PMC:7200337 / 30819-31653 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T307","span":{"begin":25,"end":30},"obj":"Body_part"},{"id":"T308","span":{"begin":33,"end":38},"obj":"Body_part"},{"id":"T309","span":{"begin":193,"end":198},"obj":"Body_part"},{"id":"T310","span":{"begin":465,"end":474},"obj":"Body_part"},{"id":"T311","span":{"begin":484,"end":489},"obj":"Body_part"},{"id":"T312","span":{"begin":616,"end":620},"obj":"Body_part"},{"id":"T313","span":{"begin":650,"end":655},"obj":"Body_part"},{"id":"T314","span":{"begin":663,"end":670},"obj":"Body_part"},{"id":"T315","span":{"begin":819,"end":823},"obj":"Body_part"}],"attributes":[{"id":"A307","pred":"fma_id","subj":"T307","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A308","pred":"fma_id","subj":"T308","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A309","pred":"fma_id","subj":"T309","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A310","pred":"fma_id","subj":"T310","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A311","pred":"fma_id","subj":"T311","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A312","pred":"fma_id","subj":"T312","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A313","pred":"fma_id","subj":"T313","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A314","pred":"fma_id","subj":"T314","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A315","pred":"fma_id","subj":"T315","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"A decrease in peripheral blood T cells associated with disease severity and inflammation is now well documented in COVID-19. Several studies report increased numbers of activated CD4 and CD8 T cells, which display a trend toward an exhausted phenotype in persistent COVID-19, based on continuous and upregulated expression of inhibitory markers as well as potential reduced polyfunctionality and cytotoxicity. In severe disease, production of specific inflammatory cytokines by CD4 T cells has also been reported. This working model needs to be confirmed and expanded on in future studies to assess virus-specific T cell responses both in peripheral blood and in tissues. In addition, larger and more defined patient cohorts with longitudinal data are required to define the relationship between disease severity and T cell phenotype."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T36","span":{"begin":25,"end":30},"obj":"Body_part"},{"id":"T37","span":{"begin":650,"end":655},"obj":"Body_part"}],"attributes":[{"id":"A36","pred":"uberon_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A37","pred":"uberon_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"}],"text":"A decrease in peripheral blood T cells associated with disease severity and inflammation is now well documented in COVID-19. Several studies report increased numbers of activated CD4 and CD8 T cells, which display a trend toward an exhausted phenotype in persistent COVID-19, based on continuous and upregulated expression of inhibitory markers as well as potential reduced polyfunctionality and cytotoxicity. In severe disease, production of specific inflammatory cytokines by CD4 T cells has also been reported. This working model needs to be confirmed and expanded on in future studies to assess virus-specific T cell responses both in peripheral blood and in tissues. In addition, larger and more defined patient cohorts with longitudinal data are required to define the relationship between disease severity and T cell phenotype."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T209","span":{"begin":76,"end":88},"obj":"Disease"},{"id":"T210","span":{"begin":115,"end":123},"obj":"Disease"},{"id":"T211","span":{"begin":266,"end":274},"obj":"Disease"}],"attributes":[{"id":"A209","pred":"mondo_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A210","pred":"mondo_id","subj":"T210","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A211","pred":"mondo_id","subj":"T211","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"A decrease in peripheral blood T cells associated with disease severity and inflammation is now well documented in COVID-19. Several studies report increased numbers of activated CD4 and CD8 T cells, which display a trend toward an exhausted phenotype in persistent COVID-19, based on continuous and upregulated expression of inhibitory markers as well as potential reduced polyfunctionality and cytotoxicity. In severe disease, production of specific inflammatory cytokines by CD4 T cells has also been reported. This working model needs to be confirmed and expanded on in future studies to assess virus-specific T cell responses both in peripheral blood and in tissues. In addition, larger and more defined patient cohorts with longitudinal data are required to define the relationship between disease severity and T cell phenotype."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T346","span":{"begin":0,"end":1},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T347","span":{"begin":25,"end":30},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T348","span":{"begin":25,"end":30},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T349","span":{"begin":31,"end":38},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T350","span":{"begin":169,"end":178},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T351","span":{"begin":179,"end":182},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T352","span":{"begin":187,"end":190},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T353","span":{"begin":191,"end":198},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T354","span":{"begin":214,"end":215},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T355","span":{"begin":478,"end":481},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T356","span":{"begin":482,"end":489},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T357","span":{"begin":490,"end":493},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T358","span":{"begin":599,"end":604},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T359","span":{"begin":614,"end":620},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T360","span":{"begin":650,"end":655},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T361","span":{"begin":650,"end":655},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T362","span":{"begin":817,"end":823},"obj":"http://purl.obolibrary.org/obo/CL_0000084"}],"text":"A decrease in peripheral blood T cells associated with disease severity and inflammation is now well documented in COVID-19. Several studies report increased numbers of activated CD4 and CD8 T cells, which display a trend toward an exhausted phenotype in persistent COVID-19, based on continuous and upregulated expression of inhibitory markers as well as potential reduced polyfunctionality and cytotoxicity. In severe disease, production of specific inflammatory cytokines by CD4 T cells has also been reported. This working model needs to be confirmed and expanded on in future studies to assess virus-specific T cell responses both in peripheral blood and in tissues. In addition, larger and more defined patient cohorts with longitudinal data are required to define the relationship between disease severity and T cell phenotype."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T123","span":{"begin":76,"end":88},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"A decrease in peripheral blood T cells associated with disease severity and inflammation is now well documented in COVID-19. Several studies report increased numbers of activated CD4 and CD8 T cells, which display a trend toward an exhausted phenotype in persistent COVID-19, based on continuous and upregulated expression of inhibitory markers as well as potential reduced polyfunctionality and cytotoxicity. In severe disease, production of specific inflammatory cytokines by CD4 T cells has also been reported. This working model needs to be confirmed and expanded on in future studies to assess virus-specific T cell responses both in peripheral blood and in tissues. In addition, larger and more defined patient cohorts with longitudinal data are required to define the relationship between disease severity and T cell phenotype."}

{"project":"LitCovid-PubTator","denotations":[{"id":"963","span":{"begin":179,"end":182},"obj":"Gene"},{"id":"964","span":{"begin":187,"end":190},"obj":"Gene"},{"id":"965","span":{"begin":478,"end":481},"obj":"Gene"},{"id":"966","span":{"begin":761,"end":763},"obj":"Gene"},{"id":"967","span":{"begin":589,"end":591},"obj":"Gene"},{"id":"968","span":{"begin":539,"end":541},"obj":"Gene"},{"id":"969","span":{"begin":709,"end":716},"obj":"Species"},{"id":"970","span":{"begin":76,"end":88},"obj":"Disease"},{"id":"971","span":{"begin":115,"end":123},"obj":"Disease"},{"id":"972","span":{"begin":266,"end":274},"obj":"Disease"},{"id":"973","span":{"begin":396,"end":408},"obj":"Disease"}],"attributes":[{"id":"A963","pred":"tao:has_database_id","subj":"963","obj":"Gene:920"},{"id":"A964","pred":"tao:has_database_id","subj":"964","obj":"Gene:925"},{"id":"A965","pred":"tao:has_database_id","subj":"965","obj":"Gene:920"},{"id":"A966","pred":"tao:has_database_id","subj":"966","obj":"Gene:6999"},{"id":"A967","pred":"tao:has_database_id","subj":"967","obj":"Gene:6999"},{"id":"A968","pred":"tao:has_database_id","subj":"968","obj":"Gene:6999"},{"id":"A969","pred":"tao:has_database_id","subj":"969","obj":"Tax:9606"},{"id":"A970","pred":"tao:has_database_id","subj":"970","obj":"MESH:D007249"},{"id":"A971","pred":"tao:has_database_id","subj":"971","obj":"MESH:C000657245"},{"id":"A972","pred":"tao:has_database_id","subj":"972","obj":"MESH:C000657245"},{"id":"A973","pred":"tao:has_database_id","subj":"973","obj":"MESH:D064420"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"A decrease in peripheral blood T cells associated with disease severity and inflammation is now well documented in COVID-19. Several studies report increased numbers of activated CD4 and CD8 T cells, which display a trend toward an exhausted phenotype in persistent COVID-19, based on continuous and upregulated expression of inhibitory markers as well as potential reduced polyfunctionality and cytotoxicity. In severe disease, production of specific inflammatory cytokines by CD4 T cells has also been reported. This working model needs to be confirmed and expanded on in future studies to assess virus-specific T cell responses both in peripheral blood and in tissues. In addition, larger and more defined patient cohorts with longitudinal data are required to define the relationship between disease severity and T cell phenotype."}

{"project":"LitCovid-sentences","denotations":[{"id":"T173","span":{"begin":0,"end":124},"obj":"Sentence"},{"id":"T174","span":{"begin":125,"end":409},"obj":"Sentence"},{"id":"T175","span":{"begin":410,"end":513},"obj":"Sentence"},{"id":"T176","span":{"begin":514,"end":671},"obj":"Sentence"},{"id":"T177","span":{"begin":672,"end":834},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"A decrease in peripheral blood T cells associated with disease severity and inflammation is now well documented in COVID-19. Several studies report increased numbers of activated CD4 and CD8 T cells, which display a trend toward an exhausted phenotype in persistent COVID-19, based on continuous and upregulated expression of inhibitory markers as well as potential reduced polyfunctionality and cytotoxicity. In severe disease, production of specific inflammatory cytokines by CD4 T cells has also been reported. This working model needs to be confirmed and expanded on in future studies to assess virus-specific T cell responses both in peripheral blood and in tissues. In addition, larger and more defined patient cohorts with longitudinal data are required to define the relationship between disease severity and T cell phenotype."}