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PMC:7200337 / 94680-96183 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
32505227-32155444-46575426 175-179 32155444 denotes 2020
T4350 175-179 32155444 denotes 2020

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T736 297-302 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T737 626-634 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T738 803-808 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T739 973-981 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T740 1030-1038 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T98 803-808 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T541 18-26 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T542 69-77 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T543 80-89 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T544 662-670 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T545 941-949 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T546 1047-1055 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T547 1120-1128 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T548 1243-1251 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T549 1324-1332 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T550 1442-1451 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T974 295-302 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T975 843-845 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T976 939-940 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T977 1015-1016 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T978 1211-1212 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T979 1277-1278 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T980 1279-1288 http://purl.obolibrary.org/obo/CLO_0036932 denotes hybridoma
T981 1299-1300 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T982 1362-1363 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T983 1476-1477 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T210 288-294 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T211 626-658 http://purl.obolibrary.org/obo/GO_0097282 denotes antibody-mediated neutralization

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3106 0-4 Chemical denotes nAbs
3107 18-26 Disease denotes COVID-19 MESH:C000657245
3134 597-601 Gene denotes ACE2 Gene:59272
3135 717-721 Gene denotes ACE2 Gene:59272
3136 891-895 Gene denotes ACE2 Gene:59272
3137 1150-1154 Gene denotes ACE2 Gene:59272
3138 1425-1427 Gene denotes to Gene:6999
3139 1413-1415 Gene denotes to Gene:6999
3140 1106-1108 Gene denotes to Gene:6999
3141 840-842 Gene denotes to Gene:6999
3142 680-682 Gene denotes to Gene:6999
3143 353-355 Gene denotes to Gene:6999
3144 235-237 Gene denotes to Gene:6999
3145 36-44 Species denotes Patients Tax:9606
3146 662-672 Species denotes SARS-CoV-2 Tax:2697049
3147 825-833 Species denotes patients Tax:9606
3148 941-949 Species denotes SARS-CoV Tax:694009
3149 1047-1057 Species denotes SARS-CoV-2 Tax:2697049
3150 1120-1130 Species denotes SARS-CoV-2 Tax:2697049
3151 1243-1253 Species denotes SARS-CoV-2 Tax:2697049
3152 1324-1334 Species denotes SARS-CoV-2 Tax:2697049
3153 1416-1424 Species denotes patients Tax:9606
3154 364-375 Species denotes recombinant Tax:575864
3155 118-122 Chemical denotes nAbs
3156 251-255 Chemical denotes nAbs
3157 1312-1315 Chemical denotes nAb
3158 69-89 Disease denotes SARS-CoV-2 infection MESH:C000657245
3159 1442-1451 Disease denotes infection MESH:D007239

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T544 0-35 Sentence denotes nAbs Derived from COVID-19 Patients
T545 36-221 Sentence denotes Patients who have recovered from SARS-CoV-2 infection are one potential source of nAbs (Chen et al., 2020a, Ju et al., 2020, Walls et al., 2020, Wölfel et al., 2020, Yuan et al., 2020).
T546 222-452 Sentence denotes In an effort to obtain these nAbs, scientists sorted RBD-specific memory B cells and cloned their heavy and light variable regions to express recombinant forms of the corresponding antibodies (Chen et al., 2020a, Ju et al., 2020).
T547 453-614 Sentence denotes Four of the antibodies produced in these studies (31B5, 32D4, P2C-2F6, P2C-1F11) showed high neutralizing potential in vitro, and all inhibited ACE2-RBD binding.
T548 615-734 Sentence denotes Successful antibody-mediated neutralization of SARS-CoV-2 seemed to be dependent on the inhibition of ACE2/RBD binding.
T549 735-929 Sentence denotes However, Chen et al. showed that nearly all antibodies derived from serum of 26 recovered patients bound to S1 and RBD, with only three actually inhibiting ACE2/RBD binding (Chen et al., 2020a).
T550 930-1167 Sentence denotes Of note, a SARS-CoV-1-derived neutralizing antibody (47D11) (Wang et al., 2020a) and a single-chain antibody against SARS-CoV-2 (n3130) (Wu et al., 2020c) have also been shown to neutralize SARS-CoV-2 without inhibiting ACE2/RBD binding.
T551 1168-1258 Sentence denotes Thus, blocking this interaction may not be a prerequisite for an effective SARS-CoV-2 nAb.
T552 1259-1503 Sentence denotes The generation of a hybridoma producing a monoclonal nAb against SARS-CoV-2 provides the potential for a therapeutic Ab that can be directly administered to patients to block ongoing infection and potentially even as a prophylactic (Figure 6D).