PMC:7200337 / 107331-110767 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
32505227-18018769-46575459 239-243 18018769 denotes 2007
32505227-18824060-46575460 260-264 18824060 denotes 2008
32505227-31351922-46575461 284-288 31351922 denotes 2019
32505227-32249203-46575462 852-856 32249203 denotes 2020
32505227-29456015-46575463 1824-1828 29456015 denotes 2018
32505227-28151488-46575464 1850-1854 28151488 denotes 2017
32505227-31351922-46575465 2148-2152 31351922 denotes 2019
32505227-26386540-46575466 2176-2180 26386540 denotes 2015
32505227-25817373-46575467 2287-2291 25817373 denotes 2015
32505227-28017399-46575468 2305-2309 28017399 denotes 2017
32505227-28579232-46575469 2460-2464 28579232 denotes 2017
32505227-24374965-46575470 2489-2493 24374965 denotes 2014
32505227-32269218-46575471 2983-2987 32269218 denotes 2020
T97524 239-243 18018769 denotes 2007
T59957 260-264 18824060 denotes 2008
T65299 284-288 31351922 denotes 2019
T17822 852-856 32249203 denotes 2020
T14358 1824-1828 29456015 denotes 2018
T62936 1850-1854 28151488 denotes 2017
T51102 2148-2152 31351922 denotes 2019
T13962 2176-2180 26386540 denotes 2015
T50496 2287-2291 25817373 denotes 2015
T64340 2305-2309 28017399 denotes 2017
T45793 2460-2464 28579232 denotes 2017
T6171 2489-2493 24374965 denotes 2014
T33073 2983-2987 32269218 denotes 2020

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T41 127-134 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T42 810-817 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T43 1080-1087 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T44 1738-1742 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T45 1765-1769 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T46 1788-1795 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T47 1906-1910 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T48 1946-1949 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T49 2059-2062 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T50 2089-2096 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T51 2244-2251 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T52 2405-2412 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T53 2528-2543 Body_part denotes dendritic cells http://purl.org/sig/ont/fma/fma273565
T54 2538-2543 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T55 2912-2919 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T56 3129-3136 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T57 3230-3254 Body_part denotes antigen-presenting cells http://purl.org/sig/ont/fma/fma273565
T58 3249-3254 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T59 3400-3405 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T613 21-29 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T614 332-340 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T615 1031-1040 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T616 1978-1988 Disease denotes S sequence http://purl.obolibrary.org/obo/MONDO_0007821
T617 2024-2026 Disease denotes SE http://purl.obolibrary.org/obo/MONDO_0002125
T618 2194-2197 Disease denotes Ad5 http://purl.obolibrary.org/obo/MONDO_0011194
T619 2507-2515 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T620 2607-2615 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T621 2706-2714 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T622 2784-2792 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T623 3022-3030 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T624 3084-3090 Disease denotes rabies http://purl.obolibrary.org/obo/MONDO_0019173
T625 3109-3117 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T626 3283-3288 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T627 3301-3312 Disease denotes hepatitis A http://purl.obolibrary.org/obo/MONDO_0005790
T628 3301-3310 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T629 3352-3361 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T630 3376-3385 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T631 3425-3429 Disease denotes Zika http://purl.obolibrary.org/obo/MONDO_0018661

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T90 46-52 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T91 425-426 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T92 494-501 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T93 524-531 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T94 546-558 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T95 568-569 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T96 781-782 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T97 799-801 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T98 1041-1046 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T99 1156-1163 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T100 1167-1168 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T101 1223-1238 http://purl.obolibrary.org/obo/NCBITaxon_9544 denotes rhesus macaques
T102 1413-1419 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T103 1824-1828 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T104 1886-1888 http://purl.obolibrary.org/obo/CLO_0002105 denotes c2
T105 1886-1888 http://purl.obolibrary.org/obo/CLO_0051742 denotes c2
T106 2528-2543 http://purl.obolibrary.org/obo/CL_0000451 denotes dendritic cells
T107 2640-2649 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T108 2873-2881 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T109 3091-3096 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T110 3120-3122 http://purl.obolibrary.org/obo/CLO_0008882 denotes rS
T111 3249-3254 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T112 3289-3294 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T113 3311-3312 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T114 3313-3318 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T115 3325-3330 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T116 3362-3363 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T117 3364-3369 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T118 3386-3387 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T119 3388-3393 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T120 3430-3435 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T69460 127-134 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T58496 227-230 Chemical denotes Lin http://purl.obolibrary.org/obo/CHEBI_32386
T83392 810-817 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T48814 1080-1087 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T98496 1788-1795 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T58596 2024-2026 Chemical denotes SE http://purl.obolibrary.org/obo/CHEBI_74813
T56 2059-2062 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T77516 2089-2096 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T87436 2244-2251 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T71612 2351-2353 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T31898 2405-2412 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T15035 2516-2518 Chemical denotes LV http://purl.obolibrary.org/obo/CHEBI_73579
T54605 2616-2624 Chemical denotes antigens http://purl.obolibrary.org/obo/CHEBI_59132
T91585 2793-2801 Chemical denotes antigens http://purl.obolibrary.org/obo/CHEBI_59132
T38960 2912-2919 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T99016 3129-3136 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T31789 3137-3149 Chemical denotes nanoparticle http://purl.obolibrary.org/obo/CHEBI_50803
T67 3183-3191 Chemical denotes adjuvant http://purl.obolibrary.org/obo/CHEBI_60809
T43172 3230-3237 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T69 3400-3405 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T23115 3406-3418 Chemical denotes nanoparticle http://purl.obolibrary.org/obo/CHEBI_50803

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T60 3301-3310 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3562 1878-1884 Gene denotes b1, b2 Gene:931
3563 3181-3182 Gene denotes M Gene:43740571
3564 2773-2775 Gene denotes to Gene:6999
3565 2596-2598 Gene denotes to Gene:6999
3566 3123-3128 Gene denotes spike Gene:43740568
3567 2120-2128 Species denotes MERS-CoV Tax:1335626
3568 2198-2202 Species denotes nCoV Tax:2697049
3569 2203-2220 Species denotes adenovirus type 5 Tax:28285
3570 2363-2367 Species denotes nCoV Tax:2697049
3571 2371-2381 Species denotes adenovirus Tax:10508
3572 2434-2442 Species denotes MERS-CoV Tax:1335626
3573 3022-3032 Species denotes SARS-CoV-2 Tax:2697049
3574 3072-3082 Species denotes poliovirus Tax:138950
3575 3084-3096 Species denotes rabies virus Tax:11292
3576 3109-3119 Species denotes SARS-CoV-2 Tax:2697049
3577 2024-2026 Disease denotes SE
3578 2507-2515 Disease denotes COVID-19 MESH:C000657245
3579 2544-2552 Disease denotes infected MESH:D007239
3580 2607-2615 Disease denotes COVID-19 MESH:C000657245
3581 2706-2714 Disease denotes COVID-19 MESH:C000657245
3582 2715-2735 Disease denotes aAPCs aAPCs infected MESH:D007239
3583 2784-2792 Disease denotes COVID-19 MESH:C000657245
3590 3283-3294 Species denotes Ebola virus Tax:1570291
3591 3301-3318 Species denotes hepatitis A virus Tax:12092
3592 3325-3345 Species denotes human papillomavirus Tax:10566
3593 3352-3369 Species denotes influenza A virus Tax:11320
3594 3376-3393 Species denotes influenza B virus Tax:11520
3595 3425-3435 Species denotes Zika virus Tax:64320
3603 720-722 Gene denotes to Gene:6999
3604 21-29 Species denotes SARS-CoV Tax:694009
3605 36-44 Species denotes MERS-CoV Tax:1335626
3606 332-342 Species denotes SARS-CoV-2 Tax:2697049
3607 1031-1046 Species denotes influenza virus Tax:11308
3608 1223-1238 Species denotes rhesus macaques Tax:9544
3609 177-180 Chemical denotes nAb

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T638 0-16 Sentence denotes Vaccine Pipeline
T639 17-290 Sentence denotes For SARS-CoV-1 and MERS-CoV, animal studies and phase I clinical trials of potential vaccines targeting the S protein had encouraging results, with evidence of nAb induction and induction of cellular immunity (Lin et al., 2007, Martin et al., 2008, Modjarrad et al., 2019).
T640 291-407 Sentence denotes These findings are being translated into SARS-CoV-2 vaccine development efforts, hastening the progress drastically.
T641 408-567 Sentence denotes The WHO provided a report in April that reported 63 vaccine candidates in preclinical testing and three in clinical testing (World Health Organization, 2020b).
T642 568-674 Sentence denotes A recent search on May 1, 2020 on ClinicalTrials.gov revealed 10 registered vaccine candidates (Table 5 ).
T643 675-858 Sentence denotes The University of Pittsburgh is also looking to move their microneedle array vaccine candidate containing a codon-optimized S1 subunit protein into clinical trials (Kim et al., 2020).
T644 859-1123 Sentence denotes Sanofi and GlaxoSmithKline (GSK) have recently reported their intent to collaborate and bring together Sanofi’s baculovirus expression system, which is used to produce the influenza virus vaccine, Flublok, to create an S protein vaccine adjuvanted with GSK’s AS03.
T645 1124-1324 Sentence denotes Sinovac Biotech will also enter testing in a clinical trial in China after it was found to protect rhesus macaques from viral challenge without signs of detectable immunopathology (Gao et al., 2020c).
T646 1325-1595 Sentence denotes Although some of these vaccine candidates are based on platforms that have been used or tested for other purposes, there remain questions regarding their safety and immunogenicity, including the longevity of any induced responses, that will require continual evaluation.
T647 1596-1663 Sentence denotes Table 5 Vaccine Candidates Currently Registered for Clinical Trials
T648 1664-1737 Sentence denotes Candidate Design Developer Similar Strategy ClinicalTrials.gov Identifier
T649 1738-1867 Sentence denotes mRNA-1273 LNP-encapsulated mRNA for full-length S protein ModernaTX CMV (John et al., 2018), ZKV (Pardi et al., 2017) NCT04283461
T650 1868-2049 Sentence denotes BNT162a1, b1, b2, c2 LNP-encapsulated mRNA vaccines with different formats of RNA and targets, two for larger S sequence and two for optimized RBD BioNTech SE and Pfizer NCT04368728
T651 2050-2193 Sentence denotes INO-4800 DNA vaccine for full-length S protein Inovio Pharmaceuticals MERS-CoV (Modjarrad et al., 2019), HPV (Trimble et al., 2015) NCT04336410
T652 2194-2354 Sentence denotes Ad5-nCoV adenovirus type 5 encoding full-length S protein CanSino Biologics EBV (Zhu et al., 2015, Zhu et al., 2017) NCT04313127 (phase I)NCT04341389 (phase II)
T653 2355-2506 Sentence denotes ChAdOx1 nCoV-19 adenovirus encoding full-length S protein University of Oxford MERS-CoV (Alharbi et al., 2017), IAV (Antrobus et al., 2014) NCT04324606
T654 2507-2705 Sentence denotes COVID-19 LV-SMENP-DC dendritic cells infected with lentivirus expressing SMENP minigenes to express COVID-19 antigens, together with activated CTLs Shenzhen Geno-Immune Medical Institute NCT04276896
T655 2706-2852 Sentence denotes COVID-19 aAPCs aAPCs infected with lentivirus expressing minigenes to express COVID-19 antigens Shenzhen Geno-Immune Medical Institute NCT04299724
T656 2853-3000 Sentence denotes bacTRL-Spike-1 live bacteria delivering plasmid encoding S protein Symvivo Corporation therapeutics reviewed (Charbonneau et al., 2020) NCT04334980
T657 3001-3108 Sentence denotes PiCoVacc inactivated SARS-CoV-2 vaccine Sinovac Biotech HAV, IAV, IBV, poliovirus, rabies virus NCT04352608
T658 3109-3211 Sentence denotes SARS-CoV-2 rS spike protein nanoparticle vaccine with or without Matrix-M adjuvant Novavax NCT04368988
T659 3212-3436 Sentence denotes aAPCs, artificial antigen-presenting cells; CMV, cytomegalovirus; EBV, Ebola virus; HAV, hepatitis A virus; HPV, human papillomavirus; IAV, influenza A virus; IBV, influenza B virus; LPN, lipid nanoparticle; ZKV, Zika virus.