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PMC:7200337 / 72116-73067 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T648 643-646 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T649 828-833 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T430 82-90 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T431 189-197 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T432 374-382 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T433 610-618 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T434 848-856 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T824 93-98 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T825 411-412 http://purl.obolibrary.org/obo/CLO_0001020 denotes Å
T826 457-465 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T827 811-819 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T828 823-827 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T829 823-827 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T830 828-833 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T136 12-21 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T1987 159-163 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T138 347-357 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T23982 580-599 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T79279 589-599 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T142 643-666 Chemical denotes HIV protease inhibitors http://purl.obolibrary.org/obo/CHEBI_35660
T47039 647-666 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T57695 656-666 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T146 668-678 Chemical denotes nelfinavir http://purl.obolibrary.org/obo/CHEBI_7496
T62961 680-689 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T148 691-700 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T64327 702-712 Chemical denotes saquinavir http://purl.obolibrary.org/obo/CHEBI_63621
T150 714-724 Chemical denotes atazanavir http://purl.obolibrary.org/obo/CHEBI_37924
T67444 726-736 Chemical denotes tipranavir http://purl.obolibrary.org/obo/CHEBI_63628
T152 738-748 Chemical denotes amprenavir http://purl.obolibrary.org/obo/CHEBI_40050
T23276 750-759 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T12434 765-774 Chemical denotes indinavir http://purl.obolibrary.org/obo/CHEBI_44032
T52451 801-810 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T96509 888-898 Chemical denotes nelfinavir http://purl.obolibrary.org/obo/CHEBI_7496

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T182 922-950 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibiting viral replication
T183 933-950 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T184 933-950 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2313 138-142 Gene denotes Mpro Gene:8673700
2314 280-284 Gene denotes Mpro Gene:8673700
2315 600-602 Gene denotes to Gene:6999
2316 567-569 Gene denotes to Gene:6999
2317 385-389 Gene denotes Mpro Gene:8673700
2318 200-204 Gene denotes Mpro Gene:8673700
2319 82-92 Species denotes SARS-CoV-2 Tax:2697049
2320 189-199 Species denotes SARS-CoV-2 Tax:2697049
2321 374-384 Species denotes SARS-CoV-2 Tax:2697049
2322 610-620 Species denotes SARS-CoV-2 Tax:2697049
2323 848-858 Species denotes SARS-CoV-2 Tax:2697049
2324 668-678 Chemical denotes nelfinavir MESH:D019888
2325 680-689 Chemical denotes lopinavir MESH:D061466
2326 691-700 Chemical denotes ritonavir MESH:D019438
2327 702-712 Chemical denotes saquinavir MESH:D019258
2328 714-724 Chemical denotes atazanavir MESH:D000069446
2329 726-736 Chemical denotes tipranavir MESH:C107201
2330 738-748 Chemical denotes amprenavir MESH:C095108
2331 750-759 Chemical denotes darunavir MESH:D000069454
2332 765-774 Chemical denotes indinavir MESH:D019469
2333 888-898 Chemical denotes nelfinavir MESH:D019888
2334 502-510 Disease denotes toxicity MESH:D064420
2335 834-842 Disease denotes infected MESH:D007239

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T403 0-144 Sentence denotes Much of the antiviral computational and experimental data currently available for SARS-CoV-2 focus on targeting the 3CL or Main protease (Mpro).
T404 145-304 Sentence denotes Two prominent drug candidates targeting the SARS-CoV-2 Mpro were designed and synthesized by analyzing the substrate binding pocket of Mpro (Dai et al., 2020).
T405 305-413 Sentence denotes The X-ray crystal structures of the novel inhibitors in complex with SARS-CoV-2 Mpro were resolved at 1.5 Å.
T406 414-538 Sentence denotes Both compounds showed good pharmacokinetic activity in vitro, and one exhibited limited toxicity in vivo (Dai et al., 2020).
T407 539-628 Sentence denotes Multiple studies also aimed to repurpose protease inhibitors to reduce SARS-CoV-2 titers.
T408 629-951 Sentence denotes Nine existing HIV protease inhibitors (nelfinavir, lopinavir, ritonavir, saquinavir, atazanavir, tipranavir, amprenavir, darunavir, and indinavir) were evaluated for their antiviral activity in Vero cells infected with SARS-CoV-2 (Yamamoto et al., 2020), and nelfinavir was the most potent at inhibiting viral replication.