PMC:7200337 / 17372-18766
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T101 | 32-44 | Body_part | denotes | Myeloid Cell | http://purl.org/sig/ont/fma/fma70339 |
| T102 | 40-44 | Body_part | denotes | Cell | http://purl.org/sig/ont/fma/fma68646 |
| T103 | 68-75 | Body_part | denotes | NK Cell | http://purl.org/sig/ont/fma/fma63147 |
| T104 | 71-75 | Body_part | denotes | Cell | http://purl.org/sig/ont/fma/fma68646 |
| T105 | 185-189 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T106 | 230-239 | Body_part | denotes | epithelia | http://purl.org/sig/ont/fma/fma9639 |
| T107 | 297-308 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T108 | 339-348 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T109 | 361-373 | Body_part | denotes | granulocytes | http://purl.org/sig/ont/fma/fma62854 |
| T110 | 378-389 | Body_part | denotes | lymphocytes | http://purl.org/sig/ont/fma/fma62863 |
| T111 | 445-454 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T112 | 514-522 | Body_part | denotes | monocyte | http://purl.org/sig/ont/fma/fma62864 |
| T113 | 531-542 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T114 | 689-701 | Body_part | denotes | neutrophilic | http://purl.org/sig/ont/fma/fma62860 |
| T115 | 768-781 | Body_part | denotes | myeloid cells | http://purl.org/sig/ont/fma/fma70339 |
| T116 | 776-781 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T117 | 859-867 | Body_part | denotes | Monocyte | http://purl.org/sig/ont/fma/fma62864 |
| T118 | 902-910 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
| T119 | 905-910 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T120 | 916-921 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T121 | 985-993 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
| T122 | 988-993 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T123 | 1050-1055 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T124 | 1073-1082 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T125 | 1220-1229 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T126 | 1237-1248 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T127 | 1258-1269 | Body_part | denotes | eosinophils | http://purl.org/sig/ont/fma/fma62861 |
| T128 | 1279-1290 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
| T129 | 1301-1311 | Body_part | denotes | neutrophil | http://purl.org/sig/ont/fma/fma62860 |
| T130 | 1331-1335 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T10 | 230-239 | Body_part | denotes | epithelia | http://purl.obolibrary.org/obo/UBERON_0000483 |
| T11 | 916-921 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T118 | 0-8 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T119 | 11-20 | Disease | denotes | Infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T120 | 116-124 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T121 | 637-640 | Disease | denotes | CRS | http://purl.obolibrary.org/obo/MONDO_0007399|http://purl.obolibrary.org/obo/MONDO_0017361 |
| T123 | 743-751 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T124 | 1036-1040 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T125 | 1349-1393 | Disease | denotes | secondary hemophagocytic lymphohistiocytosis | http://purl.obolibrary.org/obo/MONDO_0015542 |
| T126 | 1359-1393 | Disease | denotes | hemophagocytic lymphohistiocytosis | http://purl.obolibrary.org/obo/MONDO_0015540 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T13152 | 40-44 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | Cell |
| T45733 | 45-55 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | Activation |
| T38010 | 68-75 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK Cell |
| T11301 | 339-348 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T3621 | 431-432 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | ɑ |
| T320 | 445-454 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T78868 | 514-522 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocyte |
| T1737 | 776-781 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T84467 | 859-867 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | Monocyte |
| T47301 | 885-887 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T48426 | 902-910 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
| T52652 | 916-921 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T31933 | 916-921 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T14324 | 985-993 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
| T89373 | 1050-1055 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T45576 | 1073-1082 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T99791 | 1220-1229 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T48410 | 1331-1335 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T74 | 179-181 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T76 | 185-187 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T78 | 418-420 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T80 | 876-881 | Chemical | denotes | CXCL9 | http://purl.obolibrary.org/obo/CHEBI_138154 |
| T81 | 957-966 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T82 | 1166-1178 | Chemical | denotes | nitric oxide | http://purl.obolibrary.org/obo/CHEBI_16480 |
| T83 | 1173-1178 | Chemical | denotes | oxide | http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T77 | 40-55 | http://purl.obolibrary.org/obo/GO_0001775 | denotes | Cell Activation |
| T78 | 656-677 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
| T79 | 1331-1341 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | cell death |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 493 | 0-20 | Disease | denotes | SARS-CoV-2 Infection | MESH:C000657245 |
| 496 | 164-177 | Species | denotes | coronaviruses | Tax:11118 |
| 497 | 116-124 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 508 | 179-183 | Gene | denotes | IL-6 | Gene:3569 |
| 509 | 185-190 | Gene | denotes | IL-1β | Gene:3552 |
| 510 | 418-422 | Gene | denotes | IL-6 | Gene:3569 |
| 511 | 427-432 | Gene | denotes | TNF-ɑ | Gene:7124 |
| 512 | 876-887 | Gene | denotes | CXCL9/10/11 | Gene:4283 |
| 513 | 211-219 | Disease | denotes | infected | MESH:D007239 |
| 514 | 555-568 | Disease | denotes | dysfunctional | MESH:D009461 |
| 515 | 689-729 | Disease | denotes | neutrophilic NETosis and microthrombosis | MESH:C564275 |
| 516 | 743-751 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 517 | 1036-1049 | Disease | denotes | SARS-infected | MESH:D045169 |
| 526 | 1132-1136 | Gene | denotes | Arg1 | Gene:383 |
| 527 | 1138-1148 | Gene | denotes | arginase 1 | Gene:383 |
| 528 | 1150-1154 | Gene | denotes | iNOS | Gene:4843 |
| 529 | 1231-1235 | Gene | denotes | Macs | Gene:4082 |
| 530 | 1115-1117 | Gene | denotes | to | Gene:6999 |
| 531 | 1292-1299 | Disease | denotes | NETosis | |
| 532 | 1336-1341 | Disease | denotes | death | MESH:D003643 |
| 533 | 1349-1393 | Disease | denotes | secondary hemophagocytic lymphohistiocytosis | MESH:D051359 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T97 | 85-178 | Sentence | denotes | Based on data from preliminary COVID-19 studies and earlier studies in related coronaviruses. |
| T98 | 179-407 | Sentence | denotes | IL-6, IL-1β, and IFN-I/III from infected pulmonary epithelia can induce inflammatory programs in resident (alternate) macrophages while recruiting inflammatory monocytes, as well as granulocytes and lymphocytes from circulation. |
| T99 | 408-500 | Sentence | denotes | Sustained IL-6 and TNF-ɑ by incoming monocytes can drive several hyperinflammation cascades. |
| T100 | 501-623 | Sentence | denotes | Inflammatory monocyte-derived macrophages can amplify dysfunctional responses in various ways (listed in top-left corner). |
| T101 | 624-761 | Sentence | denotes | The systemic CRS- and sHLH-like inflammatory response can induce neutrophilic NETosis and microthrombosis, aggravating COVID-19 severity. |
| T102 | 762-858 | Sentence | denotes | Other myeloid cells, such as pDCs, are purported to have an IFN-dependent role in viral control. |
| T103 | 859-922 | Sentence | denotes | Monocyte-derived CXCL9/10/11 might recruit NK cells from blood. |
| T104 | 923-1083 | Sentence | denotes | Preliminary data suggest that the antiviral function of these NK cells might be regulated through crosstalk with SARS-infected cells and inflammatory monocytes. |
| T105 | 1084-1131 | Sentence | denotes | Dashed lines indicate pathways to be confirmed. |
| T106 | 1132-1394 | Sentence | denotes | Arg1, arginase 1; iNOS, inducible-nitric oxide synthase; Inflamm., inflammatory; Mono., monocytes; Macs, macrophages; Eosino, eosinophils; Neutro, neutrophils; NETosis, neutrophil extracellular trap cell death; SHLH, secondary hemophagocytic lymphohistiocytosis. |