PMC:7200337 / 84416-85462 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7200337","sourcedb":"PMC","sourceid":"7200337","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7200337","text":"Because of their anti-inflammatory activity, corticosteroids (CSs) are an adjuvant therapy for ARDS and cytokine storm. However, the broad immunosuppression mediated by CS does raise the possibility that treatment could interfere with the development of a proper immune response against the virus. A meta-analysis of 5,270 patients with MERS-CoV, SARS-CoV-1, or SARS-CoV-2 infection found that CS treatment was associated with higher mortality rate (Yang et al., 2020c). A more recent meta-analysis of only SARS-CoV-2 infection assessed 2,636 patients and found no mortality difference associated with CS treatment, including in a subset of patients with ARDS (Gangopadhyay et al., 2020). Other studies have reported associations with delayed viral clearance and increased complications in SARS and MERS patients (Sanders et al., 2020). In fact, the interim guidelines updated by the WHO on March 13, 2020 advise against giving systemic corticosteroids for COVID-19 (World Health Organization, 2020a). Yet, new data from COVID-19 are conflicting.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T691","span":{"begin":104,"end":112},"obj":"Body_part"},{"id":"T692","span":{"begin":169,"end":171},"obj":"Body_part"},{"id":"T693","span":{"begin":394,"end":396},"obj":"Body_part"},{"id":"T694","span":{"begin":602,"end":604},"obj":"Body_part"}],"attributes":[{"id":"A691","pred":"fma_id","subj":"T691","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A692","pred":"fma_id","subj":"T692","obj":"http://purl.org/sig/ont/fma/fma284995"},{"id":"A693","pred":"fma_id","subj":"T693","obj":"http://purl.org/sig/ont/fma/fma284995"},{"id":"A694","pred":"fma_id","subj":"T694","obj":"http://purl.org/sig/ont/fma/fma284995"},{"subj":"T691","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T692","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T693","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T694","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T485","span":{"begin":95,"end":99},"obj":"Disease"},{"id":"T486","span":{"begin":347,"end":355},"obj":"Disease"},{"id":"T487","span":{"begin":362,"end":370},"obj":"Disease"},{"id":"T488","span":{"begin":373,"end":382},"obj":"Disease"},{"id":"T489","span":{"begin":507,"end":515},"obj":"Disease"},{"id":"T490","span":{"begin":518,"end":527},"obj":"Disease"},{"id":"T491","span":{"begin":655,"end":659},"obj":"Disease"},{"id":"T492","span":{"begin":790,"end":794},"obj":"Disease"},{"id":"T493","span":{"begin":957,"end":965},"obj":"Disease"},{"id":"T494","span":{"begin":1021,"end":1029},"obj":"Disease"}],"attributes":[{"id":"A485","pred":"mondo_id","subj":"T485","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A486","pred":"mondo_id","subj":"T486","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A487","pred":"mondo_id","subj":"T487","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A488","pred":"mondo_id","subj":"T488","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A489","pred":"mondo_id","subj":"T489","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A490","pred":"mondo_id","subj":"T490","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A491","pred":"mondo_id","subj":"T491","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A492","pred":"mondo_id","subj":"T492","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A493","pred":"mondo_id","subj":"T493","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A494","pred":"mondo_id","subj":"T494","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T485","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T486","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T487","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T488","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T489","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T490","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T491","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T492","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T493","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T494","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T913","span":{"begin":35,"end":43},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T914","span":{"begin":254,"end":255},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T915","span":{"begin":291,"end":296},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T916","span":{"begin":298,"end":299},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T917","span":{"begin":471,"end":472},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T918","span":{"begin":629,"end":630},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T919","span":{"begin":980,"end":992},"obj":"http://purl.obolibrary.org/obo/OBI_0000245"}],"attributes":[{"subj":"T913","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T914","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T915","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T916","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T917","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T918","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T919","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T250","span":{"begin":45,"end":60},"obj":"Chemical"},{"id":"T251","span":{"begin":62,"end":65},"obj":"Chemical"},{"id":"T252","span":{"begin":74,"end":82},"obj":"Chemical"},{"id":"T253","span":{"begin":169,"end":171},"obj":"Chemical"},{"id":"T254","span":{"begin":394,"end":396},"obj":"Chemical"},{"id":"T255","span":{"begin":602,"end":604},"obj":"Chemical"},{"id":"T256","span":{"begin":937,"end":952},"obj":"Chemical"}],"attributes":[{"id":"A250","pred":"chebi_id","subj":"T250","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A251","pred":"chebi_id","subj":"T251","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A252","pred":"chebi_id","subj":"T252","obj":"http://purl.obolibrary.org/obo/CHEBI_60809"},{"id":"A253","pred":"chebi_id","subj":"T253","obj":"http://purl.obolibrary.org/obo/CHEBI_73462"},{"id":"A254","pred":"chebi_id","subj":"T254","obj":"http://purl.obolibrary.org/obo/CHEBI_73462"},{"id":"A255","pred":"chebi_id","subj":"T255","obj":"http://purl.obolibrary.org/obo/CHEBI_73462"},{"id":"A256","pred":"chebi_id","subj":"T256","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"subj":"T250","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T251","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T252","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T253","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T254","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T255","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T256","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T49","span":{"begin":104,"end":118},"obj":"Phenotype"}],"attributes":[{"id":"A49","pred":"hp_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T195","span":{"begin":263,"end":278},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"attributes":[{"subj":"T195","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"2791","span":{"begin":394,"end":396},"obj":"Gene"},{"id":"2792","span":{"begin":169,"end":171},"obj":"Gene"},{"id":"2793","span":{"begin":602,"end":604},"obj":"Gene"},{"id":"2794","span":{"begin":323,"end":331},"obj":"Species"},{"id":"2795","span":{"begin":337,"end":345},"obj":"Species"},{"id":"2796","span":{"begin":347,"end":355},"obj":"Species"},{"id":"2797","span":{"begin":543,"end":551},"obj":"Species"},{"id":"2798","span":{"begin":641,"end":649},"obj":"Species"},{"id":"2799","span":{"begin":804,"end":812},"obj":"Species"},{"id":"2800","span":{"begin":95,"end":99},"obj":"Disease"},{"id":"2801","span":{"begin":362,"end":382},"obj":"Disease"},{"id":"2802","span":{"begin":434,"end":443},"obj":"Disease"},{"id":"2803","span":{"begin":507,"end":527},"obj":"Disease"},{"id":"2804","span":{"begin":565,"end":574},"obj":"Disease"},{"id":"2805","span":{"begin":655,"end":659},"obj":"Disease"},{"id":"2806","span":{"begin":957,"end":965},"obj":"Disease"},{"id":"2807","span":{"begin":1021,"end":1029},"obj":"Disease"}],"attributes":[{"id":"A2791","pred":"tao:has_database_id","subj":"2791","obj":"Gene:1431"},{"id":"A2792","pred":"tao:has_database_id","subj":"2792","obj":"Gene:1431"},{"id":"A2793","pred":"tao:has_database_id","subj":"2793","obj":"Gene:1431"},{"id":"A2794","pred":"tao:has_database_id","subj":"2794","obj":"Tax:9606"},{"id":"A2795","pred":"tao:has_database_id","subj":"2795","obj":"Tax:1335626"},{"id":"A2796","pred":"tao:has_database_id","subj":"2796","obj":"Tax:694009"},{"id":"A2797","pred":"tao:has_database_id","subj":"2797","obj":"Tax:9606"},{"id":"A2798","pred":"tao:has_database_id","subj":"2798","obj":"Tax:9606"},{"id":"A2799","pred":"tao:has_database_id","subj":"2799","obj":"Tax:9606"},{"id":"A2800","pred":"tao:has_database_id","subj":"2800","obj":"MESH:D012128"},{"id":"A2801","pred":"tao:has_database_id","subj":"2801","obj":"MESH:C000657245"},{"id":"A2802","pred":"tao:has_database_id","subj":"2802","obj":"MESH:D003643"},{"id":"A2803","pred":"tao:has_database_id","subj":"2803","obj":"MESH:C000657245"},{"id":"A2804","pred":"tao:has_database_id","subj":"2804","obj":"MESH:D003643"},{"id":"A2805","pred":"tao:has_database_id","subj":"2805","obj":"MESH:D012128"},{"id":"A2806","pred":"tao:has_database_id","subj":"2806","obj":"MESH:C000657245"},{"id":"A2807","pred":"tao:has_database_id","subj":"2807","obj":"MESH:C000657245"},{"subj":"2791","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2792","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2793","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2794","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2795","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2796","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2797","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2798","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2799","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2800","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2801","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2802","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2803","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2804","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2805","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2806","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2807","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T482","span":{"begin":0,"end":119},"obj":"Sentence"},{"id":"T483","span":{"begin":120,"end":297},"obj":"Sentence"},{"id":"T484","span":{"begin":298,"end":470},"obj":"Sentence"},{"id":"T485","span":{"begin":471,"end":688},"obj":"Sentence"},{"id":"T486","span":{"begin":689,"end":836},"obj":"Sentence"},{"id":"T487","span":{"begin":837,"end":1001},"obj":"Sentence"},{"id":"T488","span":{"begin":1002,"end":1046},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T482","pred":"source","obj":"LitCovid-sentences"},{"subj":"T483","pred":"source","obj":"LitCovid-sentences"},{"subj":"T484","pred":"source","obj":"LitCovid-sentences"},{"subj":"T485","pred":"source","obj":"LitCovid-sentences"},{"subj":"T486","pred":"source","obj":"LitCovid-sentences"},{"subj":"T487","pred":"source","obj":"LitCovid-sentences"},{"subj":"T488","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ecc993","default":true},{"id":"LitCovid-PD-MONDO","color":"#af93ec"},{"id":"LitCovid-PD-CLO","color":"#93ec95"},{"id":"LitCovid-PD-CHEBI","color":"#ec93aa"},{"id":"LitCovid-PD-HP","color":"#93c4ec"},{"id":"LitCovid-PD-GO-BP","color":"#deec93"},{"id":"LitCovid-PubTator","color":"#e093ec"},{"id":"LitCovid-sentences","color":"#93ecc6"}]}]}}