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PMC:7200337 / 26025-27804 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
32505227-9486650-46575289 207-211 9486650 denotes 1998
32505227-9034158-46575290 228-232 9034158 denotes 1997
32505227-29302013-46575291 334-338 29302013 denotes 2018
32505227-26251193-46575293 1033-1037 26251193 denotes 2015
32505227-19559672-46575295 1367-1371 19559672 denotes 2009
32505227-30524877-46575296 1430-1434 30524877 denotes 2017
T58402 207-211 9486650 denotes 1998
T11232 228-232 9034158 denotes 1997
T15390 334-338 29302013 denotes 2018
T84673 1033-1037 26251193 denotes 2015
T83308 1367-1371 19559672 denotes 2009
T78837 1430-1434 30524877 denotes 2017

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T246 44-52 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T247 47-52 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T248 63-68 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T249 130-134 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T250 177-180 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T251 300-303 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T252 419-427 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T253 422-427 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T254 532-540 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T255 535-540 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T256 619-625 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T257 713-720 Body_part denotes NK cell http://purl.org/sig/ont/fma/fma63147
T258 716-720 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T259 933-941 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T260 936-941 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T261 1073-1079 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T262 1179-1184 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T263 1214-1222 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T264 1269-1277 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T265 1272-1277 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T266 1330-1337 Body_part denotes NK cell http://purl.org/sig/ont/fma/fma63147
T267 1333-1337 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T268 1474-1481 Body_part denotes NK cell http://purl.org/sig/ont/fma/fma63147
T269 1477-1481 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T270 1575-1584 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T271 1598-1605 Body_part denotes NK cell http://purl.org/sig/ont/fma/fma63147
T272 1601-1605 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T273 1653-1658 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T274 1729-1736 Body_part denotes NK cell http://purl.org/sig/ont/fma/fma63147
T275 1732-1736 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T28 1179-1184 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T176 74-82 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T177 306-315 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T178 433-441 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T179 589-597 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T180 1083-1091 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T181 1491-1495 Disease denotes ADCC http://purl.obolibrary.org/obo/MONDO_0008734
T182 1633-1641 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T183 1750-1758 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T270 44-52 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cells
T271 57-60 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T272 61-68 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T273 130-134 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T274 334-338 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T275 341-346 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Genes
T276 419-427 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cells
T277 532-540 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cells
T278 619-625 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T279 713-720 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cell
T280 826-829 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T281 902-903 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T282 933-941 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cells
T283 1073-1079 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T284 1179-1184 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T285 1179-1184 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T286 1214-1222 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T287 1269-1277 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cells
T288 1330-1337 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cell
T289 1474-1481 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cell
T290 1496-1499 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T291 1575-1584 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T292 1598-1605 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cell
T293 1653-1658 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T294 1698-1707 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T295 1729-1736 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cell

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T113 183-191 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T114 644-646 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T116 795-797 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T118 812-814 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T120 927-932 Chemical denotes donor http://purl.obolibrary.org/obo/CHEBI_17891
T121 987-998 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T122 1000-1002 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T124 1128-1134 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T125 1279-1282 Chemical denotes Guo http://purl.obolibrary.org/obo/CHEBI_16750
T126 1466-1468 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T128 1685-1687 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T111 893-914 http://purl.obolibrary.org/obo/GO_0071613 denotes granzyme B production
T112 1000-1005 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T113 1330-1353 http://purl.obolibrary.org/obo/GO_0001779 denotes NK cell differentiation
T114 1333-1353 http://purl.obolibrary.org/obo/GO_0030154 denotes cell differentiation
T115 1491-1495 http://purl.obolibrary.org/obo/GO_0001788 denotes ADCC
T116 1601-1617 http://purl.obolibrary.org/obo/GO_0008037 denotes cell recognition
T117 1698-1707 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
852 22-27 Gene denotes NKG2A Gene:3821
853 115-120 Gene denotes NKG2A Gene:3821
854 177-182 Gene denotes HLA-E Gene:3133
855 381-385 Gene denotes LAG3 Gene:3902
856 390-394 Gene denotes TIM3 Gene:84868
857 644-648 Gene denotes IL-6 Gene:3569
858 795-799 Gene denotes IL-6 Gene:3569
859 893-903 Gene denotes granzyme B Gene:3002
860 1000-1005 Gene denotes IL-6R Gene:3570
861 1040-1045 Gene denotes TNF-α Gene:7124
862 1232-1237 Gene denotes TNF-α Gene:7124
863 1298-1303 Gene denotes TNF-α Gene:7124
864 1407-1412 Gene denotes NKp46 Gene:9437
865 1457-1462 Gene denotes TNF-α Gene:7124
866 1466-1470 Gene denotes IL-6 Gene:3569
867 1685-1689 Gene denotes IL-6 Gene:3569
868 1694-1697 Gene denotes TNF Gene:7124
869 1327-1329 Gene denotes to Gene:6999
870 1313-1315 Gene denotes to Gene:6999
871 1249-1251 Gene denotes to Gene:6999
872 558-560 Gene denotes to Gene:6999
873 57-60 Gene denotes CD8 Gene:925
874 83-91 Species denotes patients Tax:9606
875 442-450 Species denotes patients Tax:9606
876 598-606 Species denotes patients Tax:9606
877 1092-1100 Species denotes patients Tax:9606
878 1759-1767 Species denotes patients Tax:9606
879 987-998 Chemical denotes tocilizumab MESH:C502936
880 74-82 Disease denotes COVID-19 MESH:C000657245
881 135-147 Disease denotes cytotoxicity MESH:D064420
882 300-315 Disease denotes HIV-1 infection MESH:D015658
883 433-441 Disease denotes COVID-19 MESH:C000657245
884 589-597 Disease denotes COVID-19 MESH:C000657245
885 1083-1091 Disease denotes COVID-19 MESH:C000657245
886 1633-1652 Disease denotes SARS-CoV-2-infected MESH:C000657245
887 1750-1758 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T145 0-114 Sentence denotes The immune checkpoint NKG2A is increased on NK cells and CD8 T cells from COVID-19 patients (Zheng et al., 2020b).
T146 115-340 Sentence denotes NKG2A inhibits cell cytotoxicity by binding the non-classical HLA-E molecule (Braud et al., 1998, Brooks et al., 1997), and this interaction is strongly correlated with poor control of HIV-1 infection (Ramsuran et al., 2018).
T147 341-493 Sentence denotes Genes encoding the inhibitory receptors LAG3 and TIM3 are also upregulated in NK cells from COVID-19 patients (Wilk et al., 2020, Hadjadj et al., 2020).
T148 494-574 Sentence denotes Thus, increased immune checkpoints on NK cells might contribute to viral escape.
T149 575-770 Sentence denotes Additionally, COVID-19 patients have higher plasma concentrations of IL-6 (Huang et al., 2020b), which significantly correlate with lower NK cell numbers (Wang et al., 2020d, Wang et al., 2020f).
T150 771-1039 Sentence denotes In vitro stimulation by IL-6 and soluble IL-6 receptor has previously revealed impaired cytolytic functions (perforin and granzyme B production) by healthy donor NK cells, which can be restored following addition of tocilizumab (IL-6R blockade) (Cifaldi et al., 2015).
T151 1040-1297 Sentence denotes TNF-α is also upregulated in the plasma of COVID-19 patients (Huang et al., 2020b), and ligand-receptor interaction analysis of peripheral blood scRNA-seq data suggests that monocyte-secreted TNF-α might bind to its receptors on NK cells (Guo et al., 2020).
T152 1298-1521 Sentence denotes TNF-α is known to contribute to NK cell differentiation (Lee et al., 2009), which includes downregulation of NKp46 (Ivagnès et al., 2017), though no effect of TNF-α or IL-6 on NK cell-mediated ADCC has been reported so far.
T153 1522-1779 Sentence denotes Collectively, these data suggest that crosstalk with monocytes might impair NK cell recognition and killing of SARS-CoV-2-infected cells, and antibodies targeting IL-6 and TNF-signaling may benefit enhanced NK cell functions in COVID-19 patients (Figure 2).