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PMC:7200337 / 11403-13171 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
32505227-26867177-46575246 475-479 26867177 denotes 2016
32505227-26867177-46575247 644-648 26867177 denotes 2016
32505227-30761102-46575248 1039-1043 30761102 denotes 2019
32505227-26331680-46575249 1066-1070 26331680 denotes 2015
32505227-31231549-46575250 1084-1088 31231549 denotes 2019
32505227-31034780-46575251 1102-1106 31034780 denotes 2019
T64773 475-479 26867177 denotes 2016
T66903 644-648 26867177 denotes 2016
T63051 1039-1043 30761102 denotes 2019
T37267 1066-1070 26331680 denotes 2015
T42183 1084-1088 31231549 denotes 2019
T82803 1102-1106 31034780 denotes 2019

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T89236 738-747 Body_part denotes epithelia http://purl.org/sig/ont/fma/fma9639
T67531 984-992 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T82844 1133-1137 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T26270 1444-1452 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 738-747 Body_part denotes epithelia http://purl.obolibrary.org/obo/UBERON_0000483

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T77 266-274 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T78 321-329 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T79 345-354 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T80 953-961 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T81 1197-1209 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T82 1222-1230 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T83 1472-1480 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T84 1759-1767 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T46300 201-202 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T30392 304-310 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T99176 731-737 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T92879 847-856 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T54720 867-875 http://purl.obolibrary.org/obo/CLO_0001658 denotes actively
T62975 1014-1024 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T55060 1146-1148 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T96273 1270-1274 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T33585 1339-1341 http://purl.obolibrary.org/obo/CLO_0007074 denotes kB
T27677 1339-1341 http://purl.obolibrary.org/obo/CLO_0051988 denotes kB
T80865 1353-1355 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T85633 1353-1355 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li
T17975 1507-1508 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T96342 1581-1582 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T44 688-698 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T45 984-992 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T46 1133-1135 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T48 1143-1145 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T50 1261-1263 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T52 1270-1272 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T54 1336-1338 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T57 1353-1355 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145
T58 1635-1644 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T9 1444-1458 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T62 847-856 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T63 1120-1129 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T64 1197-1209 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T65 1270-1285 http://purl.obolibrary.org/obo/GO_0032637 denotes IL-8 production
T66 1662-1675 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
414 723-727 Gene denotes ACE2 Gene:59272
415 1133-1138 Gene denotes IL-1β Gene:3552
416 1143-1148 Gene denotes IL-18 Gene:3606
417 1233-1237 Gene denotes NSP9 Gene:43740578
418 1242-1247 Gene denotes NSP10 Gene:43740578
419 1261-1265 Gene denotes IL-6 Gene:3569
420 1270-1274 Gene denotes IL-8 Gene:3576
421 1316-1320 Gene denotes NKRF Gene:55922
422 1117-1119 Gene denotes to Gene:6999
423 763-765 Gene denotes to Gene:6999
424 377-379 Gene denotes to Gene:6999
425 129-133 Species denotes CoVs Tax:11118
426 321-329 Species denotes SARS-CoV Tax:694009
427 832-836 Species denotes CoVs Tax:11118
428 953-961 Species denotes SARS-CoV Tax:694009
429 1222-1232 Species denotes SARS-CoV-2 Tax:2697049
430 1481-1489 Species denotes patients Tax:9606
431 266-274 Disease denotes COVID-19 MESH:C000657245
432 336-354 Disease denotes MERS-CoV infection MESH:D018352
433 1197-1209 Disease denotes inflammation MESH:D007249
434 1472-1480 Disease denotes COVID-19 MESH:C000657245
435 1759-1767 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T67 0-57 Sentence denotes Imbalance between Antiviral and Proinflammatory Responses
T68 58-289 Sentence denotes Taken together, the multiplicity of strategies developed by pathogenic CoVs to escape immune sensing, particularly the IFN-I pathway, suggests a critical role played by the dysregulation of IFN-I response in COVID-19 pathogenicity.
T69 290-481 Sentence denotes Concordantly, animal models of SARS-CoV-1 and MERS-CoV infection indicate that failure to elicit an early IFN-I response correlates with the severity of disease (Channappanavar et al., 2016).
T70 482-679 Sentence denotes Perhaps more importantly, these models demonstrate that timing is key, as IFN is protective early in disease but later becomes pathologic (Channappanavar et al., 2016, Channappanavar et al., 2019).
T71 680-801 Sentence denotes Perhaps interferon-induced upregulation of ACE2 in airway epithelia may contribute to this effect (Ziegler et al., 2020).
T72 802-938 Sentence denotes Furthermore, while pathogenic CoVs block IFN signaling, they may actively promote other inflammatory pathways contributing to pathology.
T73 939-1210 Sentence denotes For instance, SARS-CoV-1 ORF3a, ORF8b, and E proteins enhance inflammasome activation (Chen et al., 2019, Nieto-Torres et al., 2015, Shi et al., 2019, Siu et al., 2019), leading to secretion of IL-1β and IL-18, which are likely to contribute to pathological inflammation.
T74 1211-1371 Sentence denotes Similarly, SARS-CoV-2 NSP9 and NSP10 might induce IL-6 and IL-8 production, potentially by inhibition of NKRF, an endogenous NF-kB repressor (Li et al., 2020a).
T75 1372-1564 Sentence denotes Collectively, these proinflammatory processes likely contribute to the “cytokine storm” observed in COVID-19 patients and substantiate a role for targeted immunosuppressive treatment regimens.
T76 1565-1768 Sentence denotes Moving forward, a clear understanding of the delicate balance between antiviral and inflammatory innate immune programs will be essential to developing effective biomarkers and therapeutics for COVID-19.