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PMC:7200337 / 98523-99871 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
32505227-31774948-46575433 704-708 31774948 denotes 2019
T74065 704-708 31774948 denotes 2019

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T749 325-333 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T750 398-406 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T751 567-575 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T752 961-969 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T753 1081-1088 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T569 88-96 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T570 372-380 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T571 481-489 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T572 683-688 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T573 757-765 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T574 1313-1321 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T575 1328-1336 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1022 18-25 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes Animals
T1023 26-32 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes Animal
T1024 146-147 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1025 171-176 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1026 226-227 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1027 421-422 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1028 423-428 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1029 429-431 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T1030 500-502 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T1031 557-566 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humanized
T1032 576-581 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T1033 689-694 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T1034 735-742 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T1035 819-825 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T1036 1097-1099 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T1037 1222-1224 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T1038 1256-1258 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T1039 1260-1262 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T1040 1260-1262 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T320 244-246 Chemical denotes VH http://purl.obolibrary.org/obo/CHEBI_73700
T321 398-406 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T322 1081-1088 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T323 1260-1262 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3249 0-4 Chemical denotes nAbs
3276 1076-1080 Gene denotes ACE2 Gene:59272
3277 1217-1221 Gene denotes ACE2 Gene:59272
3278 1294-1296 Gene denotes to Gene:6999
3279 862-864 Gene denotes to Gene:6999
3280 783-785 Gene denotes to Gene:6999
3281 599-601 Gene denotes to Gene:93898
3282 418-420 Gene denotes to Gene:6999
3283 157-159 Gene denotes to Gene:6999
3284 63-65 Gene denotes to Gene:6999
3285 88-98 Species denotes SARS-CoV-2 Tax:2697049
3286 171-176 Species denotes human Tax:9606
3287 372-380 Species denotes SARS-CoV Tax:694009
3288 387-395 Species denotes MERS-CoV Tax:1335626
3289 423-428 Species denotes human Tax:9606
3290 481-491 Species denotes SARS-CoV-2 Tax:2697049
3291 547-551 Species denotes mice Tax:10090
3292 683-694 Species denotes Ebola virus Tax:1570291
3293 757-767 Species denotes SARS-CoV-2 Tax:2697049
3294 874-882 Species denotes patients Tax:9606
3295 1188-1192 Species denotes CoVs Tax:11118
3296 1313-1321 Species denotes SARS-CoV Tax:694009
3297 1328-1338 Species denotes SARS-CoV-2 Tax:2697049
3298 75-79 Chemical denotes nAbs
3299 812-815 Chemical denotes nAb
3300 1049-1052 Chemical denotes nAb
3301 865-873 Disease denotes infected MESH:D007239

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T577 0-25 Sentence denotes nAbs Derived from Animals
T578 26-109 Sentence denotes Animal models represent another tool to generate nAbs against SARS-CoV-2 (Table 3).
T579 110-316 Sentence denotes In one study, the authors developed a protocol to synthetize human nanobodies, smaller antibodies that only contain a variable heavy (VH) chain as first described in camelids (Wu et al., 2020c) (Figure 6D).
T580 317-525 Sentence denotes Another antibody isolated from camelids immunized with SARS-CoV-1 and MERS-CoV S proteins then fused to a human Fc fragment showed neutralization potential against SARS-CoV-2 (VHH-72-Fc) (Wrapp et al., 2020).
T581 526-710 Sentence denotes Genetically modified mice with humanized antibody genes can also be used to generate therapeutic monoclonal antibodies, as successfully experimented against Ebola virus (Levine, 2019).
T582 711-1019 Sentence denotes Similar studies are now focused on the use of SARS-CoV-2 or derivatives to generate highly effective nAb in animal models, which can be directly given to infected patients, and efforts are already underway with estimates of clinical trials of pooled antibody cocktails beginning in early summer by Regeneron.
T583 1020-1205 Sentence denotes Finally, another approach to nAb development is to fuse ACE2 protein and the Fc part of antibodies, as they would bind RBD and potentially be crossreactive among other CoVs (Figure 6D).
T584 1206-1348 Sentence denotes Indeed, an ACE2-Fc (Lei et al., 2020a) and an RBD-Fc (Li et al., 2020d) have been shown to neutralize both SARS-CoV-1 and SARS-CoV-2 in vitro.