PMC:7199903 / 15455-16161 JSONTXT

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{"project":"LitCovid-sample-sentences","denotations":[{"id":"T101","span":{"begin":0,"end":155},"obj":"Sentence"},{"id":"T102","span":{"begin":156,"end":415},"obj":"Sentence"},{"id":"T103","span":{"begin":416,"end":543},"obj":"Sentence"},{"id":"T104","span":{"begin":544,"end":706},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Our glycosylation analysis of SARS-CoV-2 offers a detailed benchmark of site-specific glycan signatures characteristic of a natively folded trimeric spike. As an increasing number of glycoprotein-based vaccine candidates are being developed, their detailed glycan analysis offers a route for comparing immunogen integrity and will also be important to monitor as manufacturing processes are scaled for clinical use. Glycan profiling will therefore also be an important measure of antigen quality in the manufacture of serological testing kits. Last, with the advent of nucleotide-based vaccines, it will be important to understand how those delivery mechanisms affect immunogen processing and presentation."}

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{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T40","span":{"begin":4,"end":17},"obj":"http://purl.obolibrary.org/obo/GO_0070085"}],"text":"Our glycosylation analysis of SARS-CoV-2 offers a detailed benchmark of site-specific glycan signatures characteristic of a natively folded trimeric spike. As an increasing number of glycoprotein-based vaccine candidates are being developed, their detailed glycan analysis offers a route for comparing immunogen integrity and will also be important to monitor as manufacturing processes are scaled for clinical use. Glycan profiling will therefore also be an important measure of antigen quality in the manufacture of serological testing kits. Last, with the advent of nucleotide-based vaccines, it will be important to understand how those delivery mechanisms affect immunogen processing and presentation."}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T38","span":{"begin":4,"end":17},"obj":"http://purl.obolibrary.org/obo/GO_0070085"}],"text":"Our glycosylation analysis of SARS-CoV-2 offers a detailed benchmark of site-specific glycan signatures characteristic of a natively folded trimeric spike. As an increasing number of glycoprotein-based vaccine candidates are being developed, their detailed glycan analysis offers a route for comparing immunogen integrity and will also be important to monitor as manufacturing processes are scaled for clinical use. Glycan profiling will therefore also be an important measure of antigen quality in the manufacture of serological testing kits. Last, with the advent of nucleotide-based vaccines, it will be important to understand how those delivery mechanisms affect immunogen processing and presentation."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T46","span":{"begin":4,"end":17},"obj":"http://purl.obolibrary.org/obo/GO_0070085"}],"text":"Our glycosylation analysis of SARS-CoV-2 offers a detailed benchmark of site-specific glycan signatures characteristic of a natively folded trimeric spike. As an increasing number of glycoprotein-based vaccine candidates are being developed, their detailed glycan analysis offers a route for comparing immunogen integrity and will also be important to monitor as manufacturing processes are scaled for clinical use. Glycan profiling will therefore also be an important measure of antigen quality in the manufacture of serological testing kits. Last, with the advent of nucleotide-based vaccines, it will be important to understand how those delivery mechanisms affect immunogen processing and presentation."}

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