PMC:7200337 / 46164-46982
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T459 | 18-21 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
| T460 | 32-37 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T461 | 50-54 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T462 | 181-189 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T463 | 190-194 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T464 | 711-719 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T293 | 85-93 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T294 | 210-218 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T295 | 487-497 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T296 | 523-531 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T297 | 628-636 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T578 | 13-17 | http://purl.obolibrary.org/obo/CLO_0053432 | denotes | CD19 |
| T579 | 30-37 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cells |
| T580 | 50-54 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T581 | 67-68 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T582 | 190-194 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T583 | 297-298 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T584 | 747-752 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T145 | 23-29 | http://purl.obolibrary.org/obo/GO_0007613 | denotes | memory |
| T146 | 711-743 | http://purl.obolibrary.org/obo/GO_0097282 | denotes | antibody mediated neutralization |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1538 | 451-453 | Gene | denotes | to | Gene:6999 |
| 1539 | 434-436 | Gene | denotes | to | Gene:6999 |
| 1540 | 523-533 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1541 | 628-636 | Species | denotes | SARS-CoV | Tax:694009 |
| 1542 | 642-650 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1543 | 210-220 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1544 | 85-93 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1545 | 481-497 | Disease | denotes | acute infections | MESH:D007239 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T250 | 0-169 | Sentence | denotes | RBD-specific CD19+IgG+ memory B cells were single-cell sorted from a cohort of eight COVID-19 donors between days 9 and 28 after the onset of symptoms (Ju et al., 2020). |
| T251 | 170-266 | Sentence | denotes | From their antibody gene sequences, 209 SARS-CoV-2-specific monoclonal antibodies were produced. |
| T252 | 267-498 | Sentence | denotes | The monoclonal antibodies had a diverse repertoire, relatively low or no somatic mutations, and variable binding reactivity, with dissociation constants reaching 10−8 to 10−9, similar to antibodies isolated during acute infections. |
| T253 | 499-669 | Sentence | denotes | Two potent neutralizing SARS-CoV-2 RBD-specific monoclonal antibodies were characterized that did not crossreact with the RBD of SARS-CoV-1 or MERS-CoV (Ju et al., 2020). |
| T254 | 670-818 | Sentence | denotes | Together, these results demonstrate that antibody mediated neutralization is virus specific and likely driven by binding of epitopes within the RBD. |