PMC:7200337 / 100788-103276 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7200337","sourcedb":"PMC","sourceid":"7200337","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7200337","text":"Some studies and case reports on CP therapy for COVID-19 have evaluated the safety and the potential effectiveness of CP therapy in patients with severe disease (Ahn et al., 2020, Duan et al., 2020, Pei et al., 2020, Shen et al., 2020, Zhang et al., 2020b) (Table 4 ). These studies were neither controlled nor randomized, but they suggest that CP therapy is safe and can have a beneficial effect on the clinical course of disease. Further controlled trials are needed to determine the optimal timing and indication for CP therapy. CP therapy has also been proposed for prophylactic use in at-risk individuals, such as those with underlying health conditions or health care workers exposed to COVID-19 patients. The FDA has approved the use of CP to treat critically ill patients (Tanne, 2020). Determining when to administer the CP is also of great importance, as a study in SARS-CoV-1 patients showed that CP was much more efficient when given to patients before day 14 day of illness (Cheng et al., 2005b), as previously shown in influenza (Luke et al., 2006). This study also showed that CP therapy was more efficient in PCR-positive, seronegative patients. The amount of plasma and number of transfusions needed requires further investigation (Table 4).\nTable 4 Clinical Studies of Convalescent Plasma Therapy in COVID-19 Patients\nPatient Characteristics Start of CP Therapy Results Reference\n5 severe patients (30–70 yo) between 10 and 22 days after hospital admission body temperature normalized within 3 days in 4 of 5 patients Shen et al., 2020\nclinical improvement\nviral loads became negative within 12 days of the transfusion\nnAb titers increased\n10 severe patients (34–78 yo) median 16.5 dpo disappearance of clinical symptoms after 3d Duan et al., 2020\nchest CT improved\nelevation of lymphocyte counts in patients with lymphocytopenia.\nincrease in SaO2 in all patients\nresolution of SARS-CoV-2 viremia in 7 patients\nincrease in neutralizing antibody titers in 5 patients\n4 critical patients (31–73 yo) at degradation of symptoms,between 11 and 19 days after hospital admission clinical improvement Zhang et al., 2020b\nreduced viral load\nchest CT improved\n1 moderate patient, 2 critical patients 12 dpo, 27 dpo viral detection negative 4 days after CP Pei et al., 2020\nclinical improvement of 2 patients\n2 severe patients (67 and 71 yo) 7 dpo or 22 dpo clinical improvement Ahn et al., 2020\nreduced viral load\nchest CT improved\nyo, years old; dpo, days post onset of 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