PMC:7200337 / 107348-110767 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
32505227-18018769-46575459 222-226 18018769 denotes 2007
32505227-18824060-46575460 243-247 18824060 denotes 2008
32505227-31351922-46575461 267-271 31351922 denotes 2019
32505227-32249203-46575462 835-839 32249203 denotes 2020
32505227-29456015-46575463 1807-1811 29456015 denotes 2018
32505227-28151488-46575464 1833-1837 28151488 denotes 2017
32505227-31351922-46575465 2131-2135 31351922 denotes 2019
32505227-26386540-46575466 2159-2163 26386540 denotes 2015
32505227-25817373-46575467 2270-2274 25817373 denotes 2015
32505227-28017399-46575468 2288-2292 28017399 denotes 2017
32505227-28579232-46575469 2443-2447 28579232 denotes 2017
32505227-24374965-46575470 2472-2476 24374965 denotes 2014
32505227-32269218-46575471 2966-2970 32269218 denotes 2020
T97524 222-226 18018769 denotes 2007
T59957 243-247 18824060 denotes 2008
T65299 267-271 31351922 denotes 2019
T17822 835-839 32249203 denotes 2020
T14358 1807-1811 29456015 denotes 2018
T62936 1833-1837 28151488 denotes 2017
T51102 2131-2135 31351922 denotes 2019
T13962 2159-2163 26386540 denotes 2015
T50496 2270-2274 25817373 denotes 2015
T64340 2288-2292 28017399 denotes 2017
T45793 2443-2447 28579232 denotes 2017
T6171 2472-2476 24374965 denotes 2014
T33073 2966-2970 32269218 denotes 2020

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T41 110-117 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T42 793-800 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T43 1063-1070 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T44 1721-1725 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T45 1748-1752 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T46 1771-1778 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T47 1889-1893 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T48 1929-1932 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T49 2042-2045 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T50 2072-2079 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T51 2227-2234 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T52 2388-2395 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T53 2511-2526 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T54 2521-2526 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T55 2895-2902 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T56 3112-3119 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T57 3213-3237 Body_part denotes antigen-presenting cells http://purl.org/sig/ont/fma/fma273565
T58 3232-3237 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T59 3383-3388 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T613 4-12 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T614 315-323 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T615 1014-1023 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T616 1961-1971 Disease denotes S sequence http://purl.obolibrary.org/obo/MONDO_0007821
T617 2007-2009 Disease denotes SE http://purl.obolibrary.org/obo/MONDO_0002125
T618 2177-2180 Disease denotes Ad5 http://purl.obolibrary.org/obo/MONDO_0011194
T619 2490-2498 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T620 2590-2598 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T621 2689-2697 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T622 2767-2775 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T623 3005-3013 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T624 3067-3073 Disease denotes rabies http://purl.obolibrary.org/obo/MONDO_0019173
T625 3092-3100 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T626 3266-3271 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T627 3284-3295 Disease denotes hepatitis A http://purl.obolibrary.org/obo/MONDO_0005790
T628 3284-3293 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T629 3335-3344 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T630 3359-3368 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T631 3408-3412 Disease denotes Zika http://purl.obolibrary.org/obo/MONDO_0018661

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T90 29-35 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T91 408-409 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T92 477-484 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T93 507-514 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T94 529-541 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T95 551-552 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T96 764-765 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T97 782-784 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T98 1024-1029 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T99 1139-1146 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T100 1150-1151 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T101 1206-1221 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes rhesus macaques
T102 1396-1402 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T103 1807-1811 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T104 1869-1871 http://purl.obolibrary.org/obo/CLO_0002105 denotes c2
T105 1869-1871 http://purl.obolibrary.org/obo/CLO_0051742 denotes c2
T106 2511-2526 http://purl.obolibrary.org/obo/CL_0000451 denotes dendritic cells
T107 2623-2632 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T108 2856-2864 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T109 3074-3079 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T110 3103-3105 http://purl.obolibrary.org/obo/CLO_0008882 denotes rS
T111 3232-3237 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T112 3272-3277 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T113 3294-3295 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T114 3296-3301 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T115 3308-3313 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T116 3345-3346 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T117 3347-3352 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T118 3369-3370 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T119 3371-3376 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T120 3413-3418 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T69460 110-117 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T58496 210-213 Chemical denotes Lin http://purl.obolibrary.org/obo/CHEBI_32386
T83392 793-800 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T48814 1063-1070 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T98496 1771-1778 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T58596 2007-2009 Chemical denotes SE http://purl.obolibrary.org/obo/CHEBI_74813
T56 2042-2045 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T77516 2072-2079 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T87436 2227-2234 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T71612 2334-2336 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T31898 2388-2395 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T15035 2499-2501 Chemical denotes LV http://purl.obolibrary.org/obo/CHEBI_73579
T54605 2599-2607 Chemical denotes antigens http://purl.obolibrary.org/obo/CHEBI_59132
T91585 2776-2784 Chemical denotes antigens http://purl.obolibrary.org/obo/CHEBI_59132
T38960 2895-2902 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T99016 3112-3119 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T31789 3120-3132 Chemical denotes nanoparticle http://purl.obolibrary.org/obo/CHEBI_50803
T67 3166-3174 Chemical denotes adjuvant http://purl.obolibrary.org/obo/CHEBI_60809
T43172 3213-3220 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T69 3383-3388 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T23115 3389-3401 Chemical denotes nanoparticle http://purl.obolibrary.org/obo/CHEBI_50803

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T60 3284-3293 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3562 1861-1867 Gene denotes b1, b2 Gene:931
3563 3164-3165 Gene denotes M Gene:43740571
3564 2756-2758 Gene denotes to Gene:6999
3565 2579-2581 Gene denotes to Gene:6999
3566 3106-3111 Gene denotes spike Gene:43740568
3567 2103-2111 Species denotes MERS-CoV Tax:1335626
3568 2181-2185 Species denotes nCoV Tax:2697049
3569 2186-2203 Species denotes adenovirus type 5 Tax:28285
3570 2346-2350 Species denotes nCoV Tax:2697049
3571 2354-2364 Species denotes adenovirus Tax:10508
3572 2417-2425 Species denotes MERS-CoV Tax:1335626
3573 3005-3015 Species denotes SARS-CoV-2 Tax:2697049
3574 3055-3065 Species denotes poliovirus Tax:138950
3575 3067-3079 Species denotes rabies virus Tax:11292
3576 3092-3102 Species denotes SARS-CoV-2 Tax:2697049
3577 2007-2009 Disease denotes SE
3578 2490-2498 Disease denotes COVID-19 MESH:C000657245
3579 2527-2535 Disease denotes infected MESH:D007239
3580 2590-2598 Disease denotes COVID-19 MESH:C000657245
3581 2689-2697 Disease denotes COVID-19 MESH:C000657245
3582 2698-2718 Disease denotes aAPCs aAPCs infected MESH:D007239
3583 2767-2775 Disease denotes COVID-19 MESH:C000657245
3590 3266-3277 Species denotes Ebola virus Tax:1570291
3591 3284-3301 Species denotes hepatitis A virus Tax:12092
3592 3308-3328 Species denotes human papillomavirus Tax:10566
3593 3335-3352 Species denotes influenza A virus Tax:11320
3594 3359-3376 Species denotes influenza B virus Tax:11520
3595 3408-3418 Species denotes Zika virus Tax:64320
3603 703-705 Gene denotes to Gene:6999
3604 4-12 Species denotes SARS-CoV Tax:694009
3605 19-27 Species denotes MERS-CoV Tax:1335626
3606 315-325 Species denotes SARS-CoV-2 Tax:2697049
3607 1014-1029 Species denotes influenza virus Tax:11308
3608 1206-1221 Species denotes rhesus macaques Tax:9544
3609 160-163 Chemical denotes nAb

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T639 0-273 Sentence denotes For SARS-CoV-1 and MERS-CoV, animal studies and phase I clinical trials of potential vaccines targeting the S protein had encouraging results, with evidence of nAb induction and induction of cellular immunity (Lin et al., 2007, Martin et al., 2008, Modjarrad et al., 2019).
T640 274-390 Sentence denotes These findings are being translated into SARS-CoV-2 vaccine development efforts, hastening the progress drastically.
T641 391-550 Sentence denotes The WHO provided a report in April that reported 63 vaccine candidates in preclinical testing and three in clinical testing (World Health Organization, 2020b).
T642 551-657 Sentence denotes A recent search on May 1, 2020 on ClinicalTrials.gov revealed 10 registered vaccine candidates (Table 5 ).
T643 658-841 Sentence denotes The University of Pittsburgh is also looking to move their microneedle array vaccine candidate containing a codon-optimized S1 subunit protein into clinical trials (Kim et al., 2020).
T644 842-1106 Sentence denotes Sanofi and GlaxoSmithKline (GSK) have recently reported their intent to collaborate and bring together Sanofi’s baculovirus expression system, which is used to produce the influenza virus vaccine, Flublok, to create an S protein vaccine adjuvanted with GSK’s AS03.
T645 1107-1307 Sentence denotes Sinovac Biotech will also enter testing in a clinical trial in China after it was found to protect rhesus macaques from viral challenge without signs of detectable immunopathology (Gao et al., 2020c).
T646 1308-1578 Sentence denotes Although some of these vaccine candidates are based on platforms that have been used or tested for other purposes, there remain questions regarding their safety and immunogenicity, including the longevity of any induced responses, that will require continual evaluation.
T647 1579-1646 Sentence denotes Table 5 Vaccine Candidates Currently Registered for Clinical Trials
T648 1647-1720 Sentence denotes Candidate Design Developer Similar Strategy ClinicalTrials.gov Identifier
T649 1721-1850 Sentence denotes mRNA-1273 LNP-encapsulated mRNA for full-length S protein ModernaTX CMV (John et al., 2018), ZKV (Pardi et al., 2017) NCT04283461
T650 1851-2032 Sentence denotes BNT162a1, b1, b2, c2 LNP-encapsulated mRNA vaccines with different formats of RNA and targets, two for larger S sequence and two for optimized RBD BioNTech SE and Pfizer NCT04368728
T651 2033-2176 Sentence denotes INO-4800 DNA vaccine for full-length S protein Inovio Pharmaceuticals MERS-CoV (Modjarrad et al., 2019), HPV (Trimble et al., 2015) NCT04336410
T652 2177-2337 Sentence denotes Ad5-nCoV adenovirus type 5 encoding full-length S protein CanSino Biologics EBV (Zhu et al., 2015, Zhu et al., 2017) NCT04313127 (phase I)NCT04341389 (phase II)
T653 2338-2489 Sentence denotes ChAdOx1 nCoV-19 adenovirus encoding full-length S protein University of Oxford MERS-CoV (Alharbi et al., 2017), IAV (Antrobus et al., 2014) NCT04324606
T654 2490-2688 Sentence denotes COVID-19 LV-SMENP-DC dendritic cells infected with lentivirus expressing SMENP minigenes to express COVID-19 antigens, together with activated CTLs Shenzhen Geno-Immune Medical Institute NCT04276896
T655 2689-2835 Sentence denotes COVID-19 aAPCs aAPCs infected with lentivirus expressing minigenes to express COVID-19 antigens Shenzhen Geno-Immune Medical Institute NCT04299724
T656 2836-2983 Sentence denotes bacTRL-Spike-1 live bacteria delivering plasmid encoding S protein Symvivo Corporation therapeutics reviewed (Charbonneau et al., 2020) NCT04334980
T657 2984-3091 Sentence denotes PiCoVacc inactivated SARS-CoV-2 vaccine Sinovac Biotech HAV, IAV, IBV, poliovirus, rabies virus NCT04352608
T658 3092-3194 Sentence denotes SARS-CoV-2 rS spike protein nanoparticle vaccine with or without Matrix-M adjuvant Novavax NCT04368988
T659 3195-3419 Sentence denotes aAPCs, artificial antigen-presenting cells; CMV, cytomegalovirus; EBV, Ebola virus; HAV, hepatitis A virus; HPV, human papillomavirus; IAV, influenza A virus; IBV, influenza B virus; LPN, lipid nanoparticle; ZKV, Zika virus.