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PMC:7200337 / 70983-72094 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
32505227-28659436-46575383 358-362 28659436 denotes 2017
T24626 358-362 28659436 denotes 2017

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T642 104-107 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T643 253-257 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T644 337-340 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T645 428-438 Body_part denotes pyrimidine http://purl.org/sig/ont/fma/fma82773
T646 1070-1086 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T647 1081-1086 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T84 253-257 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T423 161-169 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T424 258-264 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T425 287-295 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T426 470-478 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T427 756-764 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T428 938-947 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T429 1043-1051 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T811 26-27 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T812 75-83 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T813 98-103 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T814 108-115 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T815 253-257 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T816 253-257 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T817 402-403 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T818 605-606 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T819 971-976 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T820 1057-1062 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T821 1063-1069 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T822 1070-1080 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T823 1081-1086 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T99513 44-53 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T54847 65-74 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T123 177-191 Chemical denotes ribonucleoside http://purl.obolibrary.org/obo/CHEBI_18254
T53505 223-226 Chemical denotes NHC http://purl.obolibrary.org/obo/CHEBI_51369
T67115 377-386 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T95482 428-438 Chemical denotes pyrimidine http://purl.obolibrary.org/obo/CHEBI_16898
T127 524-534 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T52801 538-549 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T129 623-632 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T59496 647-654 Chemical denotes inosine http://purl.obolibrary.org/obo/CHEBI_17596
T57709 712-721 Chemical denotes guanosine http://purl.obolibrary.org/obo/CHEBI_16750
T132 845-862 Chemical denotes trimethylammonium http://purl.obolibrary.org/obo/CHEBI_58389
T1063 863-871 Chemical denotes chitosan http://purl.obolibrary.org/obo/CHEBI_16261|http://purl.obolibrary.org/obo/CHEBI_57704
T135 872-880 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T178 439-448 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T179 481-487 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T180 712-734 http://purl.obolibrary.org/obo/GO_0046114 denotes guanosine biosynthesis
T181 722-734 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2260 395-400 Gene denotes DHODH Gene:1723
2261 1007-1009 Gene denotes to Gene:6999
2262 916-918 Gene denotes to Gene:6999
2263 744-746 Gene denotes to Gene:6999
2264 459-461 Gene denotes to Gene:6999
2265 98-103 Species denotes human Tax:9606
2266 161-171 Species denotes SARS-CoV-2 Tax:2697049
2267 268-272 Species denotes mice Tax:10090
2268 287-297 Species denotes SARS-CoV-2 Tax:2697049
2269 470-480 Species denotes SARS-CoV-2 Tax:2697049
2270 756-766 Species denotes SARS-CoV-2 Tax:2697049
2271 971-976 Species denotes human Tax:9606
2272 977-980 Species denotes CoV Tax:11118
2273 981-990 Species denotes HCoV-NL63 Tax:277944
2274 1018-1026 Species denotes MERS-CoV Tax:1335626
2275 1043-1053 Species denotes SARS-CoV-2 Tax:2697049
2276 1057-1062 Species denotes human Tax:9606
2277 177-191 Chemical denotes ribonucleoside MESH:D012263
2278 199-221 Chemical denotes β-D-N4-hydroxycytidine MESH:C010737
2279 223-226 Chemical denotes NHC MESH:C010737
2280 428-438 Chemical denotes pyrimidine MESH:C030986
2281 524-534 Chemical denotes remdesivir MESH:C000606551
2282 538-549 Chemical denotes chloroquine MESH:D002738
2283 592-603 Chemical denotes Merimepodib MESH:C407002
2284 712-721 Chemical denotes guanosine MESH:D006151
2285 823-880 Chemical denotes N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride
2286 882-886 Chemical denotes HTCC
2287 253-264 Disease denotes lung injury MESH:D055370
2288 273-281 Disease denotes infected MESH:D007239
2289 938-947 Disease denotes infection MESH:D007239

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T396 0-25 Sentence denotes Broad-Spectrum Antivirals
T397 26-172 Sentence denotes A number of small molecules with known antiviral activity against other human RNA viruses are being evaluated for efficacy in treating SARS-CoV-2.
T398 173-364 Sentence denotes The ribonucleoside analog β-D-N4-hydroxycytidine (NHC) reduced viral titers and lung injury in mice infected with SARS-CoV-2 via introduction of mutations in viral RNA (Sheahan et al., 2017).
T399 365-591 Sentence denotes Further, an inhibitor of host DHODH, a rate-limiting enzyme in pyrimidine synthesis, was able to inhibit SARS-CoV-2 growth in vitro with greater efficacy than remdesivir or chloroquine (Wang et al., 2020e, Xiong et al., 2020).
T400 592-813 Sentence denotes Merimepodib, a non-competitive inhibitor of the enzyme inosine-5′-monophosphate dehydrogenase (IMPDH), involved in host guanosine biosynthesis, is able to suppress SARS-CoV-2 replication in vitro (Bukreyeva et al., 2020).
T401 814-1111 Sentence denotes Finally, N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC), which was previously shown to efficiently reduce infection by the less-pathogenic human CoV HCoV-NL63, was also found to inhibit MERS-CoV and pseudotyped SARS-CoV-2 in human airway epithelial cells (Milewska et al., 2020).