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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id tao:has_standard_notation
2 27-35 Disease denotes COVID-19 MESH:C000657245
3 47-67 Disease denotes sudden cardiac death MESH:D016757
12 151-198 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
13 200-210 Species denotes SARS-CoV-2 Tax:2697049
14 239-263 Disease denotes coronavirus disease 2019 MESH:C000657245
15 265-273 Disease denotes COVID-19 MESH:C000657245
16 280-288 Disease denotes infected MESH:D007239
17 458-466 Disease denotes COVID-19 MESH:C000657245
18 608-617 Disease denotes mortality MESH:D003643
19 728-741 Disease denotes sudden deaths MESH:D003645
32 967-977 Species denotes outpatient Tax:9606
33 1275-1283 Species denotes patients Tax:9606
34 1091-1109 Chemical denotes hydroxychloroquine MESH:D006886
35 1311-1322 Chemical denotes chloroquine MESH:D002738
36 1326-1344 Chemical denotes hydroxychloroquine MESH:D006886
37 1349-1361 Chemical denotes azithromycin MESH:D017963
38 789-795 Disease denotes deaths MESH:D003643
39 832-840 Disease denotes COVID-19 MESH:C000657245
40 876-895 Disease denotes respiratory arrests MESH:D012131
41 1001-1009 Disease denotes COVID-19 MESH:C000657245
42 1289-1297 Disease denotes COVID-19 MESH:C000657245
43 1366-1381 Disease denotes QTc values rise MESH:D006261
57 1461-1469 Species denotes patients Tax:9606
58 1841-1852 Chemical denotes chloroquine MESH:D002738
59 1853-1871 Chemical denotes hydroxychloroquine MESH:D006886
60 1959-1970 Chemical denotes chloroquine MESH:D002738
61 1971-1989 Chemical denotes hydroxychloroquine MESH:D006886
62 1475-1483 Disease denotes COVID-19 MESH:C000657245
63 1585-1601 Disease denotes long QT syndrome MESH:D008133
64 1655-1674 Disease denotes torsades de pointes MESH:D016171
65 1676-1682 Disease denotes DI-TdP MESH:C564703
66 1706-1726 Disease denotes sudden cardiac death MESH:D016757
67 1799-1813 Disease denotes DI-LQTS/DI-TdP MESH:C564703
68 2107-2120 Disease denotes sudden deaths MESH:D003645
69 2138-2146 Disease denotes COVID-19 MESH:C000657245
82 2176-2184 Disease denotes COVID-19 MESH:C000657245
83 2358-2366 Disease denotes COVID-19 MESH:C000657245
84 2421-2429 Disease denotes COVID-19 MESH:C000657245
85 2447-2455 Disease denotes COVID-19 MESH:C000657245
86 2456-2462 Disease denotes deaths MESH:D003643
87 2531-2539 Disease denotes COVID-19 MESH:C000657245
88 2540-2549 Disease denotes mortality MESH:D003643
89 2805-2825 Disease denotes SARS-CoV-2 infection MESH:C000657245
90 2849-2856 Disease denotes hypoxia MESH:D000860
91 2861-2873 Disease denotes inflammation MESH:D007249
92 2918-2926 Disease denotes COVID-19 MESH:C000657245
93 2951-2957 Disease denotes DI-TdP MESH:C564703
105 4035-4038 Gene denotes MAF Gene:4094
106 4075-4078 Gene denotes MAF Gene:4094
107 4118-4121 Gene denotes MAF Gene:4094
108 4221-4226 Gene denotes SCN5A Gene:6331
109 4415-4420 Gene denotes KCNE1 Gene:3753
110 4056-4059 Gene denotes MAF Gene:4094
111 4097-4100 Gene denotes MAF Gene:4094
112 4384-4392 Disease denotes acidosis MESH:D000138
113 4227-4236 Mutation denotes rs7626962 rs7626962
114 4237-4243 Mutation denotes S1103Y rs7626962
115 4421-4430 Mutation denotes rs1805128 rs1805128
120 3952-3957 Gene denotes SCN5A Gene:6331
121 3973-3978 Gene denotes KCNE1 Gene:3753
122 3939-3951 Mutation denotes p.Ser1103Tyr rs7626962
123 3962-3972 Mutation denotes p.Asp85Asn rs1805128
129 4837-4840 Gene denotes MAF Gene:4094
130 4734-4743 Chemical denotes potassium MESH:D011188
131 4796-4805 Chemical denotes potassium MESH:D011188
132 4821-4827 Chemical denotes sodium MESH:D012964
133 4634-4650 Disease denotes long QT syndrome MESH:D008133
139 5098-5103 Gene denotes SCN5A Gene:6331
140 5148-5153 Gene denotes SCN5A Gene:6331
141 5085-5097 Mutation denotes p.Ser1103Tyr rs7626962
160 3125-3130 Gene denotes KCNE1 Gene:3753
161 3148-3153 Gene denotes SCN5A Gene:6331
162 3241-3246 Gene denotes SCN5A Gene:6331
163 3385-3390 Gene denotes KCNE1 Gene:3753
164 3508-3513 Gene denotes KCNE1 Gene:3753
165 3660-3665 Gene denotes SCN5A Gene:6331
166 3808-3811 Gene denotes SCD Gene:6319
167 3619-3625 Chemical denotes sodium MESH:D012964
168 3182-3200 Disease denotes DI-LQTS and DI-SCD MESH:C564703
169 3693-3709 Disease denotes hypoxia/acidosis MESH:D000860
170 3754-3776 Disease denotes ventricular arrhythmia MESH:D001145
171 3786-3806 Disease denotes sudden cardiac death MESH:D016757
172 3497-3507 Mutation denotes p.Asp85Asn rs1805128
173 3647-3659 Mutation denotes p.Ser1103Tyr rs7626962
174 3228-3240 Mutation denotes p.Ser1103Tyr rs7626962
175 3374-3384 Mutation denotes p.Asp85Asn rs1805128
176 3114-3124 Mutation denotes p.Asp85Asn rs1805128
177 3135-3147 Mutation denotes p.Ser1103Tyr rs7626962
185 5191-5196 Gene denotes SCN5A Gene:6331
186 5385-5390 Gene denotes SCN5A Gene:6331
187 5434-5437 Gene denotes SCD Gene:6319
188 5253-5261 Disease denotes COVID-19 MESH:C000657245
189 5535-5544 Disease denotes mortality MESH:D003643
190 5556-5564 Disease denotes COVID-19 MESH:C000657245
191 5372-5384 Mutation denotes p.Ser1103Tyr rs7626962
195 5589-5594 Gene denotes SCN5A Gene:6331
196 5602-5605 Gene denotes SCD Gene:6319
197 5576-5588 Mutation denotes p.Ser1103Tyr rs7626962
218 5701-5706 Gene denotes SCN5A Gene:6331
219 5715-5721 Gene denotes Nav1.5 Gene:6331
220 5758-5763 Gene denotes SCN5A Gene:6331
221 6236-6241 Gene denotes SCN5A Gene:6331
222 6400-6405 Gene denotes SCN5A Gene:6331
223 6563-6568 Gene denotes SCN5A Gene:6331
224 6719-6724 Gene denotes SCN5A Gene:6331
225 5813-5816 Gene denotes SCD Gene:6319
226 6330-6342 Species denotes participants Tax:9606
227 5722-5728 Chemical denotes sodium MESH:D012964
228 5980-5991 Disease denotes hypokalemia MESH:D007008
229 6114-6127 Disease denotes heart disease MESH:D006331
230 6306-6317 Disease denotes hypokalemia MESH:D007008
231 6622-6636 Disease denotes death syndrome MESH:D003643
232 6754-6766 Disease denotes sudden death MESH:D003645
233 6706-6718 Mutation denotes p.Ser1103Tyr rs7626962
234 6550-6562 Mutation denotes p.Ser1103Tyr rs7626962
235 6387-6399 Mutation denotes p.Ser1103Tyr rs7626962
236 6223-6235 Mutation denotes p.Ser1103Tyr rs7626962
237 5745-5757 Mutation denotes p.Ser1103Tyr rs7626962
262 6938-6943 Gene denotes SCN5A Gene:6331
263 6982-6988 Gene denotes Nav1.5 Gene:6331
264 7384-7389 Gene denotes SCN5A Gene:6331
265 7590-7595 Gene denotes SCN5A Gene:6331
266 7894-7899 Gene denotes SCN5A Gene:6331
267 8181-8186 Gene denotes SCN5A Gene:6331
268 7240-7244 Gene denotes LQT3 Gene:6331
269 7909-7921 Species denotes participants Tax:9606
270 8007-8014 Species denotes infants Tax:9606
271 6989-6995 Chemical denotes sodium MESH:D012964
272 7118-7124 Chemical denotes sodium MESH:D012964
273 7409-7415 Chemical denotes sodium MESH:D012964
274 7741-7750 Chemical denotes potassium MESH:D011188
275 7222-7238 Disease denotes long QT syndrome MESH:D008133
276 7638-7641 Disease denotes APD MESH:C585640
277 7776-7784 Disease denotes acidosis MESH:D000138
278 7857-7868 Disease denotes hypokalemia MESH:D007008
279 8016-8036 Disease denotes respiratory acidosis MESH:D000142
280 8047-8054 Disease denotes hypoxia MESH:D000860
281 8055-8060 Disease denotes apnea MESH:D001049
282 8153-8166 Disease denotes heart disease MESH:D006331
283 8168-8180 Mutation denotes p.Ser1103Tyr rs7626962
284 7881-7893 Mutation denotes p.Ser1103Tyr rs7626962
285 6925-6937 Mutation denotes p.Ser1103Tyr rs7626962
289 8255-8260 Gene denotes SCN5A Gene:6331
290 8272-8280 Disease denotes COVID-19 MESH:C000657245
291 8242-8254 Mutation denotes p.Ser1103Tyr rs7626962
306 8396-8426 Gene denotes brain-type natriuretic peptide Gene:4879
307 8949-8957 Species denotes patients Tax:9606
308 8313-8330 Disease denotes myocardial injury MESH:D009202
309 8331-8337 Disease denotes stress MESH:D000079225
310 8488-8496 Disease denotes COVID-19 MESH:C000657245
311 8558-8567 Disease denotes mortality MESH:D003643
312 8623-8637 Disease denotes cardiac injury MESH:D006331
313 8710-8756 Disease denotes chronic obstructive/fibrotic pulmonary disease MESH:D029424
314 8758-8766 Disease denotes diabetes MESH:D003920
315 8785-8807 Disease denotes cardiovascular disease MESH:D002318
316 8855-8878 Disease denotes ventricular tachycardia MESH:D017180
317 8879-8903 Disease denotes ventricular fibrillation MESH:D014693
318 8963-8971 Disease denotes COVID-19 MESH:C000657245
319 9010-9027 Disease denotes myocardial injury MESH:D009202
343 9738-9743 Gene denotes SCN5A Gene:6331
344 9955-9959 Gene denotes IL-6 Gene:3569
345 9962-9975 Gene denotes interleukin-6 Gene:3569
346 10092-10095 Gene denotes SCD Gene:6319
347 9753-9761 Species denotes patients Tax:9606
348 10030-10040 Species denotes SARS-CoV-2 Tax:2697049
349 10043-10090 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
350 9977-9980 Chemical denotes INa MESH:C076773
351 9983-9989 Chemical denotes sodium MESH:D012964
352 10137-10146 Chemical denotes serotonin MESH:D012701
353 9673-9696 Disease denotes ventricular arrhythmias MESH:D001145
354 9708-9721 Disease denotes cardiac death MESH:D003643
355 9767-9775 Disease denotes COVID-19 MESH:C000657245
356 9777-9780 Disease denotes APD MESH:C585640
357 9810-9813 Disease denotes CHF
358 9816-9840 Disease denotes congestive heart failure MESH:D006333
359 9848-9870 Disease denotes chronic kidney disease MESH:D051436
360 9872-9876 Disease denotes COPD MESH:D029424
361 9879-9916 Disease denotes chronic obstructive pulmonary disease MESH:D029424
362 9929-9953 Disease denotes coronavirus disease 2019 MESH:C000657245
363 10098-10118 Disease denotes sudden cardiac death MESH:D016757
364 10172-10194 Disease denotes ventricular arrhythmia MESH:D001145
365 9725-9737 Mutation denotes p.Ser1103Tyr rs7626962
377 9364-9377 Gene denotes interleukin-6 Gene:3569
378 9379-9383 Gene denotes IL-6 Gene:3569
379 9386-9409 Gene denotes tumor necrosis factor-α Gene:7124
380 9481-9485 Gene denotes IL-6 Gene:3569
381 9107-9115 Species denotes patients Tax:9606
382 9058-9081 Disease denotes acute myocardial injury MESH:D009202
383 9121-9129 Disease denotes COVID-19 MESH:C000657245
384 9149-9180 Disease denotes SARS-CoV-2 myocardial infection MESH:C000657245
385 9186-9197 Disease denotes myocarditis MESH:D009205
386 9215-9221 Disease denotes stress MESH:D000079225
387 9243-9262 Disease denotes respiratory failure MESH:D012131
401 10238-10244 Gene denotes Nav1.5 Gene:6331
402 10526-10530 Gene denotes LQT3 Gene:6331
403 10541-10546 Gene denotes SCN5A Gene:6331
404 10792-10798 Gene denotes VA/SCD Gene:6319
405 10253-10259 Chemical denotes sodium MESH:D012964
406 10310-10316 Chemical denotes sodium MESH:D012964
407 10425-10431 Chemical denotes sodium MESH:D012964
408 10612-10618 Chemical denotes sodium MESH:D012964
409 10731-10737 Chemical denotes sodium MESH:D012964
410 10477-10484 Disease denotes hypoxia MESH:D000860
411 10486-10505 Disease denotes myocardial ischemia MESH:D003324
412 10507-10520 Disease denotes heart failure MESH:D006333
413 10758-10773 Disease denotes ventricular APD MESH:C585640
438 10838-10843 Gene denotes SCN5A Gene:6331
439 11150-11155 Gene denotes SCN5A Gene:6331
440 11424-11429 Gene denotes SCN5A Gene:6331
441 11572-11577 Gene denotes SCN5A Gene:6331
442 11662-11668 Gene denotes VA/SCD Gene:6319
443 11205-11209 Gene denotes LQT3 Gene:6331
444 11156-11162 Gene denotes Nav1.5 Gene:6331
445 10844-10850 Gene denotes Nav1.5 Gene:6331
446 10851-10857 Chemical denotes sodium MESH:D012964
447 11163-11169 Chemical denotes sodium MESH:D012964
448 11243-11249 Chemical denotes sodium MESH:D012964
449 11032-11052 Disease denotes respiratory acidosis MESH:D000142
450 11078-11085 Disease denotes hypoxia MESH:D000860
451 11096-11101 Disease denotes apnea MESH:D001049
452 11434-11462 Disease denotes sudden infant death syndrome MESH:D013398
453 11488-11495 Disease denotes hypoxia MESH:D000860
454 11513-11521 Disease denotes COVID-19 MESH:C000657245
455 11646-11653 Disease denotes hypoxia MESH:D000860
456 11687-11707 Disease denotes SARS-CoV-2 infection MESH:C000657245
457 11708-11716 Disease denotes COVID-19 MESH:C000657245
458 11559-11571 Mutation denotes p.Ser1103Tyr rs7626962
459 11411-11423 Mutation denotes p.Ser1103Tyr rs7626962
460 11137-11149 Mutation denotes p.Ser1103Tyr rs7626962
461 10825-10837 Mutation denotes p.Ser1103Tyr rs7626962
476 12874-12884 Species denotes SARS-CoV-2 Tax:2697049
477 13006-13017 Chemical denotes Chloroquine MESH:D002738
478 13055-13073 Chemical denotes Hydroxychloroquine MESH:D006886
479 13136-13155 Chemical denotes Lopinavir/ritonavir MESH:C558899
480 13216-13228 Chemical denotes Azithromycin MESH:D017963
481 12834-12842 Disease denotes COVID-19 MESH:C000657245
482 12913-12915 Disease denotes VT MESH:D017180
483 12916-12918 Disease denotes VF MESH:D014693
484 12919-12922 Disease denotes TdP MESH:D016171
485 12938-12952 Disease denotes Cardiac arrest MESH:D006323
486 13028-13031 Disease denotes TdP MESH:D016171
487 13084-13087 Disease denotes TdP MESH:D016171
488 13174-13177 Disease denotes TdP MESH:D016171
489 13243-13246 Disease denotes TdP MESH:D016171
492 12765-12773 Disease denotes COVID-19 MESH:C000657245
493 12806-12812 Disease denotes DI-TdP MESH:C564703
507 13484-13494 Species denotes SARS-CoV-2 Tax:2697049
508 13497-13544 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
509 13277-13301 Disease denotes coronavirus disease 2019 MESH:C000657245
510 13325-13345 Disease denotes sudden cardiac death MESH:D016757
511 13347-13353 Disease denotes DI-TdP MESH:C564703
512 13369-13388 Disease denotes torsades de pointes MESH:D016171
513 13466-13482 Disease denotes long QT syndrome MESH:D008133
514 13546-13549 Disease denotes TdP MESH:D016171
515 13552-13571 Disease denotes torsades de pointes MESH:D016171
516 13573-13575 Disease denotes VF MESH:D014693
517 13578-13602 Disease denotes ventricular fibrillation MESH:D014693
518 13604-13606 Disease denotes VT MESH:D017180
519 13609-13632 Disease denotes ventricular tachycardia MESH:D017180
522 13952-13971 Chemical denotes Lopinavir/ritonavir MESH:C558899
523 14072-14080 Disease denotes COVID-19 MESH:C000657245
546 11826-11831 Gene denotes SCN5A Gene:6331
547 12068-12072 Gene denotes IL-6 Gene:3569
548 12209-12213 Gene denotes IL-6 Gene:3569
549 12235-12239 Gene denotes hERG Gene:2078
550 12240-12246 Gene denotes Kv11.1 Gene:3757
551 12344-12359 Gene denotes cytochrome P450 Gene:4051
552 12429-12433 Gene denotes IL-6 Gene:3569
553 12438-12444 Gene denotes CYP3A4 Gene:1576
554 12479-12483 Gene denotes IL-6 Gene:3569
555 11907-11913 Gene denotes VA/SCD Gene:6319
556 11766-11772 Gene denotes VA/SCD Gene:6319
557 12565-12583 Chemical denotes hydroxychloroquine MESH:D006886
558 12586-12598 Chemical denotes azithromycin MESH:D017963
559 12603-12622 Chemical denotes lopinavir/ritonavir MESH:C558899
560 11891-11898 Disease denotes hypoxia MESH:D000860
561 12020-12040 Disease denotes SARS-CoV-2 infection MESH:C000657245
562 12091-12101 Disease denotes arrhythmia MESH:D001145
563 12180-12196 Disease denotes APD prolongation MESH:C585640
564 12307-12320 Disease denotes hyperactivity MESH:D006948
565 12533-12541 Disease denotes COVID-19 MESH:C000657245
566 12725-12738 Disease denotes DI-TdP/DI-SCD MESH:C564703
567 11813-11825 Mutation denotes p.Ser1103Tyr rs7626962
579 14353-14358 Gene denotes SCN5A Gene:6331
580 14640-14645 Gene denotes SCN5A Gene:6331
581 14229-14235 Disease denotes DI-TdP MESH:C564703
582 14248-14256 Disease denotes COVID-19 MESH:C000657245
583 14420-14433 Disease denotes abnormalities MESH:D018376
584 14483-14488 Disease denotes COVID MESH:C000657245
585 14528-14537 Disease denotes hypoxemia MESH:D000860
586 14679-14692 Disease denotes sudden deaths MESH:D003645
587 14735-14743 Disease denotes COVID-19 MESH:C000657245
588 14627-14639 Mutation denotes p.Ser1103Tyr rs7626962
589 14340-14352 Mutation denotes p.Ser1103Tyr rs7626962
607 15991-15999 Species denotes patients Tax:9606
608 16150-16157 Species denotes patient Tax:9606
609 16227-16230 Species denotes men Tax:9606
610 16247-16252 Species denotes women Tax:9606
611 16822-16832 Species denotes SARS-CoV-2 Tax:2697049
612 16835-16882 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
613 16030-16033 Chemical denotes QTc
614 16603-16621 Chemical denotes hydroxychloroquine MESH:D006886
615 15974-15987 Disease denotes DI-TdP/DI-SCD MESH:C564703
616 16005-16013 Disease denotes COVID-19 MESH:C000657245
617 16495-16503 Disease denotes COVID-19 MESH:C000657245
618 16634-16656 Disease denotes coronavirus disease 19 MESH:C000657245
619 16701-16721 Disease denotes sudden cardiac death MESH:D016757
620 16723-16729 Disease denotes DI-TdP MESH:C564703
621 16745-16764 Disease denotes torsades de pointes MESH:D016171
622 16884-16887 Disease denotes TdP MESH:D016171
623 16890-16909 Disease denotes torsades de pointes MESH:D016171
646 15028-15033 Gene denotes SCN5A Gene:6331
647 15371-15376 Gene denotes SCN5A Gene:6331
648 15574-15579 Gene denotes SCN5A Gene:6331
649 15741-15745 Gene denotes IL-6 Gene:3569
650 15107-15110 Chemical denotes QTc
651 15133-15151 Chemical denotes hydroxychloroquine MESH:D006886
652 15154-15166 Chemical denotes azithromycin MESH:D017963
653 15171-15190 Chemical denotes lopinavir/ritonavir MESH:C558899
654 15677-15683 Chemical denotes sodium MESH:D012964
655 15706-15716 Chemical denotes mexiletine MESH:D008801
656 15721-15730 Chemical denotes lidocaine MESH:D008012
657 15770-15781 Chemical denotes tocilizumab MESH:C502936
658 15786-15795 Chemical denotes sarilumab MESH:C000592401
659 14912-14920 Disease denotes COVID-19 MESH:C000657245
660 15089-15097 Disease denotes COVID-19 MESH:C000657245
661 15397-15402 Disease denotes death MESH:D003643
662 15407-15415 Disease denotes COVID-19 MESH:C000657245
663 15424-15433 Disease denotes mortality MESH:D003643
664 15902-15910 Disease denotes COVID-19 MESH:C000657245
665 15561-15573 Mutation denotes p.Ser1103Tyr rs7626962
666 15358-15370 Mutation denotes p.Ser1103Tyr rs7626962
667 15015-15027 Mutation denotes p.Ser1103Tyr rs7626962
677 17058-17063 Gene denotes SCN5A Gene:6331
678 17417-17435 Chemical denotes hydroxychloroquine MESH:D006886
679 17440-17452 Chemical denotes azithromycin MESH:D017963
680 17171-17178 Disease denotes hypoxia MESH:D000860
681 17187-17210 Disease denotes ventricular arrhythmias MESH:D001145
682 17211-17231 Disease denotes sudden cardiac death MESH:D016757
683 17292-17300 Disease denotes COVID-19 MESH:C000657245
684 17341-17364 Disease denotes QTc-prolonging COVID-19 MESH:C000657245
685 17045-17057 Mutation denotes p.Ser1103Tyr rs7626962

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 1019-1024 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T2 3995-3999 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T3 4009-4019 Body_part denotes Amino acid http://purl.org/sig/ont/fma/fma82739
T4 4577-4587 Body_part denotes Nucleotide http://purl.org/sig/ont/fma/fma82740
T5 4661-4667 Body_part denotes Genome http://purl.org/sig/ont/fma/fma84116
T6 6114-6119 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T7 6358-6363 Body_part denotes Heart http://purl.org/sig/ont/fma/fma7088
T8 7076-7078 Body_part denotes V1 http://purl.org/sig/ont/fma/fma13444|http://purl.org/sig/ont/fma/fma68614
T10 7937-7942 Body_part denotes Heart http://purl.org/sig/ont/fma/fma7088
T11 8153-8158 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T12 8381-8391 Body_part denotes troponin I http://purl.org/sig/ont/fma/fma62340
T13 8381-8389 Body_part denotes troponin http://purl.org/sig/ont/fma/fma62338
T14 8396-8401 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T15 9349-9358 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T16 9364-9377 Body_part denotes interleukin-6 http://purl.org/sig/ont/fma/fma264829
T17 9434-9448 Body_part denotes cardiomyocytes http://purl.org/sig/ont/fma/fma14067
T18 9611-9615 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T19 9827-9832 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T20 9856-9862 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T21 9962-9975 Body_part denotes interleukin-6 http://purl.org/sig/ont/fma/fma264829
T22 10005-10010 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T23 10137-10146 Body_part denotes serotonin http://purl.org/sig/ont/fma/fma67245
T24 10507-10512 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T25 11339-11343 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T26 12280-12306 Body_part denotes sympathetic nervous system http://purl.org/sig/ont/fma/fma9906
T27 14542-14550 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T28 14806-14809 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T29 14941-14945 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T30 15470-15473 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T31 16797-16802 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1019-1024 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T2 6114-6119 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T3 6358-6363 Body_part denotes Heart http://purl.obolibrary.org/obo/UBERON_0000948
T4 7937-7942 Body_part denotes Heart http://purl.obolibrary.org/obo/UBERON_0000948
T5 8153-8158 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T6 8396-8401 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T7 9827-9832 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T8 9856-9862 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T9 10005-10010 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T10 10507-10512 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T11 12280-12306 Body_part denotes sympathetic nervous system http://purl.obolibrary.org/obo/UBERON_0000013
T12 12292-12306 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T13 16797-16802 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 27-35 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T2 47-67 Disease denotes sudden cardiac death http://purl.obolibrary.org/obo/MONDO_0007264
T3 151-198 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T4 151-184 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T5 200-208 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 239-263 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T7 265-273 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T8 458-466 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T9 832-840 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T10 1001-1009 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T11 1289-1297 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T12 1475-1483 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T13 1585-1601 Disease denotes long QT syndrome http://purl.obolibrary.org/obo/MONDO_0002442
T14 1603-1605 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T15 1655-1674 Disease denotes torsades de pointes http://purl.obolibrary.org/obo/MONDO_0005478
T16 1676-1678 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T17 1706-1726 Disease denotes sudden cardiac death http://purl.obolibrary.org/obo/MONDO_0007264
T18 1728-1730 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T19 1731-1734 Disease denotes SCD http://purl.obolibrary.org/obo/MONDO_0007264
T20 1799-1801 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T21 1807-1809 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T22 2138-2146 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T23 2176-2184 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T24 2358-2366 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T25 2421-2429 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T26 2447-2455 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T27 2531-2539 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T28 2805-2813 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T29 2816-2825 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T30 2861-2873 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T31 2918-2926 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T32 2951-2953 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T33 2962-2964 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T34 2965-2968 Disease denotes SCD http://purl.obolibrary.org/obo/MONDO_0007264
T35 3182-3184 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T36 3194-3196 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T37 3197-3200 Disease denotes SCD http://purl.obolibrary.org/obo/MONDO_0007264
T38 3566-3568 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T39 3701-3709 Disease denotes acidosis http://purl.obolibrary.org/obo/MONDO_0006022
T40 3766-3776 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T41 3786-3806 Disease denotes sudden cardiac death http://purl.obolibrary.org/obo/MONDO_0007264
T42 3808-3811 Disease denotes SCD http://purl.obolibrary.org/obo/MONDO_0007264
T43 3982-3984 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T44 4384-4392 Disease denotes acidosis http://purl.obolibrary.org/obo/MONDO_0006022
T45 4611-4613 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T46 4634-4650 Disease denotes long QT syndrome http://purl.obolibrary.org/obo/MONDO_0002442
T47 5253-5261 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T48 5434-5437 Disease denotes SCD http://purl.obolibrary.org/obo/MONDO_0007264
T49 5556-5564 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T50 5602-5605 Disease denotes SCD http://purl.obolibrary.org/obo/MONDO_0007264
T51 5813-5816 Disease denotes SCD http://purl.obolibrary.org/obo/MONDO_0007264
T52 5980-5991 Disease denotes hypokalemia http://purl.obolibrary.org/obo/MONDO_0003019
T53 6114-6127 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267
T54 6306-6317 Disease denotes hypokalemia http://purl.obolibrary.org/obo/MONDO_0003019
T55 6608-6636 Disease denotes sudden infant death syndrome http://purl.obolibrary.org/obo/MONDO_0010086
T56 7222-7238 Disease denotes long QT syndrome http://purl.obolibrary.org/obo/MONDO_0002442
T57 7240-7244 Disease denotes LQT3 http://purl.obolibrary.org/obo/MONDO_0011377
T58 7638-7641 Disease denotes APD http://purl.obolibrary.org/obo/MONDO_0021952
T59 7776-7784 Disease denotes acidosis http://purl.obolibrary.org/obo/MONDO_0006022
T60 7857-7868 Disease denotes hypokalemia http://purl.obolibrary.org/obo/MONDO_0003019
T61 8028-8036 Disease denotes acidosis http://purl.obolibrary.org/obo/MONDO_0006022
T62 8080-8082 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T63 8153-8166 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267
T64 8272-8280 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T65 8324-8330 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T66 8631-8637 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T67 8739-8756 Disease denotes pulmonary disease http://purl.obolibrary.org/obo/MONDO_0005275
T68 8758-8766 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T69 8785-8807 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T70 8855-8878 Disease denotes ventricular tachycardia http://purl.obolibrary.org/obo/MONDO_0005477
T71 8879-8903 Disease denotes ventricular fibrillation http://purl.obolibrary.org/obo/MONDO_0000190
T72 8963-8971 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T73 9021-9027 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T74 9075-9081 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T75 9121-9129 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T76 9149-9157 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T77 9171-9180 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T78 9186-9197 Disease denotes myocarditis http://purl.obolibrary.org/obo/MONDO_0004496
T79 9243-9262 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T80 9386-9391 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T81 9685-9696 Disease denotes arrhythmias http://purl.obolibrary.org/obo/MONDO_0007263
T82 9701-9721 Disease denotes sudden cardiac death http://purl.obolibrary.org/obo/MONDO_0007264
T83 9767-9775 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T84 9777-9780 Disease denotes APD http://purl.obolibrary.org/obo/MONDO_0021952
T85 9810-9813 Disease denotes CHF http://purl.obolibrary.org/obo/MONDO_0005009
T86 9816-9840 Disease denotes congestive heart failure http://purl.obolibrary.org/obo/MONDO_0005009
T87 9827-9840 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T88 9842-9845 Disease denotes CKD http://purl.obolibrary.org/obo/MONDO_0005300
T89 9848-9870 Disease denotes chronic kidney disease http://purl.obolibrary.org/obo/MONDO_0005300
T90 9856-9870 Disease denotes kidney disease http://purl.obolibrary.org/obo/MONDO_0001343|http://purl.obolibrary.org/obo/MONDO_0005240
T92 9872-9876 Disease denotes COPD http://purl.obolibrary.org/obo/MONDO_0005002
T93 9879-9916 Disease denotes chronic obstructive pulmonary disease http://purl.obolibrary.org/obo/MONDO_0005002
T94 9899-9916 Disease denotes pulmonary disease http://purl.obolibrary.org/obo/MONDO_0005275
T95 9918-9926 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T96 9929-9953 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T97 10030-10038 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T98 10043-10090 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T99 10043-10076 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T100 10092-10095 Disease denotes SCD http://purl.obolibrary.org/obo/MONDO_0007264
T101 10098-10118 Disease denotes sudden cardiac death http://purl.obolibrary.org/obo/MONDO_0007264
T102 10184-10194 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T103 10486-10505 Disease denotes myocardial ischemia http://purl.obolibrary.org/obo/MONDO_0024644
T104 10497-10505 Disease denotes ischemia http://purl.obolibrary.org/obo/MONDO_0005053
T105 10507-10520 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T106 10526-10530 Disease denotes LQT3 http://purl.obolibrary.org/obo/MONDO_0011377
T107 10770-10773 Disease denotes APD http://purl.obolibrary.org/obo/MONDO_0021952
T108 10795-10798 Disease denotes SCD http://purl.obolibrary.org/obo/MONDO_0007264
T109 11044-11052 Disease denotes acidosis http://purl.obolibrary.org/obo/MONDO_0006022
T110 11205-11209 Disease denotes LQT3 http://purl.obolibrary.org/obo/MONDO_0011377
T111 11434-11462 Disease denotes sudden infant death syndrome http://purl.obolibrary.org/obo/MONDO_0010086
T112 11513-11521 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T113 11665-11668 Disease denotes SCD http://purl.obolibrary.org/obo/MONDO_0007264
T114 11687-11695 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T115 11698-11707 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T116 11708-11716 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T117 11769-11772 Disease denotes SCD http://purl.obolibrary.org/obo/MONDO_0007264
T118 11910-11913 Disease denotes SCD http://purl.obolibrary.org/obo/MONDO_0007264
T119 12020-12028 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T120 12031-12040 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T121 12091-12101 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T122 12180-12183 Disease denotes APD http://purl.obolibrary.org/obo/MONDO_0021952
T123 12533-12541 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T124 12725-12727 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T125 12732-12734 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T126 12735-12738 Disease denotes SCD http://purl.obolibrary.org/obo/MONDO_0007264
T127 12765-12773 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T128 12806-12808 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T129 12813-12815 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T130 12816-12819 Disease denotes SCD http://purl.obolibrary.org/obo/MONDO_0007264
T131 12834-12842 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T132 12874-12882 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T133 12916-12918 Disease denotes VF http://purl.obolibrary.org/obo/MONDO_0000190
T134 12938-12952 Disease denotes Cardiac arrest http://purl.obolibrary.org/obo/MONDO_0000745
T135 13266-13274 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T136 13277-13301 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T137 13303-13305 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T138 13306-13309 Disease denotes SCD http://purl.obolibrary.org/obo/MONDO_0007264
T139 13325-13345 Disease denotes sudden cardiac death http://purl.obolibrary.org/obo/MONDO_0007264
T140 13347-13349 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T141 13369-13388 Disease denotes torsades de pointes http://purl.obolibrary.org/obo/MONDO_0005478
T142 13466-13482 Disease denotes long QT syndrome http://purl.obolibrary.org/obo/MONDO_0002442
T143 13484-13492 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T144 13497-13544 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T145 13497-13530 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T146 13552-13571 Disease denotes torsades de pointes http://purl.obolibrary.org/obo/MONDO_0005478
T147 13573-13575 Disease denotes VF http://purl.obolibrary.org/obo/MONDO_0000190
T148 13578-13602 Disease denotes ventricular fibrillation http://purl.obolibrary.org/obo/MONDO_0000190
T149 13609-13632 Disease denotes ventricular tachycardia http://purl.obolibrary.org/obo/MONDO_0005477
T150 13987-13991 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T151 14072-14080 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T152 14229-14231 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T153 14248-14256 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T154 14483-14491 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T155 14735-14743 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T156 14912-14920 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T157 15089-15097 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T158 15407-15415 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T159 15902-15910 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T160 15974-15976 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T161 15981-15983 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T162 15984-15987 Disease denotes SCD http://purl.obolibrary.org/obo/MONDO_0007264
T163 16005-16013 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T164 16495-16503 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T165 16623-16631 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T166 16679-16681 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T167 16682-16685 Disease denotes SCD http://purl.obolibrary.org/obo/MONDO_0007264
T168 16701-16721 Disease denotes sudden cardiac death http://purl.obolibrary.org/obo/MONDO_0007264
T169 16723-16725 Disease denotes DI http://purl.obolibrary.org/obo/MONDO_0018849
T170 16745-16764 Disease denotes torsades de pointes http://purl.obolibrary.org/obo/MONDO_0005478
T171 16822-16830 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T172 16835-16882 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T173 16835-16868 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T174 16890-16909 Disease denotes torsades de pointes http://purl.obolibrary.org/obo/MONDO_0005478
T175 17199-17210 Disease denotes arrhythmias http://purl.obolibrary.org/obo/MONDO_0007263
T176 17211-17231 Disease denotes sudden cardiac death http://purl.obolibrary.org/obo/MONDO_0007264
T177 17292-17300 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T178 17356-17364 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T179 17675-17695 Disease denotes Sudden Cardiac Death http://purl.obolibrary.org/obo/MONDO_0007264
T180 17796-17799 Disease denotes LQT http://purl.obolibrary.org/obo/MONDO_0002442

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 217-222 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T2 276-279 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T3 467-470 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T4 717-718 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 760-765 http://purl.obolibrary.org/obo/CLO_0001302 denotes 3 , 4
T6 867-875 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T7 1019-1024 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T8 1019-1024 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T9 1019-1024 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T10 1019-1024 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T11 1247-1257 http://purl.obolibrary.org/obo/CLO_0053003 denotes 11% and 25
T12 1405-1407 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T13 1427-1428 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 1437-1438 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T15 1820-1823 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T16 2194-2197 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T17 2463-2465 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T18 2466-2467 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T19 2482-2485 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T20 3714-3717 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T21 3928-3929 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T22 3995-3999 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T23 4511-4521 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T24 4705-4715 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T25 4767-4777 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T26 4963-4967 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T27 5764-5767 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T28 5868-5871 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T29 6114-6119 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T30 6114-6119 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T31 6114-6119 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T32 6114-6119 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T33 6358-6363 http://purl.obolibrary.org/obo/UBERON_0000948 denotes Heart
T34 6358-6363 http://purl.obolibrary.org/obo/UBERON_0007100 denotes Heart
T35 6358-6363 http://purl.obolibrary.org/obo/UBERON_0015228 denotes Heart
T36 6358-6363 http://www.ebi.ac.uk/efo/EFO_0000815 denotes Heart
T37 6465-6466 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T38 6493-6495 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T39 7661-7662 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T40 7937-7942 http://purl.obolibrary.org/obo/UBERON_0000948 denotes Heart
T41 7937-7942 http://purl.obolibrary.org/obo/UBERON_0007100 denotes Heart
T42 7937-7942 http://purl.obolibrary.org/obo/UBERON_0015228 denotes Heart
T43 7937-7942 http://www.ebi.ac.uk/efo/EFO_0000815 denotes Heart
T44 7955-7960 http://purl.obolibrary.org/obo/CLO_0001236 denotes (2) a
T45 8153-8158 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T46 8153-8158 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T47 8153-8158 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T48 8153-8158 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T49 8396-8401 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T50 8396-8401 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T51 8419-8426 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T52 8428-8431 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T53 8448-8449 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T54 8464-8465 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T55 8501-8503 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T56 8772-8773 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T57 9364-9377 http://purl.obolibrary.org/obo/PR_000001393 denotes interleukin-6
T58 9434-9448 http://purl.obolibrary.org/obo/CL_0000746 denotes cardiomyocytes
T59 9469-9471 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T60 9589-9591 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T61 9611-9615 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T62 9827-9832 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T63 9827-9832 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T64 9827-9832 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T65 9827-9832 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T66 9856-9862 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T67 9856-9862 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T68 9856-9862 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T69 9962-9975 http://purl.obolibrary.org/obo/PR_000001393 denotes interleukin-6
T70 10005-10010 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T71 10005-10010 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T72 10005-10010 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T73 10005-10010 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T74 10137-10146 http://purl.obolibrary.org/obo/CHEBI_28790 denotes serotonin
T75 10277-10278 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T76 10507-10512 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T77 10507-10512 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T78 10507-10512 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T79 10507-10512 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T80 10657-10661 http://purl.obolibrary.org/obo/CLO_0053799 denotes 4%–5
T81 11188-11189 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T82 11339-11343 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T83 11592-11593 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T84 11972-11974 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T85 12521-12522 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T86 13043-13045 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T87 13047-13049 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T88 13051-13053 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T89 13183-13185 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T90 13186-13188 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T91 13197-13199 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T92 13992-13999 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T93 14019-14020 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94 14158-14159 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T95 14941-14945 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T96 15588-15595 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T97 15796-15798 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T98 16148-16149 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T99 16197-16199 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T100 16221-16223 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T101 16241-16243 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T102 16797-16802 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T103 16797-16802 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T104 16797-16802 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T105 16797-16802 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T106 17000-17001 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T107 17119-17122 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T108 17720-17721 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 1069-1073 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T2 1091-1109 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T3 1311-1322 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T4 1326-1344 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T5 1349-1361 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T6 1512-1518 Chemical denotes corona http://purl.obolibrary.org/obo/CHEBI_37409
T7 1572-1576 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T8 1642-1646 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T9 1693-1697 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T10 1841-1852 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T11 1853-1871 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T12 1959-1970 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T13 1971-1989 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T14 3093-3096 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T15 3619-3625 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T16 3778-3780 Chemical denotes VA http://purl.obolibrary.org/obo/CHEBI_75008
T17 4006-4008 Chemical denotes ID http://purl.obolibrary.org/obo/CHEBI_141439
T18 4009-4019 Chemical denotes Amino acid http://purl.obolibrary.org/obo/CHEBI_33704
T19 4015-4019 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T20 4577-4587 Chemical denotes Nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T21 4621-4625 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T22 4734-4743 Chemical denotes potassium http://purl.obolibrary.org/obo/CHEBI_26216
T23 4796-4805 Chemical denotes potassium http://purl.obolibrary.org/obo/CHEBI_26216
T24 4821-4827 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T25 5431-5433 Chemical denotes VA http://purl.obolibrary.org/obo/CHEBI_75008
T26 5599-5601 Chemical denotes VA http://purl.obolibrary.org/obo/CHEBI_75008
T27 5722-5728 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T28 5810-5812 Chemical denotes VA http://purl.obolibrary.org/obo/CHEBI_75008
T29 6989-6995 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T30 7118-7124 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T31 7409-7415 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T32 7741-7750 Chemical denotes potassium http://purl.obolibrary.org/obo/CHEBI_26216
T33 8124-8128 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T34 8419-8426 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T35 9096-9098 Chemical denotes VA http://purl.obolibrary.org/obo/CHEBI_75008
T36 9379-9381 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T38 9481-9483 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T40 9557-9560 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T41 9955-9957 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T43 9983-9989 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T44 10120-10124 Chemical denotes SSRI http://purl.obolibrary.org/obo/CHEBI_50949
T45 10137-10165 Chemical denotes serotonin reuptake inhibitor http://purl.obolibrary.org/obo/CHEBI_50949
T46 10137-10146 Chemical denotes serotonin http://purl.obolibrary.org/obo/CHEBI_28790|http://purl.obolibrary.org/obo/CHEBI_350546
T48 10156-10165 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T49 10167-10169 Chemical denotes VA http://purl.obolibrary.org/obo/CHEBI_75008
T50 10253-10259 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T51 10310-10316 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T52 10425-10431 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T53 10612-10618 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T54 10731-10737 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T55 10792-10794 Chemical denotes VA http://purl.obolibrary.org/obo/CHEBI_75008
T56 10851-10857 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T57 11163-11169 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T58 11243-11249 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T59 11662-11664 Chemical denotes VA http://purl.obolibrary.org/obo/CHEBI_75008
T60 11766-11768 Chemical denotes VA http://purl.obolibrary.org/obo/CHEBI_75008
T61 11907-11909 Chemical denotes VA http://purl.obolibrary.org/obo/CHEBI_75008
T62 12068-12070 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T64 12137-12140 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T65 12209-12211 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T67 12247-12256 Chemical denotes potassium http://purl.obolibrary.org/obo/CHEBI_26216
T68 12344-12359 Chemical denotes cytochrome P450 http://purl.obolibrary.org/obo/CHEBI_38559
T69 12344-12354 Chemical denotes cytochrome http://purl.obolibrary.org/obo/CHEBI_4056
T70 12418-12423 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T71 12429-12431 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T73 12479-12481 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T75 12565-12583 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T76 12586-12598 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T77 12603-12622 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T78 12603-12612 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T79 12613-12622 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T80 12913-12915 Chemical denotes VT http://purl.obolibrary.org/obo/CHEBI_90330
T81 12916-12918 Chemical denotes VF http://purl.obolibrary.org/obo/CHEBI_75016
T82 12985-12997 Chemical denotes antimalarial http://purl.obolibrary.org/obo/CHEBI_38068
T83 13006-13017 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T84 13118-13134 Chemical denotes antiviral agents http://purl.obolibrary.org/obo/CHEBI_22587
T85 13136-13145 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T86 13146-13155 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T87 13312-13316 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T88 13356-13360 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T89 13573-13575 Chemical denotes VF http://purl.obolibrary.org/obo/CHEBI_75016
T90 13604-13606 Chemical denotes VT http://purl.obolibrary.org/obo/CHEBI_90330
T91 13952-13961 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T92 13962-13971 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T93 14464-14468 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T94 14806-14809 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T95 15122-15127 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T96 15133-15151 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T97 15154-15166 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T98 15171-15190 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T99 15171-15180 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T100 15181-15190 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T101 15470-15473 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T102 15677-15683 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T103 15706-15716 Chemical denotes mexiletine http://purl.obolibrary.org/obo/CHEBI_6916
T104 15721-15730 Chemical denotes lidocaine http://purl.obolibrary.org/obo/CHEBI_6456
T105 15741-15743 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T107 15770-15781 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T108 16045-16049 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T109 16528-16533 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T110 16603-16621 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T111 16688-16692 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T112 16732-16736 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T113 16766-16769 Chemical denotes ECG http://purl.obolibrary.org/obo/CHEBI_70255
T114 17161-17165 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T115 17417-17435 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T116 17440-17452 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 47-67 Phenotype denotes sudden cardiac death http://purl.obolibrary.org/obo/HP_0001645
T2 728-741 Phenotype denotes sudden deaths http://purl.obolibrary.org/obo/HP_0001699
T3 876-895 Phenotype denotes respiratory arrests http://purl.obolibrary.org/obo/HP_0005943
T4 1585-1601 Phenotype denotes long QT syndrome http://purl.obolibrary.org/obo/HP_0001657
T5 1655-1674 Phenotype denotes torsades de pointes http://purl.obolibrary.org/obo/HP_0001664
T6 1706-1726 Phenotype denotes sudden cardiac death http://purl.obolibrary.org/obo/HP_0001645
T7 1731-1734 Phenotype denotes SCD http://purl.obolibrary.org/obo/HP_0001645
T8 2107-2120 Phenotype denotes sudden deaths http://purl.obolibrary.org/obo/HP_0001699
T9 2849-2856 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T10 2965-2968 Phenotype denotes SCD http://purl.obolibrary.org/obo/HP_0001645
T11 3197-3200 Phenotype denotes SCD http://purl.obolibrary.org/obo/HP_0001645
T12 3693-3700 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T13 3701-3709 Phenotype denotes acidosis http://purl.obolibrary.org/obo/HP_0001941
T14 3754-3776 Phenotype denotes ventricular arrhythmia http://purl.obolibrary.org/obo/HP_0004308
T15 3778-3780 Phenotype denotes VA http://purl.obolibrary.org/obo/HP_0004308
T16 3786-3806 Phenotype denotes sudden cardiac death http://purl.obolibrary.org/obo/HP_0001645
T17 3808-3811 Phenotype denotes SCD http://purl.obolibrary.org/obo/HP_0001645
T18 4384-4392 Phenotype denotes acidosis http://purl.obolibrary.org/obo/HP_0001941
T19 4634-4650 Phenotype denotes long QT syndrome http://purl.obolibrary.org/obo/HP_0001657
T20 5431-5433 Phenotype denotes VA http://purl.obolibrary.org/obo/HP_0004308
T21 5434-5437 Phenotype denotes SCD http://purl.obolibrary.org/obo/HP_0001645
T22 5599-5601 Phenotype denotes VA http://purl.obolibrary.org/obo/HP_0004308
T23 5602-5605 Phenotype denotes SCD http://purl.obolibrary.org/obo/HP_0001645
T24 5810-5812 Phenotype denotes VA http://purl.obolibrary.org/obo/HP_0004308
T25 5813-5816 Phenotype denotes SCD http://purl.obolibrary.org/obo/HP_0001645
T26 5980-5991 Phenotype denotes hypokalemia http://purl.obolibrary.org/obo/HP_0002900
T27 6306-6317 Phenotype denotes hypokalemia http://purl.obolibrary.org/obo/HP_0002900
T28 6754-6766 Phenotype denotes sudden death http://purl.obolibrary.org/obo/HP_0001699
T29 7222-7238 Phenotype denotes long QT syndrome http://purl.obolibrary.org/obo/HP_0001657
T30 7776-7784 Phenotype denotes acidosis http://purl.obolibrary.org/obo/HP_0001941
T31 7857-7868 Phenotype denotes hypokalemia http://purl.obolibrary.org/obo/HP_0002900
T32 8016-8036 Phenotype denotes respiratory acidosis http://purl.obolibrary.org/obo/HP_0005972
T33 8047-8054 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T34 8055-8060 Phenotype denotes apnea http://purl.obolibrary.org/obo/HP_0002104
T35 8785-8807 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T36 8855-8878 Phenotype denotes ventricular tachycardia http://purl.obolibrary.org/obo/HP_0004756
T37 8879-8903 Phenotype denotes ventricular fibrillation http://purl.obolibrary.org/obo/HP_0001663
T38 9096-9098 Phenotype denotes VA http://purl.obolibrary.org/obo/HP_0004308
T39 9186-9197 Phenotype denotes myocarditis http://purl.obolibrary.org/obo/HP_0012819
T40 9243-9262 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T41 9386-9391 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T42 9673-9696 Phenotype denotes ventricular arrhythmias http://purl.obolibrary.org/obo/HP_0004308
T43 9701-9721 Phenotype denotes sudden cardiac death http://purl.obolibrary.org/obo/HP_0001645
T44 9810-9813 Phenotype denotes CHF http://purl.obolibrary.org/obo/HP_0001635
T45 9816-9840 Phenotype denotes congestive heart failure http://purl.obolibrary.org/obo/HP_0001635
T46 9848-9870 Phenotype denotes chronic kidney disease http://purl.obolibrary.org/obo/HP_0012622
T47 9872-9876 Phenotype denotes COPD http://purl.obolibrary.org/obo/HP_0006510
T48 9879-9916 Phenotype denotes chronic obstructive pulmonary disease http://purl.obolibrary.org/obo/HP_0006510
T49 10092-10095 Phenotype denotes SCD http://purl.obolibrary.org/obo/HP_0001645
T50 10098-10118 Phenotype denotes sudden cardiac death http://purl.obolibrary.org/obo/HP_0001645
T51 10167-10169 Phenotype denotes VA http://purl.obolibrary.org/obo/HP_0004308
T52 10172-10194 Phenotype denotes ventricular arrhythmia http://purl.obolibrary.org/obo/HP_0004308
T53 10477-10484 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T54 10507-10520 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T55 10792-10794 Phenotype denotes VA http://purl.obolibrary.org/obo/HP_0004308
T56 10795-10798 Phenotype denotes SCD http://purl.obolibrary.org/obo/HP_0001645
T57 11032-11052 Phenotype denotes respiratory acidosis http://purl.obolibrary.org/obo/HP_0005972
T58 11078-11085 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T59 11096-11101 Phenotype denotes apnea http://purl.obolibrary.org/obo/HP_0002104
T60 11488-11495 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T61 11646-11653 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T62 11662-11664 Phenotype denotes VA http://purl.obolibrary.org/obo/HP_0004308
T63 11665-11668 Phenotype denotes SCD http://purl.obolibrary.org/obo/HP_0001645
T64 11766-11768 Phenotype denotes VA http://purl.obolibrary.org/obo/HP_0004308
T65 11769-11772 Phenotype denotes SCD http://purl.obolibrary.org/obo/HP_0001645
T66 11891-11898 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T67 11907-11909 Phenotype denotes VA http://purl.obolibrary.org/obo/HP_0004308
T68 11910-11913 Phenotype denotes SCD http://purl.obolibrary.org/obo/HP_0001645
T69 12091-12101 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T70 12307-12320 Phenotype denotes hyperactivity http://purl.obolibrary.org/obo/HP_0000752
T71 12682-12706 Phenotype denotes prolong the QTc interval http://purl.obolibrary.org/obo/HP_0005184
T72 12735-12738 Phenotype denotes SCD http://purl.obolibrary.org/obo/HP_0001645
T73 12816-12819 Phenotype denotes SCD http://purl.obolibrary.org/obo/HP_0001645
T74 12938-12952 Phenotype denotes Cardiac arrest http://purl.obolibrary.org/obo/HP_0001695
T75 13306-13309 Phenotype denotes SCD http://purl.obolibrary.org/obo/HP_0001645
T76 13325-13345 Phenotype denotes sudden cardiac death http://purl.obolibrary.org/obo/HP_0001645
T77 13369-13388 Phenotype denotes torsades de pointes http://purl.obolibrary.org/obo/HP_0001664
T78 13466-13482 Phenotype denotes long QT syndrome http://purl.obolibrary.org/obo/HP_0001657
T79 13552-13571 Phenotype denotes torsades de pointes http://purl.obolibrary.org/obo/HP_0001664
T80 13578-13602 Phenotype denotes ventricular fibrillation http://purl.obolibrary.org/obo/HP_0001663
T81 13609-13632 Phenotype denotes ventricular tachycardia http://purl.obolibrary.org/obo/HP_0004756
T82 14528-14537 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T83 14542-14556 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T84 14679-14692 Phenotype denotes sudden deaths http://purl.obolibrary.org/obo/HP_0001699
T85 15390-15402 Phenotype denotes sudden death http://purl.obolibrary.org/obo/HP_0001699
T86 15984-15987 Phenotype denotes SCD http://purl.obolibrary.org/obo/HP_0001645
T87 16682-16685 Phenotype denotes SCD http://purl.obolibrary.org/obo/HP_0001645
T88 16701-16721 Phenotype denotes sudden cardiac death http://purl.obolibrary.org/obo/HP_0001645
T89 16745-16764 Phenotype denotes torsades de pointes http://purl.obolibrary.org/obo/HP_0001664
T90 16890-16909 Phenotype denotes torsades de pointes http://purl.obolibrary.org/obo/HP_0001664
T91 17171-17178 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T92 17187-17210 Phenotype denotes ventricular arrhythmias http://purl.obolibrary.org/obo/HP_0004308
T93 17211-17231 Phenotype denotes sudden cardiac death http://purl.obolibrary.org/obo/HP_0001645
T94 17675-17695 Phenotype denotes Sudden Cardiac Death http://purl.obolibrary.org/obo/HP_0001645

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 2861-2873 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T2 3093-3104 http://purl.obolibrary.org/obo/GO_0022831 denotes ion channel
T3 5068-5078 http://purl.obolibrary.org/obo/GO_0006351 denotes transcript
T4 7611-7627 http://purl.obolibrary.org/obo/GO_0001508 denotes action potential
T5 9290-9305 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T6 9392-9400 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T7 9392-9400 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T8 9392-9400 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T9 9392-9400 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T10 9514-9530 http://purl.obolibrary.org/obo/GO_0001508 denotes action potential
T11 9557-9568 http://purl.obolibrary.org/obo/GO_0022831 denotes ion channel
T12 9783-9799 http://purl.obolibrary.org/obo/GO_0001508 denotes action potential
T13 10378-10394 http://purl.obolibrary.org/obo/GO_0001508 denotes action potential
T14 11991-12006 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T15 12137-12148 http://purl.obolibrary.org/obo/GO_0022831 denotes ion channel
T16 12344-12354 http://purl.obolibrary.org/obo/GO_0045158 denotes cytochrome
T17 12344-12354 http://purl.obolibrary.org/obo/GO_0045157 denotes cytochrome
T18 12344-12354 http://purl.obolibrary.org/obo/GO_0045156 denotes cytochrome
T19 12344-12354 http://purl.obolibrary.org/obo/GO_0008121 denotes cytochrome
T20 12384-12394 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T21 16207-16214 http://purl.obolibrary.org/obo/GO_0003006 denotes puberty

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-88 Sentence denotes Genetic susceptibility for COVID-19–associated sudden cardiac death in African Americans
T2 90-102 Sentence denotes Introduction
T3 103-765 Sentence denotes Since emerging from Wuhan, China, in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), has infected >3.2 million individuals worldwide and ∼1 million in the United States (as of April 29, 2020).1 , 2 Despite the institution of measures designed to “flatten the curve,” COVID-19 has claimed the lives of >225,000 individuals worldwide and >60,000 individuals in the United States alone (as of April 29, 2020).2 Of note, mortality estimates in some of the hardest hit regions have already or may need to be revised to account for a spike in sudden deaths occurring at home.3 , 4
T4 766-1423 Sentence denotes Although most of these deaths are likely directly attributable to COVID-19 (eg, pulseless electrical activity/respiratory arrests), many of the same regions within the United States have also seen the outpatient prescription volume of COVID-19–directed heart rate–corrected QT interval (QTc)–prolonging drug(s), specifically hydroxychloroquine, rise by as much as 22,700% compared to the same time period (March 15–31) in 2019.5 Importantly, recent studies have shown that between 11% and 25% of hospitalized patients with COVID-19 treated with chloroquine or hydroxychloroquine and azithromycin had QTc values rise above the critical 500 ms threshold.6 , 7
T5 1424-2158 Sentence denotes As a result, a substantial number of patients with COVID-19, prescribed these so-called corona cocktails, may be at an increased risk of developing drug-induced long QT syndrome (DI-LQTS), which could deteriorate into drug-induced torsades de pointes (DI-TdP) or worse drug-induced sudden cardiac death (DI-SCD).8 , 9 Therefore, it stands to reason that the same phenomenon (DI-LQTS/DI-TdP) that has already halted 1 chloroquine/hydroxychloroquine clinical trial7 and led the Food and Drug Administration to caution against the use of chloroquine/hydroxychloroquine outside the hospital setting/clinical trial10 could also be contributing, at least in small part, to the increase in sudden deaths observed in some COVID-19 epicenters.
T6 2159-2267 Sentence denotes In addition, the COVID-19 pandemic has already highlighted alarming health disparities in the United States.
T7 2268-3039 Sentence denotes For example, in Illinois where age, sex, and racial demographic data are reported for all COVID-19 cases, African Americans account for 26% of confirmed COVID-19 cases but 43% of COVID-19 deaths.11 A similar trend has been observed across the United States where COVID-19 mortality rates in predominantly black counties are 6-fold higher than that in predominantly white counties.12 Although this phenomenon is likely explained by the convergence of multiple cultural and socioeconomic factors,12 an underlying genetic susceptibility to SARS-CoV-2 infection, its sequelae (such as hypoxia and inflammation), or the potentially lethal side effects of COVID-19–directed therapies (ie, DI-TdP and DI-SCD), assuming equal exposure to these medications, could also contribute.
T8 3040-3872 Sentence denotes Current evidence supports the notion that the common ion channel variants p.Asp85Asn-KCNE1 and p.Ser1103Tyr-SCN5A confer an increased risk of DI-LQTS and DI-SCD (Table 1 ).13 Importantly, p.Ser1103Tyr-SCN5A is seen almost exclusively in individuals of African descent and its frequency in that population (∼8%) is higher than that of p.Asp85Asn-KCNE1 (0.2%–2.5% depending on ancestry; 0.2% in individuals of African origin) (Table 1).13 Furthermore, unlike p.Asp85Asn-KCNE1 whose proarrhythmic potential is largely limited to DI-LQTS risk, the modest increase in late/persistent sodium current generated by p.Ser1103Tyr-SCN5A is accentuated markedly by hypoxia/acidosis and has been linked to an increased risk of ventricular arrhythmia (VA) and sudden cardiac death (SCD) in African Americans across the age spectrum.13, 14, 15, 16
T9 3873-3994 Sentence denotes Table 1 Epidemiological and functional data supporting a role for p.Ser1103Tyr-SCN5A and p.Asp85Asn-KCNE1 in DI-LQTS risk
T10 3995-4220 Sentence denotes Gene dbSNP ID Amino acid change Overall MAF (gnomAD) African MAF (gnomAD) Asian MAF (gnomAD) European MAF (gnomAD)∗ Latino MAF (gnomAD) Electrophysiological phenotype (in vitro) Odds ratio (95% confidence interval) References
T11 4221-4414 Sentence denotes SCN5A rs7626962 S1103Y† 0.008 0.08 0.00003 0.0003 0.004 Increased sustained/late INa secondary to altered inactivation gating that is accentuated by intracellular acidosis 8.7 (3.2–23.9) 16, 17
T12 4415-4561 Sentence denotes KCNE1 rs1805128 D85N 0.009 0.002 0.003 0.01 0.003 Decreased IKs and/or IKr secondary to altered activation/inactivation kinetics 9.0 (3.5–22.9) 33
T13 4562-4866 Sentence denotes dbSNP = Single Nucleotide Polymorphism Database; DI-LQTS = drug-induced long QT syndrome; gnomAD = Genome Aggregation Consortium; IKs = slowly activating delayed rectifier potassium current; IKr = rapidly activating delayed rectifier potassium current; INa = sodium current; MAF = minor allele frequency.
T14 4867-4916 Sentence denotes Adapted from Giudicessi et al,13 with permission.
T15 4917-4968 Sentence denotes Copyright © Lippincott, Williams and Wilkins, 2018.
T16 4969-5042 Sentence denotes ∗ Includes individuals of both Finnish and non-Finnish European ancestry.
T17 5043-5154 Sentence denotes † Based on the reference transcript used. p.Ser1103Tyr-SCN5A is also occasionally listed as p.Ser1102Tyr-SCN5A.
T18 5155-5574 Sentence denotes Given the potential of p.Ser1103Tyr-SCN5A to exacerbate outcome-related health disparities in the COVID-19 pandemic, this review was assembled to raise awareness of the multiple mechanism(s) whereby the proarrhythmic p.Ser1103Tyr-SCN5A common variant may increase the risk of VA/SCD in those of African descent as well as the importance of identifying modifiable risk factors for mortality during the COVID-19 pandemic.
T19 5576-5654 Sentence denotes p.Ser1103Tyr-SCN5A and VA/SCD susceptibility in individuals of African descent
T20 5655-6806 Sentence denotes In individuals of African descent, the common SCN5A-encoded Nav1.5 sodium channel variant p.Ser1103Tyr-SCN5A has been associated with an increased risk of VA/SCD.14 , 15 , 17 Of note, this proarrhythmic potential has been reported to be enhanced by nongenetic risk factors known to reduce cardiac repolarization reserve (eg, hypokalemia and QTc-prolonging medication exposure; odds ratio 8.7; 95% confidence interval 3.2–23.9; P = .00003)17 and/or structural heart disease (relative risk 8.4; 95% confidence interval 2.1–28.6; P = .001) (Table 1).14 , 15 Furthermore, p.Ser1103Tyr-SCN5A was associated with potentiation of the QT-prolonging effect of hypokalemia in the 4476 participants of the Jackson Heart Study, suggesting that p.Ser1103Tyr-SCN5A contributes to decreased cardiac repolarization reserve at a population-specific level.18 In addition, 2 population-based studies reported that p.Ser1103Tyr-SCN5A is overrepresented in African American sudden infant death syndrome decedents,16 , 19 providing additional epidemiological evidence that p.Ser1103Tyr-SCN5A confers an increased risk of sudden death in African Americans regardless of age.
T21 6807-7500 Sentence denotes Besides this epidemiological evidence, in vitro functional characterization by 2 independent groups demonstrated that p.Ser1103Tyr-SCN5A alters the inactivation gating of the Nav1.5 sodium channel (negative shift in the voltage dependence of steady-state inactivation [V1/2]) and accentuates the sustained/late sodium current that is also the signature of the electrophysiological phenotype displayed by the type 3 long QT syndrome (LQT3) pathogenic variants.16 , 17 , 20 That said, the experimental conditions—physiological pH vs low intracellular pH—under which p.Ser1103Tyr-SCN5A increased the late sodium current differed in the studies of Splawski et al17 and Plant et al,16 respectively.
T22 7501-7785 Sentence denotes Furthermore, neither study demonstrated an in vitro or in silico ability of p.Ser1103Tyr-SCN5A to prolong the action potential duration (APD) in the absence of a “second hit” such as blockade of the rapid component of the delayed rectifier potassium current or intracellular acidosis.
T23 7786-8224 Sentence denotes This appears to be consistent with (1) the exaggerated QTc response to hypokalemia observed in p.Ser1103Tyr-SCN5A–positive participants of the Jackson Heart Study18 and (2) a circumstance-dependent proarrhythmic state in infants (respiratory acidosis caused by hypoxia/apnea)16 , 19 and older (DI-LQTS in the setting of ≥1 QTc-prolonging drug and advanced structural heart disease) p.Ser1103Tyr-SCN5A–positive African Americans.14, 15, 16
T24 8226-8289 Sentence denotes Implications of p.Ser1103Tyr-SCN5A during the COVID-19 pandemic
T25 8290-9030 Sentence denotes Direct and/or indirect myocardial injury/stress, as assessed by cardiac biomarkers such as troponin I and brain-type natriuretic peptide, has emerged as both a prominent and a prognostic feature in COVID-19.21, 22, 23 Of note, in an adjusted Cox regression model, the mortality risk associated with elevated cardiac biomarkers/acute cardiac injury was more significant than age and high-risk comorbid conditions such as chronic obstructive/fibrotic pulmonary disease, diabetes, and a history of cardiovascular disease.23 , 24 In addition, life-threatening VAs (eg, ventricular tachycardia/ventricular fibrillation) have been documented in ∼6% of hospitalized patients with COVID-19 and appear to be driven by underlying myocardial injury.25
T26 9031-9591 Sentence denotes The proposed mechanisms of acute myocardial injury and resulting VA risk in patients with COVID-19 include (1) direct SARS-CoV-2 myocardial infection (eg, myocarditis), (2) myocardial stress induced by hypoxemic respiratory failure, and/or (3) an exaggerated immune response that results in high levels of circulating cytokines (ie, interleukin-6 [IL-6], tumor necrosis factor-α, etc) directly injuring cardiomyocytes (Figure 1 ).25, 26, 27 Notably, IL-6 may prolong the ventricular action potential via modulation of cardiac ion channel expression/function.27
T27 9592-9776 Sentence denotes Figure 1 Potential gene-environment interactions leading to an increased risk of ventricular arrhythmias and sudden cardiac death in p.Ser1103Tyr-SCN5A–positive patients with COVID-19.
T28 9777-10195 Sentence denotes APD = action potential duration; CHF = congestive heart failure; CKD = chronic kidney disease; COPD = chronic obstructive pulmonary disease; COVID-19 = coronavirus disease 2019; IL-6 = interleukin-6; INa = sodium current; QTc = heart rate–corrected QT; SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2; SCD = sudden cardiac death; SSRI = selective serotonin reuptake inhibitor; VA = ventricular arrhythmia.
T29 10196-10799 Sentence denotes Under normal physiological circumstances, Nav1.5 cardiac sodium channels conduct a tiny amount of persistent/late sodium current that contributes minimally to the maintenance of the action potential plateau (ie ≤0.5% of the peak sodium current [INa]).28 However, in the setting of hypoxia, myocardial ischemia, heart failure, and LQT3-causative SCN5A gain-of-function variants, the relative contribution of the late sodium current can increase up to 10-fold to 4%–5% of the peak INa.16 , 20 , 28 , 29 In turn, this “pathological” late sodium current can prolong ventricular APD and predispose to VA/SCD.
T30 10800-11728 Sentence denotes As discussed previously, p.Ser1103Tyr-SCN5A Nav1.5 sodium channels function normally under physiological conditions (eg, intracellular pH of 6.9–7.1).16 However, when intracellular pH is decreased in vitro to levels consistent with respiratory acidosis that occurs secondary to hypoxia/prolonged apnea (eg, intracellular pH of 6.6–6.8), p.Ser1103Tyr-SCN5A Nav1.5 sodium channels generate a proarrhythmic, LQT3-like increase in persistent/late sodium current (∼5% of the peak INa).16 This mechanism was put forward initially to explain the gene-environment interaction(s) responsible for the association between p.Ser1103Tyr-SCN5A and sudden infant death syndrome.16 However, the profound hypoxia observed in many COVID-19 cases raises reasonable concern that p.Ser1103Tyr-SCN5A could produce a similar African American–specific susceptibility to hypoxia-induced VA/SCD in the setting of SARS-CoV-2 infection/COVID-19 (Figure 1).
T31 11729-11914 Sentence denotes Unfortunately, the increased risk of VA/SCD linked to the potentially proarrhythmic p.Ser1103Tyr-SCN5A common variant is likely not limited to the possibility of hypoxia-induced VA/SCD.
T32 11915-12457 Sentence denotes As succinctly outlined in recent work by Lazzerini et al,27 the exaggerated immune response triggered by SARS-CoV-2 infection, specifically elevation of IL-6, likely increases arrhythmia risk via (1) modulation of cardiac ion channel expression/function leading to APD prolongation (eg, direct IL-6–mediated blockade of hERG/Kv11.1 potassium channels), (2) cardiac sympathetic nervous system hyperactivity, and (3) inhibition of cytochrome P450 enzymes involved in the metabolism of some QTc-prolonging drugs (eg, IL-6 and CYP3A4) (Figure 1).
T33 12458-12756 Sentence denotes The latter effect of IL-6 is particularly important given that a number of COVID-19 pharmacotherapies (eg, hydroxychloroquine ± azithromycin and lopinavir/ritonavir) under investigation and/or in use clinically are known to prolong the QTc interval and predispose to DI-TdP/DI-SCD (Table 2 ).8 , 30
T34 12757-12824 Sentence denotes Table 2 COVID-19–directed pharmacotherapies with DI-TdP/DI-SCD risk
T35 12825-12973 Sentence denotes Possible COVID-19 therapy In vitro inhibition of SARS-CoV-2 CredibleMeds classification VT/VF/TdP/LQTS in FAERS∗ Cardiac arrest in FAERS∗ References
T36 12974-13004 Sentence denotes Repurposed antimalarial agents
T37 13005-13053 Sentence denotes  Chloroquine Yes Known TdP risk 72 54 34, 35, 36
T38 13054-13106 Sentence denotes  Hydroxychloroquine Yes Known TdP risk 222 105 37,38
T39 13107-13134 Sentence denotes Repurposed antiviral agents
T40 13135-13199 Sentence denotes  Lopinavir/ritonavir Unknown† Possible TdP risk 27 48 39, 40, 41
T41 13200-13214 Sentence denotes Adjunct agents
T42 13215-13265 Sentence denotes  Azithromycin Unknown Known TdP risk 396 251 42,43
T43 13266-13633 Sentence denotes COVID-19 = coronavirus disease 2019; DI-SCD = drug-induced sudden cardiac death; DI-TdP = drug-induced torsades de pointes; FAERS = Food and Drug Administration Adverse Event Reporting System; LQTS = long QT syndrome; SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2; TdP = torsades de pointes; VF = ventricular fibrillation; VT = ventricular tachycardia.
T44 13634-13682 Sentence denotes Adapted from Giudicessi et al,8 with permission.
T45 13683-13710 Sentence denotes Copyright © Elsevier, 2020.
T46 13711-13949 Sentence denotes ∗ Adverse event reporting from postmarketing surveillance does not account for prescription volume and is often subjected to significant bias from confounding variables, quality of reported data, duplication, and underreporting of events.
T47 13950-14009 Sentence denotes † Lopinavir/ritonavir inhibits other SARS viruses in vitro.
T48 14010-14081 Sentence denotes However, a recent randomized trial demonstrated no benefit in COVID-19.
T49 14082-14569 Sentence denotes Taken together, these data suggest that 1 in 13 African Americans may be at a substantially increased risk of potentially lethal VAs, most notably DI-TdP, during the COVID-19 pandemic because of the perfect storm of (1) intrinsic genetic susceptibility (ie, p.Ser1103Tyr-SCN5A), (2) modifiable environmental risk factors (eg, electrolyte abnormalities and concurrent QTc-prolonging drug use), and (3) COVID-19–specific risk factors (eg, profound hypoxemia and cytokine storm) (Figure 1).
T50 14570-14873 Sentence denotes Whether population-specific genetic risk factors such as p.Ser1103Tyr-SCN5A are contributing to the spike in sudden deaths and racial health disparities observed in COVID-19 epicenters remains to be proven, and given the lack of banked DNA in these epicenters, this speculation may not even be testable.
T51 14874-15920 Sentence denotes Nevertheless, given the potential for COVID-19 to exacerbate known gene-environment interactions pertaining to the potentially proarrhythmic p.Ser1103Tyr-SCN5A common variant, it seems reasonable (1) to avoid using COVID-19–directed QTc-prolonging drugs (eg, hydroxychloroquine ± azithromycin and lopinavir/ritonavir) unless careful, and preferably personal protective equipment–sparing, cardiac monitoring can be implemented (Figure 2 )8 , 31; (2) to explore the association between p.Ser1103Tyr-SCN5A and rates of sudden death and COVID-19–related mortality in areas with medical record–linked DNA biobanks (eg, UK Biobank); (3) to investigate further the feasibility of point-of-care p.Ser1103Tyr-SCN5A genetic testing; and (4) to determine the clinical utility of QTc-shortening agents such as late sodium current blockers (eg, mexiletine and lidocaine) and anti-IL-6–targeted therapies (eg, tocilizumab and sarilumab)27 , 32 to better protect at-risk individuals, especially African Americans in the context of the ongoing COVID-19 pandemic.
T52 15921-16050 Sentence denotes Figure 2 Proposed approach to mitigating the risk of DI-TdP/DI-SCD in patients with COVID-19 treated with ≥1 QTc-prolonging drug.
T53 16051-16253 Sentence denotes The estimated 99th percentile QTc values, derived from otherwise healthy individuals, that place a patient in the “green light” category are <460 ms before puberty, <470 ms in men, and <480 ms in women.
T54 16254-16397 Sentence denotes We estimate that the baseline QTc assessment will place 90% in the “green light,” 9% in the “yellow light,” and 1% in the “red light” category.
T55 16398-16622 Sentence denotes No randomized controlled trial data are available to support the clinical efficacy of any of the COVID-19–directed QTc-prolonging drugs despite the Food and Drug Administration’s Emergency Use Approval of hydroxychloroquine.
T56 16623-16910 Sentence denotes COVID-19 = coronavirus disease 19; CV = cardiovascular; DI-SCD = drug-induced sudden cardiac death; DI-TdP = drug-induced torsades de pointes; ECG = electrocardiogram; QTc = heart rate–corrected QT; SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2; TdP = torsades de pointes.
T57 16911-16959 Sentence denotes Adapted from Giudicessi et al,8 with permission.
T58 16960-16987 Sentence denotes Copyright © Elsevier, 2020.
T59 16989-16999 Sentence denotes Conclusion
T60 17000-17310 Sentence denotes A potentially pro-arrhythmic common variant, p.Ser1103Tyr-SCN5A, present in 1 out of 13 individuals of African descent has the potential to increase the risk of drug- and hypoxia-induced ventricular arrhythmias/sudden cardiac death and contribute to observed racial health disparities in the COVID-19 pandemic.
T61 17311-17578 Sentence denotes As such, the use of unproven, QTc-prolonging COVID-19-directed therapies, most notably the combination of hydroxychloroquine and azithromycin, should be limited to settings where careful cardiac monitoring can be implemented (e.g. hospital setting or clinical trial).
T62 17580-17704 Sentence denotes This work was supported by the 10.13039/100000871Mayo Clinic Windland Smith Rice Comprehensive Sudden Cardiac Death Program.
T63 17705-17849 Sentence denotes Dr Ackerman is a consultant for Abbott, Audentes Therapeutics, Boston Scientific, Invitae, LQT Therapeutics, Medtronic, MyoKardia, and UpToDate.
T64 17850-17939 Sentence denotes Dr Ackerman and Mayo Clinic are involved in an equity/royalty relationship with AliveCor.
T65 17940-17989 Sentence denotes However, AliveCor was not involved in this study.
T66 17990-18046 Sentence denotes The rest of the authors report no conflicts of interest.

2_test

Id Subject Object Predicate Lexical cue
32380288-31986264-45815350 383-384 31986264 denotes 1
32380288-32087114-45815351 387-388 32087114 denotes 2
32380288-32087114-45815352 597-598 32087114 denotes 2
32380288-32359771-45815353 1736-1737 32359771 denotes 8
32380288-29431662-45815354 3212-3214 29431662 denotes 13
32380288-29431662-45815355 3474-3476 29431662 denotes 13
32380288-29431662-45815356 3858-3860 29431662 denotes 13
32380288-16061744-45815357 3862-3864 16061744 denotes 14
32380288-21498565-45815358 3866-3868 21498565 denotes 15
32380288-16453024-45815359 3870-3872 16453024 denotes 16
32380288-16453024-45815360 4408-4410 16453024 denotes 16
32380288-12193783-45815361 4412-4414 12193783 denotes 17
32380288-22100668-45815362 4559-4561 22100668 denotes 33
32380288-29431662-45815363 4897-4899 29431662 denotes 13
32380288-16061744-45815364 5817-5819 16061744 denotes 14
32380288-21498565-45815365 5822-5824 21498565 denotes 15
32380288-12193783-45815366 5827-5829 12193783 denotes 17
32380288-12193783-45815367 6093-6095 12193783 denotes 17
32380288-16061744-45815368 6202-6204 16061744 denotes 14
32380288-21498565-45815369 6207-6209 21498565 denotes 15
32380288-24332150-45815370 6493-6495 24332150 denotes 18
32380288-16453024-45815371 6647-6649 16453024 denotes 16
32380288-18452875-45815372 6652-6654 18452875 denotes 19
32380288-16453024-45815373 7266-7268 16453024 denotes 16
32380288-12193783-45815374 7271-7273 12193783 denotes 17
32380288-7651517-45815375 7276-7278 7651517 denotes 20
32380288-12193783-45815376 7465-7467 12193783 denotes 17
32380288-16453024-45815377 7484-7486 16453024 denotes 16
32380288-24332150-45815378 7948-7950 24332150 denotes 18
32380288-16453024-45815379 8061-8063 16453024 denotes 16
32380288-18452875-45815380 8066-8068 18452875 denotes 19
32380288-16061744-45815381 8214-8216 16061744 denotes 14
32380288-21498565-45815382 8218-8220 21498565 denotes 15
32380288-16453024-45815383 8222-8224 16453024 denotes 16
32380288-32171076-45815384 8501-8503 32171076 denotes 22
32380288-32201335-45815385 9028-9030 32201335 denotes 25
32380288-32201335-45815386 9461-9463 32201335 denotes 25
32380288-32252591-45815387 9465-9467 32252591 denotes 26
32380288-32286863-45815388 9469-9471 32286863 denotes 27
32380288-32286863-45815389 9589-9591 32286863 denotes 27
32380288-26092781-45815390 10447-10449 26092781 denotes 28
32380288-16453024-45815391 10679-10681 16453024 denotes 16
32380288-7651517-45815392 10684-10686 7651517 denotes 20
32380288-26092781-45815393 10689-10691 26092781 denotes 28
32380288-25460862-45815394 10694-10696 25460862 denotes 29
32380288-16453024-45815395 10950-10952 16453024 denotes 16
32380288-16453024-45815396 11280-11282 16453024 denotes 16
32380288-16453024-45815397 11463-11465 16453024 denotes 16
32380288-32286863-45815398 11972-11974 32286863 denotes 27
32380288-32359771-45815399 12750-12751 32359771 denotes 8
32380288-32267732-45815400 12754-12756 32267732 denotes 30
32380288-32020029-45815401 13037-13045 32020029 denotes 72 54 34
32380288-14729380-45815402 13047-13049 14729380 denotes 35
32380288-17590456-45815403 13051-13053 17590456 denotes 36
32380288-32150618-45815404 13093-13103 32150618 denotes 222 105 37
32380288-16615675-45815405 13104-13106 16615675 denotes 38
32380288-15288617-45815406 13183-13191 15288617 denotes 27 48 39
32380288-32187464-45815407 13193-13195 32187464 denotes 40
32380288-21150558-45815408 13197-13199 21150558 denotes 41
32380288-24001961-45815409 13252-13262 24001961 denotes 396 251 42
32380288-11459586-45815410 13263-13265 11459586 denotes 43
32380288-32359771-45815411 13664-13665 32359771 denotes 8
32380288-32359771-45815412 15311-15312 32359771 denotes 8
32380288-31180747-45815413 15315-15317 31180747 denotes 31
32380288-32286863-45815414 15796-15798 32286863 denotes 27
32380288-32363145-45815415 15801-15803 32363145 denotes 32
32380288-32359771-45815411 13664-13665 32359771 denotes 8
T22307 383-384 31986264 denotes 1
T86135 387-388 32087114 denotes 2
T509 597-598 32087114 denotes 2
T23015 1736-1737 32359771 denotes 8
T69475 3212-3214 29431662 denotes 13
T59593 3474-3476 29431662 denotes 13
T43634 3858-3860 29431662 denotes 13
T13042 3862-3864 16061744 denotes 14
T5430 3866-3868 21498565 denotes 15
T76709 3870-3872 16453024 denotes 16
T40383 4408-4410 16453024 denotes 16
T19044 4412-4414 12193783 denotes 17
T56693 4559-4561 22100668 denotes 33
T34981 4897-4899 29431662 denotes 13
T1660 5817-5819 16061744 denotes 14
T67143 5822-5824 21498565 denotes 15
T28825 5827-5829 12193783 denotes 17
T57146 6093-6095 12193783 denotes 17
T66225 6202-6204 16061744 denotes 14
T53722 6207-6209 21498565 denotes 15
T38432 6493-6495 24332150 denotes 18
T4187 6647-6649 16453024 denotes 16
T35133 6652-6654 18452875 denotes 19
T96522 7266-7268 16453024 denotes 16
T22985 7271-7273 12193783 denotes 17
T67910 7276-7278 7651517 denotes 20
T61322 7465-7467 12193783 denotes 17
T15651 7484-7486 16453024 denotes 16
T18867 7948-7950 24332150 denotes 18
T1613 8061-8063 16453024 denotes 16
T80213 8066-8068 18452875 denotes 19
T75523 8214-8216 16061744 denotes 14
T1716 8218-8220 21498565 denotes 15
T67548 8222-8224 16453024 denotes 16
T24055 8501-8503 32171076 denotes 22
T93588 9028-9030 32201335 denotes 25
T97969 9461-9463 32201335 denotes 25
T98134 9465-9467 32252591 denotes 26
T20408 9469-9471 32286863 denotes 27
T51011 9589-9591 32286863 denotes 27
T28294 10447-10449 26092781 denotes 28
T4756 10679-10681 16453024 denotes 16
T12719 10684-10686 7651517 denotes 20
T76900 10689-10691 26092781 denotes 28
T37978 10694-10696 25460862 denotes 29
T65943 10950-10952 16453024 denotes 16
T73854 11280-11282 16453024 denotes 16
T12532 11463-11465 16453024 denotes 16
T8283 11972-11974 32286863 denotes 27
T75272 12750-12751 32359771 denotes 8
T79624 12754-12756 32267732 denotes 30
T64002 13037-13045 32020029 denotes 72 54 34
T64042 13047-13049 14729380 denotes 35
T40542 13051-13053 17590456 denotes 36
T53939 13093-13103 32150618 denotes 222 105 37
T96635 13104-13106 16615675 denotes 38
T13284 13183-13191 15288617 denotes 27 48 39
T63283 13193-13195 32187464 denotes 40
T30804 13197-13199 21150558 denotes 41
T32587 13252-13262 24001961 denotes 396 251 42
T24305 13263-13265 11459586 denotes 43
T2264 13664-13665 32359771 denotes 8
T79845 15311-15312 32359771 denotes 8
T88811 15315-15317 31180747 denotes 31
T49643 15796-15798 32286863 denotes 27
T47488 15801-15803 32363145 denotes 32
T61924 13664-13665 32359771 denotes 8

PubTator4TogoVar

Id Subject Object Predicate Lexical cue resolved_to
5040 4421-4430 SNP denotes rs1805128 tmVar:rs1805128;VariantGroup:1;CorrespondingGene:3753;RS#:1805128;CorrespondingSpecies:9606
5041 4227-4236 SNP denotes rs7626962 tmVar:rs7626962;VariantGroup:0;CorrespondingGene:6331;RS#:7626962;CorrespondingSpecies:9606

PubTatorOnTogoVar

Id Subject Object Predicate Lexical cue resolved_to
5040 4421-4430 SNP denotes rs1805128 tmVar:rs1805128;VariantGroup:1;CorrespondingGene:3753;RS#:1805128;CorrespondingSpecies:9606
5041 4227-4236 SNP denotes rs7626962 tmVar:rs7626962;VariantGroup:0;CorrespondingGene:6331;RS#:7626962;CorrespondingSpecies:9606
T1 4421-4430 SNP denotes rs1805128 tmVar:rs1805128;VariantGroup:1;CorrespondingGene:3753;RS#:1805128;CorrespondingSpecies:9606
T2 4227-4236 SNP denotes rs7626962 tmVar:rs7626962;VariantGroup:0;CorrespondingGene:6331;RS#:7626962;CorrespondingSpecies:9606