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PMC:7200337 / 85463-87514 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
32505227-32272008-46575401 1585-1589 32272008 denotes 2020
32505227-32122468-46575402 1646-1650 32122468 denotes 2020
T29195 1585-1589 32272008 denotes 2020
T83732 1646-1650 32122468 denotes 2020

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T695 645-647 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T696 1419-1424 Body_part denotes chest http://purl.org/sig/ont/fma/fma9576
T697 1733-1735 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T94 1419-1424 Body_part denotes chest http://purl.obolibrary.org/obo/UBERON_0001443

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T495 397-401 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T496 980-988 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T497 1068-1072 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T498 1743-1751 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T920 726-727 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T921 919-920 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T922 1261-1262 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T923 1419-1424 http://www.ebi.ac.uk/efo/EFO_0000965 denotes chest
T924 1952-1954 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T925 2042-2044 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T257 4-9 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T258 102-120 Chemical denotes methylprednisolone http://purl.obolibrary.org/obo/CHEBI_6888
T259 349-352 Chemical denotes CSs http://purl.obolibrary.org/obo/CHEBI_50858
T260 415-433 Chemical denotes methylprednisolone http://purl.obolibrary.org/obo/CHEBI_6888
T261 558-561 Chemical denotes CSs http://purl.obolibrary.org/obo/CHEBI_50858
T262 645-647 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462
T263 656-661 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T264 800-814 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T265 937-945 Chemical denotes adjuvant http://purl.obolibrary.org/obo/CHEBI_60809
T266 946-949 Chemical denotes CSs http://purl.obolibrary.org/obo/CHEBI_50858
T267 1117-1120 Chemical denotes CSs http://purl.obolibrary.org/obo/CHEBI_50858
T268 1144-1146 Chemical denotes Lu http://purl.obolibrary.org/obo/CHEBI_33382
T269 1325-1343 Chemical denotes methylprednisolone http://purl.obolibrary.org/obo/CHEBI_6888
T270 1480-1486 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T271 1733-1735 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462
T272 1918-1921 Chemical denotes CSs http://purl.obolibrary.org/obo/CHEBI_50858
T273 1981-1996 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T50 1437-1442 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2839 1733-1735 Gene denotes CS Gene:1431
2840 645-647 Gene denotes CS Gene:1431
2841 1878-1880 Gene denotes to Gene:6999
2842 1434-1436 Gene denotes to Gene:6999
2843 834-836 Gene denotes to Gene:6999
2844 608-610 Gene denotes to Gene:6999
2845 579-581 Gene denotes to Gene:6999
2846 332-334 Gene denotes to Gene:6999
2847 304-306 Gene denotes to Gene:6999
2848 53-55 Gene denotes to Gene:6999
2849 80-88 Species denotes patients Tax:9606
2850 274-282 Species denotes patients Tax:9606
2851 383-391 Species denotes patients Tax:9606
2852 536-544 Species denotes patients Tax:9606
2853 762-770 Species denotes patients Tax:9606
2854 957-965 Species denotes patients Tax:9606
2855 1054-1062 Species denotes patients Tax:9606
2856 1290-1298 Species denotes patients Tax:9606
2857 1932-1940 Species denotes patients Tax:9606
2858 102-120 Chemical denotes methylprednisolone MESH:D008775
2859 415-433 Chemical denotes methylprednisolone MESH:D008775
2860 1325-1343 Chemical denotes methylprednisolone MESH:D008775
2861 1480-1486 Chemical denotes oxygen MESH:D010100
2862 397-401 Disease denotes ARDS MESH:D012128
2863 446-455 Disease denotes mortality MESH:D003643
2864 980-988 Disease denotes COVID-19 MESH:C000657245
2865 1022-1031 Disease denotes mortality MESH:D003643
2866 1068-1072 Disease denotes ARDS MESH:D012128
2867 1245-1254 Disease denotes mortality MESH:D003643
2868 1437-1442 Disease denotes fever MESH:D005334
2869 1743-1751 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T489 0-218 Sentence denotes One group reported no significant difference in time to viral clearance between patients who received methylprednisolone orally (mild disease) or intravenously (i.v.) (severe) and those who did not (Fang et al., 2020).
T490 219-480 Sentence denotes Retrospective studies from groups in China report that patients who were transferred to the ICU were less likely to have received CSs (Wang et al., 2020b) and that patients with ARDS who received methylprednisolone had reduced mortality risk (Wu et al., 2020a).
T491 481-725 Sentence denotes In contrast, another retrospective analysis found that patients who received CSs were more likely to have either been admitted to the ICU or perished, although the CS-treated group also had significantly more comorbidities (Wang et al., 2020c).
T492 726-918 Sentence denotes A smaller observational study of 31 patients found no association between corticosteroid treatment and time to viral clearance, length of hospital stay, or symptom duration (Zha et al., 2020).
T493 919-1162 Sentence denotes A larger study of adjuvant CSs in 244 patients with critical COVID-19 found no association with 28-day mortality; subgroup analysis of patients with ARDS found no association between treatment with CSs and clinical outcomes (Lu et al., 2020b).
T494 1163-1260 Sentence denotes They also found that increased dosage was significantly associated with increased mortality risk.
T495 1261-1516 Sentence denotes A retrospective review of 46 patients, of whom 26 received i.v. methylprednisolone, found that early, low-dose administration significantly improved SpO2 and chest CT, time to fever resolution, and time on supplemental oxygen therapy (Wang et al., 2020h).
T496 1517-1704 Sentence denotes Others have published perspectives in support of early (Lee et al., 2020) and short-term, low-dose administration (Shang et al., 2020) based on anecdotal evidence but not clinical trials.
T497 1705-1851 Sentence denotes Most of the current data on CS use in COVID-19 are from observational studies and support either modest clinical benefit or no meaningful effects.
T498 1852-2051 Sentence denotes Larger RCTs are necessary to understand the risks and benefits of CSs for these patients; there are 22 trials evaluating various corticosteroids registered on ClinicalTrials.gov as of April 27, 2020.