fragment showed neutralization potential against SARS-CoV-2 (VHH-72-Fc) (Wrapp et al., 2020).
T581 500-684 Sentence denotes Genetically modified mice with humanized antibody genes can also be used to generate therapeutic monoclonal antibodies, as successfully experimented against Ebola virus (Levine, 2019).
T582 685-993 Sentence denotes Similar studies are now focused on the use of SARS-CoV-2 or derivatives to generate highly effective nAb in animal models, which can be directly given to infected patients, and efforts are already underway with estimates of clinical trials of pooled antibody cocktails beginning in early summer by Regeneron.
T583 994-1179 Sentence denotes Finally, another approach to nAb development is to fuse ACE2 protein and the Fc part of antibodies, as they would bind RBD and potentially be crossreactive among other CoVs (Figure 6D).
T584 1180-1322 Sentence denotes Indeed, an ACE2-Fc (Lei et al., 2020a) and an RBD-Fc (Li et al., 2020d) have been shown to neutralize both SARS-CoV-1 and SARS-CoV-2 in vitro.