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PMC:7200337 / 54101-70538 JSONTXT

Annnotations TAB JSON ListView MergeView

2_test

Id Subject Object Predicate Lexical cue
32505227-12692541-46575358 1201-1205 12692541 denotes 2003
32505227-17570115-46575359 1748-1752 17570115 denotes 2007
32505227-21958371-46575360 1767-1771 21958371 denotes 2011
32505227-21745520-46575361 1786-1790 21745520 denotes 2011
32505227-32265220-46575366 4769-4773 32265220 denotes 2020
32505227-32265220-46575368 5303-5307 32265220 denotes 2020
32505227-32265220-46575369 5615-5619 32265220 denotes 2020
32505227-32265220-46575370 5926-5930 32265220 denotes 2020
32505227-32265220-46575378 11829-11833 32265220 denotes 2020
32505227-32325026-46575379 12415-12419 32325026 denotes 2020
32505227-22363001-46575382 15594-15598 22363001 denotes 2012
T67844 4769-4773 32265220 denotes 2020
T81666 5303-5307 32265220 denotes 2020
T24032 5615-5619 32265220 denotes 2020
T75549 5926-5930 32265220 denotes 2020
T74386 11829-11833 32265220 denotes 2020
T78562 12415-12419 32325026 denotes 2020
T77645 15594-15598 22363001 denotes 2012
T65249 1201-1205 12692541 denotes 2003
T5000 1748-1752 17570115 denotes 2007
T67612 1767-1771 21958371 denotes 2011
T29548 1786-1790 21745520 denotes 2011

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T534 712-717 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T535 868-873 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T536 964-969 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T537 978-983 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T538 2248-2255 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T539 2496-2500 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T540 3165-3169 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T541 3242-3247 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T542 3610-3618 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T543 3633-3638 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T544 3647-3654 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T545 3671-3678 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T546 3966-3971 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T547 4409-4414 Body_part denotes Blood http://purl.org/sig/ont/fma/fma9670
T548 4512-4522 Body_part denotes Lymphocyte http://purl.org/sig/ont/fma/fma62863
T549 5472-5476 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T550 6786-6794 Body_part denotes Platelet http://purl.org/sig/ont/fma/fma62851
T551 6806-6814 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T552 6818-6828 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T553 7059-7066 Body_part denotes NK cell http://purl.org/sig/ont/fma/fma63147
T554 7062-7066 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T555 7096-7104 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T556 7099-7104 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T557 7275-7280 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T558 7323-7328 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T559 7560-7565 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T560 7610-7636 Body_part denotes peripheral blood monocytes http://purl.org/sig/ont/fma/fma86713
T561 7678-7687 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T562 7929-7938 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T563 8065-8074 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T564 8923-8932 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T565 8987-8997 Body_part denotes eosinophil http://purl.org/sig/ont/fma/fma62861
T566 9049-9053 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T567 9060-9064 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T568 9067-9076 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T569 9138-9142 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T570 9143-9146 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T571 9194-9202 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T572 9229-9233 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T573 9403-9407 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T574 9534-9538 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T575 9569-9574 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T576 9648-9652 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T577 9744-9747 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T578 9751-9754 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T579 9764-9769 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T580 9827-9830 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T581 9832-9841 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T582 9928-9932 Body_part denotes IL-2 http://purl.org/sig/ont/fma/fma84051
T583 9943-9947 Body_part denotes IL-2 http://purl.org/sig/ont/fma/fma84051
T584 10045-10053 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T585 10082-10085 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T586 10198-10201 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T587 10316-10322 Body_part denotes Organs http://purl.org/sig/ont/fma/fma67498
T588 10392-10414 Body_part denotes gastrointestinal tract http://purl.org/sig/ont/fma/fma71132
T589 10416-10423 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T590 10429-10435 Body_part denotes testis http://purl.org/sig/ont/fma/fma7210
T591 10497-10501 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T592 10559-10564 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T593 10566-10591 Body_part denotes alveolar epithelial cells http://purl.org/sig/ont/fma/fma62499
T594 10586-10591 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T595 10642-10658 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T596 10653-10658 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T597 10667-10672 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T598 10699-10710 Body_part denotes hepatocytes http://purl.org/sig/ont/fma/fma14515
T599 10712-10725 Body_part denotes Kupffer cells http://purl.org/sig/ont/fma/fma14656
T600 10720-10725 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T601 10730-10747 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T602 10742-10747 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T603 10801-10806 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T604 10874-10885 Body_part denotes enterocytes http://purl.org/sig/ont/fma/fma62122
T605 10893-10908 Body_part denotes small intestine http://purl.org/sig/ont/fma/fma7200
T606 10925-10930 Body_part denotes colon http://purl.org/sig/ont/fma/fma14543
T607 11020-11027 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T608 11033-11044 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T609 11051-11061 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T610 11065-11075 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T611 11375-11385 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T612 11441-11452 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T613 11696-11706 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T614 11710-11720 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T615 12136-12150 Body_part denotes blood platelet http://purl.org/sig/ont/fma/fma62851
T616 12155-12165 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T617 12342-12353 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T618 12358-12367 Body_part denotes monocytic http://purl.org/sig/ont/fma/fma62864
T619 12657-12662 Body_part denotes Blood http://purl.org/sig/ont/fma/fma9670
T620 12824-12833 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T621 13230-13233 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T622 13474-13478 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T623 13582-13590 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T624 14445-14458 Body_part denotes helper T cell http://purl.org/sig/ont/fma/fma70572
T625 14454-14458 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T626 14488-14492 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T627 14554-14558 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T628 14560-14573 Body_part denotes helper T cell http://purl.org/sig/ont/fma/fma70572
T629 14569-14573 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T630 14592-14596 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T631 15667-15676 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T632 15692-15697 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T633 15781-15789 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T634 15975-15984 Body_part denotes leukocyte http://purl.org/sig/ont/fma/fma62852
T635 15989-15999 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T636 16105-16128 Body_part denotes gastrointestinal tracts http://purl.org/sig/ont/fma/fma71132
T637 16133-16140 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T638 16281-16290 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T639 16395-16405 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T57 712-717 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T58 868-873 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T59 964-969 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T60 978-983 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T61 2998-3003 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T62 3242-3247 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T63 3633-3638 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T64 3966-3971 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T65 4266-4272 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T66 4409-4414 Body_part denotes Blood http://purl.obolibrary.org/obo/UBERON_0000178
T67 5472-5476 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T68 7621-7626 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T69 9403-9407 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T70 10316-10322 Body_part denotes Organs http://purl.obolibrary.org/obo/UBERON_0000062
T71 10429-10435 Body_part denotes testis http://purl.obolibrary.org/obo/UBERON_0000473
T72 10479-10485 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T73 10667-10672 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T74 10801-10806 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T75 10893-10908 Body_part denotes small intestine http://purl.obolibrary.org/obo/UBERON_0002108
T76 10899-10908 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T77 10925-10930 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T78 12136-12141 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T79 12342-12353 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T80 12657-12662 Body_part denotes Blood http://purl.obolibrary.org/obo/UBERON_0000178
T81 15692-15697 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T82 16085-16091 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T83 16377-16383 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T347 14-22 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T348 149-157 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T349 353-361 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T350 364-373 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T351 620-628 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T352 758-766 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T353 932-940 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T354 1020-1029 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T355 1218-1226 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T356 1416-1424 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T357 1489-1497 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T358 1596-1604 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T359 1877-1885 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T360 2208-2216 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T361 2941-2949 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T362 3639-3646 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T363 3760-3768 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T364 3801-3817 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T365 3901-3904 Disease denotes PCT http://purl.obolibrary.org/obo/MONDO_0008296|http://purl.obolibrary.org/obo/MONDO_0015104
T367 4122-4130 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T368 4283-4291 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T369 4458-4466 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T370 5149-5158 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T371 5169-5178 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T372 5239-5247 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T373 5720-5726 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T374 5879-5887 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T375 6103-6141 Disease denotes disseminated intravascular coagulation http://purl.obolibrary.org/obo/MONDO_0001243
T376 6237-6243 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T377 6756-6764 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T378 6888-6904 Disease denotes Thrombocytopenia http://purl.obolibrary.org/obo/MONDO_0002049
T379 6971-6977 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T380 6981-6989 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T381 7142-7150 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T382 8151-8159 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T383 8455-8474 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T384 8971-8974 Disease denotes PCT http://purl.obolibrary.org/obo/MONDO_0008296|http://purl.obolibrary.org/obo/MONDO_0015104
T386 9010-9018 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T387 9592-9600 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T388 9856-9864 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T389 10034-10042 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T390 10071-10079 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T391 10187-10195 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T392 10365-10373 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T393 10807-10813 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T394 11150-11161 Disease denotes Lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783
T395 11216-11224 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T396 11871-11879 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T397 12422-12438 Disease denotes thrombocytopenia http://purl.obolibrary.org/obo/MONDO_0002049
T398 12512-12520 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T399 12806-12814 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T400 12893-12901 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T401 13091-13110 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T402 13636-13644 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T403 13998-14017 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T404 14375-14383 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T405 14500-14502 Disease denotes TS http://purl.obolibrary.org/obo/MONDO_0010979|http://purl.obolibrary.org/obo/MONDO_0016455
T407 14516-14518 Disease denotes TS http://purl.obolibrary.org/obo/MONDO_0010979|http://purl.obolibrary.org/obo/MONDO_0016455
T409 14640-14642 Disease denotes TS http://purl.obolibrary.org/obo/MONDO_0010979|http://purl.obolibrary.org/obo/MONDO_0016455
T411 14700-14709 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T412 15485-15493 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T413 15613-15624 Disease denotes lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783
T414 15698-15716 Disease denotes hypercoagulability http://purl.obolibrary.org/obo/MONDO_0002305
T415 15737-15745 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T416 15966-15984 Disease denotes disease, leukocyte http://purl.obolibrary.org/obo/MONDO_0004805
T417 16045-16053 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T418 16168-16180 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T419 16331-16342 Disease denotes lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T663 437-438 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T664 445-450 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T665 644-647 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T666 712-717 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T667 712-717 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T668 740-741 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T669 868-873 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T670 868-873 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T671 880-881 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T672 904-905 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T673 962-963 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T674 964-969 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T675 964-969 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T676 978-983 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T677 978-983 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T678 1173-1180 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T679 1388-1393 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T680 1854-1859 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T681 1952-1958 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T682 2089-2096 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T683 2163-2168 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T684 2256-2265 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T685 2496-2500 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T686 3163-3164 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T687 3165-3169 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T688 3242-3247 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T689 3242-3247 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T690 4266-4272 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T691 4409-4414 http://purl.obolibrary.org/obo/UBERON_0000178 denotes Blood
T692 4409-4414 http://www.ebi.ac.uk/efo/EFO_0000296 denotes Blood
T693 5082-5083 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T694 5472-5476 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T695 5472-5476 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T696 6345-6356 http://purl.obolibrary.org/obo/PR_000007299 denotes prothrombin
T697 6367-6376 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T698 6582-6583 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T699 6642-6643 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T700 6661-6668 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T701 7043-7046 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T702 7049-7052 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T703 7059-7066 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cell
T704 7080-7083 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T705 7086-7089 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T706 7096-7104 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cells
T707 7249-7256 http://purl.obolibrary.org/obo/CLO_0001914 denotes and Tim
T708 7273-7280 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T709 7297-7304 http://purl.obolibrary.org/obo/CLO_0001914 denotes and Tim
T710 7321-7328 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T711 7546-7549 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T712 7554-7557 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T713 7558-7565 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T714 7621-7626 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T715 7621-7626 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T716 7627-7636 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T717 7653-7654 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T718 7678-7687 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T719 7737-7741 http://purl.obolibrary.org/obo/PR_000002064 denotes CD68
T720 7744-7748 http://purl.obolibrary.org/obo/PR_000001438 denotes CD80
T721 7929-7938 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T722 8053-8055 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T723 8163-8164 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T724 8496-8500 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T725 8624-8628 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T726 8761-8762 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T727 8855-8860 http://purl.obolibrary.org/obo/PR_000001380 denotes IL-2R
T728 8897-8898 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T729 9067-9076 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T730 9129-9130 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T731 9138-9142 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T732 9278-9279 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T733 9403-9407 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T734 9403-9407 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T735 9461-9462 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T736 9512-9514 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T737 9534-9538 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T738 9567-9574 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T739 9614-9616 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T740 9646-9652 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T741 9762-9769 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T742 9832-9841 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T743 9928-9932 http://purl.obolibrary.org/obo/PR_000001379 denotes IL-2
T744 9943-9947 http://purl.obolibrary.org/obo/PR_000001379 denotes IL-2
T745 10118-10119 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T746 10316-10334 http://purl.obolibrary.org/obo/UBERON_0000467 denotes Organs and Systems
T747 10392-10414 http://purl.obolibrary.org/obo/UBERON_0005409 denotes gastrointestinal tract
T748 10416-10423 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T749 10416-10423 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T750 10416-10423 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T751 10429-10435 http://www.ebi.ac.uk/efo/EFO_0000984 denotes testis
T752 10479-10485 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T753 10497-10507 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T754 10559-10564 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T755 10575-10585 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T756 10586-10591 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T757 10642-10652 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T758 10653-10658 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T759 10667-10672 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T96254 10667-10672 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T761 10720-10725 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T762 10730-10747 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T763 10801-10806 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T764 10801-10806 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T765 10893-10908 http://purl.obolibrary.org/obo/UBERON_0002108 denotes small intestine
T766 10925-10930 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
T767 10976-10977 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T768 10995-11002 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T769 11087-11098 http://purl.obolibrary.org/obo/PR_000007299 denotes prothrombin
T770 11111-11120 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T771 11347-11348 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T772 11849-11850 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T773 11893-11894 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T774 12136-12141 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T775 12136-12141 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T776 12269-12279 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T777 12342-12353 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
T778 12358-12367 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytic
T779 12657-12662 http://purl.obolibrary.org/obo/UBERON_0000178 denotes Blood
T780 12657-12662 http://www.ebi.ac.uk/efo/EFO_0000296 denotes Blood
T781 12735-12738 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T782 12757-12758 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T783 13203-13208 http://purl.obolibrary.org/obo/PR_000001380 denotes IL-2R
T784 13210-13214 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T785 13700-13702 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T786 14269-14270 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T787 14445-14458 http://purl.obolibrary.org/obo/CL_0000912 denotes helper T cell
T788 14475-14492 http://purl.obolibrary.org/obo/CL_0000792 denotes suppressor T cell
T789 14475-14492 http://purl.obolibrary.org/obo/CL_0000815 denotes suppressor T cell
T790 14552-14558 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T791 14560-14573 http://purl.obolibrary.org/obo/CL_0000912 denotes helper T cell
T792 14579-14596 http://purl.obolibrary.org/obo/CL_0000792 denotes suppressor T cell
T793 14579-14596 http://purl.obolibrary.org/obo/CL_0000815 denotes suppressor T cell
T794 15410-15411 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T795 15692-15697 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T796 15692-15697 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T797 15830-15831 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T798 16085-16091 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T799 16105-16128 http://purl.obolibrary.org/obo/UBERON_0005409 denotes gastrointestinal tracts
T800 16133-16140 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T801 16133-16140 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T802 16133-16140 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T803 16225-16226 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T804 16368-16383 http://purl.obolibrary.org/obo/UBERON_0004177 denotes lymphoid organs

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T85513 718-723 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T35249 874-879 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T1068 984-989 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T22429 2248-2255 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T9 3610-3618 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T87618 3647-3654 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T11 3671-3678 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T30523 3910-3912 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T86952 3972-3976 Chemical denotes urea http://purl.obolibrary.org/obo/CHEBI_16199
T22214 3978-3988 Chemical denotes creatinine http://purl.obolibrary.org/obo/CHEBI_16737
T32726 4009-4018 Chemical denotes bilirubin http://purl.obolibrary.org/obo/CHEBI_16990
T93079 5355-5364 Chemical denotes biomarker http://purl.obolibrary.org/obo/CHEBI_59163
T80180 6661-6668 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T44665 7244-7246 Chemical denotes PD http://purl.obolibrary.org/obo/CHEBI_74756
T10664 7292-7294 Chemical denotes PD http://purl.obolibrary.org/obo/CHEBI_74756
T42987 7785-7787 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T62277 7791-7793 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T25505 7923-7925 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T7879 7991-7996 Chemical denotes IP-10 http://purl.obolibrary.org/obo/CHEBI_138157
T28 7991-7993 Chemical denotes IP http://purl.obolibrary.org/obo/CHEBI_74076
T29 7998-8001 Chemical denotes MCP http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099
T91847 8009-8011 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T46613 8016-8021 Chemical denotes IP-10 http://purl.obolibrary.org/obo/CHEBI_138157
T39459 8016-8018 Chemical denotes IP http://purl.obolibrary.org/obo/CHEBI_74076
T9315 8023-8026 Chemical denotes MCP http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099
T37 8034-8036 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T51658 8208-8210 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T54106 8496-8498 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T25821 8624-8626 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T24408 8637-8639 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T47 8855-8857 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T49 9049-9051 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T51 9060-9062 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T53 9229-9231 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T55 9364-9366 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T88508 9369-9371 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T55493 9509-9511 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T61 9611-9613 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T15544 9741-9743 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T25513 9748-9750 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T38568 9824-9826 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T49266 9928-9930 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T1095 9943-9945 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T49020 10938-10949 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T9385 10971-10974 Chemical denotes BNP http://purl.obolibrary.org/obo/CHEBI_80234
T32155 10995-11002 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T73 11020-11027 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T34446 11029-11031 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T67041 11083-11085 Chemical denotes PT http://purl.obolibrary.org/obo/CHEBI_141395
T77 11738-11745 Chemical denotes lactate http://purl.obolibrary.org/obo/CHEBI_24996
T69698 12945-12947 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T190 13203-13205 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T45248 13210-13212 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T84 13216-13218 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T21224 13227-13229 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T87 13474-13476 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T89 13484-13486 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T91 13684-13686 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T93 13690-13692 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T95 13697-13699 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T61341 13894-13899 Chemical denotes IP-10 http://purl.obolibrary.org/obo/CHEBI_138157
T84432 13894-13896 Chemical denotes IP http://purl.obolibrary.org/obo/CHEBI_74076
T99 13901-13904 Chemical denotes MCP http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099
T37885 13912-13914 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T6533 13959-13961 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T45920 14105-14107 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T21432 14466-14468 Chemical denotes TH http://purl.obolibrary.org/obo/CHEBI_73663
T58899 14500-14502 Chemical denotes TS http://purl.obolibrary.org/obo/CHEBI_73664
T37325 14513-14515 Chemical denotes TH http://purl.obolibrary.org/obo/CHEBI_73663
T64186 14516-14518 Chemical denotes TS http://purl.obolibrary.org/obo/CHEBI_73664
T35858 14637-14639 Chemical denotes TH http://purl.obolibrary.org/obo/CHEBI_73663
T79862 14640-14642 Chemical denotes TS http://purl.obolibrary.org/obo/CHEBI_73664

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T30 5149-5158 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T31 5169-5178 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T32 6103-6141 Phenotype denotes disseminated intravascular coagulation http://purl.obolibrary.org/obo/HP_0005521
T33 6888-6904 Phenotype denotes Thrombocytopenia http://purl.obolibrary.org/obo/HP_0001873
T34 8455-8474 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T35 9194-9208 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T36 11150-11161 Phenotype denotes Lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T37 12422-12438 Phenotype denotes thrombocytopenia http://purl.obolibrary.org/obo/HP_0001873
T38 12443-12459 Phenotype denotes elevated D-dimer http://purl.obolibrary.org/obo/HP_0033106
T39 12494-12508 Phenotype denotes coagulopathies http://purl.obolibrary.org/obo/HP_0003256
T40 13091-13110 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T41 13998-14017 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T42 15613-15624 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T43 15698-15716 Phenotype denotes hypercoagulability http://purl.obolibrary.org/obo/HP_0100724
T44 15781-15807 Phenotype denotes cytokine release syndromes http://purl.obolibrary.org/obo/HP_0033041
T45 16331-16342 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T163 2496-2511 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T164 3801-3817 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T165 3990-3998 http://purl.obolibrary.org/obo/GO_0004869 denotes cystatin
T166 5985-5996 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T167 6130-6141 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T168 6271-6282 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T169 6310-6321 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T170 8009-8015 http://purl.obolibrary.org/obo/GO_0005152 denotes IL-1ra
T171 8034-8040 http://purl.obolibrary.org/obo/GO_0005152 denotes IL-1ra
T172 8855-8860 http://purl.obolibrary.org/obo/GO_0004911 denotes IL-2R
T173 12297-12308 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T174 13203-13208 http://purl.obolibrary.org/obo/GO_0004911 denotes IL-2R
T175 13912-13918 http://purl.obolibrary.org/obo/GO_0005152 denotes IL-1ra
T176 16168-16180 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1747 14-22 Disease denotes COVID-19 MESH:C000657245
1750 149-157 Disease denotes COVID-19 MESH:C000657245
1751 358-373 Disease denotes CoV-2 infection MESH:C000657245
1764 708-723 Gene denotes ABO blood group Gene:28
1765 955-957 Gene denotes to Gene:6999
1766 882-884 Gene denotes to Gene:6999
1767 776-778 Gene denotes to Gene:6999
1768 617-619 Gene denotes to Gene:6999
1769 767-775 Species denotes patients Tax:9606
1770 958-963 Species denotes non-A Tax:12440
1771 1218-1225 Species denotes SARS-Co Tax:694009
1772 620-628 Disease denotes COVID-19 MESH:C000657245
1773 758-766 Disease denotes COVID-19 MESH:C000657245
1774 932-940 Disease denotes COVID-19 MESH:C000657245
1775 1020-1029 Disease denotes infection MESH:D007239
1791 2202-2206 Gene denotes ACE2 Gene:59272
1792 2233-2240 Gene denotes TMPRSS2 Gene:7113
1793 2242-2247 Gene denotes spike Gene:43740568
1794 2452-2456 Gene denotes ACE2 Gene:59272
1795 2491-2495 Gene denotes ACE2 Gene:59272
1796 2646-2650 Gene denotes ACE2 Gene:59272
1797 1946-1948 Gene denotes to Gene:6999
1798 1356-1358 Gene denotes to Gene:6999
1799 1311-1313 Gene denotes to Gene:6999
1800 1388-1393 Species denotes human Tax:9606
1801 1596-1604 Species denotes SARS-CoV Tax:694009
1802 1877-1887 Species denotes SARS-CoV-2 Tax:2697049
1803 2208-2218 Species denotes SARS-CoV-2 Tax:2697049
1804 1416-1424 Disease denotes COVID-19 MESH:C000657245
1805 1489-1497 Disease denotes COVID-19 MESH:C000657245
1808 2821-2823 Gene denotes to Gene:6999
1809 2941-2949 Disease denotes COVID-19 MESH:C000657245
1901 5429-5432 Gene denotes CRP Gene:1401
1902 7043-7046 Gene denotes CD4 Gene:920
1903 7049-7052 Gene denotes CD8 Gene:925
1904 7080-7083 Gene denotes CD4 Gene:920
1905 7086-7089 Gene denotes CD8 Gene:925
1906 7253-7258 Gene denotes Tim-3 Gene:84868
1907 7301-7306 Gene denotes Tim-3 Gene:84868
1908 7546-7549 Gene denotes CD4 Gene:920
1909 7554-7557 Gene denotes CD8 Gene:925
1910 7715-7720 Gene denotes CD11b Gene:3684
1911 7751-7756 Gene denotes CD163 Gene:9332
1912 7763-7768 Gene denotes CD206 Gene:4360
1913 7785-7789 Gene denotes IL-6 Gene:3569
1914 7791-7796 Gene denotes IL-10 Gene:3586
1915 7802-7807 Gene denotes TNF-α Gene:7124
1916 7923-7927 Gene denotes IL-6 Gene:3569
1917 7991-7996 Gene denotes IP-10 Gene:3627
1918 8009-8013 Gene denotes IL-1 Gene:3552
1919 8016-8021 Gene denotes IP-10 Gene:3627
1920 8034-8040 Gene denotes IL-1ra Gene:3554
1921 8208-8212 Gene denotes IL-6 Gene:3569
1922 8496-8500 Gene denotes IL-8 Gene:3576
1923 8624-8628 Gene denotes IL-8 Gene:3576
1924 8637-8642 Gene denotes IL-10 Gene:3586
1925 8855-8860 Gene denotes IL-2R Gene:3559
1926 9049-9054 Gene denotes IL-1β Gene:3552
1927 9060-9065 Gene denotes IL-1β Gene:3552
1928 9229-9234 Gene denotes IL-1β Gene:3552
1929 9364-9373 Gene denotes IL-4 IL-4 Gene:3565
1930 9509-9514 Gene denotes IL-18 Gene:3606
1931 9611-9616 Gene denotes IL-18 Gene:3606
1932 9755-9760 Gene denotes IFN-γ Gene:3458
1933 9824-9830 Gene denotes GM-CSF Gene:1437
1934 9928-9932 Gene denotes IL-2 Gene:3558
1935 9952-9957 Gene denotes IFN-γ Gene:3458
1936 5330-5333 Gene denotes CRP Gene:1401
1937 8696-8698 Gene denotes to Gene:6999
1938 7385-7387 Gene denotes to Gene:6999
1939 6815-6817 Gene denotes to Gene:6999
1940 6490-6492 Gene denotes to Gene:6999
1941 5851-5853 Gene denotes to Gene:6999
1942 5210-5212 Gene denotes to Gene:6999
1943 5159-5161 Gene denotes to Gene:6999
1944 5016-5018 Gene denotes to Gene:6999
1945 4986-4988 Gene denotes to Gene:6999
1946 4968-4970 Gene denotes to Gene:6999
1947 4593-4601 Species denotes patients Tax:9606
1948 4895-4903 Species denotes patients Tax:9606
1949 4930-4938 Species denotes Patients Tax:9606
1950 5126-5134 Species denotes patients Tax:9606
1951 6202-6210 Species denotes patients Tax:9606
1952 6570-6578 Species denotes patients Tax:9606
1953 6735-6743 Species denotes patients Tax:9606
1954 7350-7358 Species denotes patients Tax:9606
1955 7470-7478 Species denotes patients Tax:9606
1956 7529-7537 Species denotes patients Tax:9606
1957 7827-7835 Species denotes patients Tax:9606
1958 7960-7968 Species denotes patients Tax:9606
1959 8675-8683 Species denotes patients Tax:9606
1960 8704-8712 Species denotes patients Tax:9606
1961 9108-9116 Species denotes patients Tax:9606
1962 9334-9342 Species denotes patients Tax:9606
1963 9601-9609 Species denotes patients Tax:9606
1964 9804-9812 Species denotes patients Tax:9606
1965 9865-9873 Species denotes patients Tax:9606
1966 10071-10081 Species denotes SARS-CoV-2 Tax:2697049
1967 10034-10044 Species denotes SARS-CoV-2 Tax:2697049
1968 10187-10197 Species denotes SARS-CoV-2 Tax:2697049
1969 6616-6625 Chemical denotes NT-proBNP
1970 6670-6679 Chemical denotes NT-proBNP
1971 5149-5158 Disease denotes pneumonia MESH:D011014
1972 5169-5178 Disease denotes pneumonia MESH:D011014
1973 5239-5247 Disease denotes COVID-19 MESH:C000657245
1974 5472-5484 Disease denotes lung lesions MESH:D008171
1975 5709-5726 Disease denotes myocardial injury MESH:D009202
1976 5879-5887 Disease denotes COVID-19 MESH:C000657245
1977 6103-6141 Disease denotes disseminated intravascular coagulation MESH:D004211
1978 6229-6243 Disease denotes cardiac injury MESH:D006331
1979 6726-6731 Disease denotes death MESH:D003643
1980 6756-6764 Disease denotes COVID-19 MESH:C000657245
1981 6888-6904 Disease denotes Thrombocytopenia MESH:D013921
1982 6960-6977 Disease denotes myocardial injury MESH:D009202
1983 6981-6989 Disease denotes COVID-19 MESH:C000657245
1984 7142-7150 Disease denotes COVID-19 MESH:C000657245
1985 7461-7469 Disease denotes infected MESH:D007239
1986 8151-8159 Disease denotes COVID-19 MESH:C000657245
1987 8455-8474 Disease denotes respiratory failure MESH:D012131
1988 9010-9018 Disease denotes COVID-19 MESH:C000657245
1989 9394-9415 Disease denotes impaired lung lesions MESH:D009422
1990 9592-9600 Disease denotes COVID-19 MESH:C000657245
1991 9856-9864 Disease denotes COVID-19 MESH:C000657245
1993 4458-4466 Disease denotes COVID-19 MESH:C000657245
1996 10297-10301 Gene denotes ACE2 Gene:59272
1997 10365-10373 Disease denotes COVID-19 MESH:C000657245
2005 10453-10457 Gene denotes ACE2 Gene:59272
2006 10604-10608 Gene denotes ACE2 Gene:59272
2007 10674-10678 Gene denotes ACE2 Gene:59272
2008 10843-10847 Gene denotes ACE2 Gene:59272
2009 10918-10920 Gene denotes to Gene:6999
2010 10814-10816 Gene denotes to Gene:6999
2011 10801-10813 Disease denotes liver injury MESH:D017093
2018 10932-10936 Gene denotes ACE2 Gene:59272
2019 10938-10969 Gene denotes angiotensin-converting enzyme 2 Gene:59272
2020 10971-10974 Gene denotes BNP Gene:4879
2021 11004-11007 Gene denotes CRP Gene:1401
2022 11009-11027 Gene denotes C-reactive protein Gene:1401
2023 11062-11064 Gene denotes to Gene:6999
2051 3660-3678 Gene denotes C-reactive protein Gene:1401
2052 3680-3683 Gene denotes CRP Gene:1401
2053 3733-3736 Gene denotes CRP Gene:1401
2054 3910-3914 Gene denotes IL-6 Gene:3569
2055 3990-4000 Gene denotes cystatin C Gene:1471
2056 4024-4038 Gene denotes cholinesterase Gene:590
2057 4357-4361 Gene denotes ACE2 Gene:59272
2058 3365-3368 Gene denotes aid Gene:57379
2059 4321-4323 Gene denotes to Gene:6999
2060 4142-4144 Gene denotes to Gene:6999
2061 3792-3794 Gene denotes to Gene:6999
2062 3757-3759 Gene denotes to Gene:6999
2063 3744-3746 Gene denotes to Gene:6999
2064 3543-3545 Gene denotes to Gene:6999
2065 3362-3364 Gene denotes to Gene:6999
2066 3295-3297 Gene denotes to Gene:6999
2067 3307-3315 Species denotes patients Tax:9606
2068 3503-3511 Species denotes patients Tax:9606
2069 3769-3777 Species denotes patients Tax:9606
2070 4292-4300 Species denotes patients Tax:9606
2071 3972-3976 Chemical denotes urea MESH:D014508
2072 3978-3988 Chemical denotes creatinine MESH:D003404
2073 4009-4018 Chemical denotes bilirubin MESH:D001663
2074 3760-3768 Disease denotes COVID-19 MESH:C000657245
2075 3801-3817 Disease denotes viral infections MESH:D001102
2076 4122-4130 Disease denotes COVID-19 MESH:C000657245
2077 4283-4291 Disease denotes COVID-19 MESH:C000657245
2096 11691-11694 Gene denotes CRP Gene:1401
2097 12092-12095 Gene denotes CRP Gene:1401
2098 11935-11937 Gene denotes to Gene:6999
2099 11707-11709 Gene denotes to Gene:6999
2100 11251-11253 Gene denotes to Gene:6999
2101 11413-11421 Species denotes patients Tax:9606
2102 11667-11675 Species denotes patients Tax:9606
2103 11911-11919 Species denotes patients Tax:9606
2104 11959-11967 Species denotes patients Tax:9606
2105 12521-12529 Species denotes patients Tax:9606
2106 11150-11161 Disease denotes Lymphopenia MESH:D008231
2107 11216-11224 Disease denotes COVID-19 MESH:C000657245
2108 11276-11285 Disease denotes mortality MESH:D003643
2109 11871-11879 Disease denotes COVID-19 MESH:C000657245
2110 12227-12244 Disease denotes pulmonary thrombi MESH:D008171
2111 12328-12341 Disease denotes dysfunctional MESH:D009461
2112 12422-12438 Disease denotes thrombocytopenia MESH:D013921
2113 12512-12520 Disease denotes COVID-19 MESH:C000657245
2142 12945-12949 Gene denotes IL-6 Gene:3569
2143 13203-13208 Gene denotes IL-2R Gene:3559
2144 13210-13214 Gene denotes IL-8 Gene:3576
2145 13216-13221 Gene denotes IL-10 Gene:3586
2146 13227-13233 Gene denotes GM-CSF Gene:1437
2147 13474-13479 Gene denotes IL-1β Gene:3552
2148 13484-13488 Gene denotes IL-4 Gene:3565
2149 13684-13688 Gene denotes IL-6 Gene:3569
2150 13690-13695 Gene denotes IL-10 Gene:3586
2151 13697-13702 Gene denotes IL-18 Gene:3606
2152 13704-13709 Gene denotes CTACK Gene:10850
2153 13715-13720 Gene denotes IFN-γ Gene:3458
2154 13894-13899 Gene denotes IP-10 Gene:3627
2155 13912-13918 Gene denotes IL-1ra Gene:3554
2156 13959-13963 Gene denotes IL-6 Gene:3569
2157 14105-14109 Gene denotes IL-6 Gene:3569
2158 13374-13376 Gene denotes to Gene:6999
2159 12987-12995 Species denotes patients Tax:9606
2160 13023-13031 Species denotes patients Tax:9606
2161 13354-13362 Species denotes patients Tax:9606
2162 13645-13653 Species denotes patients Tax:9606
2163 12791-12800 Disease denotes mortality MESH:D003643
2164 12806-12814 Disease denotes COVID-19 MESH:C000657245
2165 12893-12901 Disease denotes COVID-19 MESH:C000657245
2166 13008-13022 Disease denotes critically ill MESH:D016638
2167 13091-13110 Disease denotes respiratory failure MESH:D012131
2168 13636-13644 Disease denotes COVID-19 MESH:C000657245
2169 13998-14017 Disease denotes respiratory failure MESH:D012131
2179 14722-14724 Gene denotes to Gene:6999
2180 14311-14313 Gene denotes to Gene:6999
2181 14384-14392 Species denotes patients Tax:9606
2182 14677-14685 Species denotes patients Tax:9606
2183 14725-14733 Species denotes patients Tax:9606
2184 14344-14349 Disease denotes death MESH:D003643
2185 14375-14383 Disease denotes COVID-19 MESH:C000657245
2186 14690-14694 Disease denotes died MESH:D003643
2187 14700-14709 Disease denotes infection MESH:D007239
2194 15399-15401 Gene denotes to Gene:6999
2195 15206-15208 Gene denotes to Gene:6999
2196 14981-14989 Species denotes patients Tax:9606
2197 15362-15369 Species denotes patient Tax:9606
2198 15472-15481 Disease denotes mortality MESH:D003643
2199 15485-15493 Disease denotes COVID-19 MESH:C000657245
2210 16065-16069 Gene denotes ACE2 Gene:59272
2211 16062-16064 Gene denotes to Gene:6999
2212 15884-15886 Gene denotes to Gene:6999
2213 16045-16055 Species denotes SARS-CoV-2 Tax:2697049
2214 15613-15624 Disease denotes lymphopenia MESH:D008231
2215 15692-15716 Disease denotes blood hypercoagulability MESH:D007022
2216 15737-15745 Disease denotes COVID-19 MESH:C000657245
2217 16168-16180 Disease denotes inflammation MESH:D007249
2218 16331-16342 Disease denotes lymphopenia MESH:D008231
2219 16357-16383 Disease denotes atrophy of lymphoid organs MESH:D000072717

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T296 0-48 Sentence denotes Predictors of COVID-19 Disease Risk and Severity
T297 49-200 Sentence denotes With the rapidly growing number of cases in the first few months, numerous reports on predictors of COVID-19 severity with small cohorts were released.
T298 201-374 Sentence denotes These offered clinicians and immunologists the first understanding of the clinical course and pathological processes that are associated with the novel SARS-CoV-2 infection.
T299 375-514 Sentence denotes This section highlights key findings from those studies, with a major focus on the immune factors associated with disease risk or severity.
T300 516-550 Sentence denotes Susceptibility and Risk Biomarkers
T301 551-682 Sentence denotes There are currently limited known risk factors for susceptibility to COVID-19, although this has been evaluated in several studies.
T302 683-856 Sentence denotes Zhao et al. compared the ABO blood group distribution in a cohort of 2,173 COVID-19 patients to that of healthy controls from the corresponding regions (Zhao et al., 2020b).
T303 857-1030 Sentence denotes They found blood group A to be associated with a higher risk for acquiring COVID-19 when compared to non-A blood groups; blood group O had the lowest risk for the infection.
T304 1031-1251 Sentence denotes Another study demonstrated an identical association (Zietz and Tatonetti, 2020), and similar results have been previously described for other viruses (Lindesmith et al., 2003), including SARS-CoV-1 (Cheng et al., 2005a).
T305 1252-1539 Sentence denotes Several large collaborative efforts are currently underway to generate, share, and analyze genetic data to understand the links between human genetic variation and COVID-19 susceptibility and severity, the most prominent of which is the COVID-19 Host Genetics Initiative (covid19hg.org).
T306 1540-1792 Sentence denotes These studies are supported by previous observations on SARS-CoV-1 that followed the 2003 outbreak, which have identified significant associations between genetic variants and immune phenotypes (Chan et al., 2007, Wang et al., 2011, Zhao et al., 2011).
T307 1793-2069 Sentence denotes Although identifying such polymorphisms and their associated genes and pathways for SARS-CoV-2 will require large cohorts, several studies, which remain to be tested in clinical trials, have already highlighted genetic polymorphisms that may potentially impact susceptibility.
T308 2070-2354 Sentence denotes These studies have focused on genetic variants that may impact the expression or function of genes important in viral entry, namely ACE2 (SARS-CoV-2 receptor) and TMPRSS2 (spike protein activator) (Asselta et al., 2020, Cao et al., 2020c, Renieri et al., 2020, Stawiski et al., 2020).
T309 2355-2589 Sentence denotes Cao et al. identified variants that are potentially expression quantitative trait loci (eQTL) of ACE2 (i.e., they may potentially alter ACE2 gene expression) and analyzed their frequencies in different populations (Cao et al., 2020c).
T310 2590-2784 Sentence denotes Stawiski et al. listed variants that may be critical in ACE2 binding and thereby its function and compared the frequencies of these variants within different populations (Stawiski et al., 2020).
T311 2785-3049 Sentence denotes While there are several limitations to these studies, the major question is whether the utility of these biomarkers is replicable in large populations with COVID-19 clinical outcomes data and in targeted or large-scale genomic analyses that are currently underway.
T312 3050-3195 Sentence denotes In addition, these studies will reveal the potential associations between genetic variants and susceptibility in a gene or loci agnostic fashion.
T313 3197-3225 Sentence denotes Routine Bloodwork Biomarkers
T314 3226-3434 Sentence denotes Several routine blood and serological parameters have been suggested to stratify patients who might be at higher risk for complications to aid in allocation of healthcare resources in the pandemic (Table 1 ).
T315 3435-3573 Sentence denotes Serologic markers from routine bloodwork were reported by comparing patients with mild or moderate symptoms to those with severe symptoms.
T316 3574-3703 Sentence denotes This includes different acute phase proteins, such as SAA (serum amyloid protein) and C-reactive protein (CRP) (Ji et al., 2020).
T317 3704-3818 Sentence denotes Interestingly, elevations in CRP appear to be unique to COVID-19 patients when compared to other viral infections.
T318 3819-4061 Sentence denotes Other consistently reported markers in non-survivors are increased procalcitonin (PCT) and IL-6 levels (Huang et al., 2020d), as well as increased serum urea, creatinine, cystatin C, direct bilirubin, and cholinesterase (Xiang et al., 2020a).
T319 4062-4210 Sentence denotes Overall, inflammatory markers are common in severe cases of COVID-19 and appear to correlate with the severity of the symptoms and clinical outcome.
T320 4211-4392 Sentence denotes Moreover, the extensive damage that occurs in specific organs of severe COVID-19 patients is possibly related to differences in the expression of ACE2 (Figure 5 ) (Du et al., 2020).
T321 4393-4475 Sentence denotes Table 1 Routine Blood and Immunological Prognostic Biomarkers in COVID-19 Patients
T322 4476-4493 Sentence denotes Biomarker Purpose
T323 4494-4925 Sentence denotes Routine Bloodwork Lymphocyte count Predicted the disease severity and the outcomes of hospitalized patients (Tan et al., 2020a).Prognostic value was confirmed in numerous studies (Huang et al., 2020d, Liu et al., 2020b, Song et al., 2020, Wang et al., 2020f, Wynants et al., 2020, Yan et al., 2020b, Yang et al., 2020b, Zhang et al., 2020c, Zhao et al., 2020d).Decreased continuously in non-surviving patients (Wang et al., 2020b).
T324 4926-5199 Sentence denotes N/L Patients with N/L ≥3.13 were reported to be more likely to develop severe illness and to require ICU admission (Liu et al., 2020c).N/L on admission was a risk factor for short-term progression of patients with moderate pneumonia to severe pneumonia (Feng et al., 2020).
T325 5200-5329 Sentence denotes Confirmed to be of prognostic value in COVID-19 in several studies (Song et al., 2020, Wynants et al., 2020, Zhou et al., 2020d).
T326 5330-5406 Sentence denotes CRP Proposed as an early biomarker of disease progression (Ji et al., 2020).
T327 5407-5529 Sentence denotes Even in early stages, CRP levels were positively correlated with lung lesions and reflected disease severity (Wang, 2020).
T328 5530-5680 Sentence denotes Confirmed in numerous studies (Fu et al., 2020, Huang et al., 2020d, Wynants et al., 2020, Yan et al., 2020b, Zhao et al., 2020d, Zhou et al., 2020b).
T329 5681-5765 Sentence denotes Predicted the risk of acute myocardial injury (Liu et al., 2020g, Xu et al., 2020a).
T330 5766-5834 Sentence denotes LDH Higher in severe cases than in mild cases (Xiang et al., 2020a).
T331 5835-5971 Sentence denotes Widely proposed to have prognostic value in COVID-19 (Huang et al., 2020d, Wynants et al., 2020, Yan et al., 2020b, Zhao et al., 2020d).
T332 5972-6082 Sentence denotes D-dimer (and coagulation parameters) Predicted severity independently of other variables (Zhou et al., 2020d).
T333 6083-6190 Sentence denotes Elevated levels and disseminated intravascular coagulation are found in non-survivors (Wang et al., 2020b).
T334 6191-6264 Sentence denotes Identified patients at risk for acute cardiac injury (Liu et al., 2020g).
T335 6265-6468 Sentence denotes Other coagulation parameters, such as fibrin degradation product levels, longer prothrombin time, and activated partial thromboplastin time, were also associated with poor prognosis (Tang et al., 2020a).
T336 6469-6615 Sentence denotes SAA SAA was proposed to be used as an auxiliary index for diagnosis as it was elevated in 80% of the patients in a small cohort (Ji et al., 2020).
T337 6616-6785 Sentence denotes NT-proBNP (N-terminal pro B type natriuretic peptide) NT-proBNP was an independent risk factor of in-hospital death in patients with severe COVID-19 (Gao et al., 2020b).
T338 6786-6887 Sentence denotes Platelet count High platelet-to-lymphocyte ratio was associated with worse outcome (Qu et al., 2020).
T339 6888-7028 Sentence denotes Thrombocytopenia was associated with poor outcome and with incidence of myocardial injury in COVID-19 (Liu et al., 2020h, Shi et al., 2020).
T340 7029-7171 Sentence denotes Immunological CD4+, CD8+, and NK cell counts Lower CD4+, CD8+, and NK cells in PBMCs correlated with severity of COVID-19 (Nie et al., 2020b).
T341 7172-7243 Sentence denotes Validated by several studies (Wang et al., 2020f, Zheng et al., 2020b).
T342 7244-7435 Sentence denotes PD-1 and Tim-3 expression on T cells Increasing PD-1 and Tim-3 expression on T cells could be detected as patients progressed from prodromal to overtly symptomatic stages (Diao et al., 2020).
T343 7436-7587 Sentence denotes Expression was higher in infected patients versus healthy controls and in ICU versus non-ICU patients in both CD4 and CD8 T cells (Zhou et al., 2020b).
T344 7588-7912 Sentence denotes phenotypic changes in peripheral blood monocytes The presence of a distinct population of monocytes with high forward scatter (CD11b+, CD14+, CD16+, CD68+, CD80+, CD163+, and CD206+, which secrete IL-6, IL-10, and TNF-α) was identified in patients requiring prolonged hospitalization and ICU admission (Zhang et al., 2020c).
T345 7913-7990 Sentence denotes CD14+CD16+IL-6+ monocytes are increased in ICU patients (Zhou et al., 2020b).
T346 7991-8207 Sentence denotes IP-10, MCP-3, and IL-1ra IP-10, MCP-3, and IL-1ra were, among 48 examined cytokines, the only ones that closely associated with disease severity and outcome of COVID-19 in a study by Yang et al. (Yang et al., 2020b).
T347 8208-8401 Sentence denotes IL-6 Associated with disease severity (hospitalization and ICU admission) and poor prognosis (Chen et al., 2020g, Huang et al., 2020b, Liu et al., 2020b, Liu et al., 2020f, Wang et al., 2020b).
T348 8402-8495 Sentence denotes Increased levels were associated with higher risk of respiratory failure (Yao et al., 2020b).
T349 8496-8636 Sentence denotes IL-8 Positively correlated with disease severity (Chen et al., 2020e, Gong et al., 2020), with severe cases showing the highest IL-8 levels.
T350 8637-8854 Sentence denotes IL-10 Increased in severe or critical patients as compared to mild patients (Gong et al., 2020, Zhou et al., 2020d) without a statistically significant difference between severe and critical cases (Gong et al., 2020).
T351 8855-9048 Sentence denotes IL-2R Associated with disease severity in a study that, among other cytokines, also associated ferroprotein levels, PCT levels, and eosinophil counts with COVID-19 severity (Gong et al., 2020).
T352 9049-9228 Sentence denotes IL-1β CD14+IL-1β+ monocytes are abundant in early-recovery patients as shown in a single-cell RNA-seq analysis and thought to be associated with cytokine storm (Wen et al., 2020).
T353 9229-9363 Sentence denotes IL-1β did not correlate with disease severity in a cross-sectional study with mild, severe, and critical patients (Gong et al., 2020).
T354 9364-9508 Sentence denotes IL-4 IL-4 was associated with impaired lung lesions (Fu et al., 2020), but some reports point to a potential mediator effect (Wen et al., 2020).
T355 9509-9740 Sentence denotes IL-18 In modeling immune cell interaction between DCs and B cells in late recovery COVID-19 patients, IL-18 was found to be important in B cell production of antibodies, which suggests its importance in recovery (Wen et al., 2020).
T356 9741-9813 Sentence denotes GM-CSF GM-CSF+IFN-γ+ T cells are higher in ICU than in non-ICU patients.
T357 9814-9927 Sentence denotes CD14+CD16+GM-CSF+ monocytes are higher in COVID-19 patients as compared to healthy controls (Zhou et al., 2020b).
T358 9928-10028 Sentence denotes IL-2 and IFN-γ IL-2 and IFN-γ levels were shown to be increased in severe cases (Liu et al., 2020b).
T359 10029-10174 Sentence denotes anti-SARS-CoV-2 antibody levels Prolonged SARS-CoV-2 IgM positivity could be utilized as a predictive factor for poor recovery (Fu et al., 2020).
T360 10175-10287 Sentence denotes Higher anti-SARS-CoV-2 IgG levels and higher N/L were more commonly found in severe cases (Zhang et al., 2020a).
T361 10288-10387 Sentence denotes Figure 5 ACE2 Expression in Organs and Systems Most Frequently Implicated in COVID-19 Complications
T362 10388-10470 Sentence denotes The gastrointestinal tract, kidneys, and testis have the highest ACE2 expressions.
T363 10471-10829 Sentence denotes In some organs, different cell types have remarkably distinct expressions; e.g., in the lungs, alveolar epithelial cells have higher ACE2 expression levels than bronchial epithelial cells; in the liver, ACE2 is not expressed in hepatocytes, Kupffer cells, or endothelial cells but is detected in cholangiocytes, which can explain liver injury to some extent.
T364 10830-10931 Sentence denotes Furthermore, ACE2 expression is enriched on enterocytes of the small intestine compared to the colon.
T365 10932-11149 Sentence denotes ACE2, angiotensin-converting enzyme 2; BNP, B-type natriuretic peptide; CRP, C-reactive protein; IL, interleukin; N/L, neutrophil-to-lymphocyte ratio; PT, prothrombin time; aPTT, activated partial thromboplastin time.
T366 11150-11326 Sentence denotes Lymphopenia is the most frequently described prognostic marker in COVID-19 (Table 1), and it appears to predict morbidity and mortality even at early stages (Fei et al., 2020).
T367 11327-11582 Sentence denotes Tan et al. proposed a prognostic model based on lymphocyte counts at two time points: patients with less than 20% lymphocytes at days 10–12 from the onset of symptoms and less than 5% at days 17–19 had the worst outcomes in this study (Tan et al., 2020a).
T368 11583-11835 Sentence denotes Wynants et al. compared predictors of disease severity across seven studies (>1,330 patients), highlighting CRP, neutrophil-to-lymphocyte ratio (N/L), and lactate dehydrogenase (LDH) as the most significant predictive biomarkers (Wynants et al., 2020).
T369 11836-12009 Sentence denotes Furthermore, a meta-analysis of 30 COVID-19 studies with a total of 53,000 patients also attempted to identify early-stage patients with poor prognosis (Zhao et al., 2020d).
T370 12010-12213 Sentence denotes The most consistent findings across the different studies were elevated levels of CRP, LDH, and D-dimer, as well as decreased blood platelet and lymphocyte counts (Yan et al., 2020b, Zhou et al., 2020d).
T371 12214-12612 Sentence denotes Systemic and pulmonary thrombi have been reported with activation of the extrinsic coagulation cascade, involving dysfunctional endothelium and monocytic infiltration (Poor et al., 2020, Varga et al., 2020); thrombocytopenia and elevated D-dimer levels may be indicative of these coagulopathies in COVID-19 patients with important therapeutic implications (Fogarty et al., 2020, Poor et al., 2020).
T372 12614-12662 Sentence denotes Immunological Biomarkers in the Peripheral Blood
T373 12663-12815 Sentence denotes Immunological biomarkers are particularly important, as immunopathology has been suggested as a primary driver of morbidity and mortality with COVID-19.
T374 12816-12921 Sentence denotes Several cytokines and other immunologic parameters have been correlated with COVID-19 severity (Table 1).
T375 12922-13192 Sentence denotes Most notably, elevated IL-6 levels were detected in hospitalized patients, especially critically ill patients, in several studies and are associated with ICU admission, respiratory failure, and poor prognosis (Chen et al., 2020g, Huang et al., 2020b, Liu et al., 2020f).
T376 13193-13443 Sentence denotes Increased IL-2R, IL-8, IL-10, and GM-CSF have been associated with disease severity as well, but studies are limited, and further studies with larger cohorts of patients are needed to indicate predictive power (Gong et al., 2020, Zhou et al., 2020b).
T377 13444-13563 Sentence denotes Conflicting results regarding IL-1β and IL-4 have been reported (Fu et al., 2020, Gong et al., 2020, Wen et al., 2020).
T378 13564-13855 Sentence denotes Although elevated cytokine concentrations have been widely described in COVID-19 patients, the vast majority (including IL-6, IL-10, IL-18, CTACK, and IFN-γ) do not seem to have prognostic value, because they do not always differentiate moderate cases from severe cases (Yang et al., 2020b).
T379 13856-13919 Sentence denotes This stratification was possible with IP-10, MCP-3, and IL-1ra.
T380 13920-14247 Sentence denotes While there are reports that levels of IL-6 at first assessment might predict respiratory failure (Herold et al., 2020), other publications with longitudinal analyses demonstrated that IL-6 increases fairly late during the disease’s course, consequently compromising its prognostic value at earlier stages (Zhou et al., 2020a).
T381 14248-14545 Sentence denotes Liu et al. developed a web-based tool using k-means clustering to predict prognosis in terms of death or hospital discharge of COVID-19 patients using age, comorbidities (binary), and baseline log helper T cell count (TH), log suppressor T cell count (TS), and log TH/TS ratio (Liu et al., 2020e).
T382 14546-14754 Sentence denotes Total T cell, helper T cell, and suppressor T cell counts were significantly lower and the TH/TS ratio was significantly higher in patients who died from infection as compared to patients who were discharged.
T383 14755-15005 Sentence denotes Importantly, most serological and immunological changes observed in severe cases are associated with disease severity but cannot necessarily serve as predictive factors, as they may not have utility in early identification of patients at higher risk.
T384 15006-15214 Sentence denotes Discovery of truly predictive biomarkers and potential drivers of hyperinflammatory processes requires comprehensive profiling of asymptomatic and mild cases and longitudinal studies that are limited to date.
T385 15215-15324 Sentence denotes Confounding variables including age, gender, and comorbidities may dramatically affect associations observed.
T386 15325-15600 Sentence denotes In addition, direct correlation with patient viral load will be important to provide a greater understanding of underlying causes of morbidity and mortality in COVID-19 and the contribution of viral infectivity, hyperinflammation, and host tolerance (Medzhitov et al., 2012).
T387 15601-15808 Sentence denotes In summary, lymphopenia, increases in proinflammatory markers and cytokines, and potential blood hypercoagulability characterize severe COVID-19 cases with features reminiscent of cytokine release syndromes.
T388 15809-15913 Sentence denotes This correlates with a diverse clinical spectrum ranging from asymptomatic to severe and critical cases.
T389 15914-16038 Sentence denotes During the incubation period and early phase of the disease, leukocyte and lymphocyte counts are normal or slightly reduced.
T390 16039-16202 Sentence denotes After SARS-CoV-2 binds to ACE2 overexpressing organs, such as the gastrointestinal tracts and kidneys, increases in non-specific inflammation markers are observed.
T391 16203-16437 Sentence denotes In more severe cases, a marked systemic release of inflammatory mediators and cytokines occurs, with corresponding worsening of lymphopenia and potential atrophy of lymphoid organs, impairing lymphocyte turnover (Terpos et al., 2020).