PMC:7200337 / 93461-93973
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T727 | 49-57 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T728 | 63-72 | Body_part | denotes | chemokine | http://purl.org/sig/ont/fma/fma241981 |
T729 | 114-117 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
T730 | 127-136 | Body_part | denotes | chemokine | http://purl.org/sig/ont/fma/fma241981 |
T731 | 305-310 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
T732 | 419-427 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T531 | 215-223 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T532 | 224-227 | Disease | denotes | CRS | http://purl.obolibrary.org/obo/MONDO_0007399|http://purl.obolibrary.org/obo/MONDO_0017361 |
T534 | 314-322 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T535 | 474-482 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T965 | 24-33 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
T966 | 261-271 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T967 | 305-310 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T306 | 19-21 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T308 | 104-106 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T310 | 111-113 | Chemical | denotes | GM | http://purl.obolibrary.org/obo/CHEBI_74120 |
T311 | 236-238 | Chemical | denotes | 6C | http://purl.obolibrary.org/obo/CHEBI_27594 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T206 | 24-41 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathway |
T207 | 24-33 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
T208 | 104-109 | http://purl.obolibrary.org/obo/GO_0004908 | denotes | IL-1R |
T209 | 250-271 | http://purl.obolibrary.org/obo/GO_0006956 | denotes | complement activation |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
3064 | 19-23 | Gene | denotes | IL-6 | Gene:3569 |
3065 | 104-109 | Gene | denotes | IL-1R | Gene:3554 |
3066 | 111-117 | Gene | denotes | GM-CSF | Gene:1437 |
3067 | 146-150 | Gene | denotes | CCR5 | Gene:1234 |
3068 | 404-407 | Gene | denotes | C5a | Gene:728 |
3069 | 282-284 | Gene | denotes | to | Gene:6999 |
3070 | 205-207 | Gene | denotes | to | Gene:6999 |
3071 | 12-14 | Gene | denotes | to | Gene:6999 |
3072 | 323-331 | Species | denotes | patients | Tax:9606 |
3073 | 483-491 | Species | denotes | patients | Tax:9606 |
3074 | 215-223 | Disease | denotes | COVID-19 | MESH:C000657245 |
3075 | 314-322 | Disease | denotes | COVID-19 | MESH:C000657245 |
3076 | 459-473 | Disease | denotes | critically ill | MESH:D016638 |
3077 | 474-482 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T537 | 0-240 | Sentence | denotes | In addition to the IL-6 signaling pathway, other cytokine- and chemokine-associated elements, including IL-1R, GM-CSF, and the chemokine receptor CCR5, have been proposed as potential targets for blockade to manage COVID-19 CRS (Figure 6C). |
T538 | 241-332 | Sentence | denotes | Finally, complement activation was shown to be overactivated in lungs of COVID-19 patients. |
T539 | 333-512 | Sentence | denotes | Although results from the randomized trial are not yet published, anti-C5a monoclonal antibody therapy showed benefits in two critically ill COVID-19 patients (Gao et al., 2020d). |