PMC:7200337 / 38413-39805
Annnotations
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32505227-30327490-46575324 | 805-809 | 30327490 | denotes | 2019 |
| 32505227-30564234-46575325 | 1274-1278 | 30564234 | denotes | 2018 |
| 32505227-23064104-46575326 | 1294-1298 | 23064104 | denotes | 2013 |
| T1317 | 805-809 | 30327490 | denotes | 2019 |
| T1331 | 1274-1278 | 30564234 | denotes | 2018 |
| T77685 | 1294-1298 | 23064104 | denotes | 2013 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T391 | 2-6 | Body_part | denotes | Cell | http://purl.org/sig/ont/fma/fma68646 |
| T392 | 82-86 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T393 | 160-164 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T394 | 387-390 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
| T395 | 398-403 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T396 | 535-538 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
| T397 | 546-551 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T398 | 716-719 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
| T399 | 727-732 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T400 | 875-880 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T401 | 957-962 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T402 | 1113-1117 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T403 | 1166-1171 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T404 | 1187-1192 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T49 | 1113-1117 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T248 | 23-31 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T249 | 239-247 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T250 | 483-491 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T251 | 600-619 | Disease | denotes | autoimmune diseases | http://purl.obolibrary.org/obo/MONDO_0007179 |
| T252 | 629-647 | Disease | denotes | multiple sclerosis | http://purl.obolibrary.org/obo/MONDO_0005301 |
| T253 | 651-680 | Disease | denotes | juvenile rheumatoid arthritis | http://purl.obolibrary.org/obo/MONDO_0011429 |
| T254 | 660-680 | Disease | denotes | rheumatoid arthritis | http://purl.obolibrary.org/obo/MONDO_0008383 |
| T255 | 671-680 | Disease | denotes | arthritis | http://purl.obolibrary.org/obo/MONDO_0005578 |
| T256 | 891-899 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T257 | 995-999 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T258 | 1000-1012 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T259 | 1104-1112 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T260 | 1240-1249 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T261 | 1250-1259 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T262 | 1336-1344 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T470 | 0-6 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T Cell |
| T471 | 80-86 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T472 | 130-135 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T473 | 158-164 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T474 | 290-291 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T475 | 329-330 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T476 | 392-395 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T477 | 396-403 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T478 | 540-543 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T479 | 544-551 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T480 | 721-724 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T481 | 725-732 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T482 | 870-874 | http://purl.obolibrary.org/obo/CL_0000792 | denotes | Treg |
| T483 | 875-880 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T484 | 952-956 | http://purl.obolibrary.org/obo/CL_0000792 | denotes | Treg |
| T485 | 957-962 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T486 | 1016-1021 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
| T487 | 1045-1049 | http://purl.obolibrary.org/obo/CLO_0001185 | denotes | 2018 |
| T488 | 1052-1053 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T489 | 1062-1067 | http://purl.obolibrary.org/obo/CL_0000792 | denotes | Tregs |
| T490 | 1113-1117 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T491 | 1113-1117 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T492 | 1146-1147 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T493 | 1164-1171 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T494 | 1173-1174 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T495 | 1185-1192 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T496 | 1274-1278 | http://purl.obolibrary.org/obo/CLO_0001185 | denotes | 2018 |
| T497 | 1301-1304 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T196 | 384-386 | Chemical | denotes | GM | http://purl.obolibrary.org/obo/CHEBI_74120 |
| T197 | 434-436 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T199 | 532-534 | Chemical | denotes | GM | http://purl.obolibrary.org/obo/CHEBI_74120 |
| T200 | 713-715 | Chemical | denotes | GM | http://purl.obolibrary.org/obo/CHEBI_74120 |
| T201 | 1218-1227 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T202 | 1355-1358 | Chemical | denotes | Guo | http://purl.obolibrary.org/obo/CHEBI_16750 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T24 | 600-619 | Phenotype | denotes | autoimmune diseases | http://purl.obolibrary.org/obo/HP_0002960 |
| T25 | 651-680 | Phenotype | denotes | juvenile rheumatoid arthritis | http://purl.obolibrary.org/obo/HP_0005681 |
| T26 | 783-789 | Phenotype | denotes | sepsis | http://purl.obolibrary.org/obo/HP_0100806 |
| T27 | 1250-1259 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T137 | 1000-1012 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1260 | 20-22 | Gene | denotes | to | Gene:6999 |
| 1261 | 23-49 | Disease | denotes | COVID-19 Hyperinflammation | MESH:C000657245 |
| 1288 | 384-390 | Gene | denotes | GM-CSF | Gene:1437 |
| 1289 | 392-395 | Gene | denotes | CD4 | Gene:920 |
| 1290 | 434-438 | Gene | denotes | IL-6 | Gene:3569 |
| 1291 | 443-448 | Gene | denotes | IFN-γ | Gene:3458 |
| 1292 | 532-538 | Gene | denotes | GM-CSF | Gene:1437 |
| 1293 | 540-543 | Gene | denotes | CD4 | Gene:920 |
| 1294 | 713-719 | Gene | denotes | GM-CSF | Gene:1437 |
| 1295 | 721-724 | Gene | denotes | CD4 | Gene:920 |
| 1296 | 216-218 | Gene | denotes | to | Gene:6999 |
| 1297 | 248-256 | Species | denotes | patients | Tax:9606 |
| 1298 | 492-500 | Species | denotes | patients | Tax:9606 |
| 1299 | 1016-1021 | Species | denotes | mouse | Tax:10090 |
| 1300 | 1345-1353 | Species | denotes | patients | Tax:9606 |
| 1301 | 1240-1249 | Species | denotes | influenza | Tax:11520 |
| 1302 | 239-247 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1303 | 468-482 | Disease | denotes | critically ill | MESH:D016638 |
| 1304 | 483-491 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1305 | 600-619 | Disease | denotes | autoimmune diseases | MESH:D001327 |
| 1306 | 629-647 | Disease | denotes | multiple sclerosis | MESH:D009103 |
| 1307 | 651-680 | Disease | denotes | juvenile rheumatoid arthritis | MESH:D001171 |
| 1308 | 783-789 | Disease | denotes | sepsis | MESH:D018805 |
| 1309 | 891-899 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1310 | 995-1012 | Disease | denotes | ARDS inflammation | MESH:D012128 |
| 1311 | 1104-1112 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1312 | 1250-1259 | Disease | denotes | pneumonia | MESH:D011014 |
| 1313 | 1336-1344 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T209 | 0-49 | Sentence | denotes | T Cell Contribution to COVID-19 Hyperinflammation |
| T210 | 50-268 | Sentence | denotes | While the induction of robust T cell immunity is likely essential for efficient virus control, dysregulated T cell responses may cause immunopathology and contribute to disease severity in COVID-19 patients (Figure 3). |
| T211 | 269-522 | Sentence | denotes | This is suggested in a study by Zhou et al., which reported a significantly increased PBMC frequency of polyclonal GM-CSF+ CD4 T cells capable of prodigious ex vivo IL-6 and IFN-γ production only in critically ill COVID-19 patients (Zhou et al., 2020c). |
| T212 | 523-811 | Sentence | denotes | Of note, GM-CSF+ CD4 T cells have been previously implicated in inflammatory autoimmune diseases, such as multiple sclerosis or juvenile rheumatoid arthritis, and high levels of circulating GM-CSF+ CD4 T cells were found to be associated with poor outcomes in sepsis (Huang et al., 2019). |
| T213 | 812-945 | Sentence | denotes | Additionally, two studies observed reduced frequencies of Treg cells in severe COVID-19 cases (Chen et al., 2020c, Qin et al., 2020). |
| T214 | 946-1134 | Sentence | denotes | Since Treg cells have been shown to help resolve ARDS inflammation in mouse models (Walter et al., 2018), a loss of Tregs might facilitate the development of COVID-19 lung immunopathology. |
| T215 | 1135-1392 | Sentence | denotes | Similarly, a reduction of γδ-T cells, a subset of T cells with apparent protective antiviral function in influenza pneumonia (Dong et al., 2018, Zheng et al., 2013), has been reported in severely sick COVID-19 patients (Guo et al., 2020, Lei et al., 2020b). |