PMC:7200337 / 97274-98521 JSONTXT

{"project":"2_test","denotations":[{"id":"32505227-32416259-46575430","span":{"begin":430,"end":434},"obj":"32416259"},{"id":"32505227-32155444-46575431","span":{"begin":848,"end":852},"obj":"32155444"},{"id":"T64637","span":{"begin":430,"end":434},"obj":"32416259"},{"id":"T33611","span":{"begin":848,"end":852},"obj":"32155444"}],"text":"Table 3 Strategies to Isolate SARS-CoV-2 Neutralizing Antibodies\nAb Source Clone Target Type of Antibody Neutralization Inhibition of ACE2/RBD Binding Reference\nDerived from COVID-19 patients 31B532D4 RBD human monoclonal yes yes Chen et al., 2020a\nP2C-2F6P2C-1F11 RBD human monoclonal yes yes Ju et al., 2020\nDerived from SARS-CoV-1 patients CR3022 RBD human monoclonal no no Tian et al., 2020b, Yuan et al., 2020, Giron et al., 2020\nS309 RBD human monoclonal yes no Pinto et al., 2020\nDerived from SARS-CoV-1 or MERS-CoV-1 animal models R325R302R007 S1 rabbit monoclonal yes no Sun et al., 2020\n47D11 S1 recombinant human monoclonal (derived from hybridomas of immunized transgenic H2L2 mice) yes no Wang et al., 2020a\nVHH-72-Fc S Fc-fusion derived from camelids VHH yes yes Wrapp et al., 2020\nS polyclonal mouse antibodies yes N/A Walls et al., 2020, Yuan et al., 2020\nOther ACE2-Fc RBD ACE2-Fc fusion yes N/A Lei et al., 2020a, Li et al., 2020d\nRBD-Fc ACE2 RBD-Fc fusion yes N/A Li et al., 2020d\nN3130 S1 human monoclonal single domain antibody isolated by phage display yes no Wu et al., 2020c\nIVIg N/A polyclonal human IVIg N/A N/A Díez et al., 2020, Shao et al., 2020\nF(ab′)2 RBD horse polyclonal yes N/A Pan et al., 2020\nN/A, not assessed."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T746","span":{"begin":54,"end":64},"obj":"Body_part"},{"id":"T747","span":{"begin":96,"end":104},"obj":"Body_part"},{"id":"T748","span":{"begin":1040,"end":1048},"obj":"Body_part"}],"attributes":[{"id":"A746","pred":"fma_id","subj":"T746","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A747","pred":"fma_id","subj":"T747","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A748","pred":"fma_id","subj":"T748","obj":"http://purl.org/sig/ont/fma/fma62871"}],"text":"Table 3 Strategies to Isolate SARS-CoV-2 Neutralizing Antibodies\nAb Source Clone Target Type of Antibody Neutralization Inhibition of ACE2/RBD Binding Reference\nDerived from COVID-19 patients 31B532D4 RBD human monoclonal yes yes Chen et al., 2020a\nP2C-2F6P2C-1F11 RBD human monoclonal yes yes Ju et al., 2020\nDerived from SARS-CoV-1 patients CR3022 RBD human monoclonal no no Tian et al., 2020b, Yuan et al., 2020, Giron et al., 2020\nS309 RBD human monoclonal yes no Pinto et al., 2020\nDerived from SARS-CoV-1 or MERS-CoV-1 animal models R325R302R007 S1 rabbit monoclonal yes no Sun et al., 2020\n47D11 S1 recombinant human monoclonal (derived from hybridomas of immunized transgenic H2L2 mice) yes no Wang et al., 2020a\nVHH-72-Fc S Fc-fusion derived from camelids VHH yes yes Wrapp et al., 2020\nS polyclonal mouse antibodies yes N/A Walls et al., 2020, Yuan et al., 2020\nOther ACE2-Fc RBD ACE2-Fc fusion yes N/A Lei et al., 2020a, Li et al., 2020d\nRBD-Fc ACE2 RBD-Fc fusion yes N/A Li et al., 2020d\nN3130 S1 human monoclonal single domain antibody isolated by phage display yes no Wu et al., 2020c\nIVIg N/A polyclonal human IVIg N/A N/A Díez et al., 2020, Shao et al., 2020\nF(ab′)2 RBD horse polyclonal yes N/A Pan et al., 2020\nN/A, not assessed."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T565","span":{"begin":30,"end":38},"obj":"Disease"},{"id":"T566","span":{"begin":174,"end":182},"obj":"Disease"},{"id":"T567","span":{"begin":323,"end":331},"obj":"Disease"},{"id":"T568","span":{"begin":500,"end":508},"obj":"Disease"}],"attributes":[{"id":"A565","pred":"mondo_id","subj":"T565","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A566","pred":"mondo_id","subj":"T566","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A567","pred":"mondo_id","subj":"T567","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A568","pred":"mondo_id","subj":"T568","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Table 3 Strategies to Isolate SARS-CoV-2 Neutralizing Antibodies\nAb Source Clone Target Type of Antibody Neutralization Inhibition of ACE2/RBD Binding Reference\nDerived from COVID-19 patients 31B532D4 RBD human monoclonal yes yes Chen et al., 2020a\nP2C-2F6P2C-1F11 RBD human monoclonal yes yes Ju et al., 2020\nDerived from SARS-CoV-1 patients CR3022 RBD human monoclonal no no Tian et al., 2020b, Yuan et al., 2020, Giron et al., 2020\nS309 RBD human monoclonal yes no Pinto et al., 2020\nDerived from SARS-CoV-1 or MERS-CoV-1 animal models R325R302R007 S1 rabbit monoclonal yes no Sun et al., 2020\n47D11 S1 recombinant human monoclonal (derived from hybridomas of immunized transgenic H2L2 mice) yes no Wang et al., 2020a\nVHH-72-Fc S Fc-fusion derived from camelids VHH yes yes Wrapp et al., 2020\nS polyclonal mouse antibodies yes N/A Walls et al., 2020, Yuan et al., 2020\nOther ACE2-Fc RBD ACE2-Fc fusion yes N/A Lei et al., 2020a, Li et al., 2020d\nRBD-Fc ACE2 RBD-Fc fusion yes N/A Li et al., 2020d\nN3130 S1 human monoclonal single domain antibody isolated by phage display yes no Wu et al., 2020c\nIVIg N/A polyclonal human IVIg N/A N/A Díez et al., 2020, Shao et al., 2020\nF(ab′)2 RBD horse polyclonal yes N/A Pan et al., 2020\nN/A, not assessed."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T989","span":{"begin":205,"end":210},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T990","span":{"begin":269,"end":274},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T991","span":{"begin":354,"end":359},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T992","span":{"begin":444,"end":449},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T993","span":{"begin":525,"end":531},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T994","span":{"begin":552,"end":554},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T995","span":{"begin":603,"end":605},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T996","span":{"begin":618,"end":623},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T997","span":{"begin":649,"end":659},"obj":"http://purl.obolibrary.org/obo/CLO_0036932"},{"id":"T998","span":{"begin":728,"end":730},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T999","span":{"begin":733,"end":735},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T1000","span":{"begin":809,"end":814},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T1001","span":{"begin":832,"end":833},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1002","span":{"begin":883,"end":885},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T1003","span":{"begin":895,"end":897},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T1004","span":{"begin":911,"end":912},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1005","span":{"begin":932,"end":934},"obj":"http://purl.obolibrary.org/obo/CLO_0001022"},{"id":"T1006","span":{"begin":932,"end":934},"obj":"http://purl.obolibrary.org/obo/CLO_0007314"},{"id":"T1007","span":{"begin":953,"end":955},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T1008","span":{"begin":965,"end":967},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T1009","span":{"begin":981,"end":982},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1010","span":{"begin":983,"end":985},"obj":"http://purl.obolibrary.org/obo/CLO_0001022"},{"id":"T1011","span":{"begin":983,"end":985},"obj":"http://purl.obolibrary.org/obo/CLO_0007314"},{"id":"T1012","span":{"begin":1006,"end":1008},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T1013","span":{"begin":1009,"end":1014},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T1014","span":{"begin":1106,"end":1107},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1015","span":{"begin":1119,"end":1124},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T1016","span":{"begin":1132,"end":1133},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1017","span":{"begin":1136,"end":1137},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1018","span":{"begin":1187,"end":1192},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9796"},{"id":"T1019","span":{"begin":1210,"end":1211},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1020","span":{"begin":1212,"end":1215},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9596"},{"id":"T1021","span":{"begin":1231,"end":1232},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Table 3 Strategies to Isolate SARS-CoV-2 Neutralizing Antibodies\nAb Source Clone Target Type of Antibody Neutralization Inhibition of ACE2/RBD Binding Reference\nDerived from COVID-19 patients 31B532D4 RBD human monoclonal yes yes Chen et al., 2020a\nP2C-2F6P2C-1F11 RBD human monoclonal yes yes Ju et al., 2020\nDerived from SARS-CoV-1 patients CR3022 RBD human monoclonal no no Tian et al., 2020b, Yuan et al., 2020, Giron et al., 2020\nS309 RBD human monoclonal yes no Pinto et al., 2020\nDerived from SARS-CoV-1 or MERS-CoV-1 animal models R325R302R007 S1 rabbit monoclonal yes no Sun et al., 2020\n47D11 S1 recombinant human monoclonal (derived from hybridomas of immunized transgenic H2L2 mice) yes no Wang et al., 2020a\nVHH-72-Fc S Fc-fusion derived from camelids VHH yes yes Wrapp et al., 2020\nS polyclonal mouse antibodies yes N/A Walls et al., 2020, Yuan et al., 2020\nOther ACE2-Fc RBD ACE2-Fc fusion yes N/A Lei et al., 2020a, Li et al., 2020d\nRBD-Fc ACE2 RBD-Fc fusion yes N/A Li et al., 2020d\nN3130 S1 human monoclonal single domain antibody isolated by phage display yes no Wu et al., 2020c\nIVIg N/A polyclonal human IVIg N/A N/A Díez et al., 2020, Shao et al., 2020\nF(ab′)2 RBD horse polyclonal yes N/A Pan et al., 2020\nN/A, not assessed."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T318","span":{"begin":932,"end":934},"obj":"Chemical"},{"id":"T319","span":{"begin":983,"end":985},"obj":"Chemical"}],"attributes":[{"id":"A318","pred":"chebi_id","subj":"T318","obj":"http://purl.obolibrary.org/obo/CHEBI_30145"},{"id":"A319","pred":"chebi_id","subj":"T319","obj":"http://purl.obolibrary.org/obo/CHEBI_30145"}],"text":"Table 3 Strategies to Isolate SARS-CoV-2 Neutralizing Antibodies\nAb Source Clone Target Type of Antibody Neutralization Inhibition of ACE2/RBD Binding Reference\nDerived from COVID-19 patients 31B532D4 RBD human monoclonal yes yes Chen et al., 2020a\nP2C-2F6P2C-1F11 RBD human monoclonal yes yes Ju et al., 2020\nDerived from SARS-CoV-1 patients CR3022 RBD human monoclonal no no Tian et al., 2020b, Yuan et al., 2020, Giron et al., 2020\nS309 RBD human monoclonal yes no Pinto et al., 2020\nDerived from SARS-CoV-1 or MERS-CoV-1 animal models R325R302R007 S1 rabbit monoclonal yes no Sun et al., 2020\n47D11 S1 recombinant human monoclonal (derived from hybridomas of immunized transgenic H2L2 mice) yes no Wang et al., 2020a\nVHH-72-Fc S Fc-fusion derived from camelids VHH yes yes Wrapp et al., 2020\nS polyclonal mouse antibodies yes N/A Walls et al., 2020, Yuan et al., 2020\nOther ACE2-Fc RBD ACE2-Fc fusion yes N/A Lei et al., 2020a, Li et al., 2020d\nRBD-Fc ACE2 RBD-Fc fusion yes N/A Li et al., 2020d\nN3130 S1 human monoclonal single domain antibody isolated by phage display yes no Wu et al., 2020c\nIVIg N/A polyclonal human IVIg N/A N/A Díez et al., 2020, Shao et al., 2020\nF(ab′)2 RBD horse polyclonal yes N/A Pan et al., 2020\nN/A, not assessed."}

{"project":"LitCovid-PubTator","denotations":[{"id":"3184","span":{"begin":134,"end":138},"obj":"Gene"},{"id":"3185","span":{"begin":878,"end":882},"obj":"Gene"},{"id":"3186","span":{"begin":890,"end":894},"obj":"Gene"},{"id":"3187","span":{"begin":183,"end":191},"obj":"Species"},{"id":"3188","span":{"begin":323,"end":331},"obj":"Species"},{"id":"3189","span":{"begin":334,"end":342},"obj":"Species"},{"id":"3190","span":{"begin":500,"end":508},"obj":"Species"},{"id":"3191","span":{"begin":514,"end":522},"obj":"Species"},{"id":"3192","span":{"begin":689,"end":693},"obj":"Species"},{"id":"3193","span":{"begin":606,"end":617},"obj":"Species"},{"id":"3194","span":{"begin":673,"end":683},"obj":"Species"},{"id":"3195","span":{"begin":205,"end":210},"obj":"Species"},{"id":"3196","span":{"begin":269,"end":274},"obj":"Species"},{"id":"3197","span":{"begin":354,"end":359},"obj":"Species"},{"id":"3198","span":{"begin":444,"end":449},"obj":"Species"},{"id":"3199","span":{"begin":618,"end":623},"obj":"Species"},{"id":"3200","span":{"begin":809,"end":814},"obj":"Species"},{"id":"3201","span":{"begin":1009,"end":1014},"obj":"Species"},{"id":"3202","span":{"begin":1119,"end":1124},"obj":"Species"},{"id":"3203","span":{"begin":174,"end":182},"obj":"Disease"},{"id":"3204","span":{"begin":1099,"end":1105},"obj":"Disease"},{"id":"3205","span":{"begin":1125,"end":1131},"obj":"Disease"},{"id":"3208","span":{"begin":19,"end":21},"obj":"Gene"},{"id":"3209","span":{"begin":30,"end":40},"obj":"Species"}],"attributes":[{"id":"A3184","pred":"tao:has_database_id","subj":"3184","obj":"Gene:59272"},{"id":"A3185","pred":"tao:has_database_id","subj":"3185","obj":"Gene:70008"},{"id":"A3186","pred":"tao:has_database_id","subj":"3186","obj":"Gene:70008"},{"id":"A3187","pred":"tao:has_database_id","subj":"3187","obj":"Tax:9606"},{"id":"A3188","pred":"tao:has_database_id","subj":"3188","obj":"Tax:694009"},{"id":"A3189","pred":"tao:has_database_id","subj":"3189","obj":"Tax:9606"},{"id":"A3190","pred":"tao:has_database_id","subj":"3190","obj":"Tax:694009"},{"id":"A3191","pred":"tao:has_database_id","subj":"3191","obj":"Tax:1335626"},{"id":"A3192","pred":"tao:has_database_id","subj":"3192","obj":"Tax:10090"},{"id":"A3193","pred":"tao:has_database_id","subj":"3193","obj":"Tax:575864"},{"id":"A3194","pred":"tao:has_database_id","subj":"3194","obj":"Tax:10090"},{"id":"A3195","pred":"tao:has_database_id","subj":"3195","obj":"Tax:9606"},{"id":"A3196","pred":"tao:has_database_id","subj":"3196","obj":"Tax:9606"},{"id":"A3197","pred":"tao:has_database_id","subj":"3197","obj":"Tax:9606"},{"id":"A3198","pred":"tao:has_database_id","subj":"3198","obj":"Tax:9606"},{"id":"A3199","pred":"tao:has_database_id","subj":"3199","obj":"Tax:9606"},{"id":"A3200","pred":"tao:has_database_id","subj":"3200","obj":"Tax:10090"},{"id":"A3201","pred":"tao:has_database_id","subj":"3201","obj":"Tax:9606"},{"id":"A3202","pred":"tao:has_database_id","subj":"3202","obj":"Tax:9606"},{"id":"A3203","pred":"tao:has_database_id","subj":"3203","obj":"MESH:C000657245"},{"id":"A3204","pred":"tao:has_database_id","subj":"3204","obj":"MESH:C536108"},{"id":"A3205","pred":"tao:has_database_id","subj":"3205","obj":"MESH:C536108"},{"id":"A3208","pred":"tao:has_database_id","subj":"3208","obj":"Gene:6999"},{"id":"A3209","pred":"tao:has_database_id","subj":"3209","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Table 3 Strategies to Isolate SARS-CoV-2 Neutralizing Antibodies\nAb Source Clone Target Type of Antibody Neutralization Inhibition of ACE2/RBD Binding Reference\nDerived from COVID-19 patients 31B532D4 RBD human monoclonal yes yes Chen et al., 2020a\nP2C-2F6P2C-1F11 RBD human monoclonal yes yes Ju et al., 2020\nDerived from SARS-CoV-1 patients CR3022 RBD human monoclonal no no Tian et al., 2020b, Yuan et al., 2020, Giron et al., 2020\nS309 RBD human monoclonal yes no Pinto et al., 2020\nDerived from SARS-CoV-1 or MERS-CoV-1 animal models R325R302R007 S1 rabbit monoclonal yes no Sun et al., 2020\n47D11 S1 recombinant human monoclonal (derived from hybridomas of immunized transgenic H2L2 mice) yes no Wang et al., 2020a\nVHH-72-Fc S Fc-fusion derived from camelids VHH yes yes Wrapp et al., 2020\nS polyclonal mouse antibodies yes N/A Walls et al., 2020, Yuan et al., 2020\nOther ACE2-Fc RBD ACE2-Fc fusion yes N/A Lei et al., 2020a, Li et al., 2020d\nRBD-Fc ACE2 RBD-Fc fusion yes N/A Li et al., 2020d\nN3130 S1 human monoclonal single domain antibody isolated by phage display yes no Wu et al., 2020c\nIVIg N/A polyclonal human IVIg N/A N/A Díez et al., 2020, Shao et al., 2020\nF(ab′)2 RBD horse polyclonal yes N/A Pan et al., 2020\nN/A, not assessed."}

{"project":"LitCovid-sentences","denotations":[{"id":"T561","span":{"begin":0,"end":64},"obj":"Sentence"},{"id":"T562","span":{"begin":65,"end":160},"obj":"Sentence"},{"id":"T563","span":{"begin":161,"end":248},"obj":"Sentence"},{"id":"T564","span":{"begin":249,"end":309},"obj":"Sentence"},{"id":"T565","span":{"begin":310,"end":434},"obj":"Sentence"},{"id":"T566","span":{"begin":435,"end":486},"obj":"Sentence"},{"id":"T567","span":{"begin":487,"end":596},"obj":"Sentence"},{"id":"T568","span":{"begin":597,"end":720},"obj":"Sentence"},{"id":"T569","span":{"begin":721,"end":795},"obj":"Sentence"},{"id":"T570","span":{"begin":796,"end":871},"obj":"Sentence"},{"id":"T571","span":{"begin":872,"end":948},"obj":"Sentence"},{"id":"T572","span":{"begin":949,"end":999},"obj":"Sentence"},{"id":"T573","span":{"begin":1000,"end":1098},"obj":"Sentence"},{"id":"T574","span":{"begin":1099,"end":1174},"obj":"Sentence"},{"id":"T575","span":{"begin":1175,"end":1228},"obj":"Sentence"},{"id":"T576","span":{"begin":1229,"end":1247},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Table 3 Strategies to Isolate SARS-CoV-2 Neutralizing Antibodies\nAb Source Clone Target Type of Antibody Neutralization Inhibition of ACE2/RBD Binding Reference\nDerived from COVID-19 patients 31B532D4 RBD human monoclonal yes yes Chen et al., 2020a\nP2C-2F6P2C-1F11 RBD human monoclonal yes yes Ju et al., 2020\nDerived from SARS-CoV-1 patients CR3022 RBD human monoclonal no no Tian et al., 2020b, Yuan et al., 2020, Giron et al., 2020\nS309 RBD human monoclonal yes no Pinto et al., 2020\nDerived from SARS-CoV-1 or MERS-CoV-1 animal models R325R302R007 S1 rabbit monoclonal yes no Sun et al., 2020\n47D11 S1 recombinant human monoclonal (derived from hybridomas of immunized transgenic H2L2 mice) yes no Wang et al., 2020a\nVHH-72-Fc S Fc-fusion derived from camelids VHH yes yes Wrapp et al., 2020\nS polyclonal mouse antibodies yes N/A Walls et al., 2020, Yuan et al., 2020\nOther ACE2-Fc RBD ACE2-Fc fusion yes N/A Lei et al., 2020a, Li et al., 2020d\nRBD-Fc ACE2 RBD-Fc fusion yes N/A Li et al., 2020d\nN3130 S1 human monoclonal single domain antibody isolated by phage display yes no Wu et al., 2020c\nIVIg N/A polyclonal human IVIg N/A N/A Díez et al., 2020, Shao et al., 2020\nF(ab′)2 RBD horse polyclonal yes N/A Pan et al., 2020\nN/A, not assessed."}