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PMC:7200337 / 78614-80684 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
32505227-14592603-46575390 389-393 14592603 denotes 2003
32505227-15351731-46575391 439-443 15351731 denotes 2004
32505227-16115318-46575392 461-465 16115318 denotes 2005
32505227-18753338-46575393 746-750 18753338 denotes 2008
32505227-26206937-46575394 763-767 26206937 denotes 2015
32505227-32034323-46575395 795-799 32034323 denotes 2020
T12810 389-393 14592603 denotes 2003
T15719 439-443 15351731 denotes 2004
T7708 461-465 16115318 denotes 2005
T13584 746-750 18753338 denotes 2008
T382 763-767 26206937 denotes 2015
T25901 795-799 32034323 denotes 2020

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T673 494-503 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T674 605-608 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T675 656-665 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T676 710-728 Body_part denotes regulatory T cells http://purl.org/sig/ont/fma/fma84070
T677 723-728 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T678 895-900 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T679 972-981 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T680 1291-1296 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T681 1741-1752 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T682 1775-1779 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T683 1911-1915 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T87 1775-1779 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T465 165-173 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T466 322-330 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T467 410-418 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T468 877-886 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T469 906-914 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T470 1324-1333 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T471 1650-1658 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T472 1794-1802 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T473 2036-2044 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T880 494-503 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T881 504-512 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T882 698-706 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T883 710-728 http://purl.obolibrary.org/obo/CL_0000815 denotes regulatory T cells
T884 895-900 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T885 1088-1091 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T886 1291-1296 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T887 1705-1706 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T888 1775-1779 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T889 1775-1779 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T890 1911-1915 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T891 1931-1936 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T34458 0-11 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T19395 22-28 Chemical denotes Action http://purl.obolibrary.org/obo/CHEBI_5133
T95030 54-65 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T96750 67-69 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T224 90-108 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T71512 180-185 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T65672 198-210 Chemical denotes antimalarial http://purl.obolibrary.org/obo/CHEBI_38068
T24844 293-304 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T74278 308-310 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T22436 360-370 Chemical denotes antivirals http://purl.obolibrary.org/obo/CHEBI_22587
T94688 468-470 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T25441 570-572 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T11180 582-589 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T38068 621-623 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T38248 940-942 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T24270 1126-1128 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T6292 1249-1254 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T237 1540-1545 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T238 1756-1759 Chemical denotes BAL http://purl.obolibrary.org/obo/CHEBI_64198

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T192 582-600 http://purl.obolibrary.org/obo/GO_0019882 denotes antigen processing
T193 1505-1521 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T194 1911-1926 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2561 0-11 Chemical denotes Chloroquine MESH:D002738
2602 666-670 Gene denotes TLR7 Gene:51284
2603 675-679 Gene denotes TLR9 Gene:54106
2604 1753-1755 Gene denotes to Gene:6999
2605 1626-1628 Gene denotes to Gene:6999
2606 1522-1524 Gene denotes to Gene:6999
2607 1479-1481 Gene denotes To Gene:6999
2608 536-538 Gene denotes to Gene:6999
2609 319-321 Gene denotes to Gene:6999
2610 410-418 Species denotes SARS-CoV Tax:694009
2611 906-916 Species denotes SARS-CoV-2 Tax:2697049
2612 1650-1660 Species denotes SARS-CoV-2 Tax:2697049
2613 1670-1678 Species denotes patients Tax:9606
2614 1803-1811 Species denotes patients Tax:9606
2615 2036-2046 Species denotes SARS-CoV-2 Tax:2697049
2616 54-65 Chemical denotes Chloroquine MESH:D002738
2617 67-69 Chemical denotes CQ MESH:D002738
2618 90-108 Chemical denotes hydroxychloroquine MESH:D006886
2619 110-113 Chemical denotes HCQ MESH:D006886
2620 308-310 Chemical denotes CQ MESH:D002738
2621 315-318 Chemical denotes HCQ MESH:D006886
2622 468-470 Chemical denotes CQ MESH:D002738
2623 475-478 Chemical denotes HCQ MESH:D006886
2624 570-572 Chemical denotes CQ MESH:D002738
2625 940-942 Chemical denotes CQ MESH:D002738
2626 947-950 Chemical denotes HCQ MESH:D006886
2627 1126-1128 Chemical denotes CQ MESH:D002738
2628 1149-1152 Chemical denotes HCQ MESH:D006886
2629 1302-1305 Chemical denotes HCQ MESH:D006886
2630 1422-1425 Chemical denotes HCQ MESH:D006886
2631 1613-1616 Chemical denotes HCQ MESH:D006886
2632 1721-1724 Chemical denotes HCQ MESH:D006886
2633 1957-1960 Chemical denotes HCQ MESH:D006886
2634 2014-2017 Chemical denotes HCQ MESH:D006886
2635 165-173 Disease denotes COVID-19 MESH:C000657245
2636 256-278 Disease denotes rheumatologic diseases MESH:D012216
2637 322-330 Disease denotes COVID-19 MESH:C000657245
2638 877-886 Disease denotes infection MESH:D007239
2639 1282-1290 Disease denotes infected MESH:D007239
2640 1324-1333 Disease denotes infection MESH:D007239
2641 1794-1802 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T446 0-12 Sentence denotes Chloroquine:
T447 13-53 Sentence denotes Modes of Action and Immunological Impact
T448 54-174 Sentence denotes Chloroquine (CQ) and its derivative hydroxychloroquine (HCQ) have gained traction as possible therapeutics for COVID-19.
T449 175-279 Sentence denotes Both drugs are used as antimalarial agents and as immunomodulatory therapies for rheumatologic diseases.
T450 280-467 Sentence denotes However, the application of CQ and HCQ to COVID-19 stems from their past use as antivirals (Savarino et al., 2003), including for SARS-CoV-1 (Keyaerts et al., 2004, Vincent et al., 2005).
T451 468-569 Sentence denotes CQ and HCQ interfere with lysosomal activity and have been reported to have immunomodulatory effects.
T452 570-843 Sentence denotes CQ augments antigen processing for MHC class I and II presentation, directly inhibits endosomal TLR7 and TLR9, and enhances the activity of regulatory T cells (Garulli et al., 2008, Lo et al., 2015, Schrezenmeier and Dörner, 2020, Thomé et al., 2013a, Thomé et al., 2013b).
T453 844-1072 Sentence denotes Early studies involving in vitro infection of host cells with SARS-CoV-2 demonstrated that both CQ and HCQ significantly impact endosomal maturation, resulting in increased sequestration of virion particles within endolysosomes.
T454 1073-1235 Sentence denotes However, there has been conflicting evidence whether CQ is more potent than HCQ in reducing viral load (Liu et al., 2020d, Wang et al., 2020b, Yao et al., 2020a).
T455 1236-1478 Sentence denotes Notably, one group reported that treatment of infected cells with HCQ before and during infection significantly reduced viral load, suggesting that combined prophylactic and therapeutic HCQ use yields maximum efficacy (Clementi et al., 2020).
T456 1479-1834 Sentence denotes To better understand host immune responses to treatment, one group compared bulk transcriptomic changes in primary PBMCs treated with HCQ for 24 h to PBMCs from confirmed SARS-CoV-2 positive patients and controls, followed by a comparison of HCQ-treated primary macrophages to BAL and postmortem lung biopsies from COVID-19 patients (Corley et al., 2020).
T457 1835-1971 Sentence denotes Across all comparisons, there was minimal overlap between host differential gene expression and genes altered by in vitro HCQ treatment.
T458 1972-2070 Sentence denotes Thus, the potential mechanistic action of HCQ in the context of SARS-CoV-2 remains poorly defined.