PMC:7200337 / 26796-27064 JSONTXT

{"project":"2_test","denotations":[{"id":"32505227-26251193-46575293","span":{"begin":262,"end":266},"obj":"26251193"},{"id":"T84673","span":{"begin":262,"end":266},"obj":"26251193"}],"text":"In vitro stimulation by IL-6 and soluble IL-6 receptor has previously revealed impaired cytolytic functions (perforin and granzyme B production) by healthy donor NK cells, which can be restored following addition of tocilizumab (IL-6R blockade) (Cifaldi et al., 2015)."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T259","span":{"begin":162,"end":170},"obj":"Body_part"},{"id":"T260","span":{"begin":165,"end":170},"obj":"Body_part"}],"attributes":[{"id":"A259","pred":"fma_id","subj":"T259","obj":"http://purl.org/sig/ont/fma/fma63147"},{"id":"A260","pred":"fma_id","subj":"T260","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"In vitro stimulation by IL-6 and soluble IL-6 receptor has previously revealed impaired cytolytic functions (perforin and granzyme B production) by healthy donor NK cells, which can be restored following addition of tocilizumab (IL-6R blockade) (Cifaldi et al., 2015)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T280","span":{"begin":55,"end":58},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T281","span":{"begin":131,"end":132},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T282","span":{"begin":162,"end":170},"obj":"http://purl.obolibrary.org/obo/CL_0000623"}],"text":"In vitro stimulation by IL-6 and soluble IL-6 receptor has previously revealed impaired cytolytic functions (perforin and granzyme B production) by healthy donor NK cells, which can be restored following addition of tocilizumab (IL-6R blockade) (Cifaldi et al., 2015)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T116","span":{"begin":24,"end":26},"obj":"Chemical"},{"id":"T118","span":{"begin":41,"end":43},"obj":"Chemical"},{"id":"T120","span":{"begin":156,"end":161},"obj":"Chemical"},{"id":"T121","span":{"begin":216,"end":227},"obj":"Chemical"},{"id":"T122","span":{"begin":229,"end":231},"obj":"Chemical"}],"attributes":[{"id":"A116","pred":"chebi_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A117","pred":"chebi_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A118","pred":"chebi_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A119","pred":"chebi_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A120","pred":"chebi_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/CHEBI_17891"},{"id":"A121","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_64360"},{"id":"A122","pred":"chebi_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A123","pred":"chebi_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"In vitro stimulation by IL-6 and soluble IL-6 receptor has previously revealed impaired cytolytic functions (perforin and granzyme B production) by healthy donor NK cells, which can be restored following addition of tocilizumab (IL-6R blockade) (Cifaldi et al., 2015)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T111","span":{"begin":122,"end":143},"obj":"http://purl.obolibrary.org/obo/GO_0071613"},{"id":"T112","span":{"begin":229,"end":234},"obj":"http://purl.obolibrary.org/obo/GO_0004915"}],"text":"In vitro stimulation by IL-6 and soluble IL-6 receptor has previously revealed impaired cytolytic functions (perforin and granzyme B production) by healthy donor NK cells, which can be restored following addition of tocilizumab (IL-6R blockade) (Cifaldi et al., 2015)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"858","span":{"begin":24,"end":28},"obj":"Gene"},{"id":"859","span":{"begin":122,"end":132},"obj":"Gene"},{"id":"860","span":{"begin":229,"end":234},"obj":"Gene"},{"id":"879","span":{"begin":216,"end":227},"obj":"Chemical"}],"attributes":[{"id":"A858","pred":"tao:has_database_id","subj":"858","obj":"Gene:3569"},{"id":"A859","pred":"tao:has_database_id","subj":"859","obj":"Gene:3002"},{"id":"A860","pred":"tao:has_database_id","subj":"860","obj":"Gene:3570"},{"id":"A879","pred":"tao:has_database_id","subj":"879","obj":"MESH:C502936"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In vitro stimulation by IL-6 and soluble IL-6 receptor has previously revealed impaired cytolytic functions (perforin and granzyme B production) by healthy donor NK cells, which can be restored following addition of tocilizumab (IL-6R blockade) (Cifaldi et al., 2015)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T150","span":{"begin":0,"end":268},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In vitro stimulation by IL-6 and soluble IL-6 receptor has previously revealed impaired cytolytic functions (perforin and granzyme B production) by healthy donor NK cells, which can be restored following addition of tocilizumab (IL-6R blockade) (Cifaldi et al., 2015)."}