PMC:7200337 / 71348-71574 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T645","span":{"begin":63,"end":73},"obj":"Body_part"}],"attributes":[{"id":"A645","pred":"fma_id","subj":"T645","obj":"http://purl.org/sig/ont/fma/fma82773"}],"text":"Further, an inhibitor of host DHODH, a rate-limiting enzyme in pyrimidine synthesis, was able to inhibit SARS-CoV-2 growth in vitro with greater efficacy than remdesivir or chloroquine (Wang et al., 2020e, Xiong et al., 2020)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T426","span":{"begin":105,"end":113},"obj":"Disease"}],"attributes":[{"id":"A426","pred":"mondo_id","subj":"T426","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Further, an inhibitor of host DHODH, a rate-limiting enzyme in pyrimidine synthesis, was able to inhibit SARS-CoV-2 growth in vitro with greater efficacy than remdesivir or chloroquine (Wang et al., 2020e, Xiong et al., 2020)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T817","span":{"begin":37,"end":38},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Further, an inhibitor of host DHODH, a rate-limiting enzyme in pyrimidine synthesis, was able to inhibit SARS-CoV-2 growth in vitro with greater efficacy than remdesivir or chloroquine (Wang et al., 2020e, Xiong et al., 2020)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T67115","span":{"begin":12,"end":21},"obj":"Chemical"},{"id":"T95482","span":{"begin":63,"end":73},"obj":"Chemical"},{"id":"T127","span":{"begin":159,"end":169},"obj":"Chemical"},{"id":"T52801","span":{"begin":173,"end":184},"obj":"Chemical"}],"attributes":[{"id":"A39343","pred":"chebi_id","subj":"T67115","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A38094","pred":"chebi_id","subj":"T95482","obj":"http://purl.obolibrary.org/obo/CHEBI_16898"},{"id":"A44638","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_145994"},{"id":"A57022","pred":"chebi_id","subj":"T52801","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"}],"text":"Further, an inhibitor of host DHODH, a rate-limiting enzyme in pyrimidine synthesis, was able to inhibit SARS-CoV-2 growth in vitro with greater efficacy than remdesivir or chloroquine (Wang et al., 2020e, Xiong et al., 2020)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T178","span":{"begin":74,"end":83},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T179","span":{"begin":116,"end":122},"obj":"http://purl.obolibrary.org/obo/GO_0040007"}],"text":"Further, an inhibitor of host DHODH, a rate-limiting enzyme in pyrimidine synthesis, was able to inhibit SARS-CoV-2 growth in vitro with greater efficacy than remdesivir or chloroquine (Wang et al., 2020e, Xiong et al., 2020)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"2260","span":{"begin":30,"end":35},"obj":"Gene"},{"id":"2264","span":{"begin":94,"end":96},"obj":"Gene"},{"id":"2269","span":{"begin":105,"end":115},"obj":"Species"},{"id":"2280","span":{"begin":63,"end":73},"obj":"Chemical"},{"id":"2281","span":{"begin":159,"end":169},"obj":"Chemical"},{"id":"2282","span":{"begin":173,"end":184},"obj":"Chemical"}],"attributes":[{"id":"A2260","pred":"tao:has_database_id","subj":"2260","obj":"Gene:1723"},{"id":"A2264","pred":"tao:has_database_id","subj":"2264","obj":"Gene:6999"},{"id":"A2269","pred":"tao:has_database_id","subj":"2269","obj":"Tax:2697049"},{"id":"A2280","pred":"tao:has_database_id","subj":"2280","obj":"MESH:C030986"},{"id":"A2281","pred":"tao:has_database_id","subj":"2281","obj":"MESH:C000606551"},{"id":"A2282","pred":"tao:has_database_id","subj":"2282","obj":"MESH:D002738"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Further, an inhibitor of host DHODH, a rate-limiting enzyme in pyrimidine synthesis, was able to inhibit SARS-CoV-2 growth in vitro with greater efficacy than remdesivir or chloroquine (Wang et al., 2020e, Xiong et al., 2020)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T399","span":{"begin":0,"end":226},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Further, an inhibitor of host DHODH, a rate-limiting enzyme in pyrimidine synthesis, was able to inhibit SARS-CoV-2 growth in vitro with greater efficacy than remdesivir or chloroquine (Wang et al., 2020e, Xiong et al., 2020)."}